CA2000336A1 - Composes pharmaceutiques a administration intranasale contenant de la calcitonine et vaporisateur - Google Patents

Composes pharmaceutiques a administration intranasale contenant de la calcitonine et vaporisateur

Info

Publication number: CA2000336A1
Authority: CA; Canada
Prior art keywords: administration; pharmaceutical compositions; same; calcitonin; spray unit
Prior art date: 1988-10-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2000336A

Other languages

English (en)

Other versions

CA2000336C (fr

Inventor

Salvatore Mardente

Rodolfo Corneli

Marilena Carazzone

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Alfa Wasserman SpA

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-11

Filing date

1989-10-10

Publication date

1990-04-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26328146&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2000336(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-10-11 Priority claimed from IT8822257A external-priority patent/IT1227174B/it

1988-11-08 Priority claimed from IT8822548A external-priority patent/IT1227472B/it

1989-10-10 Application filed by Individual filed Critical Individual

1990-04-11 Publication of CA2000336A1 publication Critical patent/CA2000336A1/fr

2000-10-03 Application granted granted Critical

2000-10-03 Publication of CA2000336C publication Critical patent/CA2000336C/fr

2009-10-10 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

239000007921 spray Substances 0.000 title abstract 3
102000055006 Calcitonin Human genes 0.000 title abstract 2
108060001064 Calcitonin Proteins 0.000 title abstract 2
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 title abstract 2
229960004015 calcitonin Drugs 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
239000007788 liquid Substances 0.000 abstract 1
239000011780 sodium chloride Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1001—Piston pumps
- B05B11/1016—Piston pumps the outlet valve having a valve seat located downstream a movable valve element controlled by a pressure actuated controlling element
- B05B11/1018—Piston pumps the outlet valve having a valve seat located downstream a movable valve element controlled by a pressure actuated controlling element and the controlling element cooperating with means for opening or closing the inlet valve
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1042—Components or details
- B05B11/1043—Sealing or attachment arrangements between pump and container
- B05B11/1046—Sealing or attachment arrangements between pump and container the pump chamber being arranged substantially coaxially to the neck of the container
- B05B11/1047—Sealing or attachment arrangements between pump and container the pump chamber being arranged substantially coaxially to the neck of the container the pump being preassembled as an independent unit before being mounted on the container
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
- B65D83/52—Metering valves; Metering devices

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Otolaryngology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Organic Chemistry (AREA)
Dispersion Chemistry (AREA)
Mechanical Engineering (AREA)
Inorganic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Measurement Of Resistance Or Impedance (AREA)
Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

CA002000336A 1988-10-11 1989-10-10 Composes pharmaceutiques a administration intranasale contenant de la calcitonine et vaporisateur Expired - Fee Related CA2000336C (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
IT22257A/88		1988-10-11
IT8822257A IT1227174B (it)	1988-10-11	1988-10-11	Composizioni farmaceutiche a base di calcitonina, somministrabili per via intranasale.
IT22548A/88		1988-11-08
IT8822548A IT1227472B (it)	1988-11-08	1988-11-08	Confezione spray per la somministrazione intranasale di calcitonina.

Publications (2)

Publication Number	Publication Date
CA2000336A1 true CA2000336A1 (fr)	1990-04-11
CA2000336C CA2000336C (fr)	2000-10-03

Family

ID=26328146

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002000336A Expired - Fee Related CA2000336C (fr)	1988-10-11	1989-10-10	Composes pharmaceutiques a administration intranasale contenant de la calcitonine et vaporisateur

Country Status (19)

Country	Link
EP (2)	EP0438531B1 (fr)
JP (2)	JPH0649658B2 (fr)
KR (1)	KR0152065B1 (fr)
AU (1)	AU632520B2 (fr)
BR (1)	BR8907708A (fr)
CA (1)	CA2000336C (fr)
DE (1)	DE68912341T2 (fr)
DK (1)	DK64291D0 (fr)
ES (1)	ES2053905T3 (fr)
FI (1)	FI95201C (fr)
GR (1)	GR3007420T3 (fr)
HU (1)	HU212495B (fr)
IE (1)	IE62327B1 (fr)
IL (2)	IL91856A0 (fr)
NO (1)	NO301522B1 (fr)
NZ (1)	NZ230965A (fr)
RO (1)	RO113301B1 (fr)
RU (1)	RU2097064C1 (fr)
WO (1)	WO1990003796A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5026825A (en) *	1988-09-08	1991-06-25	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Intranasal calcitonin formulations
EP0432431B1 (fr) *	1989-11-16	1993-06-16	PHIDEA S.p.A.	Composition liquide pharmaceutique pour application nasale contenant un polypeptide comme ingrédient actif
IT1242019B (it) *	1990-11-20	1994-02-02	Ripari Gero Ist Farm Biolog	Composizioni farmaceutiche acquose a base di calcitonina, da somministrarsi per via nasale.
IT1282374B1 (it) *	1996-01-31	1998-03-20	Therapicon Srl	Composizioni farmaceutiche parenterali a base di calcitonine sintetiche a ph controllato con basso indice di dolorosita'
DE19731472C2 (de) *	1997-07-22	2000-05-25	Gerhard Zellner	Nasenspray-Flüssigkeit
IT1294191B1 (it) *	1997-09-05	1999-03-22	Alfa Wassermann Spa	Composizioni farmaceutiche contenenti calcitonina in un dosatore spray per somministrazione intranasale.
SE9901658D0 (sv) *	1999-05-06	1999-05-06	Astra Ab	New formulation
US6644305B2 (en)	2000-04-14	2003-11-11	Trudell Medical International	Nasal inhaler
DK1539285T4 (da) *	2002-09-03	2012-01-02	Pharmacure Health Care Ab	Næsesprayer
BRPI0819454A2 (pt)	2007-11-29	2015-05-05	Glaxo Group Ltd	Dispositivo para dispensar uma substância
GB2464282A (en) *	2008-10-08	2010-04-14	Archimedes Dev Ltd	A device for administering a dose of opioid analgesic
AU2012213170C1 (en)	2011-02-04	2016-06-30	Kyowa Kirin International UK NewCo Limited	Improved container
DE102011082420B4 (de) *	2011-09-09	2021-02-04	Aptar Radolfzell Gmbh	Flüssigkeitsspender und Austragskopf für einen Flüssigkeitsspender

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA758010B (en) *	1975-11-14	1977-08-31	Syntex Inc	Nasal spray adapter
CY1490A (en) *	1982-02-01	1990-02-16	Sandoz Ltd	Improvements in or relating to nasal pharmaceutical compositions
BE897904A (fr) *	1982-10-05	1984-04-04	Sandoz Sa	Nouvelles compositions galeniques a base de calcitonine
FR2561565B1 (fr) *	1984-03-23	1986-08-01	Norlac Plastiques Sa	Couteau electrique destine notamment a l'ouverture des huitres
GB8407907D0 (en) *	1984-03-27	1984-05-02	Sandoz Ltd	Organic compounds
JPS61118325A (ja) *	1984-11-12	1986-06-05	Yamanouchi Pharmaceut Co Ltd	塩基性および／または中性アミノ酸を含有するカルシトニン経鼻剤
JPS61126034A (ja) *	1984-11-26	1986-06-13	Yamanouchi Pharmaceut Co Ltd	アルド−スを含有するカルシトニン経鼻剤
JPS61194034A (ja) *	1985-02-25	1986-08-28	Teijin Ltd	経鼻投与用粉末状組成物
JPS6310735A (ja) *	1986-07-02	1988-01-18	Yamanouchi Pharmaceut Co Ltd	カルシトニン経鼻剤
JPS6339822A (ja) *	1986-08-04	1988-02-20	Yamanouchi Pharmaceut Co Ltd	カルシトニン経鼻剤

1989
- 1989-10-02 IL IL91856A patent/IL91856A0/xx unknown
- 1989-10-09 JP JP2500510A patent/JPH0649658B2/ja not_active Expired - Lifetime
- 1989-10-09 KR KR1019900701225A patent/KR0152065B1/ko not_active Expired - Fee Related
- 1989-10-09 RU SU4895203/14A patent/RU2097064C1/ru not_active IP Right Cessation
- 1989-10-09 RO RO147309A patent/RO113301B1/ro unknown
- 1989-10-09 BR BR898907708A patent/BR8907708A/pt not_active IP Right Cessation
- 1989-10-09 AU AU46225/89A patent/AU632520B2/en not_active Ceased
- 1989-10-09 EP EP89912812A patent/EP0438531B1/fr not_active Expired - Lifetime
- 1989-10-09 EP EP89118734A patent/EP0363876B1/fr not_active Expired - Lifetime
- 1989-10-09 WO PCT/EP1989/001186 patent/WO1990003796A1/fr not_active Ceased
- 1989-10-09 ES ES89118734T patent/ES2053905T3/es not_active Expired - Lifetime
- 1989-10-09 DE DE89912812T patent/DE68912341T2/de not_active Expired - Lifetime
- 1989-10-09 IE IE325989A patent/IE62327B1/en not_active IP Right Cessation
- 1989-10-09 HU HU896876A patent/HU212495B/hu not_active IP Right Cessation
- 1989-10-10 CA CA002000336A patent/CA2000336C/fr not_active Expired - Fee Related
- 1989-10-10 NZ NZ230965A patent/NZ230965A/en unknown
- 1989-10-10 IL IL9193189A patent/IL91931A/en not_active IP Right Cessation
1991
- 1991-04-10 NO NO911395A patent/NO301522B1/no not_active IP Right Cessation
- 1991-04-10 FI FI911722A patent/FI95201C/fi not_active IP Right Cessation
- 1991-04-10 DK DK91642A patent/DK64291D0/da not_active Application Discontinuation
1993
- 1993-03-22 GR GR930400612T patent/GR3007420T3/el unknown
- 1993-11-30 JP JP5323298A patent/JPH0796034A/ja active Pending

Also Published As

Publication number	Publication date
WO1990003796A1 (fr)	1990-04-19
FI95201B (fi)	1995-09-29
NZ230965A (en)	1992-04-28
IL91856A0 (en)	1990-06-10
EP0363876B1 (fr)	1992-12-23
NO911395D0 (no)	1991-04-10
DK64291A (da)	1991-04-10
DK64291D0 (da)	1991-04-10
JPH03505213A (ja)	1991-11-14
JPH0796034A (ja)	1995-04-11
KR0152065B1 (ko)	1998-10-15
ES2053905T3 (es)	1994-08-01
HU212495B (en)	1996-07-29
DE68912341T2 (de)	1994-05-05
IL91931A0 (en)	1990-06-10
FI95201C (fi)	1996-01-10
AU4622589A (en)	1990-05-01
HUT63577A (en)	1993-09-28
BR8907708A (pt)	1991-07-30
RU2097064C1 (ru)	1997-11-27
CA2000336C (fr)	2000-10-03
NO911395L (no)	1991-04-10
IL91931A (en)	1995-03-15
EP0438531B1 (fr)	1994-01-12
DE68912341D1 (de)	1994-02-24
HU896876D0 (en)	1991-07-29
NO301522B1 (no)	1997-11-10
AU632520B2 (en)	1993-01-07
IE62327B1 (en)	1995-01-25
EP0438531A1 (fr)	1991-07-31
JPH0649658B2 (ja)	1994-06-29
IE893259L (en)	1990-04-11
RO113301B1 (ro)	1998-06-30
EP0363876A1 (fr)	1990-04-18
GR3007420T3 (fr)	1993-07-30
FI911722A0 (fi)	1991-04-10
KR900701306A (ko)	1990-12-01

Legal Events

Date	Code	Title	Description
1996-03-18	EEER	Examination request
2005-10-11	MKLA	Lapsed

Publication	Publication Date	Title
DK356085D0 (da)	1985-08-05	Reninhaemmende peptid eller et farmaceutisk acceptabelt syreadditionssalt deraf
FI884384A0 (fi)	1988-09-23	Yliannostuksen estolla varustettu sumutinpakkaus fysiologisesti aktiivisten aineiden itseannostelemiseksi
AU3590489A (en)	1989-12-07	Use of gamma-hydroxybutyric acid salts in the treatment of alcoholism and pharmaceutical compositions thereof
HUT41631A (en)	1987-05-28	Process for producing pharmaceutical compositions with dissolving the active agents in three periods
IL76932A0 (en)	1986-04-29	Pharmaceutical compositions containing dihydrocodeine and ibuprofen
AU3073789A (en)	1989-10-05	Drug delivery using pulmonary surfactant to facilitate absorption
IL87746A (en)	1992-07-15	Pharmaceutical compositions containing pharmacologically active compounds and water soluble monoesters as solubilisers therefor
AU3449489A (en)	1989-11-03	Improvements relating to spray nozzles
GB8827737D0 (en)	1988-12-29	Improvements in & relating to dispensers
ES2053905T3 (es)	1994-08-01	Composiciones farmaceuticas que contienen calcitonina para administracion intranasal y una unidad pulverizadora para su administracion.
GB8926086D0 (en)	1990-01-10	Improvements relating to water spray systems
AU624617B2 (en)	1992-06-18	Sodium chloride in novel crystal form and aqueous solution containing the same
AU3487189A (en)	1989-11-23	Improvements in or relating to fencing
PL335208A1 (en)	2000-04-10	Aqueous pharmaceutic composition containing an active ingredient being highly insoluble in water
IL70123A0 (en)	1984-02-29	Improvements in or relating to pharmacologically active peptides
GB9316004D0 (en)	1993-09-15	Improvements in or relating to the treatment of sickle cell disease
WO1986002639A3 (fr)	1986-07-17	Application du diethyldithiocarbamate (dtc) a la preparation d'un medicament et son procede de preparation
CA2182812A1 (fr)	1995-08-10	Composition pharmaceutique pour administration transdermique systemique contenant du morphine-6-glucoronide comme principe actif
AU3887385A (en)	1985-08-27	Treatment of wash water in paint spray booths
DE3465742D1 (en)	1987-10-08	Improvements in and relating to pharmacologically active tripeptide derivatives
ZA897202B (en)	1990-06-27	Improvements relating to gerotor pumps
GB2177621B (en)	1989-01-25	Improvements in or relating to spray forming members
NO972303L (no)	1997-05-21	Intravenöse lubeluzollösninger
AU7267787A (en)	1987-11-12	Improvements in and relating to water sprinklers
ZA818149B (en)	1982-10-27	2-hydroxy-5-(2',4'-difluorophenyl)-benzoic acid derivatives,methods for their preparation,use thereof as pharmacologically active agents and pharmaceutical compositions containing them