CA2003665A1 - Compose pharmaceutique contenant des 1-{mono- ou bis (trifluoromethyl)-2-pyridinyl} piperazines - Google Patents

Compose pharmaceutique contenant des 1-{mono- ou bis (trifluoromethyl)-2-pyridinyl} piperazines

Info

Publication number
CA2003665A1
CA2003665A1 CA2003665A CA2003665A CA2003665A1 CA 2003665 A1 CA2003665 A1 CA 2003665A1 CA 2003665 A CA2003665 A CA 2003665A CA 2003665 A CA2003665 A CA 2003665A CA 2003665 A1 CA2003665 A1 CA 2003665A1
Authority
CA
Canada
Prior art keywords
pharmaceutical composition
trifluoromethyl
pyridinyl
piperazines
mono
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2003665A
Other languages
English (en)
Other versions
CA2003665C (fr
Inventor
Patrick Carlier
Andre Monteil
Claude Poisson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of CA2003665A1 publication Critical patent/CA2003665A1/fr
Application granted granted Critical
Publication of CA2003665C publication Critical patent/CA2003665C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
CA002003665A 1988-11-24 1989-11-23 Compose pharmaceutique contenant des 1-{mono- ou bis (trifluoromethyl)-2-pyridinyl} piperazines Expired - Lifetime CA2003665C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP88.402965.3 1988-11-24
EP88402965 1988-11-24

Publications (2)

Publication Number Publication Date
CA2003665A1 true CA2003665A1 (fr) 1990-05-24
CA2003665C CA2003665C (fr) 1999-04-06

Family

ID=8200442

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002003665A Expired - Lifetime CA2003665C (fr) 1988-11-24 1989-11-23 Compose pharmaceutique contenant des 1-{mono- ou bis (trifluoromethyl)-2-pyridinyl} piperazines

Country Status (12)

Country Link
US (1) US4971969A (fr)
EP (1) EP0370560B1 (fr)
JP (1) JP2873025B2 (fr)
KR (1) KR0155543B1 (fr)
AU (1) AU621419B2 (fr)
CA (1) CA2003665C (fr)
DE (1) DE68912282T2 (fr)
DK (1) DK175313B1 (fr)
ES (1) ES2061953T3 (fr)
IE (1) IE62792B1 (fr)
NZ (1) NZ231487A (fr)
ZA (1) ZA898728B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE911774A1 (en) * 1990-06-11 1991-12-18 Akzo Nv Pyridinylpiperazine derivatives
US5877183A (en) * 1996-06-06 1999-03-02 Ergo Research Corporation Treatment of lipid and glucose metabolism disorders with dopamine and serotonin agonists
AU3408097A (en) * 1996-06-06 1998-01-05 Ergo Research Corporation Treatment of lipid and glucose metabolism disorders with dopamine and seroto nin agonists
WO1998033504A1 (fr) * 1997-02-03 1998-08-06 Akzo Nobel N.V. Traitement de l'incontinence urinaire
KR100607838B1 (ko) 1997-10-27 2006-08-04 뉴로서치 에이/에스 니코틴 작용성 아세틸콜린 수용체상의 콜린 작용성 리간드로서의 호모피페라진 유도체 및 이를 포함하는 약제학적 조성물
RU2003113536A (ru) * 2000-10-13 2004-11-10 Акцо Нобель Н.В. (NL) Кристаллические формы гидрохлорида 1-[6-хлор-5-(трифторметил)-2-пиридинил]пиперазина
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
EP1213017A3 (fr) * 2000-12-05 2003-11-12 Akzo Nobel N.V. Utilisation d'un agoniste du récepteur 5-HT2C pour traiter les bouffées de chaleur
US6498184B2 (en) 2000-12-05 2002-12-24 Akzo Nobel N.V. Serotonergic compound for a method of treatment of hot flushes in post-menopausal women
SE0201544D0 (sv) 2002-05-17 2002-05-17 Biovitrum Ab Novel compounds and thier use
US20040081678A1 (en) * 2002-08-09 2004-04-29 Anthony Cincotta Therapeutic process for the treatment of obesity and associated metabolic disorders
US8821915B2 (en) 2002-08-09 2014-09-02 Veroscience, Llc Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders
MXPA05013365A (es) * 2003-06-20 2006-04-05 Arena Pharm Inc Derivados de n-fenil-piperazina y metodos para profilaxis o tratamiento de enfermedades asociadas con el receptor 5ht2c.
JP5173190B2 (ja) 2004-08-25 2013-03-27 武田薬品工業株式会社 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
TW200633721A (en) * 2004-12-14 2006-10-01 Shionogi & Co A pharmaceutical composition for treating constipation
JP5528699B2 (ja) 2006-05-16 2014-06-25 武田薬品工業株式会社 縮合複素環化合物およびその用途
CA2678630C (fr) * 2007-03-05 2015-04-14 F. Hoffmann-La Roche Ag Synthese d'inhibiteurs de glyt-1
JP5520051B2 (ja) 2007-11-15 2014-06-11 武田薬品工業株式会社 縮合ピリジン誘導体およびその用途
US9352025B2 (en) 2009-06-05 2016-05-31 Veroscience Llc Combination of dopamine agonists plus first phase insulin secretagogues for the treatment of metabolic disorders
WO2011071136A1 (fr) 2009-12-11 2011-06-16 アステラス製薬株式会社 Agent thérapeutique pour la fibromyalgie
WO2019131902A1 (fr) 2017-12-27 2019-07-04 武田薬品工業株式会社 Agent thérapeutique pour incontinence urinaire de stress et incontinence fécale

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5690060A (en) * 1979-12-24 1981-07-21 Ishihara Sangyo Kaisha Ltd 2-amino-trifluoromethylpyridine derivative and its preparation
US4547505A (en) * 1983-03-25 1985-10-15 Degussa Aktiengesellschaft N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
FR2573075B1 (fr) * 1984-09-14 1987-03-20 Innothera Lab Sa Nouvelles (pyridyl-2)-1 piperazines, leur procede de preparation et leur application en therapeutique
CA1286672C (fr) * 1985-10-16 1991-07-23 Magid A. Abou-Gharbia Imides bicycliques fusionnes ayant une activite psychotrope
FR2611713B1 (fr) * 1987-02-27 1990-11-30 Adir Nouveaux derives de l'acide (dihydro-2,3 oxo-2 benzofurannyl-3)-2 acetique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US4876256A (en) * 1988-04-29 1989-10-24 Merck & Co., Inc. Alkylpiperazinylpyridines as hypoglycemic agents

Also Published As

Publication number Publication date
EP0370560A1 (fr) 1990-05-30
EP0370560B1 (fr) 1994-01-12
JP2873025B2 (ja) 1999-03-24
CA2003665C (fr) 1999-04-06
DK587989A (da) 1990-05-25
DE68912282T2 (de) 1994-04-28
AU621419B2 (en) 1992-03-12
NZ231487A (en) 1991-01-29
ZA898728B (en) 1990-08-29
KR0155543B1 (ko) 1998-11-16
DE68912282D1 (de) 1994-02-24
AU4538789A (en) 1990-05-31
JPH02184672A (ja) 1990-07-19
DK587989D0 (da) 1989-11-22
DK175313B1 (da) 2004-08-16
US4971969A (en) 1990-11-20
IE62792B1 (en) 1995-03-08
ES2061953T3 (es) 1994-12-16
KR900007419A (ko) 1990-06-01
IE893654L (en) 1990-05-24

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Legal Events

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EEER Examination request
MKLA Lapsed
MKEC Expiry (correction)

Effective date: 20121202