CA2093798A1 - Derives pyridine et n-oxyde de pyridine de diaryle methyle piperidines ou piperazines; compositions et methodes de preparation - Google Patents

Derives pyridine et n-oxyde de pyridine de diaryle methyle piperidines ou piperazines; compositions et methodes de preparation

Info

Publication number
CA2093798A1
CA2093798A1 CA2093798A CA2093798A CA2093798A1 CA 2093798 A1 CA2093798 A1 CA 2093798A1 CA 2093798 A CA2093798 A CA 2093798A CA 2093798 A CA2093798 A CA 2093798A CA 2093798 A1 CA2093798 A1 CA 2093798A1
Authority
CA
Canada
Prior art keywords
pyridine
methods
piperazines
oxide derivatives
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2093798A
Other languages
English (en)
Other versions
CA2093798C (fr
Inventor
John J. Piwinski
Jesse Wong
Michael J. Green
Vera Seidl
Richard Friary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2093798A1 publication Critical patent/CA2093798A1/fr
Application granted granted Critical
Publication of CA2093798C publication Critical patent/CA2093798C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Pyridine et dérivés de N-oxyde de pyridine de pipéridines ou de pipérazines de méthyle diaryle correspondant à la formule structurelle (1.0), et sels pharmaceutiquement acceptables de ces composés. Ces substances présentent une activité anti-allergique et anti-inflammatoire. L'invention concerne en outre des compositions pharmaceutiques renfermant ces composés et des procédés d'utilisation de ces dernières.
CA002093798A 1990-10-10 1991-10-08 Derives pyridine et n-oxyde de pyridine de diaryle methyle piperidines ou piperazines; compositions et methodes de preparation Expired - Fee Related CA2093798C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59533090A 1990-10-10 1990-10-10
US595,330 1990-10-10
PCT/US1991/007169 WO1992006971A1 (fr) 1990-10-10 1991-10-08 Pyridine et derives de n-oxyde de pyridine, de piperidines ou de piperazines de methyle diaryle, compositions et procedes d'utilisation de ces dernieres

Publications (2)

Publication Number Publication Date
CA2093798A1 true CA2093798A1 (fr) 1992-04-11
CA2093798C CA2093798C (fr) 2000-02-01

Family

ID=24382813

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002093798A Expired - Fee Related CA2093798C (fr) 1990-10-10 1991-10-08 Derives pyridine et n-oxyde de pyridine de diaryle methyle piperidines ou piperazines; compositions et methodes de preparation

Country Status (22)

Country Link
US (1) US5432175A (fr)
EP (1) EP0553191B1 (fr)
JP (1) JPH089596B2 (fr)
KR (1) KR970005927B1 (fr)
AT (1) ATE122673T1 (fr)
AU (1) AU646519B2 (fr)
CA (1) CA2093798C (fr)
CZ (1) CZ280532B6 (fr)
DE (1) DE69109871T2 (fr)
DK (1) DK0553191T3 (fr)
ES (1) ES2072627T3 (fr)
FI (1) FI931600L (fr)
HK (1) HK186596A (fr)
HU (1) HUT66081A (fr)
IE (1) IE67808B1 (fr)
IL (1) IL99676A (fr)
MY (1) MY108616A (fr)
NO (1) NO305028B1 (fr)
PH (1) PH31566A (fr)
SK (1) SK31793A3 (fr)
WO (1) WO1992006971A1 (fr)
ZA (1) ZA918044B (fr)

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CA2136007C (fr) * 1993-03-17 1999-12-14 Kiyoaki Katano Nouveau compose agissant comme inhibiteur de l'agregation plaquettaire
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DE10035928A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
AU2002259147A1 (en) 2001-05-08 2002-11-18 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
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US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
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AR036492A1 (es) * 2001-09-06 2004-09-15 Schering Corp Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos inhibidores para la elaboracion de un medicamento para el tratamiento de enfermedades androgeno dependientes
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US7198606B2 (en) 2002-04-19 2007-04-03 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with analyte sensing
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WO2006001797A1 (fr) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Element penetrant peu douloureux
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Also Published As

Publication number Publication date
FI931600A7 (fi) 1993-05-17
WO1992006971A1 (fr) 1992-04-30
EP0553191B1 (fr) 1995-05-17
HK186596A (en) 1996-10-11
US5432175A (en) 1995-07-11
ATE122673T1 (de) 1995-06-15
IE67808B1 (en) 1996-05-01
NO931312D0 (no) 1993-04-06
NO931312L (no) 1993-06-10
CZ62293A3 (en) 1994-02-16
PH31566A (en) 1998-11-03
IL99676A (en) 1995-11-27
FI931600A0 (fi) 1993-04-08
SK31793A3 (en) 1993-09-08
AU8849091A (en) 1992-05-20
ZA918044B (en) 1992-07-29
IL99676A0 (en) 1992-08-18
NO305028B1 (no) 1999-03-22
AU646519B2 (en) 1994-02-24
DE69109871D1 (de) 1995-06-22
MY108616A (en) 1996-10-31
HUT66081A (en) 1994-09-28
KR970005927B1 (ko) 1997-04-22
DE69109871T2 (de) 1995-09-14
DK0553191T3 (da) 1995-08-07
EP0553191A1 (fr) 1993-08-04
JPH05508660A (ja) 1993-12-02
FI931600L (fi) 1993-05-17
HU9301051D0 (en) 1993-07-28
ES2072627T3 (es) 1995-07-16
JPH089596B2 (ja) 1996-01-31
CA2093798C (fr) 2000-02-01
IE913571A1 (en) 1992-04-22
CZ280532B6 (cs) 1996-02-14

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