CA2007507A1 - Sphingosine et n-methyl-sphingosine inhibiteurs de la croissance des cellules - Google Patents

Sphingosine et n-methyl-sphingosine inhibiteurs de la croissance des cellules

Info

Publication number: CA2007507A1
Authority: CA; Canada
Prior art keywords: sphingosine; methyl; pharmaceutically acceptable; prepared; growth
Prior art date: 1989-02-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2007507A

Other languages

English (en)

Other versions

CA2007507C (fr

Inventor

Yasuyuki Igarashi

Tatsushi Toyokuni

Sen-Itiroh Hakomori

Efraim Racker

Shuji Fujita

Mamoru Sugimoto

Masayoshi Ito

Yoshiyasu Shitori

Tomoya Ogawa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mect Corp

Cornell Research Foundation Inc

Biomembrane Institute

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-03

Filing date

1990-01-10

Publication date

1990-08-03

1990-01-10 Application filed by Individual filed Critical Individual

1990-08-03 Publication of CA2007507A1 publication Critical patent/CA2007507A1/fr

1998-05-19 Application granted granted Critical

1998-05-19 Publication of CA2007507C publication Critical patent/CA2007507C/fr

2010-01-10 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 title abstract 5
230000010261 cell growth Effects 0.000 title abstract 5
PTGGMPLMNDBPGB-CXISOLTFSA-N n-[(e,2s,3r)-1,3-dihydroxyoctadec-4-en-2-yl]formamide Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC=O PTGGMPLMNDBPGB-CXISOLTFSA-N 0.000 title abstract 5
WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 title abstract 5
239000003112 inhibitor Substances 0.000 title 1
230000002401 inhibitory effect Effects 0.000 abstract 8
210000004102 animal cell Anatomy 0.000 abstract 4
230000012010 growth Effects 0.000 abstract 4
239000003966 growth inhibitor Substances 0.000 abstract 4
210000005260 human cell Anatomy 0.000 abstract 4
150000003839 salts Chemical class 0.000 abstract 4
150000003408 sphingolipids Chemical class 0.000 abstract 4
210000004027 cell Anatomy 0.000 abstract 2
239000003085 diluting agent Substances 0.000 abstract 2
239000003814 drug Substances 0.000 abstract 2
239000003937 drug carrier Substances 0.000 abstract 2
238000001727 in vivo Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000000546 pharmaceutical excipient Substances 0.000 abstract 2

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002007507A 1989-02-03 1990-01-10 Sphingosine et n-methyl-sphingosine inhibiteurs de la croissance des cellules Expired - Fee Related CA2007507C (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US30637889A	1989-02-03	1989-02-03
US306,378		1989-02-03
US39013589A	1989-08-07	1989-08-07
US390,135		1989-08-07

Publications (2)

Publication Number	Publication Date
CA2007507A1 true CA2007507A1 (fr)	1990-08-03
CA2007507C CA2007507C (fr)	1998-05-19

Family

ID=26975128

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002007507A Expired - Fee Related CA2007507C (fr)	1989-02-03	1990-01-10	Sphingosine et n-methyl-sphingosine inhibiteurs de la croissance des cellules

Country Status (6)

Country	Link
EP (1)	EP0381514B1 (fr)
JP (1)	JP2976055B2 (fr)
AT (1)	ATE122560T1 (fr)
CA (1)	CA2007507C (fr)
DE (1)	DE69019388T2 (fr)
DK (1)	DK0381514T3 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5583160A (en) *	1989-02-03	1996-12-10	The Biomembrane Institute	Methylsphingosine used to treat apoptosis
US5151360A (en) *	1990-12-31	1992-09-29	Biomembrane Institute	Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
US5260288A (en) *	1992-04-03	1993-11-09	The Biomembrane Institute	Method for inhibition of cell motility by sphingosine-1-phosphate and derivatives
IL121320A (en)	1997-02-23	2000-12-06	Ibr Ltd	Extracts from cells or tissue of organisms which are capable of entering dormancy for inhibition of proliferation of target cells or tissue
US6800661B1 (en)	1997-04-15	2004-10-05	Board Of Trustees Of The University Of Illinois	Spisulosine compounds
USRE38793E1 (en)	1997-04-15	2005-09-06	Rinehart Kenneth L	Spisulosine compounds
US6107520A (en) *	1997-04-15	2000-08-22	The Board Of Trustees Of The University Of Illinois	Spisulosine compounds
AUPO900297A0 (en) *	1997-09-08	1997-10-02	Medvet Science Pty. Ltd.	A method of modulating cellular activity
US6649362B2 (en)	1997-09-08	2003-11-18	Medvet Science Pty. Ltd.	Screening method for an agent having an effect on a sphingosine kinase signaling pathway
AU2001233873B2 (en) *	2000-02-16	2006-03-02	Pharma Mar, S.A.	Oxy-and amino-substituted tetrahydrofuryl derivatives with antitumour activity
EP1195604A1 (fr) *	2000-09-29	2002-04-10	Warner-Lambert Company	Procedés et compositions pour la sondage de modulateurs de lipide kinases
WO2002060405A1 (fr) *	2001-01-29	2002-08-08	Cosmoferm B.V.	Composition dermatologique veterinaire contenant une base sphingoide et/ou un derive de base sphingoide
KR100457113B1 (ko) *	2001-12-27	2004-11-16	한국원자력연구소	세라마이드류 또는 그 유도체와 다이메틸스핑고신을 유효성분으로 포함하는 방사선민감도 증진제
KR100459484B1 (ko) *	2002-05-20	2004-12-03	한국원자력연구소	엔-아세틸 파이토스핑고신과 다이메틸 파이토스핑고신을유효 성분으로 포함하는 방사선 치료 민감제 조성물
EP1426053A1 (fr) *	2002-12-03	2004-06-09	Fresenius Kabi Deutschland GmbH	Utilisation de lipides amphiphiles pour l'inhibition de métastases
EP1830829B1 (fr)	2004-11-30	2012-01-04	Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO	Sphingolipides dans le traitement et la prevention de la steatose hepatique
CA2817198C (fr) *	2009-11-12	2018-05-01	Texas Tech University	Compositions et methodes de traitement de troubles hyperproliferatifs
LT3615544T (lt)	2017-04-27	2023-05-10	Pharma Mar S.A.	Priešnavikiniai junginiai

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4816450A (en) *	1986-09-15	1989-03-28	Duke University	Inhibition of protein kinase C by long-chain bases

1990
- 1990-01-10 CA CA002007507A patent/CA2007507C/fr not_active Expired - Fee Related
- 1990-02-02 EP EP90301099A patent/EP0381514B1/fr not_active Expired - Lifetime
- 1990-02-02 DE DE69019388T patent/DE69019388T2/de not_active Expired - Fee Related
- 1990-02-02 AT AT90301099T patent/ATE122560T1/de not_active IP Right Cessation
- 1990-02-02 JP JP2025010A patent/JP2976055B2/ja not_active Expired - Fee Related
- 1990-02-02 DK DK90301099.9T patent/DK0381514T3/da active

Also Published As

Publication number	Publication date
EP0381514A2 (fr)	1990-08-08
DE69019388D1 (de)	1995-06-22
ATE122560T1 (de)	1995-06-15
EP0381514A3 (fr)	1991-07-17
CA2007507C (fr)	1998-05-19
JPH03157336A (ja)	1991-07-05
JP2976055B2 (ja)	1999-11-10
DK0381514T3 (da)	1995-09-04
DE69019388T2 (de)	1996-01-04
EP0381514B1 (fr)	1995-05-17

Similar Documents

Publication	Publication Date	Title
EP0381514A3 (fr)	1991-07-17	Utilisation de la N-méthyl-sphingosine comme inhibiteur de la croissance cellulaire
AU576365B2 (en)	1988-08-25	Collagen and or fibrinogen as carrier of drugs for their introduction into cellular lesion areas
CA2296036A1 (fr)	1999-01-28	Derives de dolastatine 15
TW376319B (en)	1999-12-11	Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
CA2257121A1 (fr)	1998-01-08	Methodes et compositions pour le traitement de l'incontinence urinaire utilisant (s)-oxybutynine
CA2217477A1 (fr)	1996-10-10	Composes tricycliques utiles a l'inhibition de la transferase de proteine farnesyle
CA2293706A1 (fr)	1998-12-23	Nouveaux composes d'uree n-substitues inhibiteurs de la farnesyl transferase
MX9707665A (es)	1997-11-29	Compuestos triciclicos utiles para inhibir la funcion de la proteina g y para el tratamiento de enfermedades proliferativas.
GR3034974T3 (en)	2001-02-28	Treating urinary incontinence using (s)-oxybutynin and (s)-desethyloxybutynin
AU5432596A (en)	1996-10-23	Tricyclic compounds useful in the treatment of cell prolifer ative disorders
ATE226249T1 (de)	2002-11-15	Herstellung des inhibitors fuer die komplexbildung des gewebefaktors
AU7239996A (en)	1997-04-09	Inhibition of tumor necrosis factor alpha
MY110104A (en)	1998-01-27	Saccharin derivative proteolytic enzyme inhibitors
WO1990009993A3 (fr)	1990-11-01	Procede de synthese de l'huperzine a et ses analogues, et composes utiles dans cette synthese
MY143570A (en)	2011-05-31	Compounds useful for inhibition of farnesyl protein transferase
PL326554A1 (en)	1998-09-28	Derivatives of amine and thiourea and inhibitors of nitrogen oxide synthase
HUT57204A (en)	1991-11-28	Process for producing 4-fluoro-2-///4-methoxy-2-pyridinyl/-methyl/-sulfinyl/-1h-benzimidazol with gastric acid secration-diminishing activity and pharmaceutical compositions containing them
MY103871A (en)	1993-09-30	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis.
NO944407L (no)	1994-11-17	Alkoholer som kalium-kanalåpnere og ved behandling av urin-inkontinens
PL320342A1 (en)	1997-09-29	Thrombin inhibitor containing infusion solution, stable during storage
AU644621B2 (en)	1993-12-16	Pharmaceutical composition for treating or preventing retroviral infections
AU2534595A (en)	1995-12-21	Angiotensin ii for improving fertilization
DE69926078D1 (en)	2005-08-11	Farnesyl-protein transferase inhibitoren
CA2293358A1 (fr)	1998-12-23	Sulfonamides tricycliques servant a inhiber la farnesyl-proteine transferase
MX9701333A (es)	1997-05-31	Metodos para inhibir el daño neuronal.

Legal Events

Date	Code	Title	Description
1993-04-27	EEER	Examination request
2005-01-10	MKLA	Lapsed