CA2014885A1 - 6,11-dihydro-5h-pyrido[2,3-b] [1,5] benzodiazepin-5-ones et thiones et leur utilisation dans la prevention et le traitement du sida - Google Patents

6,11-dihydro-5h-pyrido[2,3-b] [1,5] benzodiazepin-5-ones et thiones et leur utilisation dans la prevention et le traitement du sida

Info

Publication number: CA2014885A1
Authority: CA; Canada
Prior art keywords: benzodiazepin; pyrido; dihydro; ones; thiones
Prior art date: 1989-04-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2014885A

Other languages

English (en)

Other versions

CA2014885C (fr

Inventor

Gunther Schmidt (Deceased)

Wolfhard Engel

Gunter Trummlitz

Wolfgang Eberlein

Karl D. Hargrave

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Boehringer Ingelheim Pharmaceuticals Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-20

Filing date

1990-04-19

Publication date

1990-10-20

1990-04-19 Application filed by Individual filed Critical Individual

1990-10-20 Publication of CA2014885A1 publication Critical patent/CA2014885A1/fr

2000-12-26 Application granted granted Critical

2000-12-26 Publication of CA2014885C publication Critical patent/CA2014885C/fr

2010-04-19 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

SFRAVXBSPHJEBZ-UHFFFAOYSA-N 6,11-dihydropyrido[3,2-c][1,5]benzodiazepin-5-one Chemical class O=C1NC2=CC=CC=C2NC2=NC=CC=C12 SFRAVXBSPHJEBZ-UHFFFAOYSA-N 0.000 title abstract 2
241001061127 Thione Species 0.000 title 1
230000002265 prevention Effects 0.000 title 1
208000030507 AIDS Diseases 0.000 abstract 1
208000031886 HIV Infections Diseases 0.000 abstract 1
208000037357 HIV infectious disease Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Virology (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

CA002014885A 1989-04-20 1990-04-19 6,11-dihydro-5h-pyrido[2,3-b] [1,5] benzodiazepin-5-ones et thiones et leur utilisation dans la prevention et le traitement du sida Expired - Fee Related CA2014885C (fr)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date
US34097389A	1989-04-20	1989-04-20
US07/340,973		1989-04-20
US37273289A	1989-06-28	1989-06-28
US07/372,732		1989-06-28
US43857089A	1989-11-17	1989-11-17
US07/438,570		1989-11-17

Publications (2)

Publication Number	Publication Date
CA2014885A1 true CA2014885A1 (fr)	1990-10-20
CA2014885C CA2014885C (fr)	2000-12-26

Family

ID=27407436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002014885A Expired - Fee Related CA2014885C (fr)	1989-04-20	1990-04-19	6,11-dihydro-5h-pyrido[2,3-b] [1,5] benzodiazepin-5-ones et thiones et leur utilisation dans la prevention et le traitement du sida

Country Status (5)

Country	Link
EP (1)	EP0393604B1 (fr)
JP (1)	JP2656133B2 (fr)
AT (1)	ATE161535T1 (fr)
CA (1)	CA2014885C (fr)
DE (1)	DE69031845T2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5366972A (en) *	1989-04-20	1994-11-22	Boehringer Ingelheim Pharmaceuticals, Inc.	5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
CA2030056C (fr) *	1989-11-17	1995-10-17	Karl D. Hargrave	5,11-dihydro-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepines et leur utilisation pour la prevention ou le traitement de l'infection par le hiv
EP0475231A1 (fr) *	1990-09-10	1992-03-18	F. Hoffmann-La Roche Ag	Benzodiazépines
DK0498290T3 (fr) *	1991-02-07	1997-02-10	Boehringer Ingelheim Pharma
GB9109557D0 (en) *	1991-05-02	1991-06-26	Wellcome Found	Chemical compounds
US6177435B1 (en)	1992-05-13	2001-01-23	Glaxo Wellcome Inc.	Therapeutic combinations
AU5883794A (en) *	1993-01-20	1994-08-15	A. Menarini Industrie Farmaceutiche Riunite S.R.L.	Diazepin derivatives and antiviral compositions
AU3754495A (en) *	1994-10-31	1996-05-23	Yamanouchi Pharmaceutical Co., Ltd.	Novel benzodiazepinone derivative and medicinal composition thereof
US6593337B1 (en)	1999-10-19	2003-07-15	Bristol-Myers Squibb Pharma Company	Tricyclic compounds useful as HIV reverse transcriptase inhibitors
FR2850654A1 (fr) *	2003-02-03	2004-08-06	Servier Lab	Nouveaux derives d'azepines tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN107428747A (zh)	2014-11-25	2017-12-01	拜耳制药股份公司	取代的吡啶并苯并二氮杂*酮衍生物及其用途
CN110818710B (zh) *	2019-12-04	2021-02-09	石河子大学	一种苯并二氮卓类化合物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2424811C3 (de) *	1974-05-22	1981-08-20	Dr. Karl Thomae Gmbh, 7950 Biberach	Pyrido-benzodiazepinone, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2644121A1 (de) *	1976-09-30	1978-04-06	Thomae Gmbh Dr K	Neue pyridobenzodiazepinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3818299A1 (de) *	1988-05-30	1989-12-07	Thomae Gmbh Dr K	Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

1990
- 1990-04-18 DE DE69031845T patent/DE69031845T2/de not_active Expired - Fee Related
- 1990-04-18 AT AT90107293T patent/ATE161535T1/de not_active IP Right Cessation
- 1990-04-18 EP EP90107293A patent/EP0393604B1/fr not_active Expired - Lifetime
- 1990-04-19 CA CA002014885A patent/CA2014885C/fr not_active Expired - Fee Related
- 1990-04-20 JP JP2105098A patent/JP2656133B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0393604B1 (fr)	1997-12-29
CA2014885C (fr)	2000-12-26
DE69031845T2 (de)	1998-05-07
ATE161535T1 (de)	1998-01-15
JP2656133B2 (ja)	1997-09-24
JPH0363274A (ja)	1991-03-19
EP0393604A2 (fr)	1990-10-24
DE69031845D1 (de)	1998-02-05
EP0393604A3 (fr)	1991-09-11

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Legal Events

Date	Code	Title	Description
1997-04-18	EEER	Examination request
2004-04-19	MKLA	Lapsed