CA2015687A1 - Polypeptide de fusion d'albumine humaine - Google Patents

Polypeptide de fusion d'albumine humaine

Info

Publication number
CA2015687A1
CA2015687A1 CA2015687A CA2015687A CA2015687A1 CA 2015687 A1 CA2015687 A1 CA 2015687A1 CA 2015687 A CA2015687 A CA 2015687A CA 2015687 A CA2015687 A CA 2015687A CA 2015687 A1 CA2015687 A1 CA 2015687A1
Authority
CA
Canada
Prior art keywords
terminal
terminal portion
human serum
fusion polypeptide
hsa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2015687A
Other languages
English (en)
Other versions
CA2015687C (fr
Inventor
David J. Ballance
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albumedix Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2015687A1 publication Critical patent/CA2015687A1/fr
Application granted granted Critical
Publication of CA2015687C publication Critical patent/CA2015687C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002015687A 1989-04-29 1990-04-27 Polypeptide de fusion d'albumine humaine Expired - Lifetime CA2015687C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB8909916.2 1989-04-29
GB898909916A GB8909916D0 (en) 1989-04-29 1989-04-29 Polypeptides

Publications (2)

Publication Number Publication Date
CA2015687A1 true CA2015687A1 (fr) 1990-10-29
CA2015687C CA2015687C (fr) 2000-08-29

Family

ID=10656000

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002015687A Expired - Lifetime CA2015687C (fr) 1989-04-29 1990-04-27 Polypeptide de fusion d'albumine humaine

Country Status (12)

Country Link
EP (1) EP0470165A1 (fr)
JP (1) JP2781459B2 (fr)
KR (1) KR100227167B1 (fr)
AU (1) AU630450B2 (fr)
CA (1) CA2015687C (fr)
FI (1) FI104255B (fr)
GB (2) GB8909916D0 (fr)
HU (1) HUT61049A (fr)
IE (1) IE67651B1 (fr)
IL (1) IL94243A (fr)
WO (1) WO1990013653A1 (fr)
ZA (1) ZA903237B (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FR2686900B1 (fr) * 1992-01-31 1995-07-21 Rhone Poulenc Rorer Sa Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant.
WO1994016085A2 (fr) * 1992-12-30 1994-07-21 Zymogenetics, Inc. Proteines hybrides presentant des activites de reticulation et de liaison tissulaire
GB9408466D0 (en) * 1994-04-27 1994-06-22 Univ Nottingham Cloning and functional expression of neurotoxins
US5543308A (en) * 1994-10-18 1996-08-06 New England Biolabs, Inc. Isolated DNA encoding the FSEI restriction endonuclease and related methods for producing the same
US7112320B1 (en) 1995-06-07 2006-09-26 Andre Beaulieu Solid wound healing formulations containing fibronectin
US5877149A (en) 1995-06-07 1999-03-02 Beaulieu; Andre Deepithelialized skin diffusion cell system
US5641483A (en) * 1995-06-07 1997-06-24 Beaulieu; Andre Wound healing formulations containing human plasma fibronectin
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US6423512B1 (en) 1996-07-26 2002-07-23 Novartis Ag Fusion polypeptides
AR008077A1 (es) * 1996-07-26 1999-12-09 Talarico Salinas Laura Beatriz Un polipeptido de fusion o una sal del mismo, su uso, un proceso para prepararlos, una composicion farmaceutica que los comprende, y un vector.
US5932693A (en) * 1996-12-10 1999-08-03 Washington University Antithrombotic peptides
AU2149899A (en) 1998-01-23 1999-08-09 Novo Nordisk A/S Process for making desired polypeptides in yeast
DE69933216T2 (de) 1998-06-15 2007-09-20 GTC Biotherapeutics, Inc., Framingham Erythropoietin-analog-menschliches serum-albumin fusionsprotein
EP2213743A1 (fr) * 2000-04-12 2010-08-04 Human Genome Sciences, Inc. Protéines de fusion d'albumine
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
KR100888915B1 (ko) 2001-08-15 2009-03-16 다카라 바이오 가부시키가이샤 항원특이적 세포상해성 ｔ 세포 확대배양방법
WO2005003296A2 (fr) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Proteines hybrides d'albumine
AU2002364586A1 (en) 2001-12-21 2003-07-30 Delta Biotechnology Limited Albumin fusion proteins
JP4406566B2 (ja) 2002-03-25 2010-01-27 タカラバイオ株式会社 細胞傷害性リンパ球の製造方法
KR101331746B1 (ko) * 2003-08-22 2013-11-20 다카라 바이오 가부시키가이샤 세포 상해성 림프구의 제조 방법
US7850970B2 (en) 2003-08-26 2010-12-14 The Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
US9057061B2 (en) 2003-12-23 2015-06-16 Novozymes Biopharma Dk A/S Gene expression technique
WO2006067511A1 (fr) 2004-12-23 2006-06-29 Novozymes Delta Limited Technique d'expression genetique
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
EP1816201A1 (fr) 2006-02-06 2007-08-08 CSL Behring GmbH Facteur de coagulation VIIa modifié ayant une stabilité 'half-life' améliorée
WO2007146038A2 (fr) 2006-06-07 2007-12-21 Human Genome Sciences, Inc. Protéines de fusion d'albumine
EP2049560B1 (fr) 2006-07-13 2013-05-15 Novozymes Biopharma DK A/S Procédé de fabrication de particules d'un matériau protéique
KR101722961B1 (ko) 2009-02-11 2017-04-04 알부메딕스 에이/에스 알부민 변이체 및 접합체
EP2493921B1 (fr) 2009-10-30 2018-09-26 Albumedix Ltd Variants d'albumine
EP2556087A1 (fr) 2010-04-09 2013-02-13 Novozymes Biopharma DK A/S Dérivés et variants d'albumine
WO2012178102A2 (fr) * 2011-06-24 2012-12-27 The Regents Of The Unversity Of Colorado, A Body Corporate Compositions, procédés et utilisations de molécules de fusion de l'alpha-1 antitrypsine
EP2780364A2 (fr) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Protéines ayant une demi-vie et d'autres propriétés améliorées
DK2825556T3 (en) 2012-03-16 2018-04-16 Albumedix As albumin Variants
MX2015005363A (es) 2012-11-08 2015-11-06 Novozymes Biopharma Dk As Variantes de albumina.
EP2968587A2 (fr) 2013-03-13 2016-01-20 Bristol-Myers Squibb Company Domaines d'échafaudage à base de fibronectine liés à une sérum albumine ou fragment se liant à celle-ci
JP7007261B2 (ja) 2015-08-20 2022-01-24 アルブミディクス リミティド アルブミン変異体及びコンジュゲート
WO2018089702A1 (fr) * 2016-11-10 2018-05-17 Keros Therapeutics, Inc. Polypeptides de fusion gdnf et leurs procédés d'utilisation
CA3117961A1 (fr) * 2018-10-29 2020-05-07 Spin Therapeutics, Llc Compositions et methodes pour les dereglements de l'alpha-1 antitrypsine
EP3711772A1 (fr) 2019-03-20 2020-09-23 Oslo Universitetssykehus HF Protéines recombinantes et protéines de fusion

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE459586B (sv) * 1987-09-14 1989-07-17 Mta Szegedi Biolog Koezponti Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning
GB8725529D0 (en) * 1987-10-30 1987-12-02 Delta Biotechnology Ltd Polypeptides

Also Published As

Publication number Publication date
GB8909916D0 (en) 1989-06-14
HU904413D0 (en) 1992-01-28
FI915073A0 (fi) 1991-10-28
HUT61049A (en) 1992-11-30
WO1990013653A1 (fr) 1990-11-15
IL94243A (en) 1995-10-31
KR920701451A (ko) 1992-08-11
EP0470165A1 (fr) 1992-02-12
GB2246783B (en) 1992-10-14
IE901554L (en) 1990-10-29
AU5564690A (en) 1990-11-29
IL94243A0 (en) 1991-01-31
FI104255B1 (fi) 1999-12-15
GB2246783A (en) 1992-02-12
JPH04506598A (ja) 1992-11-19
JP2781459B2 (ja) 1998-07-30
ZA903237B (en) 1991-03-27
AU630450B2 (en) 1992-10-29
CA2015687C (fr) 2000-08-29
KR100227167B1 (ko) 1999-10-15
GB9119043D0 (en) 1991-12-04
FI104255B (fi) 1999-12-15
IE67651B1 (en) 1996-04-17

Similar Documents

Publication Publication Date Title
CA2015687A1 (fr) Polypeptide de fusion d'albumine humaine
CA2050336A1 (fr) Systeme de traitement des levures comportant un acide amine charge negativement adjacent au site de traitement
AU9156291A (en) Polypeptide analogs of apolipoprotein e, diagnostic systems and methods using the analogs
CA2025598A1 (fr) Proteines d'antigene nucleocapsidique d'hepadnavirus chimerique
CA2083271A1 (fr) Polypeptides du domaine de liaison de la fibrine, leurs utilisations et leurs methodes de fabrication
AU543198B2 (en) Hexapeptides
EP0370989A3 (fr) Facteur de perméabilité vasculaire humain
IL70601A (en) Synthetic heat-stable enterotoxin polypeptides of escherichia coli,multimers thereof,vaccines,diagnostic systems and network polymers including same and methods for their preparation
EP0330451A3 (fr) CADN codant pour la sérumalbumine humaine normale et procédé de production de l'albumine
AU4647889A (en) Insect signal peptide mediated secretion of recombinant proteins
AU6332399A (en) Member of the tnf ligand family
ZA905480B (en) Antagonists of gm-csf derived from the carboxyl terminus
WO2001025438A3 (fr) Homologues d'interferons alpha
KR100295606B1 (fr)
EP0187721A3 (fr) Préparation de substrats peptidiques pour les protéases virus-spécifiées
Gluschankof et al. The somatostatin-28 convertase of rat brain cortex generates both somatostatin-14 and somatostatin-28 (1–12)
CA2083177A1 (fr) Proteines surfactantes alveolaires
EP0249477A3 (fr) Polypeptides-analogues fonctionnels recombinants dépourvus d'acides aminés hydrophobes
AU7166891A (en) Method of purifying recombinant polypeptides
WO1999002708A8 (fr) Proteines de fusion comprenant des structures bispiralees derivees de la proteine inhibitrice de if1 atpase bovine
AU5407190A (en) Peptides having novel polar n-terminal groups
AU2117388A (en) Recombinant htlv-iii proteins and uses thereof
AU4076189A (en) Recombinant fusion proteins for altering hormone secretion
AU637589B2 (en) Ancrod proteins, their production and use
AU1294888A (en) Recombinant alveolar surfactant protein

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry