ATE458046T1 - Verfahren zur herstellung zytotoxischer lymphozyten - Google Patents

Verfahren zur herstellung zytotoxischer lymphozyten

Info

Publication number
ATE458046T1
ATE458046T1 AT04772194T AT04772194T ATE458046T1 AT E458046 T1 ATE458046 T1 AT E458046T1 AT 04772194 T AT04772194 T AT 04772194T AT 04772194 T AT04772194 T AT 04772194T AT E458046 T1 ATE458046 T1 AT E458046T1
Authority
AT
Austria
Prior art keywords
cytotoxic lymphocytes
producing cytotoxic
volume
cytotoxic lymphocyte
producing
Prior art date
Application number
AT04772194T
Other languages
English (en)
Inventor
Mitsuko Ideno
Nobuko Muraki
Kinuko Ogawa
Masayuki Kishimoto
Tatsuji Enoki
Hiroaki Sagawa
Ikunoshin Kato
Original Assignee
Takara Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takara Bio Inc filed Critical Takara Bio Inc
Application granted granted Critical
Publication of ATE458046T1 publication Critical patent/ATE458046T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/58—Adhesion molecules, e.g. ICAM, VCAM, CD18 (ligand), CD11 (ligand), CD49 (ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT04772194T 2003-08-22 2004-08-19 Verfahren zur herstellung zytotoxischer lymphozyten ATE458046T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2003298208 2003-08-22
JP2004000699 2004-01-05
JP2004115648 2004-04-09
JP2004222441 2004-07-29
PCT/JP2004/012238 WO2005019450A1 (ja) 2003-08-22 2004-08-19 細胞傷害性リンパ球の製造方法

Publications (1)

Publication Number Publication Date
ATE458046T1 true ATE458046T1 (de) 2010-03-15

Family

ID=34222501

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04772194T ATE458046T1 (de) 2003-08-22 2004-08-19 Verfahren zur herstellung zytotoxischer lymphozyten

Country Status (13)

Country Link
US (1) US8927273B2 (de)
EP (1) EP1666589B1 (de)
JP (1) JP4870432B2 (de)
KR (2) KR101331746B1 (de)
CN (1) CN1839202B (de)
AT (1) ATE458046T1 (de)
AU (1) AU2004267313B2 (de)
CA (1) CA2536492C (de)
DE (1) DE602004025591D1 (de)
EA (1) EA012520B1 (de)
MX (1) MXPA06002039A (de)
TW (1) TW200517501A (de)
WO (1) WO2005019450A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201043699A (en) 2002-03-25 2010-12-16 Takara Bio Inc Process for producing cytotoxic lymphocyte
US8927273B2 (en) 2003-08-22 2015-01-06 Takara Bio Inc. Process for producing cytotoxic lymphocytes
ES2601896T3 (es) * 2004-11-24 2017-02-16 Fred Hutchinson Cancer Research Center Procedimientos de uso de la IL-21 en la inmunoterapia adoptiva y la identificación de antígenos tumorales
WO2007020880A1 (ja) 2005-08-17 2007-02-22 Takara Bio Inc. リンパ球の製造方法
JP4741906B2 (ja) * 2005-08-31 2011-08-10 タカラバイオ株式会社 リンパ球の製造方法
KR101408565B1 (ko) * 2005-09-30 2014-06-17 다카라 바이오 가부시키가이샤 Ｔ 세포 집단의 제조 방법
EP2028266A4 (de) * 2006-06-09 2010-08-11 Takara Bio Inc Verfahren zur herstellung von lymphozyten
US20110158954A1 (en) * 2007-03-09 2011-06-30 Mitsuko Ideno Method for producing gamma delta t cell population
JPWO2008143014A1 (ja) * 2007-05-11 2010-08-05 タカラバイオ株式会社 がん治療剤
US20110027242A1 (en) * 2008-03-27 2011-02-03 Takara Bio Inc. Method for production of transfected cell
EP2471901A4 (de) 2009-08-25 2013-06-26 Takara Bio Inc Verfahren zur herstellung einer t-zellen-population unter verwendung von retinsäure
CN106574245A (zh) * 2014-06-10 2017-04-19 保利比奥斯博特有限公司 用于细胞免疫治疗的培养基
FR3026744B1 (fr) * 2014-10-06 2024-04-19 Hopitaux Paris Assist Publique Methode de generation de progeniteurs de cellules t
RU2596505C1 (ru) * 2015-07-02 2016-09-10 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский радиологический центр" Министерства здравоохранения Российской Федерации (ФГБУ "НМИРЦ" Минздрава России) Способ лечения онкологических больных цитотоксическими лимфоцитами
US12006512B2 (en) 2017-01-20 2024-06-11 Kyoto University Method for producing CD8alpha+beta+ cytotoxic t cells
CN107099503A (zh) * 2017-06-01 2017-08-29 溯源生命科技股份有限公司 具有高杀伤力的自然杀伤性细胞高效体外扩增培养方法
RU2652752C1 (ru) * 2017-06-15 2018-04-28 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фундаментальной и клинической иммунологии" Способ лечения бронхиальной астмы
KR20200112868A (ko) 2018-01-25 2020-10-05 다카라 바이오 가부시키가이샤 림프구의 제조방법

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8516421D0 (en) 1985-06-28 1985-07-31 Biotechnology Interface Ltd Fibronectins
CA1324098C (en) * 1986-10-20 1993-11-09 Frederick J. Darfler Serum-free medium for the proliferation of lymphokine-activated killer cells
US5019646A (en) 1987-08-25 1991-05-28 Regents Of The University Of Minnesota Polypeptides with fibronectin activity
JP2561131B2 (ja) 1988-06-30 1996-12-04 寳酒造株式会社 細胞接着活性ポリペプチド
GB8909916D0 (en) 1989-04-29 1989-06-14 Delta Biotechnology Ltd Polypeptides
US5198423A (en) 1989-05-26 1993-03-30 Takara Shuzo Co., Ltd. Functional polypeptide containing a cell binding domain and a heparin binding domain of fibronectin
GR1001034B (el) 1989-07-21 1993-03-31 Ortho Pharma Corp Μεθοδος διεγερσης του πολλαπλασιασμου λεμφοκυτταρων περιφερειακου αιματος.
US5188959A (en) 1989-09-28 1993-02-23 Trustees Of Tufts College Extracellular matrix protein adherent t cells
JP3104178B2 (ja) 1990-03-30 2000-10-30 寶酒造株式会社 機能性ポリペプチド
JPH04108377A (ja) * 1990-08-27 1992-04-09 Ube Nitto Kasei Co Ltd 細胞培養用基材
JPH04297494A (ja) 1991-03-26 1992-10-21 Fuji Photo Film Co Ltd ペプチド誘導体とその用途
JP2729712B2 (ja) 1991-04-23 1998-03-18 寳酒造株式会社 機能性ポリペプチド
JPH07102131B2 (ja) 1991-07-15 1995-11-08 日本石油株式会社 ヒトリンパ球の癌細胞に対する傷害活性を高める方法
JPH06172203A (ja) 1992-12-02 1994-06-21 Takara Shuzo Co Ltd フィブロネクチンレセプター産生異常細胞抑制剤
JPH06306096A (ja) 1993-02-26 1994-11-01 Fuji Photo Film Co Ltd ペプチド誘導体及びその用途
US5405772A (en) * 1993-06-18 1995-04-11 Amgen Inc. Medium for long-term proliferation and development of cells
GB9315810D0 (en) 1993-07-30 1993-09-15 Univ London Stabilised materials
DE4336399A1 (de) 1993-10-26 1995-04-27 Augustinus Dr Med Bader Verfahren zur Verbesserung der Matrixbedingungen bipolar adhärierter Hepatozyten und zur Herstellung eines entsprechend konfigurierten Zellkulturkits
US6821778B1 (en) 1993-12-01 2004-11-23 The Board Of Trustees Of Leland Stanford Junior University Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells
DE4412794A1 (de) 1994-04-14 1995-12-14 Univ Ludwigs Albert Verfahren zur Herstellung von dendritischen Zellen, so erhaltene Zellen und Behälter zur Durchführung dieses Verfahrens
GB9413029D0 (en) 1994-06-29 1994-08-17 Common Services Agency Stem cell immobilisation
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US5824547A (en) 1994-11-29 1998-10-20 Takara Shuzo Co., Ltd. Method for production of transfected cells
CA2206449A1 (en) 1994-12-01 1996-06-06 Beth Israel Deaconess Medical Center, Inc. In vitro t-lymphopoiesis system
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
EP0824594B1 (de) 1995-05-04 2005-04-06 The United States of America as Representend by The Secretary of the Navy Verbesserte verfahren zur transfektion der t-zellen
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
DE19624887A1 (de) 1995-06-21 1997-01-02 Fraunhofer Ges Forschung Elektrochemisches Festelektrolyt-Zellsystem
JPH0925299A (ja) 1995-07-13 1997-01-28 Sumitomo Electric Ind Ltd Ｃｄ４４リガンド
CA2227327A1 (en) 1995-07-25 1997-02-13 Celltherapy, Inc. Autologous immune cell therapy: cell compositions, methods and applications to treatment of human disease
DE19537494C2 (de) 1995-09-25 1997-10-02 Desitin Arzneimittel Gmbh Kreatin zum Schutz von neuralem Gewebe
EP0873049B1 (de) 1995-09-29 2006-05-10 Indiana University Research and Technology Corporation Verfahren zum verbesserten virusvermittelten dns-transfer unter verwendung von molekülen mit virus- und zellbindenden domänen
WO1997018318A1 (fr) 1995-11-13 1997-05-22 Takara Shuzo Co., Ltd. Procede d'introduction de genes dans des cellules cibles au moyen de retrovirus
US6734014B1 (en) 1996-02-08 2004-05-11 The United States Of America As Represented By The Department Of Health And Human Services Methods and compositions for transforming dendritic cells and activating T cells
WO1997032970A1 (en) 1996-03-04 1997-09-12 Targeted Genetics Corporation Modified rapid expansion methods ('modified-rem') for in vitro propagation of t lymphocytes
JP2002516562A (ja) 1996-03-04 2002-06-04 ターゲティッド ジェネティックス コーポレイション Ｔリンパ球のインビトロ増殖のための改変された迅速な拡大方法（「改変ｒｅｍ」）
JPH1029952A (ja) 1996-07-16 1998-02-03 Takara Shuzo Co Ltd ヒト免疫不全ウイルス感染の制御用組成物および制御方法
CA2267288A1 (en) 1996-09-23 1998-03-26 Ontogeny, Inc. Hematopoietic stem cells and methods for generating such cells
GB9625175D0 (en) * 1996-12-04 1997-01-22 Medi Cult As Serum-free cell culture media
JP2001509677A (ja) 1997-01-31 2001-07-24 エピミューン，インコーポレイティド Ｃｔｌを活性化するためのペプチドおよびペプチド担持抗原提示細胞
TWI239352B (en) 1997-07-23 2005-09-11 Takara Bio Inc Gene transfer method with the use of serum-free medium
AU2010699A (en) 1997-12-24 1999-07-19 Corixa Corporation Compounds for immunotherapy and diagnosis of breast cancer and methods for theiruse
DE69838490T2 (de) 1997-12-24 2008-02-07 Bracco International B.V. Peptide chelatoren die nach der koordination mit einem metall zu einem vorherrschenden einzel-stereoisomeren führen
AU8780198A (en) 1998-08-11 2000-03-06 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The A method of transducing mammalian cells, and products related thereto
EP1163912B1 (de) 1999-03-23 2007-10-31 Takara Bio Inc. Gentherapeutika
BR0108545A (pt) 2000-02-24 2004-06-29 Xcyte Therapies Inc Estimulação e concentração simultâneas das células
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
JP3904374B2 (ja) 2000-02-29 2007-04-11 独立行政法人科学技術振興機構 キラー活性を増強したリンパ球
WO2002014481A1 (en) 2000-08-16 2002-02-21 Takara Bio Inc. Method of extensive culture of antigen-specific cytotoxic t cells
KR20040048379A (ko) 2001-06-01 2004-06-09 싸이트 테라피스 인코포레이티드 Ｔ 세포 유도된 조직 복구 및 재생
ATE429486T1 (de) 2001-08-15 2009-05-15 Takara Bio Inc Expansionskulturverfahren für antigenspezifische zytotoxische t-lymphozyten
JP4759890B2 (ja) 2001-09-12 2011-08-31 大日本印刷株式会社 パール調印刷物の印刷濃度管理方法
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
TW201043699A (en) 2002-03-25 2010-12-16 Takara Bio Inc Process for producing cytotoxic lymphocyte
AU2003254950A1 (en) 2002-08-26 2004-03-11 Kirin Beer Kabushiki Kaisha Peptides and drugs containing the same
US8927273B2 (en) 2003-08-22 2015-01-06 Takara Bio Inc. Process for producing cytotoxic lymphocytes
JP4297494B2 (ja) 2003-11-06 2009-07-15 タイヨーエレック株式会社 組合せ式遊技機

Also Published As

Publication number Publication date
CA2536492A1 (en) 2005-03-03
MXPA06002039A (es) 2006-05-25
JPWO2005019450A1 (ja) 2006-10-19
KR20060039940A (ko) 2006-05-09
TW200517501A (en) 2005-06-01
HK1095606A1 (en) 2007-05-11
AU2004267313B2 (en) 2009-09-24
EA012520B1 (ru) 2009-10-30
CN1839202A (zh) 2006-09-27
CA2536492C (en) 2013-10-08
JP4870432B2 (ja) 2012-02-08
KR101331746B1 (ko) 2013-11-20
AU2004267313A1 (en) 2005-03-03
US8927273B2 (en) 2015-01-06
EP1666589A1 (de) 2006-06-07
DE602004025591D1 (de) 2010-04-01
EP1666589A4 (de) 2006-10-04
KR20120051089A (ko) 2012-05-21
CN1839202B (zh) 2012-07-18
EP1666589B1 (de) 2010-02-17
US20090221077A1 (en) 2009-09-03
EA200600459A1 (ru) 2006-08-25
WO2005019450A1 (ja) 2005-03-03

Similar Documents

Publication Publication Date Title
DE602004025591D1 (de) Verfahren zur herstellung zytotoxischer lymphozyten
ATE491021T1 (de) Verfahren zur produktion eines zytotoxischen lymphozyten
DE60228846D1 (de) Neue mesogene, verfahren zu deren herstellung und verwendung
ATE450479T1 (de) Verfahren zur herstellung von glaskeramikartikeln
DE69810609D1 (de) Verfahren zur herstellung von uronsäureblöcken aus alginsäure
DE69901045D1 (de) Verfahren zur Herstellung von Kohlenwasserstoffen aus Synthesegas
ATE392430T1 (de) Verfahren zur herstellung von dipeptiden
DE69906884D1 (de) Verfahren zur Herstellung von Kohlenwasserstoffen aus Synthesegas
DE60110044D1 (de) Teilentwässertes umsetzungsprodukt, verfahren zur herstellung desselben, und dasselbe enthaltende emulsion
EP1424387A4 (de) Expansionskulturverfahren für antigenspezifische zytotoxische t-lymphozyten
ATE453648T1 (de) Verfahren zur herstellung von hexahydrofuroc2,3- büfuran-3-ol
ATE388135T1 (de) Verfahren zur herstellung von 1,3-substituierte indene und aryl-annellierte azapolycyclische verbindungen
DE50214577D1 (de) Verfahren zur herstellung von hartmetallgranulat
ATE363502T1 (de) Verfahren zur herstellung von polycarbonaten
TW200741000A (en) Method of producing lymphocytes
ATE366710T1 (de) Verfahren zur herstellung von molekularsieben
ATE361334T1 (de) Verfahren zur herstellung von hochreinem polycarbonat
ATE442459T1 (de) MIKROORGANISMUS MIT EINEM ßKNOCK-OUTß FADR GEN UND DESSEN VERWENDUNG IN EINEM VERFAHREN ZUR HERSTELLUNG VON L-THREONIN
ATE506351T1 (de) Verfahren zur herstellung von 10,11-dihydro-10- oxo-5h-dibenzoäb,füazepin-5-carboxamid
ATE358172T1 (de) Verfahren zur herstellung von olefinen.
ATE505535T1 (de) Verfahren zur herstellung stabiler b-lymphozyten
DE60117167D1 (de) Verfahren zur herstellung von submikropartikel-suspensionen pharmazeutischer substanzen
DE69914984D1 (de) Verfahren zur Kontrolle des Molekulargewichts von cis-1,4-Polybutadien unter Verwendung von Carboxylaten
ATE374757T1 (de) Verfahren zur herstellung von (1,4,5)- oxadiazepinderivaten
ATE437879T1 (de) Verfahren zur herstellung von imipenem

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties