CA2015687C - Polypeptide de fusion d'albumine humaine - Google Patents

Polypeptide de fusion d'albumine humaine Download PDF

Info

Publication number: CA2015687C
Authority: CA; Canada
Prior art keywords: hsa; variant; terminal; fusion polypeptide; terminal portion
Prior art date: 1989-04-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA002015687A

Other languages

English (en)

Other versions

CA2015687A1 (fr

Inventor

David J. Ballance

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Albumedix Ltd

Original Assignee

Delta Biotechnology Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-29

Filing date

1990-04-27

Publication date

2000-08-29

1990-04-27 Application filed by Delta Biotechnology Ltd filed Critical Delta Biotechnology Ltd

1990-10-29 Publication of CA2015687A1 publication Critical patent/CA2015687A1/fr

2000-08-29 Application granted granted Critical

2000-08-29 Publication of CA2015687C publication Critical patent/CA2015687C/fr

2010-04-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Mycology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CA002015687A 1989-04-29 1990-04-27 Polypeptide de fusion d'albumine humaine Expired - Lifetime CA2015687C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898909916A GB8909916D0 (en)	1989-04-29	1989-04-29	Polypeptides
GBGB8909916.2		1989-04-29

Publications (2)

Publication Number	Publication Date
CA2015687A1 CA2015687A1 (fr)	1990-10-29
CA2015687C true CA2015687C (fr)	2000-08-29

Family

ID=10656000

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002015687A Expired - Lifetime CA2015687C (fr)	1989-04-29	1990-04-27	Polypeptide de fusion d'albumine humaine

Country Status (12)

Country	Link
EP (1)	EP0470165A1 (fr)
JP (1)	JP2781459B2 (fr)
KR (1)	KR100227167B1 (fr)
AU (1)	AU630450B2 (fr)
CA (1)	CA2015687C (fr)
FI (1)	FI104255B1 (fr)
GB (2)	GB8909916D0 (fr)
HU (1)	HUT61049A (fr)
IE (1)	IE67651B1 (fr)
IL (1)	IL94243A (fr)
WO (1)	WO1990013653A1 (fr)
ZA (1)	ZA903237B (fr)

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FR2686900B1 (fr) *	1992-01-31	1995-07-21	Rhone Poulenc Rorer Sa	Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant.
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
WO1994016085A2 (fr) *	1992-12-30	1994-07-21	Zymogenetics, Inc.	Proteines hybrides presentant des activites de reticulation et de liaison tissulaire
GB9408466D0 (en) *	1994-04-27	1994-06-22	Univ Nottingham	Cloning and functional expression of neurotoxins
US5543308A (en) *	1994-10-18	1996-08-06	New England Biolabs, Inc.	Isolated DNA encoding the FSEI restriction endonuclease and related methods for producing the same
US5641483A (en) *	1995-06-07	1997-06-24	Beaulieu; Andre	Wound healing formulations containing human plasma fibronectin
US7112320B1 (en)	1995-06-07	2006-09-26	Andre Beaulieu	Solid wound healing formulations containing fibronectin
US5877149A (en)	1995-06-07	1999-03-02	Beaulieu; Andre	Deepithelialized skin diffusion cell system
GB9526733D0 (en)	1995-12-30	1996-02-28	Delta Biotechnology Ltd	Fusion proteins
US6423512B1 (en)	1996-07-26	2002-07-23	Novartis Ag	Fusion polypeptides
PE99498A1 (es) *	1996-07-26	1999-01-21	Novartis Ag	Polipeptidos de fusion
US5932693A (en) *	1996-12-10	1999-08-03	Washington University	Antithrombotic peptides
WO1999037793A1 (fr)	1998-01-23	1999-07-29	Novo Nordisk A/S	Procede servant a preparer des polypeptides souhaites dans de la levure
DE69933216T2 (de)	1998-06-15	2007-09-20	GTC Biotherapeutics, Inc., Framingham	Erythropoietin-analog-menschliches serum-albumin fusionsprotein
EP1274720A4 (fr)	2000-04-12	2004-08-18	Human Genome Sciences Inc	Proteines fusionnees a l'albumine
US6946134B1 (en)	2000-04-12	2005-09-20	Human Genome Sciences, Inc.	Albumin fusion proteins
US7507413B2 (en)	2001-04-12	2009-03-24	Human Genome Sciences, Inc.	Albumin fusion proteins
ATE429486T1 (de)	2001-08-15	2009-05-15	Takara Bio Inc	Expansionskulturverfahren für antigenspezifische zytotoxische t-lymphozyten
PT1463751E (pt)	2001-12-21	2013-08-26	Human Genome Sciences Inc	Proteínas de fusão de albumina
TW201043699A (en)	2002-03-25	2010-12-16	Takara Bio Inc	Process for producing cytotoxic lymphocyte
CA2513213C (fr)	2003-01-22	2013-07-30	Human Genome Sciences, Inc.	Proteines hybrides d'albumine
US8927273B2 (en)	2003-08-22	2015-01-06	Takara Bio Inc.	Process for producing cytotoxic lymphocytes
PL2520654T3 (pl)	2003-08-26	2017-08-31	The Regents Of The University Of Colorado, A Body Corporate	Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych
GB0329722D0 (en)	2003-12-23	2004-01-28	Delta Biotechnology Ltd	Modified plasmid and use thereof
US9057061B2 (en)	2003-12-23	2015-06-16	Novozymes Biopharma Dk A/S	Gene expression technique
GB0329681D0 (en)	2003-12-23	2004-01-28	Delta Biotechnology Ltd	Gene expression technique
WO2006067511A1 (fr)	2004-12-23	2006-06-29	Novozymes Delta Limited	Technique d'expression genetique
EP1816201A1 (fr)	2006-02-06	2007-08-08	CSL Behring GmbH	Facteur de coagulation VIIa modifié ayant une stabilité 'half-life' améliorée
AU2007258609B2 (en)	2006-06-07	2013-01-24	Human Genome Sciences, Inc.	Albumin fusion proteins
EP2049560B1 (fr)	2006-07-13	2013-05-15	Novozymes Biopharma DK A/S	Procédé de fabrication de particules d'un matériau protéique
WO2010092135A2 (fr)	2009-02-11	2010-08-19	Novozymes Biopharma Uk Ltd.	Variants de l'albumine et leurs conjugués
CN102741280B (zh)	2009-10-30	2015-12-02	诺维信生物制药丹麦公司	白蛋白变体
CN106977608A (zh)	2010-04-09	2017-07-25	阿尔布麦狄克斯公司	白蛋白衍生物和变体
KR20200044138A (ko) *	2011-06-24	2020-04-28	더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트	알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
HK1200842A1 (en)	2011-11-18	2015-08-14	Albumedix Ltd	Proteins with improved half-life and other properties
MX2014010278A (es)	2012-03-16	2015-03-05	Novozymes Biopharma Dk As	Variantes de albumina.
WO2014072481A1 (fr)	2012-11-08	2014-05-15	Novozymes Biopharma Dk A/S	Variants d'albumine
EP2968587A2 (fr)	2013-03-13	2016-01-20	Bristol-Myers Squibb Company	Domaines d'échafaudage à base de fibronectine liés à une sérum albumine ou fragment se liant à celle-ci
WO2017029407A1 (fr)	2015-08-20	2017-02-23	Albumedix A/S	Variants de l'albumine et leurs conjugués
US11912750B2 (en)	2016-11-10	2024-02-27	Keros Therapeutics, Inc.	GDNF fusion polypeptides and methods of use thereof
CA3117961A1 (fr) *	2018-10-29	2020-05-07	Spin Therapeutics, Llc	Compositions et methodes pour les dereglements de l'alpha-1 antitrypsine
EP3711772A1 (fr)	2019-03-20	2020-09-23	Oslo Universitetssykehus HF	Protéines recombinantes et protéines de fusion

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SE459586B (sv) *	1987-09-14	1989-07-17	Mta Szegedi Biolog Koezponti	Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning
GB8725529D0 (en) *	1987-10-30	1987-12-02	Delta Biotechnology Ltd	Polypeptides

1989
- 1989-04-29 GB GB898909916A patent/GB8909916D0/en active Pending
1990
- 1990-04-26 AU AU55646/90A patent/AU630450B2/en not_active Expired
- 1990-04-26 HU HU904413A patent/HUT61049A/hu unknown
- 1990-04-26 JP JP2506978A patent/JP2781459B2/ja not_active Expired - Lifetime
- 1990-04-26 WO PCT/GB1990/000650 patent/WO1990013653A1/fr not_active Ceased
- 1990-04-26 EP EP90907285A patent/EP0470165A1/fr active Pending
- 1990-04-27 ZA ZA903237A patent/ZA903237B/xx unknown
- 1990-04-27 CA CA002015687A patent/CA2015687C/fr not_active Expired - Lifetime
- 1990-04-27 IE IE155490A patent/IE67651B1/en not_active IP Right Cessation
- 1990-04-29 IL IL9424390A patent/IL94243A/en not_active IP Right Cessation
1991
- 1991-09-06 GB GB9119043A patent/GB2246783B/en not_active Expired - Lifetime
- 1991-10-14 KR KR1019910701334A patent/KR100227167B1/ko not_active Expired - Fee Related
- 1991-10-28 FI FI915073A patent/FI104255B1/fi active

Also Published As

Publication number	Publication date
AU5564690A (en)	1990-11-29
FI104255B (fi)	1999-12-15
KR100227167B1 (ko)	1999-10-15
IE67651B1 (en)	1996-04-17
AU630450B2 (en)	1992-10-29
JPH04506598A (ja)	1992-11-19
IL94243A0 (en)	1991-01-31
FI915073A0 (fi)	1991-10-28
FI104255B1 (fi)	1999-12-15
GB2246783A (en)	1992-02-12
HUT61049A (en)	1992-11-30
JP2781459B2 (ja)	1998-07-30
IL94243A (en)	1995-10-31
GB2246783B (en)	1992-10-14
KR920701451A (ko)	1992-08-11
ZA903237B (en)	1991-03-27
CA2015687A1 (fr)	1990-10-29
HU904413D0 (en)	1992-01-28
GB8909916D0 (en)	1989-06-14
GB9119043D0 (en)	1991-12-04
EP0470165A1 (fr)	1992-02-12
IE901554L (en)	1990-10-29
WO1990013653A1 (fr)	1990-11-15

Legal Events

Date	Code	Title	Description
1994-04-22	EEER	Examination request
2010-04-27	MKEX	Expiry

Publication	Publication Date	Title
EP0399666B1 (fr)	1993-07-28	Protéines de fusion contenant des fragments N-terminaux de l'albumine de sérum humaine
AU630450B2 (en)	1992-10-29	Fusion proteins containing n-terminal fragments of human serum albumin
US5766883A (en)	1998-06-16	Polypeptides
JP2708518B2 (ja)	1998-02-04	合成酵母リーダーペプチド
US4766073A (en)	1988-08-23	Expression of biologically active PDGF analogs in eucaryotic cells
DK175046B1 (da)	2004-05-10	Polypeptid, dets fremstilling og anvendelse
US5187263A (en)	1993-02-16	Expression of biologically active PDGE analogs in eucaryotic cells
JP2791418B2 (ja)	1998-08-27	異種蛋白質の製造方法、組換えｄｎａ、形質転換体
CZ290069B6 (cs)	2002-05-15	DNA expresní kazeta, kvasinkový expresní vektor,buňka kvasinky a způsob výroby heterologního polypeptidu v kvasinkách
IE892361L (en)	1990-01-23	Peptide and dna sequences
PT99848A (pt)	1993-06-30	Processo para a preparacao de sequencias lider sinteticas
JPS61135591A (ja)	1986-06-23	組み換え融合タン白質
JPS63501614A (ja)	1988-06-23	外来タンパク質を分泌することを目的としたｂａｒ１の使用法
PL178924B1 (pl)	2000-06-30	Konstrukt DNA, zrekombinowany wektor ekspresji, komórka transformowana i sposób wytwarzania heterologicznego polipeptydu
US5705484A (en)	1998-01-06	Biologically active polypeptide fusion dimers
EP0338634B1 (fr)	1994-04-06	Polypeptides d'après le venin de vipère et leur expression génétique
PT87688B (pt)	1992-09-30	Processo para a preparacao de proteina hibrida c
JPH07503368A (ja)	1995-04-13	新規な生物活性ポリペプチド類，ならびにそれらの製造および含有薬学組成物
JPH01240191A (ja)	1989-09-25	酵母で機能する新規シグナルペプチドおよびこれを用いた異種蛋白質の分泌発現
AU665034B2 (en)	1995-12-14	Production of human parathyroid hormone from microorganisms
EP0129073B1 (fr)	1991-03-06	Synthèse de l'ADN hybride de facteur mûr de déclenchement de l'hormone de croissance
IL88925A (en)	1995-11-27	Hirudin derivative and pharmaceutical composition containing same
Can et al.	1989	High-level expression in Escherichia coli of a chemically synthesized gene for [Leu-28] echistatin
JP4180112B2 (ja)	2008-11-12	酵母細胞におけるｎ末端を伸長されたタンパクの発現のためのベクター
IE890559L (en)	1989-08-23	A hirudin derivative