CA2015687C - Polypeptide de fusion d'albumine humaine - Google Patents

Polypeptide de fusion d'albumine humaine Download PDF

Info

Publication number: CA2015687C
Authority: CA; Canada
Prior art keywords: hsa; variant; terminal; fusion polypeptide; terminal portion
Prior art date: 1989-04-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

CA002015687A

Other languages

English (en)

Other versions

CA2015687A1 (fr

Inventor

David J. Ballance

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Albumedix Ltd

Original Assignee

Delta Biotechnology Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-29

Filing date

1990-04-27

Publication date

2000-08-29

1990-04-27 Application filed by Delta Biotechnology Ltd filed Critical Delta Biotechnology Ltd

1990-10-29 Publication of CA2015687A1 publication Critical patent/CA2015687A1/fr

2000-08-29 Application granted granted Critical

2000-08-29 Publication of CA2015687C publication Critical patent/CA2015687C/fr

2010-04-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Mycology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002015687A 1989-04-29 1990-04-27 Polypeptide de fusion d'albumine humaine Expired - Lifetime CA2015687C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB8909916.2		1989-04-29
GB898909916A GB8909916D0 (en)	1989-04-29	1989-04-29	Polypeptides

Publications (2)

Publication Number	Publication Date
CA2015687A1 CA2015687A1 (fr)	1990-10-29
CA2015687C true CA2015687C (fr)	2000-08-29

Family

ID=10656000

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002015687A Expired - Lifetime CA2015687C (fr)	1989-04-29	1990-04-27	Polypeptide de fusion d'albumine humaine

Country Status (12)

Country	Link
EP (1)	EP0470165A1 (fr)
JP (1)	JP2781459B2 (fr)
KR (1)	KR100227167B1 (fr)
AU (1)	AU630450B2 (fr)
CA (1)	CA2015687C (fr)
FI (1)	FI104255B (fr)
GB (2)	GB8909916D0 (fr)
HU (1)	HUT61049A (fr)
IE (1)	IE67651B1 (fr)
IL (1)	IL94243A (fr)
WO (1)	WO1990013653A1 (fr)
ZA (1)	ZA903237B (fr)

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FR2686899B1 (fr) *	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FR2686900B1 (fr) *	1992-01-31	1995-07-21	Rhone Poulenc Rorer Sa	Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant.
WO1994016085A2 (fr) *	1992-12-30	1994-07-21	Zymogenetics, Inc.	Proteines hybrides presentant des activites de reticulation et de liaison tissulaire
GB9408466D0 (en) *	1994-04-27	1994-06-22	Univ Nottingham	Cloning and functional expression of neurotoxins
US5543308A (en) *	1994-10-18	1996-08-06	New England Biolabs, Inc.	Isolated DNA encoding the FSEI restriction endonuclease and related methods for producing the same
US7112320B1 (en)	1995-06-07	2006-09-26	Andre Beaulieu	Solid wound healing formulations containing fibronectin
US5877149A (en)	1995-06-07	1999-03-02	Beaulieu; Andre	Deepithelialized skin diffusion cell system
US5641483A (en) *	1995-06-07	1997-06-24	Beaulieu; Andre	Wound healing formulations containing human plasma fibronectin
GB9526733D0 (en)	1995-12-30	1996-02-28	Delta Biotechnology Ltd	Fusion proteins
US6423512B1 (en)	1996-07-26	2002-07-23	Novartis Ag	Fusion polypeptides
AR008077A1 (es) *	1996-07-26	1999-12-09	Talarico Salinas Laura Beatriz	Un polipeptido de fusion o una sal del mismo, su uso, un proceso para prepararlos, una composicion farmaceutica que los comprende, y un vector.
US5932693A (en) *	1996-12-10	1999-08-03	Washington University	Antithrombotic peptides
AU2149899A (en)	1998-01-23	1999-08-09	Novo Nordisk A/S	Process for making desired polypeptides in yeast
DE69933216T2 (de)	1998-06-15	2007-09-20	GTC Biotherapeutics, Inc., Framingham	Erythropoietin-analog-menschliches serum-albumin fusionsprotein
EP2213743A1 (fr) *	2000-04-12	2010-08-04	Human Genome Sciences, Inc.	Protéines de fusion d'albumine
US6946134B1 (en)	2000-04-12	2005-09-20	Human Genome Sciences, Inc.	Albumin fusion proteins
US7507413B2 (en)	2001-04-12	2009-03-24	Human Genome Sciences, Inc.	Albumin fusion proteins
KR100888915B1 (ko)	2001-08-15	2009-03-16	다카라 바이오 가부시키가이샤	항원특이적 세포상해성 ｔ 세포 확대배양방법
WO2005003296A2 (fr)	2003-01-22	2005-01-13	Human Genome Sciences, Inc.	Proteines hybrides d'albumine
AU2002364586A1 (en)	2001-12-21	2003-07-30	Delta Biotechnology Limited	Albumin fusion proteins
JP4406566B2 (ja)	2002-03-25	2010-01-27	タカラバイオ株式会社	細胞傷害性リンパ球の製造方法
KR101331746B1 (ko) *	2003-08-22	2013-11-20	다카라 바이오 가부시키가이샤	세포 상해성 림프구의 제조 방법
US7850970B2 (en)	2003-08-26	2010-12-14	The Regents Of The University Of Colorado	Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
GB0329681D0 (en)	2003-12-23	2004-01-28	Delta Biotechnology Ltd	Gene expression technique
US9057061B2 (en)	2003-12-23	2015-06-16	Novozymes Biopharma Dk A/S	Gene expression technique
WO2006067511A1 (fr)	2004-12-23	2006-06-29	Novozymes Delta Limited	Technique d'expression genetique
GB0329722D0 (en)	2003-12-23	2004-01-28	Delta Biotechnology Ltd	Modified plasmid and use thereof
EP1816201A1 (fr)	2006-02-06	2007-08-08	CSL Behring GmbH	Facteur de coagulation VIIa modifié ayant une stabilité 'half-life' améliorée
WO2007146038A2 (fr)	2006-06-07	2007-12-21	Human Genome Sciences, Inc.	Protéines de fusion d'albumine
EP2049560B1 (fr)	2006-07-13	2013-05-15	Novozymes Biopharma DK A/S	Procédé de fabrication de particules d'un matériau protéique
KR101722961B1 (ko)	2009-02-11	2017-04-04	알부메딕스 에이/에스	알부민 변이체 및 접합체
EP2493921B1 (fr)	2009-10-30	2018-09-26	Albumedix Ltd	Variants d'albumine
EP2556087A1 (fr)	2010-04-09	2013-02-13	Novozymes Biopharma DK A/S	Dérivés et variants d'albumine
WO2012178102A2 (fr) *	2011-06-24	2012-12-27	The Regents Of The Unversity Of Colorado, A Body Corporate	Compositions, procédés et utilisations de molécules de fusion de l'alpha-1 antitrypsine
EP2780364A2 (fr)	2011-11-18	2014-09-24	Eleven Biotherapeutics, Inc.	Protéines ayant une demi-vie et d'autres propriétés améliorées
DK2825556T3 (en)	2012-03-16	2018-04-16	Albumedix As	albumin Variants
MX2015005363A (es)	2012-11-08	2015-11-06	Novozymes Biopharma Dk As	Variantes de albumina.
EP2968587A2 (fr)	2013-03-13	2016-01-20	Bristol-Myers Squibb Company	Domaines d'échafaudage à base de fibronectine liés à une sérum albumine ou fragment se liant à celle-ci
JP7007261B2 (ja)	2015-08-20	2022-01-24	アルブミディクスリミティド	アルブミン変異体及びコンジュゲート
WO2018089702A1 (fr) *	2016-11-10	2018-05-17	Keros Therapeutics, Inc.	Polypeptides de fusion gdnf et leurs procédés d'utilisation
CA3117961A1 (fr) *	2018-10-29	2020-05-07	Spin Therapeutics, Llc	Compositions et methodes pour les dereglements de l'alpha-1 antitrypsine
EP3711772A1 (fr)	2019-03-20	2020-09-23	Oslo Universitetssykehus HF	Protéines recombinantes et protéines de fusion

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* Cited by examiner, † Cited by third party
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SE459586B (sv) *	1987-09-14	1989-07-17	Mta Szegedi Biolog Koezponti	Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning
GB8725529D0 (en) *	1987-10-30	1987-12-02	Delta Biotechnology Ltd	Polypeptides

1989
- 1989-04-29 GB GB898909916A patent/GB8909916D0/en active Pending
1990
- 1990-04-26 HU HU904413A patent/HUT61049A/hu unknown
- 1990-04-26 WO PCT/GB1990/000650 patent/WO1990013653A1/fr not_active Ceased
- 1990-04-26 EP EP90907285A patent/EP0470165A1/fr active Pending
- 1990-04-26 AU AU55646/90A patent/AU630450B2/en not_active Expired
- 1990-04-26 JP JP2506978A patent/JP2781459B2/ja not_active Expired - Lifetime
- 1990-04-27 IE IE155490A patent/IE67651B1/en not_active IP Right Cessation
- 1990-04-27 ZA ZA903237A patent/ZA903237B/xx unknown
- 1990-04-27 CA CA002015687A patent/CA2015687C/fr not_active Expired - Lifetime
- 1990-04-29 IL IL9424390A patent/IL94243A/en not_active IP Right Cessation
1991
- 1991-09-06 GB GB9119043A patent/GB2246783B/en not_active Expired - Lifetime
- 1991-10-14 KR KR1019910701334A patent/KR100227167B1/ko not_active Expired - Fee Related
- 1991-10-28 FI FI915073A patent/FI104255B/fi active

Also Published As

Publication number	Publication date
GB8909916D0 (en)	1989-06-14
HU904413D0 (en)	1992-01-28
FI915073A0 (fi)	1991-10-28
HUT61049A (en)	1992-11-30
WO1990013653A1 (fr)	1990-11-15
IL94243A (en)	1995-10-31
KR920701451A (ko)	1992-08-11
EP0470165A1 (fr)	1992-02-12
GB2246783B (en)	1992-10-14
IE901554L (en)	1990-10-29
AU5564690A (en)	1990-11-29
IL94243A0 (en)	1991-01-31
FI104255B1 (fi)	1999-12-15
GB2246783A (en)	1992-02-12
JPH04506598A (ja)	1992-11-19
JP2781459B2 (ja)	1998-07-30
ZA903237B (en)	1991-03-27
AU630450B2 (en)	1992-10-29
KR100227167B1 (ko)	1999-10-15
GB9119043D0 (en)	1991-12-04
FI104255B (fi)	1999-12-15
IE67651B1 (en)	1996-04-17
CA2015687A1 (fr)	1990-10-29

Legal Events

Date	Code	Title	Description
1994-04-22	EEER	Examination request
2010-04-27	MKEX	Expiry

Publication	Publication Date	Title
CA2015687C (fr)	2000-08-29	Polypeptide de fusion d'albumine humaine
EP0399666B1 (fr)	1993-07-28	Protéines de fusion contenant des fragments N-terminaux de l'albumine de sérum humaine
US5766883A (en)	1998-06-16	Polypeptides
JP2708518B2 (ja)	1998-02-04	合成酵母リーダーペプチド
US4766073A (en)	1988-08-23	Expression of biologically active PDGF analogs in eucaryotic cells
DK175046B1 (da)	2004-05-10	Polypeptid, dets fremstilling og anvendelse
US5187263A (en)	1993-02-16	Expression of biologically active PDGE analogs in eucaryotic cells
JP2791418B2 (ja)	1998-08-27	異種蛋白質の製造方法、組換えｄｎａ、形質転換体
CZ290069B6 (cs)	2002-05-15	DNA expresní kazeta, kvasinkový expresní vektor,buňka kvasinky a způsob výroby heterologního polypeptidu v kvasinkách
IE892361L (en)	1990-01-23	Peptide and dna sequences
PT99848A (pt)	1993-06-30	Processo para a preparacao de sequencias lider sinteticas
JPS61135591A (ja)	1986-06-23	組み換え融合タン白質
JPS63501614A (ja)	1988-06-23	外来タンパク質を分泌することを目的としたｂａｒ１の使用法
PL178924B1 (pl)	2000-06-30	Konstrukt DNA, zrekombinowany wektor ekspresji, komórka transformowana i sposób wytwarzania heterologicznego polipeptydu
US5705484A (en)	1998-01-06	Biologically active polypeptide fusion dimers
PT87688B (pt)	1992-09-30	Processo para a preparacao de proteina hibrida c
JPH01240191A (ja)	1989-09-25	酵母で機能する新規シグナルペプチドおよびこれを用いた異種蛋白質の分泌発現
AU665034B2 (en)	1995-12-14	Production of human parathyroid hormone from microorganisms
EP0129073B1 (fr)	1991-03-06	Synthèse de l'ADN hybride de facteur mûr de déclenchement de l'hormone de croissance
IL88925A (en)	1995-11-27	Hirudin derivative and pharmaceutical composition containing same
US5420242A (en)	1995-05-30	Production of human parathyroid hormone from microorganisms
Can et al.	1989	High-level expression in Escherichia coli of a chemically synthesized gene for [Leu-28] echistatin
JP4180112B2 (ja)	2008-11-12	酵母細胞におけるｎ末端を伸長されたタンパクの発現のためのベクター
IE890559L (en)	1989-08-23	A hirudin derivative
IE62522B1 (en)	1995-02-08	A process for the preparation of foreign proteins in streptomycetes