CA2017193A1 - N-(aryloxyalkyl) heteroarylpiperidines et -heteroarylpiperazines, procede de preparation et leur utilisation comme medicaments - Google Patents

N-(aryloxyalkyl) heteroarylpiperidines et -heteroarylpiperazines, procede de preparation et leur utilisation comme medicaments

Info

Publication number
CA2017193A1
CA2017193A1 CA2017193A CA2017193A CA2017193A1 CA 2017193 A1 CA2017193 A1 CA 2017193A1 CA 2017193 A CA2017193 A CA 2017193A CA 2017193 A CA2017193 A CA 2017193A CA 2017193 A1 CA2017193 A1 CA 2017193A1
Authority
CA
Canada
Prior art keywords
see formula
lower alkyl
alkyl
alkoxy
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2017193A
Other languages
English (en)
Other versions
CA2017193C (fr
Inventor
Joseph Thomas Strupczewski
Grover Cleveland Helsley
Yulin Chiang
Kenneth J. Bordeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002284569A priority Critical patent/CA2284569A1/fr
Publication of CA2017193A1 publication Critical patent/CA2017193A1/fr
Application granted granted Critical
Publication of CA2017193C publication Critical patent/CA2017193C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CA002017193A 1989-05-19 1990-05-18 N-(aryloxyalkyl) heteroarylpiperidines et -heteroarylpiperazines, procede de preparation et leur utilisation comme medicaments Expired - Lifetime CA2017193C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002284569A CA2284569A1 (fr) 1989-05-19 1990-05-18 N-(aryloxyalkyl) heteroarylpiperidines et -heteroarylpiperazines, procede de preparation et leur utilisation comme medicaments

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35441189A 1989-05-19 1989-05-19
US354,411 1989-05-19
US45679089A 1989-12-29 1989-12-29
US456,790 1989-12-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002284569A Division CA2284569A1 (fr) 1989-05-19 1990-05-18 N-(aryloxyalkyl) heteroarylpiperidines et -heteroarylpiperazines, procede de preparation et leur utilisation comme medicaments

Publications (2)

Publication Number Publication Date
CA2017193A1 true CA2017193A1 (fr) 1990-11-19
CA2017193C CA2017193C (fr) 2000-06-27

Family

ID=26998389

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002017193A Expired - Lifetime CA2017193C (fr) 1989-05-19 1990-05-18 N-(aryloxyalkyl) heteroarylpiperidines et -heteroarylpiperazines, procede de preparation et leur utilisation comme medicaments

Country Status (23)

Country Link
EP (1) EP0402644B1 (fr)
JP (1) JPH0662580B2 (fr)
KR (1) KR0157308B1 (fr)
CN (2) CN1086387C (fr)
AT (1) ATE126512T1 (fr)
AU (1) AU640653B2 (fr)
CA (1) CA2017193C (fr)
CZ (1) CZ282385B6 (fr)
DD (1) DD300433A5 (fr)
DE (1) DE69021645T2 (fr)
DK (1) DK0402644T3 (fr)
ES (1) ES2076253T3 (fr)
FI (2) FI104072B (fr)
GR (1) GR3017447T3 (fr)
HU (2) HU218200B (fr)
IE (1) IE68431B1 (fr)
IL (1) IL94425A (fr)
NO (1) NO177301C (fr)
NZ (1) NZ233710A (fr)
PL (1) PL163965B1 (fr)
PT (1) PT94084B (fr)
RU (3) RU2147583C1 (fr)
SK (1) SK279474B6 (fr)

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US5776963A (en) * 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
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US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5177088A (en) * 1991-04-17 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 3-(pyridinylamino)-indoles
TW241263B (fr) * 1991-08-22 1995-02-21 Hoechst Roussel Pharma
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
AU672182B2 (en) * 1991-11-27 1996-09-26 Novo Nordisk A/S Piperidine derivatives and their use in treating psychosis
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
WO1993013068A1 (fr) * 1991-12-25 1993-07-08 Zeria Pharmaceutical Co., Ltd. Compose tricyclique et medicament renfermant ce compose
ES2133416T3 (es) * 1992-10-23 1999-09-16 Merck Sharp & Dohme Ligandos de subtipos de receptores de dopamina.
US5670522A (en) * 1992-10-23 1997-09-23 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands
DK60793D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DK60593D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
GB9318691D0 (en) * 1993-09-09 1993-10-27 Merck Sharp & Dohme Therapeutic agents
ATE174591T1 (de) * 1993-09-15 1999-01-15 Merck Sharp & Dohme Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor- subtyps
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
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US5880121A (en) * 1996-01-05 1999-03-09 Hoechst Marion Roussel Inc. 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
CA2241845C (fr) * 1996-01-05 2002-10-01 Hoechst Marion Roussel, Inc. 4,5-dihydronaphth[1,2-c]isoxazoles et leurs derives ayant une activite au niveau du systeme nerveux central
ES2144355B1 (es) * 1997-12-30 2001-01-01 Ferrer Int Compuestos derivados del cromeno.
AU7547100A (en) * 1999-09-09 2001-04-10 Egis Gyogyszergyar Rt. Alkylpiperidi nylbenzo [d] isoxazole derivatives having psychotropic activity, pharmaceutical compositions containing the same, and a process for the preparation of the active ingredient
GB0102841D0 (en) * 2001-02-05 2001-03-21 Novartis Ag Organic compounds
AU2006201188B2 (en) * 2001-02-05 2007-11-15 Novartis Ag New use of iloperidone
RU2426730C2 (ru) * 2001-04-18 2011-08-20 Эро-Селтик, С.А. Аналоги ноцицептина
DK2305656T3 (da) * 2001-08-31 2013-02-11 Novartis Ag Optiske isomerer of en iloperidonmetabolit
EP1441727B1 (fr) 2001-10-30 2010-12-29 Novartis AG Preparations de depot d'iloperidone et de polymere en etoile
US6995144B2 (en) * 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
GB0216416D0 (en) * 2002-07-15 2002-08-21 Novartis Ag Organic compounds
AP2005003250A0 (en) * 2002-09-17 2005-03-31 Warner Lambert Co Heterocyclic substituted piperazines for the treatment of schizophrenia.
AU2003272030A1 (en) * 2002-11-08 2004-06-07 Warner-Lambert Company Llc Phenylalkyl and pyridylalkyl piperazine derivatives
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
GB0322994D0 (en) * 2003-10-01 2003-11-05 Novartis Ag Organic compounds
RU2283650C1 (ru) * 2005-02-24 2006-09-20 Закрытое Акционерное Общество "Канонфарма Продакшн" Твердая лекарственная форма для улучшения мужской эректильной функции
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
AU2007217040A1 (en) 2006-02-17 2007-08-30 Memory Pharmaceuticals Corporation Compounds having 5-HT6 receptor affinity
RS55585B1 (sr) 2006-11-22 2017-06-30 Clinical Research Associates LLC Postupci za lečenje daunovog sindroma, krhkog x sindroma i autizma
WO2008128166A1 (fr) * 2007-04-13 2008-10-23 Concert Pharmaceuticals Inc. Dérivés deutériés de composés 4-(6-fluoro-1,2-benzisoxazol-3-yl) pipéridine
CN101824030B (zh) * 2009-03-04 2014-06-18 北京德众万全药物技术开发有限公司 一种伊潘立酮的制备方法
EP2445502B2 (fr) 2009-06-25 2022-09-28 Alkermes Pharma Ireland Limited Composés hétérocycliques destinés au traitement de troubles neurologiques et psychologiques
US8802855B2 (en) 2009-09-19 2014-08-12 Zhejiang Huahai Pharmaceutical Co., Ltd. Method for preparation of iloperidone and crystallization method thereof
CN102030744B (zh) * 2009-09-30 2013-04-17 天津药物研究院 伊潘立酮晶体、其制备方法及药物组合物
WO2011061750A2 (fr) * 2009-11-19 2011-05-26 Symed Labs Limited Procédé pour la préparation d'ilopéridone à l'aide d'un nouvel intermédiaire
WO2011154860A1 (fr) * 2010-06-08 2011-12-15 Alembic Pharmaceuticals Limited Procédé amélioré pour la préparation de l'ilopéridone
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WO2014078568A1 (fr) 2012-11-14 2014-05-22 The Johns Hopkins University Méthodes et compositions pour le traitement de la schizophrénie
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IL256354B (en) 2015-06-19 2022-09-01 Agenebio Inc Benzodiazepine derivatives, compositions, and uses thereof for treating cognitive impairment
BR112019012821A2 (pt) 2016-12-19 2019-11-26 Agenebio, Inc. derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
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Also Published As

Publication number Publication date
JPH0363263A (ja) 1991-03-19
DK0402644T3 (da) 1996-01-02
FI902449A0 (fi) 1990-05-17
NO902214D0 (no) 1990-05-18
FI19991869A7 (fi) 1999-09-02
NO177301C (no) 1995-08-23
AU5577090A (en) 1990-11-22
CA2017193C (fr) 2000-06-27
RU2147583C1 (ru) 2000-04-20
ATE126512T1 (de) 1995-09-15
PT94084A (pt) 1991-01-08
IE68431B1 (en) 1996-06-12
NZ233710A (en) 1992-05-26
SK242590A3 (en) 1998-11-04
IE901809L (en) 1990-11-19
FI104072B1 (fi) 1999-11-15
NO177301B (no) 1995-05-15
CZ242590A3 (en) 1997-03-12
HK1006710A1 (en) 1999-03-12
CN1048037A (zh) 1990-12-26
CZ282385B6 (cs) 1997-07-16
RU2239434C2 (ru) 2004-11-10
RU2062776C1 (ru) 1996-06-27
PT94084B (pt) 1996-12-31
PL163965B1 (pl) 1994-05-31
EP0402644A1 (fr) 1990-12-19
KR900018070A (ko) 1990-12-20
KR0157308B1 (ko) 1998-11-16
HUT58720A (en) 1992-03-30
HU903090D0 (en) 1990-09-28
IL94425A (en) 1994-02-27
PL285247A1 (en) 1991-02-11
CN1086387C (zh) 2002-06-19
DE69021645D1 (de) 1995-09-21
ES2076253T3 (es) 1995-11-01
HU211853A9 (en) 1995-12-28
AU640653B2 (en) 1993-09-02
CN1305812A (zh) 2001-08-01
CN1223348C (zh) 2005-10-19
JPH0662580B2 (ja) 1994-08-17
FI19991869L (fi) 1999-09-02
EP0402644B1 (fr) 1995-08-16
HK1038316A1 (en) 2002-03-15
FI104072B (fi) 1999-11-15
HU218200B (hu) 2000-06-28
DE69021645T2 (de) 1996-02-22
GR3017447T3 (en) 1995-12-31
NO902214L (no) 1990-11-20
DD300433A5 (de) 1992-06-11
IL94425A0 (en) 1991-03-10
SK279474B6 (sk) 1998-11-04

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