CA2023340A1 - (quinoline-2-ylmethoxy) indoles comme inhibiteurs de la biosynthese des leukotrienes - Google Patents

(quinoline-2-ylmethoxy) indoles comme inhibiteurs de la biosynthese des leukotrienes

Info

Publication number
CA2023340A1
CA2023340A1 CA2023340A CA2023340A CA2023340A1 CA 2023340 A1 CA2023340 A1 CA 2023340A1 CA 2023340 A CA2023340 A CA 2023340A CA 2023340 A CA2023340 A CA 2023340A CA 2023340 A1 CA2023340 A1 CA 2023340A1
Authority
CA
Canada
Prior art keywords
inhibitors
biosynthesis
leukotrienes
ylmethoxy
indoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2023340A
Other languages
English (en)
Other versions
CA2023340C (fr
Inventor
Petpiboon Prasit
Rejean Fortin
John H. Hutchinson
Michel L. Belley
Serge Leger
John Gillard
Richard Frenette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Merck Frosst Canada and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada and Co filed Critical Merck Frosst Canada and Co
Publication of CA2023340A1 publication Critical patent/CA2023340A1/fr
Application granted granted Critical
Publication of CA2023340C publication Critical patent/CA2023340C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002023340A 1989-08-22 1990-08-15 (quinoline-2-ylmethoxy) indoles comme inhibiteurs de la biosynthese des leukotrienes Expired - Fee Related CA2023340C (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39714489A 1989-08-22 1989-08-22
US397,144 1989-08-22
US55230090A 1990-07-18 1990-07-18
US552,300 1990-07-18

Publications (2)

Publication Number Publication Date
CA2023340A1 true CA2023340A1 (fr) 1991-02-23
CA2023340C CA2023340C (fr) 2000-07-11

Family

ID=27015763

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002023340A Expired - Fee Related CA2023340C (fr) 1989-08-22 1990-08-15 (quinoline-2-ylmethoxy) indoles comme inhibiteurs de la biosynthese des leukotrienes

Country Status (13)

Country Link
EP (1) EP0419049B1 (fr)
JP (1) JPH0786101B2 (fr)
KR (1) KR910004600A (fr)
AT (1) ATE121085T1 (fr)
AU (1) AU650185B2 (fr)
CA (1) CA2023340C (fr)
DE (1) DE69018553T2 (fr)
FI (1) FI904132A7 (fr)
IE (1) IE903022A1 (fr)
IL (1) IL95371A (fr)
NO (1) NO176606C (fr)
NZ (1) NZ234883A (fr)
PT (1) PT95055A (fr)

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US5204344A (en) * 1989-08-22 1993-04-20 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
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US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
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US5202321A (en) * 1991-06-13 1993-04-13 Merck Frosst Canada, Inc. Thiopyrano[2,3,4-c,d]indoles as inhibitors of leukotriene biosynthesis
CA2079374C (fr) * 1991-09-30 2003-08-05 Merck Frosst Canada Incorporated Indol (azaarylmethoxy bicyclique) comme inhibiteur de leucotriene biosynthetique
US5308850A (en) * 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5190968A (en) * 1991-09-30 1993-03-02 Merck Frosst Canada, Inc. (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5290798A (en) * 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5389650A (en) * 1991-09-30 1995-02-14 Merck Frosst Canada, Inc. (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5254541A (en) * 1991-11-15 1993-10-19 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indole/cyclodextrin complex
US5254567A (en) * 1991-11-15 1993-10-19 Merck Frosst Canada, Inc. Amorphous (quinolin-2-ylmethoxy)indole compounds which have useful pharmaceutical utility
US5321033A (en) * 1991-11-15 1994-06-14 Merck Frosst Canada, Inc. Amorphous (quinolin-2-ylmethoxy)indole compounds useful for treating inflammatory diseases
EP0542355A1 (fr) * 1991-11-15 1993-05-19 Merck Frosst Canada Inc. (Quinolin-2-ylméthoxy)indoles amorphes comme leukotriene antagonistes
WO1993016069A1 (fr) * 1992-02-13 1993-08-19 Merck Frosst Canada Inc. (alcoxy azaaromatique) indoles inhibiteurs de biosynthese de leucotriene
US5274096A (en) * 1992-03-17 1993-12-28 Merck & Co., Inc. Hydrazine synthesis
US5334719A (en) * 1992-06-17 1994-08-02 Merck Frosst Canada, Inc. Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis
CA2136241C (fr) * 1992-06-22 2004-01-27 Richard Frenette Indoles a base de quinoleines fluores en tant qu'inhibiteurs de la biosynthese de leucotrienes
US5314900A (en) * 1992-11-19 1994-05-24 Merck Frosst Canada, Inc. Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene biosynthesis
US5288743A (en) * 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
US5374635A (en) * 1993-03-29 1994-12-20 Merck Frosst Canada, Inc. Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis
US5399699A (en) * 1994-01-24 1995-03-21 Abbott Laboratories Indole iminooxy derivatives which inhibit leukotriene biosynthesis
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US6187784B1 (en) 1998-06-03 2001-02-13 Gpi Nil Holdings, Inc. Pipecolic acid derivative hair growth compositions and uses
US6271244B1 (en) 1998-06-03 2001-08-07 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses
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US6172087B1 (en) 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
IL140040A0 (en) 1998-06-03 2002-02-10 Guilford Pharm Inc N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres
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US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
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US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US6384056B1 (en) 1998-08-14 2002-05-07 Gpi Nil Holdings, Inc. Heterocyclic thioesters or ketones for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6335348B1 (en) 1998-08-14 2002-01-01 Gpi Nil Holdings, Inc. Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
US6339101B1 (en) 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
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Also Published As

Publication number Publication date
JPH03163075A (ja) 1991-07-15
NO903678L (no) 1991-03-21
IE903022A1 (en) 1991-02-27
NO176606C (no) 1995-05-03
AU6121190A (en) 1991-02-28
IL95371A (en) 1994-08-26
JPH0786101B2 (ja) 1995-09-20
ATE121085T1 (de) 1995-04-15
DE69018553T2 (de) 1995-10-19
KR910004600A (ko) 1991-03-29
DE69018553D1 (de) 1995-05-18
IL95371A0 (en) 1991-06-30
NO176606B (no) 1995-01-23
FI904132A0 (fi) 1990-08-21
AU628212B2 (en) 1992-09-10
CA2023340C (fr) 2000-07-11
FI904132A7 (fi) 1991-02-23
PT95055A (pt) 1991-04-18
AU3012692A (en) 1993-02-11
EP0419049A1 (fr) 1991-03-27
NO903678D0 (no) 1990-08-21
AU650185B2 (en) 1994-06-09
EP0419049B1 (fr) 1995-04-12
NZ234883A (en) 1995-01-27

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