CA2027596A1 - Compositions renfermant des acides hyaluronique complexes contenant du zinc ou du cobalt - Google Patents

Compositions renfermant des acides hyaluronique complexes contenant du zinc ou du cobalt

Info

Publication number: CA2027596A1
Authority: CA; Canada
Prior art keywords: zinc; cobalt; hyaluronic acid; complexes; compositions containing
Prior art date: 1989-02-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA2027596A

Other languages

English (en)

Other versions

CA2027596C (fr

Inventor

Kalman Burger

Geza Takacsi Nagy

Ivan Rethey

Janos Illes

Bela Stefko

Erzsebet Neszmelyi

Istvan Gebhardt

Istvan Racz

Arpadne Kiraly

Viktoria Varkonyi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Richter Gedeon Vegyeszeti Gyar Nyrt

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-24

Filing date

1990-02-20

Publication date

1990-08-25

1990-02-20 Application filed by Individual filed Critical Individual

1990-08-25 Publication of CA2027596A1 publication Critical patent/CA2027596A1/fr

2001-01-02 Application granted granted Critical

2001-01-02 Publication of CA2027596C publication Critical patent/CA2027596C/fr

2010-02-20 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title abstract 4
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title abstract 3
229910052725 zinc Inorganic materials 0.000 title abstract 3
239000011701 zinc Substances 0.000 title abstract 3
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
229910017052 cobalt Inorganic materials 0.000 title abstract 2
239000010941 cobalt Substances 0.000 title abstract 2
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 title abstract 2
239000004480 active ingredient Substances 0.000 abstract 3
WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 abstract 1
229910001429 cobalt ion Inorganic materials 0.000 abstract 1
XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical compound [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 abstract 1
239000002537 cosmetic Substances 0.000 abstract 1
229940014041 hyaluronate Drugs 0.000 abstract 1
229910021645 metal ion Inorganic materials 0.000 abstract 1
230000000737 periodic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/58—Metal complex; Coordination compounds

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Inorganic Chemistry (AREA)
Birds (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
Polymers & Plastics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Thiazole And Isothizaole Compounds (AREA)

CA002027596A 1989-02-24 1990-02-20 Compositions renfermant des acides hyaluronique complexes contenant du zinc ou du cobalt Expired - Lifetime CA2027596C (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
HU891/89		1989-02-24
HU89891A HU203372B (en)	1989-02-24	1989-02-24	Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient
HUPCT/HU90/00013		1990-02-20
PCT/HU1990/000013 WO1990010020A1 (fr)	1989-02-24	1990-02-20	Nouvelles compositions contenant des associes d'acide hyaluronique et leur procede de preparation

Publications (2)

Publication Number	Publication Date
CA2027596A1 true CA2027596A1 (fr)	1990-08-25
CA2027596C CA2027596C (fr)	2001-01-02

Family

ID=10951903

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002027596A Expired - Lifetime CA2027596C (fr)	1989-02-24	1990-02-20	Compositions renfermant des acides hyaluronique complexes contenant du zinc ou du cobalt

Country Status (33)

Country	Link
US (1)	US5554598A (fr)
EP (1)	EP0413016B1 (fr)
JP (1)	JP2571312B2 (fr)
KR (1)	KR960015624B1 (fr)
CN (2)	CN1024557C (fr)
AR (1)	AR243538A1 (fr)
AT (1)	ATE98964T1 (fr)
AU (1)	AU623232B2 (fr)
BG (1)	BG61515B2 (fr)
CA (1)	CA2027596C (fr)
CZ (1)	CZ281000B6 (fr)
DD (1)	DD292263A5 (fr)
DE (1)	DE69005394T2 (fr)
DK (1)	DK0413016T3 (fr)
ES (1)	ES2061016T3 (fr)
FI (1)	FI101707B (fr)
GE (2)	GEP19981358B (fr)
GR (1)	GR1000869B (fr)
HK (1)	HK1003003A1 (fr)
HU (2)	HU203372B (fr)
IE (1)	IE62408B1 (fr)
IL (1)	IL93489A (fr)
LT (2)	LT3806B (fr)
LV (2)	LV10112B (fr)
MY (1)	MY105168A (fr)
NO (1)	NO301169B1 (fr)
PL (1)	PL163417B1 (fr)
PT (1)	PT93237B (fr)
RU (2)	RU2099350C1 (fr)
SK (1)	SK279530B6 (fr)
UA (2)	UA26324A (fr)
WO (1)	WO1990010020A1 (fr)
ZA (1)	ZA901357B (fr)

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HUP0303779A2 (en) *	2003-11-20	2006-02-28	Richter Gedeon Vegyeszet	Pharmaceutical compositions containing hyaluronan complex for the treatment of sclerosis multiplex
RU2280041C1 (ru) *	2005-04-21	2006-07-20	Общество с ограниченной ответственностью Научно-производственное предприятие "Тульская индустрия ЛТД"	Способ получения водорастворимых солевых комплексов гиалуроновой кислоты (варианты)
JPWO2006121210A1 (ja) *	2005-05-13	2008-12-18	高田製薬株式会社	皮膚状態改善剤
JPWO2006121209A1 (ja) *	2005-05-13	2008-12-18	高田製薬株式会社	湿疹・皮膚炎群治療剤
JP4220513B2 (ja) *	2005-12-01	2009-02-04	株式会社資生堂	カチオン化ヒアルロン酸
CN1329414C (zh) *	2005-12-02	2007-08-01	凌沛学	透明质酸铋钾及其制备方法和应用
CN100348621C (zh) *	2005-12-02	2007-11-14	凌沛学	透明质酸铋及其制备方法和应用
FR2918565B1 (fr) *	2007-07-12	2009-10-30	Biopharmex Holding Sa	Hydrogel de carboxyalkylamide de chitosan, sa preparation et son utilisation cosmetique et dermatologique
ES2326721B1 (es) *	2008-01-04	2010-07-16	Endor Nanotechnologies, S.L.	Conjugado de acido hialuronico para el tratamiento cosmetico y procedimiento de preparacion.
TWI516269B (zh)	2009-08-14	2016-01-11	禾伸堂生技股份有限公司	使用於炎症性腸疾病（ｉｂｄ）治療和預防之透明質酸混合物
TWI383796B (zh)	2009-08-14	2013-02-01	Holy Stone Healthcare Co Ltd	Use of hyaluronic acid mixture for the treatment and prevention of peptic ulcer and duodenal ulcer
HUP0900717A3 (en)	2009-11-18	2012-02-28	Richter Gedeon Nyrt	Pharmaceutical composition for urological use containing zinc hyaluronate
JP5728865B2 (ja)	2010-01-07	2015-06-03	株式会社リコー	放熱機構、及び放熱板の支え金具
CN102834417B (zh) *	2010-04-14	2015-11-25	丘比株式会社	透明质酸金属盐的制造方法、包含透明质酸金属盐的化妆品的制造方法以及透明质酸锌及其制造方法
ES2376680B8 (es)	2010-08-16	2013-04-30	Nylstar, S.A.	Fibra textil cosmética, procedimiento de obtención y su empleo.
CN102552309B (zh) *	2010-12-15	2013-06-05	北京理工大学	一种透明质酸金的用途及其制备方法
JP5763953B2 (ja) *	2011-03-31	2015-08-12	ロート製薬株式会社	外用組成物
CN102961396A (zh) *	2012-12-17	2013-03-13	程玉李	透明质酸金属盐在制备治疗皮肤病药物中的应用、其药物组合物及其制备方法
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CA3035414C (fr) *	2016-08-29	2022-02-22	The Regents Of The University Of California	Formulations topiques a base d'especes ioniques pour le traitement de la peau
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US4623539A (en) *	1983-02-04	1986-11-18	Tunc Deger C	Nutrient barrier polysaccharide compositions and method of use
NO161573C (no)	1983-11-25	1989-08-30	Miles Inc	Fremgangsmaate til fremstilling av hyaluronsyre.
JPS61286310A (ja) *	1985-06-10	1986-12-16	Kanebo Ltd	メ−クアツプ化粧料
US4746504A (en) *	1986-03-14	1988-05-24	Bio-Technology General Corp.	Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
EP0259485A4 (fr) *	1986-03-14	1988-07-29	Bio Technology General Corp	Sels de metaux lourds de l'acide hyaluronique utiles en tant qu'agents antimicrobiens.
US4742215A (en) *	1986-05-07	1988-05-03	Personal Computer Card Corporation	IC card system
EP0356435B1 (fr) *	1987-03-19	1995-10-18	Arthropharm Pty. Limited	Composes et compositions anti-inflammatoires

1989
- 1989-02-24 HU HU89891A patent/HU203372B/hu unknown
1990
- 1990-02-20 HK HK98102052A patent/HK1003003A1/en not_active IP Right Cessation
- 1990-02-20 UA UA4895005A patent/UA26324A/uk unknown
- 1990-02-20 DE DE69005394T patent/DE69005394T2/de not_active Expired - Lifetime
- 1990-02-20 KR KR1019900702327A patent/KR960015624B1/ko not_active Expired - Lifetime
- 1990-02-20 AT AT90903397T patent/ATE98964T1/de not_active IP Right Cessation
- 1990-02-20 UA UA94061636A patent/UA39174C2/uk unknown
- 1990-02-20 JP JP2503644A patent/JP2571312B2/ja not_active Expired - Lifetime
- 1990-02-20 DK DK90903397.9T patent/DK0413016T3/da not_active Application Discontinuation
- 1990-02-20 WO PCT/HU1990/000013 patent/WO1990010020A1/fr not_active Ceased
- 1990-02-20 AU AU51088/90A patent/AU623232B2/en not_active Expired
- 1990-02-20 CA CA002027596A patent/CA2027596C/fr not_active Expired - Lifetime
- 1990-02-20 RU SU904831382A patent/RU2099350C1/ru active
- 1990-02-20 ES ES90903397T patent/ES2061016T3/es not_active Expired - Lifetime
- 1990-02-20 EP EP90903397A patent/EP0413016B1/fr not_active Expired - Lifetime
- 1990-02-22 PT PT93237A patent/PT93237B/pt active IP Right Grant
- 1990-02-22 MY MYPI90000280A patent/MY105168A/en unknown
- 1990-02-22 GR GR900100137A patent/GR1000869B/el not_active IP Right Cessation
- 1990-02-22 IL IL9348990A patent/IL93489A/en not_active IP Right Cessation
- 1990-02-22 CZ CS90857A patent/CZ281000B6/cs not_active IP Right Cessation
- 1990-02-22 SK SK857-90A patent/SK279530B6/sk not_active IP Right Cessation
- 1990-02-22 IE IE63790A patent/IE62408B1/en not_active IP Right Cessation
- 1990-02-22 ZA ZA901357A patent/ZA901357B/xx unknown
- 1990-02-22 DD DD90338061A patent/DD292263A5/de not_active IP Right Cessation
- 1990-02-23 AR AR90316230A patent/AR243538A1/es active
- 1990-02-23 CN CN90100904A patent/CN1024557C/zh not_active Expired - Lifetime
- 1990-02-23 PL PL90283942A patent/PL163417B1/pl unknown
- 1990-02-23 CN CN93109689A patent/CN1051228C/zh not_active Expired - Lifetime
- 1990-10-17 FI FI905109A patent/FI101707B/fi active IP Right Grant
- 1990-10-23 NO NO904584A patent/NO301169B1/no not_active IP Right Cessation
1991
- 1991-04-11 RU SU914895005A patent/RU2021304C1/ru active
1992
- 1992-08-10 US US07/928,154 patent/US5554598A/en not_active Expired - Lifetime
- 1992-12-30 LV LVP-92-687A patent/LV10112B/lv unknown
1993
- 1993-06-17 GE GEAP1993894A patent/GEP19981358B/en unknown
- 1993-06-29 LV LVP-93-747A patent/LV10965B/lv unknown
- 1993-08-12 GE GEAP19931400A patent/GEP19971015B/en unknown
- 1993-10-26 LT LTIP1418A patent/LT3806B/lt not_active IP Right Cessation
- 1993-11-18 LT LTIP1474A patent/LT3873B/lt not_active IP Right Cessation
1994
- 1994-03-01 BG BG098631A patent/BG61515B2/bg unknown
1995
- 1995-06-07 HU HU95P/P00167P patent/HU211465A9/hu unknown

Also Published As

Publication number	Publication date
HU211465A9 (en)	1995-11-28
UA39174C2 (uk)	2001-06-15
GEP19971015B (en)	1997-05-30
LT3806B (en)	1996-03-25
PT93237A (pt)	1990-08-31
KR960015624B1 (ko)	1996-11-18
SK85790A3 (en)	1998-12-02
GR1000869B (el)	1993-03-16
FI101707B1 (fi)	1998-08-14
LV10112A (lv)	1994-05-10
FI905109A0 (fi)	1990-10-17
IE62408B1 (en)	1995-01-25
EP0413016A1 (fr)	1991-02-20
DE69005394D1 (de)	1994-02-03
LV10112B (en)	1995-02-20
LV10965B (en)	1996-08-20
AR243538A1 (es)	1993-08-31
CA2027596C (fr)	2001-01-02
ZA901357B (en)	1990-11-28
FI101707B (fi)	1998-08-14
EP0413016B1 (fr)	1993-12-22
CN1051228C (zh)	2000-04-12
LTIP1418A (en)	1995-05-25
ATE98964T1 (de)	1994-01-15
MY105168A (en)	1994-08-30
CZ281000B6 (cs)	1996-05-15
UA26324A (uk)	1999-08-30
ES2061016T3 (es)	1994-12-01
DE69005394T2 (de)	1994-07-28
AU623232B2 (en)	1992-05-07
CZ85790A3 (en)	1995-02-15
SK279530B6 (sk)	1998-12-02
CN1045394A (zh)	1990-09-19
JPH03505231A (ja)	1991-11-14
NO301169B1 (no)	1997-09-22
IE900637L (en)	1990-08-24
DK0413016T3 (da)	1994-02-14
PL163417B1 (pl)	1994-03-31
WO1990010020A1 (fr)	1990-09-07
KR920700231A (ko)	1992-02-19
NO904584D0 (no)	1990-10-23
LTIP1474A (en)	1995-06-26
AU5108890A (en)	1990-09-26
US5554598A (en)	1996-09-10
PT93237B (pt)	1996-01-31
LV10965A (lv)	1995-12-20
IL93489A (en)	1994-05-30
RU2021304C1 (ru)	1994-10-15
DD292263A5 (de)	1991-07-25
LT3873B (en)	1996-04-25
RU2099350C1 (ru)	1997-12-20
BG61515B2 (bg)	1997-10-31
GEP19981358B (en)	1998-08-25
PL283942A1 (en)	1991-01-28
NO904584L (no)	1990-12-21
HK1003003A1 (en)	1998-09-30
JP2571312B2 (ja)	1997-01-16
CN1024557C (zh)	1994-05-18
CN1086422A (zh)	1994-05-11
HUT53128A (en)	1990-09-28
GR900100137A (en)	1991-06-28
HU203372B (en)	1991-07-29

Legal Events

Date	Code	Title	Description
1997-01-08	EEER	Examination request
2010-02-20	MKEX	Expiry

Publication	Publication Date	Title
IE900637L (en)	1990-08-24	Novel compositions containing hyaluronic acid associates and¹a process for preparing same
CA2016659A1 (fr)	1990-11-16	Compose stabilise contenant un facteur de croissance epidermique
IE830870L (en)	1983-10-20	Oral hygiene compositions
CA2095776A1 (fr)	1993-11-13	Compositions a base de polydextrose, facilement dispersables
CS653586A3 (en)	1992-10-14	Pharmaceutical containing 7-isopropoxyisoflavone
HUT61031A (en)	1992-11-30	Process for producing chemically modified, stable haemoglobin substituting for non-immunogehic red blood cell, and pharmaceutical compositions comprising same as active ingredient
IL95691A0 (en)	1991-06-30	Thienylcarboxylates of amino alcohols,their preparation and pharmaceutical compositions containing them
EP0369356A3 (fr)	1992-03-25	Compositions pour le traitement des cheveux ayant des propriétés de fixation durable des cheveux
ZA948669B (en)	1995-07-04	New pyrazine carboxamide derivatives the preparation thereof and their use in pharmaceutical compositions
EP0166440A3 (fr)	1987-06-03	Compostion antiacide
US4704280A (en)	1987-11-03	Cosmetic lotion
HU9602498D0 (en)	1996-11-28	Pharmaceutical compositions of antimicrobial activity
CA2286756A1 (fr)	1998-11-05	Utilisation d'hyaluronate de zinc pour traiter un ulcere gastro-duodenal
UA40636C2 (uk)	2001-08-15	Фармацевтична композиція для одержання стабільного порошку, яка містить як активний компонент асоціацію ацетилсаліцилової кислоти та метоклопраміду, фармацевтичний препарат у формі порошку та спосіб одержання цього препарату
HUT55598A (en)	1991-06-28	Fungicidal composition comprising new amino acid amide derivatives as active ingredient and process for producing the active ingredients
CA2016221A1 (fr)	1990-11-08	Composes
CA2020346A1 (fr)	1991-01-05	Facteurs a1, a2, a3 et h de l'antibiotique ge 2270
HUT54289A (en)	1991-02-28	Fungicidal compositions comprising guanidine derivatives as active ingredient and process for producing the active ingredients
GR3020575T3 (en)	1996-10-31	New 2-amino-5-cyano-1,4-dihydropyridines, process for their preparation and use in pharmaceutical compositions
HUT54166A (en)	1991-01-28	Process for producing 1,1-dioxocefem-4-carbothiol acid derivatives and pharmaceutical compositions comprising same as active ingredient
GEP20032968B (en)	2003-05-27	Use of Ketolides in Pharmaceutical Compositions for Preventing Thrombotic Arterial Complications Linked to Atherosclerosis
HUT46364A (en)	1988-10-28	Process for producing 1,12-dihydroxy-1,6,12,13-tetraaza-dicyclodocosane-2,5,13,16-tetron and pharmaceutical compositions comprising this compound as active ingredient
CA2075926A1 (fr)	1991-08-16	Esters d'acides amines et d'hydroquinone, methodes d'obtention et compositions phramaceutiques ou cosmetiques qui en contiennent
AU8452791A (en)	1992-03-26	1-phenyl-3-aryl-2-propyne-1-ones
NZ232648A (en)	1991-09-25	Associates (complexes) of deprotonated hyaluronic acid with 3d metal ions of the fourth period of the periodic table and pharmaceutical and cosmetic compositions thereof