HK1003003A1 - Novel compositions containing hyaluronic acid associates and a process for preparing same - Google Patents

Novel compositions containing hyaluronic acid associates and a process for preparing same Download PDF

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Publication number
HK1003003A1
HK1003003A1 HK98102052A HK98102052A HK1003003A1 HK 1003003 A1 HK1003003 A1 HK 1003003A1 HK 98102052 A HK98102052 A HK 98102052A HK 98102052 A HK98102052 A HK 98102052A HK 1003003 A1 HK1003003 A1 HK 1003003A1
Authority
HK
Hong Kong
Prior art keywords
zinc
hyaluronate
solution
complex
sodium
Prior art date
Application number
HK98102052A
Other languages
German (de)
English (en)
Chinese (zh)
Other versions
HK1003003B (en
Inventor
Burger Kalman
Takacsi Nagy Geza
Rethey Ivan
Illes Janos
Stefko Bela
Neszmelyi Erzsebet
Gebhardt Istvan
Racz Istvan
Kiraly Arpadne
Varkonyi Viktoria
Original Assignee
Richter Gedeon Vegyeszeti Gyar R.T.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar R.T. filed Critical Richter Gedeon Vegyeszeti Gyar R.T.
Publication of HK1003003B publication Critical patent/HK1003003B/en
Publication of HK1003003A1 publication Critical patent/HK1003003A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Claims (8)

  1. Complexe d'acide hyaluronique déprotoné et d'un ion cobalt ou zinc.
  2. Complexe selon la revendication 1, comprenant un ion zinc en tant qu'ion métallique.
  3. Complexe selon la revendication 1, comprenant un ion cobalt en tant qu'ion métallique.
  4. Composition pharmaceutique, comprenant un complexe selon l'une quelconque des revendications précédentes, en mélange avec un ou plusieurs supports et/ou additifs, de préférence qui sont couramment utilisés dans l'industrie pharmaceutique, et comprenant de plus, éventuellement, un ou plusieurs agents thérapeutiquement actifs supplémentaires.
  5. Composition cosmétique, comprenant un complexe tel que défini selon l'une quelconque des revendications 1 à 3, éventuellement avec des additifs.
  6. Utilisation d'un complexe tel que défini selon l'une quelconque des revendications 1 à 3 dans la fabrication d'un médicament pour accélérer l'épithélisation de surfaces corporelles déficientes en épithélium, particulièrement dans l'ulcère crural, le décubitus, les plaies chroniques, les brûlures, les plaies provoquées par la chaleur ou un rayonnement, l'acné vulgaire et/ou l'acné conglobata.
  7. Procédé pour la préparation d'un complexe tel que défini selon l'une quelconque des revendications 1 à 3, comprenant les étapes consistant:
    (a) à ajouter une solution aqueuse contenant une quantité équivalente d'un sel, de préférence le chlorure, de l'ion métallique à une solution aqueuse d'un sel hyaluronate, éventuellement le sel d'argent ou de métal alcalino-terreux ou alcalin, de préférence le sel de sodium; ou
    (b) à dissoudre un complexe formé à partir de l'acide hyaluronique et d'un sel d'ammonium quaternaire en solution aqueuse de l'ion métallique et un solvant qui est partiellement miscible avec l'eau, de préférence le n-butanol; puis    à retirer par précipitation le complexe obtenu avec un alcanol ou une alcanone d'une manière connue, ou    à séparer le précipité de la solution puis, si souhaité    à le sécher dans des conditions douces.
  8. Procédé pour la préparation directe d'une composition aqueuse contenant l'hyaluronate de zinc, comprenant l'addition, à une solution d'hyaluronate de sodium, d'une solution contenant au moins une quantité stoechiométrique de chlorure de zinc nécessaire pour atteindre l'état isotonique.
HK98102052A 1989-02-24 1990-02-20 Novel compositions containing hyaluronic acid associates and a process for preparing same HK1003003A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU89891A HU203372B (en) 1989-02-24 1989-02-24 Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient
HU89189 1989-02-24
PCT/HU1990/000013 WO1990010020A1 (fr) 1989-02-24 1990-02-20 Nouvelles compositions contenant des associes d'acide hyaluronique et leur procede de preparation

Publications (2)

Publication Number Publication Date
HK1003003B HK1003003B (en) 1998-09-30
HK1003003A1 true HK1003003A1 (en) 1998-09-30

Family

ID=10951903

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98102052A HK1003003A1 (en) 1989-02-24 1990-02-20 Novel compositions containing hyaluronic acid associates and a process for preparing same

Country Status (33)

Country Link
US (1) US5554598A (fr)
EP (1) EP0413016B1 (fr)
JP (1) JP2571312B2 (fr)
KR (1) KR960015624B1 (fr)
CN (2) CN1024557C (fr)
AR (1) AR243538A1 (fr)
AT (1) ATE98964T1 (fr)
AU (1) AU623232B2 (fr)
BG (1) BG61515B2 (fr)
CA (1) CA2027596C (fr)
CZ (1) CZ281000B6 (fr)
DD (1) DD292263A5 (fr)
DE (1) DE69005394T2 (fr)
DK (1) DK0413016T3 (fr)
ES (1) ES2061016T3 (fr)
FI (1) FI101707B (fr)
GE (2) GEP19981358B (fr)
GR (1) GR1000869B (fr)
HK (1) HK1003003A1 (fr)
HU (2) HU203372B (fr)
IE (1) IE62408B1 (fr)
IL (1) IL93489A (fr)
LT (2) LT3806B (fr)
LV (2) LV10112B (fr)
MY (1) MY105168A (fr)
NO (1) NO301169B1 (fr)
PL (1) PL163417B1 (fr)
PT (1) PT93237B (fr)
RU (2) RU2099350C1 (fr)
SK (1) SK279530B6 (fr)
UA (2) UA26324A (fr)
WO (1) WO1990010020A1 (fr)
ZA (1) ZA901357B (fr)

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CA3035414C (fr) * 2016-08-29 2022-02-22 The Regents Of The University Of California Formulations topiques a base d'especes ioniques pour le traitement de la peau
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Also Published As

Publication number Publication date
HU211465A9 (en) 1995-11-28
UA39174C2 (uk) 2001-06-15
GEP19971015B (en) 1997-05-30
LT3806B (en) 1996-03-25
PT93237A (pt) 1990-08-31
KR960015624B1 (ko) 1996-11-18
SK85790A3 (en) 1998-12-02
GR1000869B (el) 1993-03-16
FI101707B1 (fi) 1998-08-14
LV10112A (lv) 1994-05-10
FI905109A0 (fi) 1990-10-17
IE62408B1 (en) 1995-01-25
EP0413016A1 (fr) 1991-02-20
DE69005394D1 (de) 1994-02-03
LV10112B (en) 1995-02-20
LV10965B (en) 1996-08-20
AR243538A1 (es) 1993-08-31
CA2027596C (fr) 2001-01-02
ZA901357B (en) 1990-11-28
FI101707B (fi) 1998-08-14
EP0413016B1 (fr) 1993-12-22
CN1051228C (zh) 2000-04-12
LTIP1418A (en) 1995-05-25
ATE98964T1 (de) 1994-01-15
CA2027596A1 (fr) 1990-08-25
MY105168A (en) 1994-08-30
CZ281000B6 (cs) 1996-05-15
UA26324A (uk) 1999-08-30
ES2061016T3 (es) 1994-12-01
DE69005394T2 (de) 1994-07-28
AU623232B2 (en) 1992-05-07
CZ85790A3 (en) 1995-02-15
SK279530B6 (sk) 1998-12-02
CN1045394A (zh) 1990-09-19
JPH03505231A (ja) 1991-11-14
NO301169B1 (no) 1997-09-22
IE900637L (en) 1990-08-24
DK0413016T3 (da) 1994-02-14
PL163417B1 (pl) 1994-03-31
WO1990010020A1 (fr) 1990-09-07
KR920700231A (ko) 1992-02-19
NO904584D0 (no) 1990-10-23
LTIP1474A (en) 1995-06-26
AU5108890A (en) 1990-09-26
US5554598A (en) 1996-09-10
PT93237B (pt) 1996-01-31
LV10965A (lv) 1995-12-20
IL93489A (en) 1994-05-30
RU2021304C1 (ru) 1994-10-15
DD292263A5 (de) 1991-07-25
LT3873B (en) 1996-04-25
RU2099350C1 (ru) 1997-12-20
BG61515B2 (bg) 1997-10-31
GEP19981358B (en) 1998-08-25
PL283942A1 (en) 1991-01-28
NO904584L (no) 1990-12-21
JP2571312B2 (ja) 1997-01-16
CN1024557C (zh) 1994-05-18
CN1086422A (zh) 1994-05-11
HUT53128A (en) 1990-09-28
GR900100137A (en) 1991-06-28
HU203372B (en) 1991-07-29

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