CA2060865A1 - 2-octynyladenosine solide et stable, et procede pour sa production - Google Patents

2-octynyladenosine solide et stable, et procede pour sa production

Info

Publication number
CA2060865A1
CA2060865A1 CA2060865A CA2060865A CA2060865A1 CA 2060865 A1 CA2060865 A1 CA 2060865A1 CA 2060865 A CA2060865 A CA 2060865A CA 2060865 A CA2060865 A CA 2060865A CA 2060865 A1 CA2060865 A1 CA 2060865A1
Authority
CA
Canada
Prior art keywords
octynyl adenosine
producing
same
solid
stable solid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2060865A
Other languages
English (en)
Other versions
CA2060865C (fr
Inventor
Manami Morozumi
Masao Kumagai
Toyofumi Yamaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2060865A1 publication Critical patent/CA2060865A1/fr
Application granted granted Critical
Publication of CA2060865C publication Critical patent/CA2060865C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
CA002060865A 1991-02-12 1992-02-07 2-octynyladenosine solide et stable, et procede pour sa production Expired - Fee Related CA2060865C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3040894A JP2740362B2 (ja) 1991-02-12 1991-02-12 安定な固体状２‐オクチニルアデノシンおよびその製造法
JP40894/1991 1991-02-12

Publications (2)

Publication Number Publication Date
CA2060865A1 true CA2060865A1 (fr) 1992-08-13
CA2060865C CA2060865C (fr) 2000-05-16

Family

ID=12593220

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002060865A Expired - Fee Related CA2060865C (fr) 1991-02-12 1992-02-07 2-octynyladenosine solide et stable, et procede pour sa production

Country Status (7)

Country Link
US (1) US5939543A (fr)
EP (1) EP0499185B1 (fr)
JP (1) JP2740362B2 (fr)
AT (1) ATE122680T1 (fr)
CA (1) CA2060865C (fr)
DE (1) DE69202483T2 (fr)
ES (1) ES2073793T3 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6403567B1 (en) * 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
CA2439222C (fr) * 2000-02-23 2009-07-14 Cv Therapeutics, Inc. Procede permettant d'identifier des agonistes partiels du recepteur a2a
WO2004011010A1 (fr) * 2002-07-29 2004-02-05 Cv Therapeutics, Inc. Imagerie de perfusion myocardique au moyen d'agonistes de recepteur a2a
US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
CA2583185A1 (fr) 2004-10-20 2006-04-27 Cv Therapeutics, Inc. Utilisation d'agonistes du recepteur de l'adenosine a2a
PL1989214T3 (pl) 2006-02-03 2017-07-31 Gilead Sciences, Inc. Proces otrzymywania agonisty receptora adenozynowego a2a i jego polimorfów
CA2655310A1 (fr) * 2006-06-22 2008-05-29 Cv Therapeutics, Inc. Utilisation d'agonistes de recepteur d'adenosine a<sb>2a</sb> dans le traitement d'une ischemie
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
JP2010502649A (ja) * 2006-09-01 2010-01-28 シーブイ・セラピューティクス・インコーポレイテッド 心筋層画像化法中の患者の耐性を増加させるための方法および組成物
JP2011502101A (ja) * 2006-09-29 2011-01-20 ギリアード・パロ・アルト・インコーポレイテッド 肺疾患の病歴を有する患者における心筋画像化法
EP2099360A2 (fr) * 2007-01-03 2009-09-16 CV Therapeutics Inc. Imagerie de perfusion myocardique
EP2344145A1 (fr) * 2008-09-29 2011-07-20 Gilead Sciences, Inc. Combinaisons d'agent de régulation de la fréquence cardiaque et d'antagoniste de récepteur a-2-alpha utilisées dans des procédés de tomographie à détecteurs multiples assistée par ordinateur

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5134443B2 (fr) * 1972-10-09 1976-09-27
JPS5140134B2 (fr) * 1972-12-27 1976-11-01
JPS50142595A (fr) * 1974-05-14 1975-11-17
JPS6299395A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
DE68916036T2 (de) * 1988-11-15 1994-09-29 Toa Eiyo Ltd Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen.
KR920700218A (ko) * 1989-06-20 1992-02-19 원본미기재 2-알키닐 아데노신의 합성중간체, 그 합성 중간체의 제조법, 그 합성중간체를 이용한 2-알키닐 아데노신의 제조법 및 안정한 2-알키닐 아데노신 유도체
JPH095526A (ja) * 1995-06-14 1997-01-10 Asahi Glass Co Ltd 重畳型ホログラム

Also Published As

Publication number Publication date
EP0499185B1 (fr) 1995-05-17
DE69202483T2 (de) 1995-09-28
DE69202483D1 (de) 1995-06-22
ES2073793T3 (es) 1995-08-16
CA2060865C (fr) 2000-05-16
EP0499185A1 (fr) 1992-08-19
US5939543A (en) 1999-08-17
JPH05194579A (ja) 1993-08-03
JP2740362B2 (ja) 1998-04-15
ATE122680T1 (de) 1995-06-15

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