CA2066248A1 - Esters d'acides thiophenecarboxyliques et d'aminoalcools; composes quaternaires obtenus par cette voie; production et utilisation de ces substances - Google Patents

Esters d'acides thiophenecarboxyliques et d'aminoalcools; composes quaternaires obtenus par cette voie; production et utilisation de ces substances

Info

Publication number
CA2066248A1
CA2066248A1 CA2066248A CA2066248A CA2066248A1 CA 2066248 A1 CA2066248 A1 CA 2066248A1 CA 2066248 A CA2066248 A CA 2066248A CA 2066248 A CA2066248 A CA 2066248A CA 2066248 A1 CA2066248 A1 CA 2066248A1
Authority
CA
Canada
Prior art keywords
compounds
esters
manufacture
carboxylic acids
amino alcohols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2066248A
Other languages
English (en)
Other versions
CA2066248C (fr
Inventor
Rolf Banholzer
Rudolf Bauer
Richard Reichl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6389619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2066248(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2066248A1 publication Critical patent/CA2066248A1/fr
Application granted granted Critical
Publication of CA2066248C publication Critical patent/CA2066248C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Disintegrating Or Milling (AREA)
  • Glass Compositions (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Les nouveaux composés dont la formule est donnée à la figure 1 (A, R1, Ra et R sont définis dans la description) peuvent être préparés suivant des procédés connus et utilisés à titre d'ingrédients actifs dans des médicaments.
CA002066248A 1989-09-16 1990-09-08 Esters d'acides thiophenecarboxyliques et d'aminoalcools; composes quaternaires obtenus par cette voie; production et utilisation de ces substances Expired - Lifetime CA2066248C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3931041.8 1989-09-16
DE3931041A DE3931041C2 (de) 1989-09-16 1989-09-16 Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
CA2066248A1 true CA2066248A1 (fr) 1991-03-17
CA2066248C CA2066248C (fr) 1998-08-04

Family

ID=6389619

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002066248A Expired - Lifetime CA2066248C (fr) 1989-09-16 1990-09-08 Esters d'acides thiophenecarboxyliques et d'aminoalcools; composes quaternaires obtenus par cette voie; production et utilisation de ces substances

Country Status (33)

Country Link
US (1) USRE39820E1 (fr)
EP (1) EP0418716B1 (fr)
JP (1) JPH0730074B2 (fr)
KR (1) KR0168432B1 (fr)
AT (1) ATE103914T1 (fr)
AU (1) AU642913B2 (fr)
BG (1) BG61295B2 (fr)
CA (1) CA2066248C (fr)
CZ (1) CZ284589B6 (fr)
DD (1) DD297647A5 (fr)
DE (3) DE3931041C2 (fr)
DK (1) DK0418716T3 (fr)
ES (1) ES2052125T3 (fr)
FI (1) FI114395B (fr)
HR (1) HRP940723B1 (fr)
HU (2) HU208823B (fr)
IE (1) IE65528B1 (fr)
IL (1) IL95691A (fr)
LU (1) LU90949I2 (fr)
MX (1) MX9203150A (fr)
NL (1) NL300084I2 (fr)
NO (2) NO301478B1 (fr)
NZ (1) NZ235306A (fr)
PH (1) PH31617A (fr)
PL (1) PL168468B1 (fr)
PT (1) PT95312B (fr)
RU (1) RU2073677C1 (fr)
SI (1) SI9011744B (fr)
SK (1) SK452390A3 (fr)
UA (1) UA41272C2 (fr)
WO (1) WO1991004252A1 (fr)
YU (1) YU47800B (fr)
ZA (1) ZA907338B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6890920B2 (en) 2001-10-26 2005-05-10 Pharmacia & Upjohn Company Quaternary ammonium compounds
AU2004285683B2 (en) * 2003-11-03 2011-04-21 Boehringer Ingelheim International Gmbh Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same

Families Citing this family (150)

* Cited by examiner, † Cited by third party
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DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
DE19921693A1 (de) 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
GB0009606D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Therapeutic combinations
GB0009583D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory formulations
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US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
WO2002012266A1 (fr) 2000-08-05 2002-02-14 Glaxo Group Limited Derives de 17-beta-carbothioate-17-alpha-arylcarbonyloxyloxy androstane utilises comme anti-inflammatoires
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US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
ATE275391T1 (de) 2000-10-12 2004-09-15 Boehringer Ingelheim Pharma Neue tiotropium-haltige inhalationspulver
CN100519558C (zh) * 2000-10-12 2009-07-29 贝林格尔英格海姆法玛两合公司 结晶单水合物、其制备方法及其在制备药物组合中的用途
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EP1837021A3 (fr) * 2000-10-31 2008-03-19 Boehringer Ingelheim Pharma GmbH & Co. KG Formulation d'une solution d'inhalation contenant un sel de tiotropium
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IL156558A0 (en) 2000-12-28 2004-01-04 Almirall Prodesfarma Ag Novel quinuclidine derivatives and medicinal compositions containing the same
US6506900B1 (en) 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
PT1383786E (pt) 2001-04-30 2008-12-30 Glaxo Group Ltd Derivados anti-inflamatórios de éster 17.beta-carbotioato de androstano com um grupo éster ciclíco na posição 17.alfa
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IE903342A1 (en) 1991-04-10
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IL95691A (en) 1996-07-23
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EP0418716B1 (fr) 1994-04-06
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HU208823B (en) 1994-01-28
DE3931041A1 (de) 1991-03-28
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PH31617A (en) 1999-01-12
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