CA2066263C - Recepteur de thyrotropine - Google Patents
Recepteur de thyrotropineInfo
- Publication number
- CA2066263C CA2066263C CA002066263A CA2066263A CA2066263C CA 2066263 C CA2066263 C CA 2066263C CA 002066263 A CA002066263 A CA 002066263A CA 2066263 A CA2066263 A CA 2066263A CA 2066263 C CA2066263 C CA 2066263C
- Authority
- CA
- Canada
- Prior art keywords
- receptor
- nucleic acid
- tsh
- cell
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000003911 Thyrotropin Receptors Human genes 0.000 title claims abstract description 75
- 108090000253 Thyrotropin Receptors Proteins 0.000 title claims abstract description 75
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 33
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 33
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 33
- 108020003175 receptors Proteins 0.000 claims description 45
- 102000005962 receptors Human genes 0.000 claims description 44
- 210000004027 cell Anatomy 0.000 claims description 29
- 108020004414 DNA Proteins 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 25
- 239000002299 complementary DNA Substances 0.000 claims description 24
- 239000013598 vector Substances 0.000 claims description 22
- 239000002773 nucleotide Substances 0.000 claims description 16
- 125000003729 nucleotide group Chemical group 0.000 claims description 16
- 238000003556 assay Methods 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 14
- 238000006243 chemical reaction Methods 0.000 claims description 9
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 claims description 8
- 210000002966 serum Anatomy 0.000 claims description 8
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 102000011923 Thyrotropin Human genes 0.000 claims description 6
- 108010061174 Thyrotropin Proteins 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 5
- 210000003850 cellular structure Anatomy 0.000 claims description 4
- 210000004962 mammalian cell Anatomy 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 108091029865 Exogenous DNA Proteins 0.000 claims 2
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- 230000000295 complement effect Effects 0.000 claims 1
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- 238000011534 incubation Methods 0.000 claims 1
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- 238000009739 binding Methods 0.000 description 6
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- 239000000463 material Substances 0.000 description 5
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- 108010066072 DNA modification methylase EcoRI Proteins 0.000 description 1
- 101150013191 E gene Proteins 0.000 description 1
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- 239000004471 Glycine Substances 0.000 description 1
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- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
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- 102100040788 Lutropin-choriogonadotropic hormone receptor Human genes 0.000 description 1
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- 108091005804 Peptidases Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000055027 Protein Methyltransferases Human genes 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
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- 108010006785 Taq Polymerase Proteins 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
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- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
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- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 102000035122 glycosylated proteins Human genes 0.000 description 1
- 108091005608 glycosylated proteins Proteins 0.000 description 1
- 230000002710 gonadal effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
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- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
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- 125000002987 valine group Chemical class [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Protéine présentant l'activité biologique d'un récepteur de thyrotropine mammifère, et acide nucléique purifié codant ladite protéine.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40489989A | 1989-09-08 | 1989-09-08 | |
| US404,899 | 1989-09-08 | ||
| US56566990A | 1990-08-10 | 1990-08-10 | |
| US565,669 | 1990-08-10 | ||
| PCT/US1990/005066 WO1991003483A1 (fr) | 1989-09-08 | 1990-09-07 | Recepteur de thyrotropine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2066263A1 CA2066263A1 (fr) | 1991-03-09 |
| CA2066263C true CA2066263C (fr) | 1999-11-02 |
Family
ID=27018824
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002066263A Expired - Fee Related CA2066263C (fr) | 1989-09-08 | 1990-09-07 | Recepteur de thyrotropine |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0493434A4 (fr) |
| JP (1) | JP3181582B2 (fr) |
| CA (1) | CA2066263C (fr) |
| WO (1) | WO1991003483A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1199361A3 (fr) * | 1989-05-05 | 2004-03-10 | Genentech Inc. | Molécules réceptrices des hormones glycoprotéiques. Leurs utilisations |
| US6261800B1 (en) | 1989-05-05 | 2001-07-17 | Genentech, Inc. | Luteinizing hormone/choriogonadotropin (LH/CG) receptor |
| US5614363A (en) * | 1990-01-25 | 1997-03-25 | New England Medical Center Hospitals, Inc. | TSH receptor |
| US5744348A (en) * | 1989-09-08 | 1998-04-28 | New England Medical Center Hospitals, Inc. | TSH receptor |
| EP0433509B1 (fr) * | 1989-12-14 | 1996-11-13 | B.R.A.H.M.S Diagnostica GmbH | Polypeptides possédant l'activité réceptrice de la thyrotropine, séquences d'acides nucléiques codant pour de tels récepteurs et polypeptides, et applications de ces polypeptides |
| EP0506890A4 (en) * | 1989-12-20 | 1993-06-30 | Nichols Institute Diagnostics | Recombinant thyrotropin receptor |
| DE19645729C1 (de) * | 1996-11-06 | 1998-06-04 | Brahms Diagnostica Gmbh | Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays |
| DE19651093C2 (de) * | 1996-12-09 | 1999-06-10 | Brahms Diagnostica Gmbh | Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays |
| CA2304986A1 (fr) * | 1997-09-24 | 1999-04-01 | Merck & Co., Inc. | Recepteur hormonal glycoproteique aomf05 couple par proteines g |
| GB9823397D0 (en) | 1998-10-27 | 1998-12-23 | Rsr Ltd | Assays for thyroid autoantibodies |
| DE50306067D1 (de) | 2002-11-26 | 2007-02-01 | Brahms Ag | Nachweis von tsh-rezeptor-autoantikörpern mit affinitätsgereinigten antikörpern |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1199361A3 (fr) * | 1989-05-05 | 2004-03-10 | Genentech Inc. | Molécules réceptrices des hormones glycoprotéiques. Leurs utilisations |
| EP0433509B1 (fr) * | 1989-12-14 | 1996-11-13 | B.R.A.H.M.S Diagnostica GmbH | Polypeptides possédant l'activité réceptrice de la thyrotropine, séquences d'acides nucléiques codant pour de tels récepteurs et polypeptides, et applications de ces polypeptides |
| EP0506890A4 (en) * | 1989-12-20 | 1993-06-30 | Nichols Institute Diagnostics | Recombinant thyrotropin receptor |
| FR2657014A1 (fr) * | 1990-01-15 | 1991-07-19 | Inst Nat Sante Rech Med | Recepteur humain de la tsh. sequence codant pour ce recepteur. |
-
1990
- 1990-09-07 EP EP19900913766 patent/EP0493434A4/en not_active Withdrawn
- 1990-09-07 WO PCT/US1990/005066 patent/WO1991003483A1/fr not_active Ceased
- 1990-09-07 CA CA002066263A patent/CA2066263C/fr not_active Expired - Fee Related
- 1990-09-07 JP JP51304090A patent/JP3181582B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0493434A4 (en) | 1993-05-05 |
| CA2066263A1 (fr) | 1991-03-09 |
| WO1991003483A1 (fr) | 1991-03-21 |
| JPH05501952A (ja) | 1993-04-15 |
| JP3181582B2 (ja) | 2001-07-03 |
| EP0493434A1 (fr) | 1992-07-08 |
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