CA2080260C - Monoclonal antibodies against tumor-associated antigens, processes for the preparation thereof and the use thereof - Google Patents

Monoclonal antibodies against tumor-associated antigens, processes for the preparation thereof and the use thereof Download PDF

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Publication number
CA2080260C
CA2080260C CA002080260A CA2080260A CA2080260C CA 2080260 C CA2080260 C CA 2080260C CA 002080260 A CA002080260 A CA 002080260A CA 2080260 A CA2080260 A CA 2080260A CA 2080260 C CA2080260 C CA 2080260C
Authority
CA
Canada
Prior art keywords
antibody
mab
monoclonal antibody
antigen
cell line
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002080260A
Other languages
English (en)
French (fr)
Other versions
CA2080260A1 (en
Inventor
Klaus Bosslet
Peter Pfleiderer
Gerhard Seemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Products GmbH
Original Assignee
Dade Behring Marburg GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6442537&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2080260(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dade Behring Marburg GmbH filed Critical Dade Behring Marburg GmbH
Publication of CA2080260A1 publication Critical patent/CA2080260A1/en
Application granted granted Critical
Publication of CA2080260C publication Critical patent/CA2080260C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3038—Kidney, bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002080260A 1991-10-11 1992-10-09 Monoclonal antibodies against tumor-associated antigens, processes for the preparation thereof and the use thereof Expired - Fee Related CA2080260C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4133791.3 1991-10-11
DE4133791A DE4133791A1 (de) 1991-10-11 1991-10-11 Monoklonale antikoerper gegen tumorassoziierte antigene, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
CA2080260A1 CA2080260A1 (en) 1993-04-12
CA2080260C true CA2080260C (en) 2002-12-17

Family

ID=6442537

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002080260A Expired - Fee Related CA2080260C (en) 1991-10-11 1992-10-09 Monoclonal antibodies against tumor-associated antigens, processes for the preparation thereof and the use thereof

Country Status (11)

Country Link
US (4) US5639621A (de)
EP (1) EP0537489B1 (de)
JP (1) JP3996649B2 (de)
AT (1) ATE187463T1 (de)
AU (1) AU670247B2 (de)
CA (1) CA2080260C (de)
DE (2) DE4133791A1 (de)
ES (1) ES2141095T3 (de)
FI (1) FI924543L (de)
NZ (1) NZ244661A (de)
ZA (1) ZA927785B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0636029B1 (de) * 1992-04-13 2000-11-08 Dana-Farber Cancer Institute, Inc. Gegen karzinom-assoziierte antigene gerichtete antikörper
US6030797A (en) * 1992-10-08 2000-02-29 Dade Behring Marburg Gmbh Monoclonal antibodies against tumor-associated antigens, processes for the preparation thereof and the use thereof
US6207805B1 (en) 1997-07-18 2001-03-27 University Of Iowa Research Foundation Prostate cell surface antigen-specific antibodies
CA2305712A1 (en) * 1997-10-03 1999-04-15 Chugai Seiyaku Kabushiki Kaisha Natural humanized antibody
IL139700A (en) * 1998-06-15 2005-09-25 Altarex Medical Corp Immunotherapeutic composition for the treatment of prostate cancer
KR100643818B1 (ko) * 2000-05-08 2006-11-10 셀덱스 쎄라퓨틱스, 인크. 수상세포에 대한 인간 모노클로날 항체
RU2198681C2 (ru) * 2000-12-27 2003-02-20 Московский научно-исследовательский онкологический институт им. П.А. Герцена Моноклональное антитело ико25, специфичное к антигену мис1, противоопухолевое средство
US6949629B2 (en) * 2002-03-13 2005-09-27 Aspenbio, Inc. Methods for purifying selected CEA family member proteins
WO2007081779A2 (en) * 2006-01-05 2007-07-19 Genentech, Inc. Methods of determining cutoff points
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5640033A (en) * 1979-09-07 1981-04-16 Fujitsu Ltd Cold water type cooling system utilizing open air for cooling water
DE3329184A1 (de) * 1983-08-12 1985-02-21 Behringwerke Ag, 3550 Marburg Monoklonale antikoerper mit spezifitaet fuer membran-assoziierte antigene
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
CA1340456C (en) * 1986-07-07 1999-03-23 Hubert J.P. Schoemaker Chimeric rodent/human immunoglobulins specific for tumor-associated antigens
DE3825615A1 (de) * 1988-07-28 1990-02-01 Behringwerke Ag Antigenkonstrukte von "major histocompatibility complex" klasse i antigenen mit spezifischen traegermolekuelen, ihre herstellung und verwendung
US5185254A (en) * 1988-12-29 1993-02-09 The Wistar Institute Gene family of tumor-associated antigens
DE3909799A1 (de) * 1989-03-24 1990-09-27 Behringwerke Ag Monoklonale antikoerper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung
EP0397419A3 (de) * 1989-05-10 1991-04-03 Hybritech Incorporated Tumorassoziiertes Antigen, Antikörper sowie Zusammensetzungen und Verwendung hierfür
AU6031090A (en) * 1989-07-31 1991-03-11 University Of British Columbia, The Monoclonal antibodies against a tumor-associated antigen
DE4005630A1 (de) * 1990-02-22 1991-09-05 Behringwerke Ag Monoklonale antikoerper gegen tumorassoziierte antigene, verfahren zu ihrer herstellung sowie ihre verwendung

Also Published As

Publication number Publication date
FI924543A7 (fi) 1993-04-12
EP0537489A1 (de) 1993-04-21
AU670247B2 (en) 1996-07-11
US5837824A (en) 1998-11-17
DE4133791A1 (de) 1993-04-15
FI924543A0 (fi) 1992-10-08
ZA927785B (en) 1994-04-11
US5639621A (en) 1997-06-17
EP0537489B1 (de) 1999-12-08
CA2080260A1 (en) 1993-04-12
ES2141095T3 (es) 2000-03-16
JP3996649B2 (ja) 2007-10-24
NZ244661A (en) 1995-10-26
JPH05317088A (ja) 1993-12-03
US5674994A (en) 1997-10-07
ATE187463T1 (de) 1999-12-15
DE59209776D1 (de) 2000-01-13
FI924543L (fi) 1993-04-12
AU2629892A (en) 1993-04-22
US5695758A (en) 1997-12-09

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