CA2085127C - Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease - Google Patents
Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease Download PDFInfo
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- CA2085127C CA2085127C CA002085127A CA2085127A CA2085127C CA 2085127 C CA2085127 C CA 2085127C CA 002085127 A CA002085127 A CA 002085127A CA 2085127 A CA2085127 A CA 2085127A CA 2085127 C CA2085127 C CA 2085127C
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
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- A01K2267/03—Animal model, e.g. for test or diseases
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- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53885790A | 1990-06-15 | 1990-06-15 | |
| US538,857 | 1990-06-15 | ||
| PCT/US1991/004447 WO1991019810A1 (en) | 1990-06-15 | 1991-06-17 | Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2085127A1 CA2085127A1 (en) | 1991-12-16 |
| CA2085127C true CA2085127C (en) | 2002-12-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002085127A Expired - Lifetime CA2085127C (en) | 1990-06-15 | 1991-06-17 | Transgenic non-human mammal displaying the amyloid-forming pathology of alzheimer's disease |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5387742A (de) |
| EP (1) | EP0647268B1 (de) |
| JP (1) | JPH06507782A (de) |
| AT (1) | ATE260974T1 (de) |
| AU (1) | AU646877B2 (de) |
| CA (1) | CA2085127C (de) |
| DE (1) | DE69133372T2 (de) |
| ES (1) | ES2217250T3 (de) |
| WO (1) | WO1991019810A1 (de) |
Families Citing this family (260)
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| US5912410A (en) * | 1990-06-15 | 1999-06-15 | Scios Inc. | Transgenic non-human mice displaying the amyloid-forming pathology of alzheimer's disease |
| ES2236682T5 (es) | 1991-01-21 | 2011-03-31 | Elan Pharmaceuticals, Inc. | Ensayo y modelo para la enfermedad de alzheimer. |
| US5672805A (en) * | 1991-07-18 | 1997-09-30 | The Regents Of The University Of California | Transgenic mice expressing the neurotoxic C-terminus of β-amyloid precursor protein |
| AU2765992A (en) | 1991-10-03 | 1993-05-03 | Indiana University Foundation | Method for screening for alzheimer's disease |
| WO1993007280A1 (en) * | 1991-10-04 | 1993-04-15 | The Government Of The United States Of America As Represented By The Department Of Health And Human Services | Astrocyte-specific transcription of human genes |
| US5604131A (en) * | 1992-01-07 | 1997-02-18 | Athena Neurosciences, Inc. | cDNA-genomic DNA hybrid sequence encoding APP770 containing a genomic DNA insert of the KI and OX-2 regions |
| AU671093B2 (en) * | 1992-01-07 | 1996-08-15 | Elan Pharmaceuticals, Inc. | Transgenic animal models for alzheimer's disease |
| US5604102A (en) * | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| US5441870A (en) * | 1992-04-15 | 1995-08-15 | Athena Neurosciences, Inc. | Methods for monitoring cellular processing of β-amyloid precursor protein |
| US6610493B1 (en) | 1993-06-17 | 2003-08-26 | Brigham And Women's Hospital | Screening compounds for the ability to alter the production of amyloid-β peptide |
| US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| US5837672A (en) * | 1992-07-10 | 1998-11-17 | Athena Neurosciences, Inc. | Methods and compositions for the detection of soluble β-amyloid peptide |
| US6264915B1 (en) | 1992-09-13 | 2001-07-24 | The President And Fellows Of Harvard College | Process for detecting potential carcinogens |
| DE69334337D1 (de) * | 1992-10-26 | 2010-08-26 | Elan Pharm Inc | Verfahren zur Identifizierung von Hemmstoffverbindungen der Freisetzung von Beta-Amyloidpeptid (BAP) |
| US5605811A (en) * | 1992-10-26 | 1997-02-25 | Athena Neurosciences, Inc. | Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein |
| CA2125467C (en) * | 1993-07-06 | 2001-02-06 | Heinz Dobeli | Process for producing hydrophobic polypeptides, proteins or peptides |
| GB9316727D0 (en) * | 1993-08-12 | 1993-09-29 | Inst Of Psychiatry | Models of alzheimers's disease |
| GB2295395B (en) * | 1993-08-12 | 1998-04-01 | Inst Of Psychiatry | Models of Alzheimer's disease |
| AU702293B2 (en) * | 1993-10-27 | 1999-02-18 | Athena Neurosciences, Inc. | Transgenic animals harboring APP allele having Swedish mutation |
| JPH07132033A (ja) * | 1993-11-12 | 1995-05-23 | Hoechst Japan Ltd | アルツハイマー病モデルトランスジェニック動物 |
| US5877399A (en) * | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
| DE69533583T2 (de) | 1994-01-27 | 2005-10-06 | Regents of the University of Minnesota, Southeast, Minneapolis | Nicht humane, transgenische säugetiere mit sich entwickelnder neurologischer krankheit |
| US6025183A (en) * | 1994-02-28 | 2000-02-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Transgenic animal assay system for anti-cholinesterase substances |
| IL113052A0 (en) * | 1994-03-23 | 1995-06-29 | Rhone Poulenc Rorer Sa | Recombinant viruses, their preparation and their use in gene therapy |
| US6020537A (en) * | 1994-05-13 | 2000-02-01 | The Regents Of The University Of California | Prion protein standard and method of making same |
| US5792901A (en) * | 1994-05-13 | 1998-08-11 | The Regents Of The University Of California | Detecting prions in a sample and prion preparation and transgenic animal used for same |
| US6008435A (en) * | 1994-05-13 | 1999-12-28 | The Regents Of The University Of California | Detecting cow, sheep and human prions in a sample and transgenic mice used for same |
| WO1995034640A1 (en) * | 1994-06-13 | 1995-12-21 | Henry Ford Health System | A novel neuronal-neonatal gene: neuronatin |
| US5686269A (en) * | 1994-07-28 | 1997-11-11 | The Mclean Hospital Corporation | Method of diagnosing Alzheimer's disease by detecting the level of cathepsin D in cerebrospinal fluid |
| WO1996006927A1 (en) * | 1994-09-01 | 1996-03-07 | Merck & Co., Inc. | Transgenic animal expressing a familial form of human amyloid precursor protein |
| US7427392B1 (en) | 1994-11-14 | 2008-09-23 | Elan Pharmaceuticals, Inc. | Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau |
| US20030152909A1 (en) * | 1994-11-16 | 2003-08-14 | Mitrani Eduardo N. | In vitro micro-organs, and uses related thereto |
| US5698766A (en) * | 1995-04-05 | 1997-12-16 | The Regents Of The University Of California | Transgenic animal model for testing drugs for treating eating disorders and epilepsy |
| US5817911A (en) * | 1995-04-07 | 1998-10-06 | Regents Of The University Of California | Transgenic mice expressing alveolar MCP-1 |
| US5777194A (en) * | 1995-04-26 | 1998-07-07 | Cephalon, Inc. | Gene-targeted mice with humanized Aβ sequence and Swedish FAD mutation |
| US5986054A (en) * | 1995-04-28 | 1999-11-16 | The Hospital For Sick Children, Hsc Research And Development Limited Partnership | Genetic sequences and proteins related to alzheimer's disease |
| DE69629563T2 (de) | 1995-05-03 | 2004-07-22 | The President And Fellows Of Harvard College, Cambridge | Bestimmung der funktion von calcineurin in immunosuppression und neurotoxizität |
| US5777093A (en) * | 1995-05-16 | 1998-07-07 | Ramot-University Authority For Applied Research & Industrial Development Ltd. | cDNAs associated with ataxia-telangiectasia |
| US5728807A (en) * | 1995-05-16 | 1998-03-17 | Ramot-University Authority For Applied Research And Industrial Development, Ltd. | Mutated proteins associated with ataxia-telangiectasia |
| US5858661A (en) | 1995-05-16 | 1999-01-12 | Ramot-University Authority For Applied Research And Industrial Development | Ataxia-telangiectasia gene and its genomic organization |
| US6187991B1 (en) | 1995-05-23 | 2001-02-13 | Pfizer Inc | Transgenic animal models for type II diabetes mellitus |
| US6717031B2 (en) | 1995-06-07 | 2004-04-06 | Kate Dora Games | Method for selecting a transgenic mouse model of alzheimer's disease |
| AU6343196A (en) * | 1995-07-18 | 1997-02-18 | University Of South Florida | Mutant s182 genes |
| US6248555B1 (en) | 1995-08-31 | 2001-06-19 | The General Hospital Corporation | Genetic alterations related to familial alzheimer's disease |
| KR19990044317A (ko) * | 1995-09-01 | 1999-06-25 | 라미 핀클러 ; 하나넬 크바탄스키 | 아밀포스파타제2C - PP 2Cα-발현의 조작 및 검출 |
| US5859311A (en) * | 1995-11-27 | 1999-01-12 | University Of Kentucky Research Foundation | Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use |
| WO1997025412A1 (en) | 1996-01-09 | 1997-07-17 | The Regents Of The University Of California | Ungulate embryonic stem-like cells, methods of making and using the cells to produce transgenic ungulates |
| WO1997025413A1 (en) | 1996-01-09 | 1997-07-17 | The Regents Of The University Of California | Ungulate embryonic stem-like cells, making and using the cells to produce a transgenic ungulate |
| JP2000506375A (ja) * | 1996-01-26 | 2000-05-30 | エイチエスシー リサーチ アンド デベロップメント リミテッド パートナーシップ | アルツハイマー病に関連する核酸およびタンパク質、ならびにその使用 |
| US6140309A (en) * | 1996-03-12 | 2000-10-31 | University Of South Florida | Vasoactive effects and free radical generation by β-amyloid peptides |
| US6077697A (en) * | 1996-04-10 | 2000-06-20 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US20030033617A1 (en) * | 1996-04-10 | 2003-02-13 | Gyula Hadlaczky | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US20020160970A1 (en) * | 1996-04-10 | 2002-10-31 | Gyula Hadlaczky | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| CA2259123C (en) | 1996-07-01 | 2003-10-21 | Lorus Therapeutics Inc. | Oligonucleotides from the untranslated regions of ribonucleotide reductase and their use to modulate cell growth |
| AU4503497A (en) | 1996-09-26 | 1998-04-17 | Leinwand, Leslie A. | Transgenic model for heart failure |
| US5849999A (en) * | 1996-10-16 | 1998-12-15 | The Mclean Hospital Corporation | Transgenic non-human mice expressing Flag-APP-C100 protein develop alzheimer's disease brain morphology and behavior |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989006693A1 (en) * | 1988-01-13 | 1989-07-27 | The Mclean Hospital Corporation | Genetic sequences coding for alzheimer amyloid from brain |
| AU3056289A (en) * | 1988-01-13 | 1989-08-11 | Mclean Hospital Corporation, The | Genetic constructs containing the alzheimer brain amyloid gene |
| EP0451700A1 (de) * | 1990-04-10 | 1991-10-16 | Miles Inc. | Rekombinante APP Minigene zur Expression in Transgen-Mäusen als Alzheimer-Krankheitsmuster |
| WO1992006187A1 (en) * | 1990-09-28 | 1992-04-16 | The Upjohn Company | Transgenic animals with alzheimer's amyloid precursor gene |
| US5672805A (en) * | 1991-07-18 | 1997-09-30 | The Regents Of The University Of California | Transgenic mice expressing the neurotoxic C-terminus of β-amyloid precursor protein |
-
1991
- 1991-06-17 ES ES91912653T patent/ES2217250T3/es not_active Expired - Lifetime
- 1991-06-17 EP EP91912653A patent/EP0647268B1/de not_active Expired - Lifetime
- 1991-06-17 AU AU82102/91A patent/AU646877B2/en not_active Expired
- 1991-06-17 WO PCT/US1991/004447 patent/WO1991019810A1/en not_active Ceased
- 1991-06-17 JP JP3511791A patent/JPH06507782A/ja active Pending
- 1991-06-17 CA CA002085127A patent/CA2085127C/en not_active Expired - Lifetime
- 1991-06-17 US US07/716,725 patent/US5387742A/en not_active Expired - Lifetime
- 1991-06-17 AT AT91912653T patent/ATE260974T1/de not_active IP Right Cessation
- 1991-06-17 DE DE69133372T patent/DE69133372T2/de not_active Expired - Lifetime
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| EP0647268A4 (de) | 1993-05-27 |
| CA2085127A1 (en) | 1991-12-16 |
| AU646877B2 (en) | 1994-03-10 |
| EP0647268B1 (de) | 2004-03-03 |
| JPH06507782A (ja) | 1994-09-08 |
| ATE260974T1 (de) | 2004-03-15 |
| US5387742A (en) | 1995-02-07 |
| ES2217250T3 (es) | 2004-11-01 |
| AU8210291A (en) | 1992-01-07 |
| EP0647268A1 (de) | 1995-04-12 |
| DE69133372T2 (de) | 2005-02-24 |
| WO1991019810A1 (en) | 1991-12-26 |
| DE69133372D1 (de) | 2004-04-08 |
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