CA2102208A1 - Domaines de liaison dans les proteines notch et delta - Google Patents

Domaines de liaison dans les proteines notch et delta

Info

Publication number
CA2102208A1
CA2102208A1 CA002102208A CA2102208A CA2102208A1 CA 2102208 A1 CA2102208 A1 CA 2102208A1 CA 002102208 A CA002102208 A CA 002102208A CA 2102208 A CA2102208 A CA 2102208A CA 2102208 A1 CA2102208 A1 CA 2102208A1
Authority
CA
Canada
Prior art keywords
proteins
genes
notch
delta
fragments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002102208A
Other languages
English (en)
Other versions
CA2102208C (fr
Inventor
Spyridon Artavanis-Tsakonas
Marc Alan Telander Muskavitch
Richard Grant Fehon
Ilaria Rebay
Christine Marie Blaumueller
Scott Brockewell Shepard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Indiana University Research and Technology Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2102208(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2102208A1 publication Critical patent/CA2102208A1/fr
Application granted granted Critical
Publication of CA2102208C publication Critical patent/CA2102208C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002102208A 1991-05-03 1992-05-01 Domaines de liaison dans les proteines notch et delta Expired - Lifetime CA2102208C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US695,189 1991-05-03
US79192391A 1991-11-14 1991-11-14
US791,923 1991-11-14
PCT/US1992/003651 WO1992019734A1 (fr) 1991-05-03 1992-05-01 DOMAINES DE LIAISON DANS DES PROTEINES NOTCH ET $i(DELTA)

Publications (2)

Publication Number Publication Date
CA2102208A1 true CA2102208A1 (fr) 1992-11-12
CA2102208C CA2102208C (fr) 2003-04-29

Family

ID=27105529

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002102208A Expired - Lifetime CA2102208C (fr) 1991-05-03 1992-05-01 Domaines de liaison dans les proteines notch et delta

Country Status (12)

Country Link
US (1) US5849869A (fr)
EP (4) EP0930365B1 (fr)
JP (7) JPH07503123A (fr)
AT (4) ATE397661T1 (fr)
AU (1) AU675203B2 (fr)
CA (1) CA2102208C (fr)
DE (4) DE69233791D1 (fr)
DK (4) DK0930365T3 (fr)
ES (4) ES2348919T3 (fr)
IE (2) IE921367A1 (fr)
IL (1) IL101728A (fr)
WO (1) WO1992019734A1 (fr)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
EP0861261B9 (fr) 1995-06-28 2010-02-24 Imperial Cancer Research Technology Limited Sequences nucleotidiques et proteiques de genes delta de vertebres et procedes fondes sur ces dernieres
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
DE69635899T2 (de) 1995-11-17 2006-11-23 Asahi Kasei Kabushiki Kaisha Polypeptid, das die differenzierung unterdrueckt
AU728798B2 (en) * 1995-11-22 2001-01-18 Yale University Vertebrate deltex proteins, nucleic acids, and antibodies, and related methods and compositions
DE69736109T2 (de) 1996-07-16 2007-01-04 Asahi Kasei Kabushiki Kaisha Differenzierungsinhibitor
GB9623236D0 (en) * 1996-11-07 1997-01-08 Imperial College Notch
CZ295997B6 (cs) * 1996-11-07 2005-12-14 Lorantis Limited Farmaceutický prostředek s obsahem ligandu Notch a způsob tvorby T-buněk
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
EP0972041B2 (fr) 1997-04-04 2017-01-18 Millennium Pharmaceuticals, Inc. Nouvelles compositions contenant des proteines d'origine humaine delta3
US20060122373A1 (en) 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
JP4171528B2 (ja) 1997-05-14 2008-10-22 旭化成株式会社 新規な分化抑制剤
US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6436650B1 (en) 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
WO1999027096A1 (fr) * 1997-11-22 1999-06-03 Hyseq, Inc. NOUVELLE PROTEINE A MOTIFS STRUCTURAUX DU FACTEUR DE CROISSANCE EPIDERMIQUE OBTENUE DANS UNE GENOTHEQUE D'ADNc DE FOIE ET DE RATE FOETAUX
CA2329053A1 (fr) * 1998-05-28 1999-12-02 Incyte Pharmaceuticals, Inc. Proteines socs humaines
US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
AU2001288628A1 (en) * 2000-08-31 2002-03-13 Loyola University Chicago Method and reagents for treatment of skin disorders by modulating the notch pathway
US7399633B2 (en) * 2000-10-27 2008-07-15 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
CA2469204A1 (fr) * 2001-12-07 2003-06-19 Regents Of The University Of Michigan Identification et caracterisation prospectives des cellules souches cancereuses du sein
EP1639090A4 (fr) * 2003-06-09 2008-04-16 Univ Michigan Compositions et methodes de traitement et de diagnostic du cancer
AU2005209909B8 (en) * 2004-02-03 2009-01-15 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
US20060252073A1 (en) * 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
EP1907858A4 (fr) * 2005-06-13 2009-04-08 Univ Michigan Compositions et procedes de traitement et de diagnostic du cancer
WO2006135886A2 (fr) * 2005-06-13 2006-12-21 The Regents Of The University Of Michigan Compositions et methodes pour le traitement et le diagnostic du cancer
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
JP5129149B2 (ja) * 2005-10-31 2013-01-23 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌を処置および診断するための組成物および方法
DK2500360T3 (en) 2005-10-31 2015-10-26 Oncomed Pharm Inc Compositions and methods for the diagnosis and treatment of cancer
US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
EA018260B1 (ru) 2006-09-29 2013-06-28 Онкомед Фармасьютикалз, Инк. Антитела к дельта-подобному лиганду 4 человека и их применение
NO347649B1 (no) * 2006-12-14 2024-02-12 Regeneron Pharma Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
JP5386364B2 (ja) 2006-12-18 2014-01-15 ジェネンテック， インコーポレイテッド 抗Ｎｏｔｃｈ３アンタゴニスト抗体とＮｏｔｃｈ３関連疾患の予防及び治療におけるその使用
EP2125887A4 (fr) 2007-01-24 2010-11-10 Oncomed Pharm Inc Compositions et procedes utilises pour le diagnostic et le traitement du cancer
WO2008092002A2 (fr) 2007-01-24 2008-07-31 The Regents Of The University Of Michigan Compositions et procédés pour le traitement et le diagnostic du cancer du pancréas
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
US8068607B2 (en) 2007-07-31 2011-11-29 Ricoh Company, Limited Information processing apparatus and information processing method
KR101323126B1 (ko) 2007-11-12 2013-10-30 가부시키가이샤 지에스 유아사 리튬 이차전지의 제조방법
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
CN104402998A (zh) 2008-07-08 2015-03-11 昂考梅德药品有限公司 分离的抗体
CN103002911B (zh) 2008-09-26 2015-08-26 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
ES2700450T3 (es) 2009-10-16 2019-02-15 Oncomed Pharm Inc Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensores
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
CA2794674A1 (fr) 2010-04-01 2011-10-06 Oncomed Pharmaceuticals, Inc. Agents de liaison aux recepteurs frizzled et leurs utilisations
US20130095080A1 (en) 2010-04-09 2013-04-18 Fred Hutchinson Cancer Reserach Center Compositions and methods for providing hematopoietic function
US20130095079A1 (en) 2010-04-09 2013-04-18 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
LT3485903T (lt) 2011-09-23 2023-02-27 Mereo Biopharma 5, Inc. Vegf/ dll4 surišantys agentai ir jų panaudojimas
CA2858069C (fr) 2011-12-08 2020-02-11 Novartis Ag Compositions et procedes pour la generation amelioree de cellules souches/progenitrices hematopoietiques
WO2014066328A1 (fr) 2012-10-23 2014-05-01 Oncomed Pharmaceuticals, Inc. Méthodes de traitement de tumeurs neuro-endocrines à l'aide d'agents liants de parcours wnt
US9599620B2 (en) 2012-10-31 2017-03-21 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a DLL4 antagonist
EP2943566A1 (fr) 2013-01-08 2015-11-18 Fred Hutchinson Cancer Research Center Compositions et procédés pour l'expansion de cellules souches hématopoïétiques embryonnaires
JP2016510411A (ja) 2013-02-04 2016-04-07 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路インヒビターによる処置の方法およびモニタリング
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
MX389160B (es) 2013-10-31 2025-03-20 Hutchinson Fred Cancer Res Células no t efectoras y madre/progenitoras hematopoyéticas modificadas y usos de estas.
BR112016028537A2 (pt) 2014-06-04 2017-08-22 Hutchinson Fred Cancer Res expansão e enxerto de células-tronco utilizando agonistas de notch 1 e/ou de notch 2
WO2016070051A2 (fr) 2014-10-31 2016-05-06 Oncomed Pharmaceuticals, Inc. Thérapie combinée pour le traitement d'une maladie
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EP3353204B1 (fr) 2015-09-23 2023-10-18 Mereo BioPharma 5, Inc. Anticorps anti-vegf/dll4 bi-spécifique pour le traitement du cancer de l'ovaire résistant au platine
MX2018006828A (es) 2015-12-04 2018-08-09 Hutchinson Fred Cancer Res Usos de poblaciones expandidas de celulas madre/progenitoras hematopoyeticas.
EP3849565A4 (fr) 2018-09-12 2022-12-28 Fred Hutchinson Cancer Research Center Réduction de l'expression de cd33 pour protéger sélectivement des cellules thérapeutiques
EP4476331A2 (fr) 2022-02-07 2024-12-18 Ensoma, Inc. Modifications de mgmt résistante aux inhibiteurs et modification d'acides nucléiques codant mgmt

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US3884853A (en) * 1973-11-14 1975-05-20 Staley Mfg Co A E Alkali-curable cationic/anionic starch for paper coating binders
US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
US5368712A (en) * 1989-11-02 1994-11-29 Synporin Technologies, Inc. Biologically mimetic synthetic ion channel transducers
WO1992010518A1 (fr) * 1990-12-07 1992-06-25 Yale University Proteine slit purifiee et ses elements de sequence
IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (fr) * 1991-12-11 1993-06-24 Yale University Sequences nucleotidiques et peptidiques du gene dentele et procedes bases sur ces sequences
PT673390E (pt) * 1992-12-11 2001-01-31 Us Health Genes semelhantes a delta expressos em tumores neuroendocrinos

Also Published As

Publication number Publication date
JP2011155979A (ja) 2011-08-18
DE69233724D1 (de) 2008-03-27
ATE226633T1 (de) 2002-11-15
DK0930366T3 (da) 2008-10-13
EP0933082B1 (fr) 2010-07-14
IE20030774A1 (en) 2003-12-10
JP2004065243A (ja) 2004-03-04
JP4604227B2 (ja) 2011-01-05
JP4430891B2 (ja) 2010-03-10
WO1992019734A1 (fr) 1992-11-12
DE69233735D1 (de) 2008-07-17
EP0930366B1 (fr) 2008-06-04
IE85350B1 (en) 2009-10-14
JPH07503123A (ja) 1995-04-06
CA2102208C (fr) 2003-04-29
EP0930365A3 (fr) 1999-07-28
DK0930365T3 (da) 2008-06-02
EP0576623B2 (fr) 2007-10-03
EP0576623A4 (fr) 1995-01-18
DE69233791D1 (de) 2010-08-26
ATE473754T1 (de) 2010-07-15
DE69232832T2 (de) 2003-06-18
AU675203B2 (en) 1997-01-30
ES2181674T5 (es) 2008-03-01
EP0930366A2 (fr) 1999-07-21
DK0933082T3 (da) 2010-10-25
DK0576623T4 (da) 2008-01-02
JP2008005843A (ja) 2008-01-17
ES2310933T3 (es) 2009-01-16
DE69233724T2 (de) 2009-04-02
IL101728A0 (en) 1992-12-30
EP0930365A2 (fr) 1999-07-21
ES2303363T3 (es) 2008-08-01
IE921367A1 (en) 1992-11-04
EP0930365B1 (fr) 2008-02-13
EP0933082A1 (fr) 1999-08-04
DE69232832T3 (de) 2008-02-28
EP0930366A3 (fr) 1999-07-28
DE69232832D1 (de) 2002-11-28
ATE386116T1 (de) 2008-03-15
ATE397661T1 (de) 2008-06-15
IL101728A (en) 2007-08-19
JP2007330258A (ja) 2007-12-27
EP0576623B1 (fr) 2002-10-23
ES2348919T3 (es) 2010-12-16
JP2011135886A (ja) 2011-07-14
ES2181674T3 (es) 2003-03-01
JP2007330259A (ja) 2007-12-27
DK0576623T3 (da) 2003-02-24
AU1919792A (en) 1992-12-21
US5849869A (en) 1998-12-15
EP0576623A1 (fr) 1994-01-05
JP4604228B2 (ja) 2011-01-05

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