CA2102208A1 - Domaines de liaison dans les proteines notch et delta - Google Patents

Domaines de liaison dans les proteines notch et delta

Info

Publication number
CA2102208A1
CA2102208A1 CA002102208A CA2102208A CA2102208A1 CA 2102208 A1 CA2102208 A1 CA 2102208A1 CA 002102208 A CA002102208 A CA 002102208A CA 2102208 A CA2102208 A CA 2102208A CA 2102208 A1 CA2102208 A1 CA 2102208A1
Authority
CA
Canada
Prior art keywords
proteins
genes
notch
delta
fragments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002102208A
Other languages
English (en)
Other versions
CA2102208C (fr
Inventor
Spyridon Artavanis-Tsakonas
Marc Alan Telander Muskavitch
Richard Grant Fehon
Ilaria Rebay
Christine Marie Blaumueller
Scott Brockewell Shepard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Indiana University Research and Technology Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2102208(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2102208A1 publication Critical patent/CA2102208A1/fr
Application granted granted Critical
Publication of CA2102208C publication Critical patent/CA2102208C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002102208A 1991-05-03 1992-05-01 Domaines de liaison dans les proteines notch et delta Expired - Lifetime CA2102208C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US695,189 1991-05-03
US79192391A 1991-11-14 1991-11-14
US791,923 1991-11-14
PCT/US1992/003651 WO1992019734A1 (fr) 1991-05-03 1992-05-01 DOMAINES DE LIAISON DANS DES PROTEINES NOTCH ET $i(DELTA)

Publications (2)

Publication Number Publication Date
CA2102208A1 true CA2102208A1 (fr) 1992-11-12
CA2102208C CA2102208C (fr) 2003-04-29

Family

ID=27105529

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002102208A Expired - Lifetime CA2102208C (fr) 1991-05-03 1992-05-01 Domaines de liaison dans les proteines notch et delta

Country Status (12)

Country Link
US (1) US5849869A (fr)
EP (4) EP0930366B1 (fr)
JP (7) JPH07503123A (fr)
AT (4) ATE386116T1 (fr)
AU (1) AU675203B2 (fr)
CA (1) CA2102208C (fr)
DE (4) DE69233735D1 (fr)
DK (4) DK0576623T4 (fr)
ES (4) ES2310933T3 (fr)
IE (2) IE921367A1 (fr)
IL (1) IL101728A (fr)
WO (1) WO1992019734A1 (fr)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US6004924A (en) 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
DK0861261T3 (da) * 1995-06-28 2009-12-14 Imp Cancer Res Tech Nukleotid- og proteinsekvenser af hvirveldyrs-Delta-gener og fremgangsmåder baseret derpå
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
EP0861894B1 (fr) 1995-11-17 2006-03-08 Asahi Kasei Kabushiki Kaisha Polypeptide suppresseur et de differenciation
EP0869802A4 (fr) * 1995-11-22 2001-11-14 Univ Yale Proteines, acides nucleiques et anticorps deltex de vertebres, et procedes et compositions relatifs a ceux-ci
EP0913404B1 (fr) 1996-07-16 2006-06-14 Asahi Kasei Kabushiki Kaisha Inhibiteur de differenciation
EP1616958A3 (fr) * 1996-11-07 2006-02-08 Lorantis Limited Notch ligand et son utilisation pour le thérapie immunogène
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
GB9623236D0 (en) * 1996-11-07 1997-01-08 Imperial College Notch
US20060122373A1 (en) 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
AU6952498A (en) 1997-04-04 1998-10-30 Millenium Pharmaceuticals, Inc. Novel human delta3 compositions and therapeutic and diagnostic uses therefor
JP4171528B2 (ja) * 1997-05-14 2008-10-22 旭化成株式会社 新規な分化抑制剤
US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
US6436650B1 (en) 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
US6392019B1 (en) 1997-11-22 2002-05-21 John Ford Antibodies specific for EGF motif proteins
AU763012B2 (en) 1997-11-22 2003-07-10 Arca Biopharma, Inc. A novel EGF motif protein obtained from a cDNA library of fetal liver-spleen
WO1999061614A2 (fr) * 1998-05-28 1999-12-02 Incyte Pharmaceuticals, Inc. Proteines socs humaines
US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US20050089518A1 (en) * 2001-12-07 2005-04-28 Clarke Michael F. Prospective identification and characterization of breast cancer stem cells
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US20020151487A1 (en) * 2000-08-31 2002-10-17 Loyola University Chicago Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway
WO2002059285A1 (fr) * 2000-10-27 2002-08-01 Fred Hutchinson Cancer Research Center Methodes permettant d'immortaliser des cellules
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
US20060019256A1 (en) * 2003-06-09 2006-01-26 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
AU2005209909B8 (en) * 2004-02-03 2009-01-15 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
US20060252073A1 (en) * 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
AU2006259583A1 (en) * 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
EP1945754B1 (fr) * 2005-10-31 2014-07-23 The Regents Of The University Of Michigan Compositions et méthodes pour traiter et diagnostiquer un cancer
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
EP2500360B1 (fr) 2005-10-31 2015-08-05 Oncomed Pharmaceuticals, Inc. Compositions et procédés pour le diagnostic et le traitement du cancer
US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
HRP20160082T1 (hr) 2006-09-29 2016-02-26 Oncomed Pharmaceuticals, Inc. Sastavi i postupci za dijagnosticiranje i lijeäśenje raka
RU2448979C2 (ru) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
EP2099827B1 (fr) 2006-12-18 2018-11-21 Genentech, Inc. Anticorps anti-notch3 antagonistes et utilisations de ces derniers dans la prophylaxie et le traitement de maladies liées à notch3
WO2008091641A2 (fr) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions et procédés utilisés pour le diagnostic et le traitement du cancer
EP2106439B1 (fr) * 2007-01-24 2014-11-12 The Regents of the University of Michigan Compositions et procédés pour le traitement et le diagnostic du cancer du pancréas
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
US8068607B2 (en) 2007-07-31 2011-11-29 Ricoh Company, Limited Information processing apparatus and information processing method
WO2009063838A1 (fr) 2007-11-12 2009-05-22 Gs Yuasa Corporation Matériau actif pour batterie rechargeable au lithium, batterie rechargeable au lithium et son procédé de fabrication
CN102112490B (zh) 2008-07-08 2014-10-22 昂考梅德药品有限公司 Notch1受体结合剂和其使用方法
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
EP2331136B1 (fr) 2008-09-26 2018-01-10 OncoMed Pharmaceuticals, Inc. Agents se liant aux récepteurs frizzled et leurs utilisations
EP3485908B1 (fr) 2009-10-16 2021-08-18 Mereo BioPharma 5, Inc. Combinaison thérapeutique et utilisation d'anticorps antagonistes de dll4 et d'agents anti-hypertenseurs
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
CN102971337B (zh) 2010-04-01 2016-09-21 昂考梅德药品有限公司 卷曲蛋白结合药剂及其应用
EP3590520B1 (fr) 2010-04-09 2021-12-29 Fred Hutchinson Cancer Research Center Compositions pour fournir une fonction hématopoïétique sans correspondance hla
EP3097916B1 (fr) 2010-04-09 2021-07-07 Fred Hutchinson Cancer Research Center Compositions et procédés pour fournir une fonction hématopoïétique
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
TWI583699B (zh) 2011-09-23 2017-05-21 安可美德藥物股份有限公司 Ｖｅｇｆ／ｄｌｌ４結合劑類及彼等之用途
WO2013086436A1 (fr) 2011-12-08 2013-06-13 Fred Hutchinson Cancer Research Center Compositions et procédés pour la génération améliorée de cellules souches/progénitrices hématopoïétiques
JP2015536933A (ja) 2012-10-23 2015-12-24 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｗｎｔ経路結合剤を用いて神経内分泌腫瘍を処置する方法
CA2889638A1 (fr) 2012-10-31 2014-05-08 Oncomed Pharmaceuticals, Inc. Methodes et surveillance d'un traitement par un antagoniste de dll4
AU2014205662B2 (en) 2013-01-08 2019-09-05 Fred Hutchinson Cancer Research Center Compositions and methods for expansion of embryonic hematopoietic stem cells
CN105073195A (zh) 2013-02-04 2015-11-18 昂科梅德制药有限公司 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US20160250258A1 (en) 2013-10-31 2016-09-01 Fred Hutchinson Cancer Research Center Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof
KR102382905B1 (ko) 2014-06-04 2022-04-04 프레드 헛친슨 켄서 리서치 센터 노치 1 및/또는 노치 2 작용제를 사용한 줄기 세포의 확장 및 생착
EP3212233B1 (fr) 2014-10-31 2020-06-24 Oncomed Pharmaceuticals, Inc. Thérapie combinée pour le traitement d'une maladie
EP3288569A4 (fr) 2015-04-29 2018-12-19 Fred Hutchinson Cancer Research Center Cellules souches/progénitrices hématopoïétiques et effectrices non t modifiées, et leurs utilisations
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CA3173213A1 (fr) 2020-03-31 2021-10-07 Roland B. WALTER Anticorps anti-cd33 et leurs utilisations
EP4476331A2 (fr) 2022-02-07 2024-12-18 Ensoma, Inc. Modifications de mgmt résistante aux inhibiteurs et modification d'acides nucléiques codant mgmt

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US3884853A (en) * 1973-11-14 1975-05-20 Staley Mfg Co A E Alkali-curable cationic/anionic starch for paper coating binders
US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
US5368712A (en) * 1989-11-02 1994-11-29 Synporin Technologies, Inc. Biologically mimetic synthetic ion channel transducers
WO1992010518A1 (fr) * 1990-12-07 1992-06-25 Yale University Proteine slit purifiee et ses elements de sequence
IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (fr) * 1991-12-11 1993-06-24 Yale University Sequences nucleotidiques et peptidiques du gene dentele et procedes bases sur ces sequences
DK0673390T3 (da) * 1992-12-11 2000-11-13 Us Gov Health & Human Serv Deltalignende gen, som udtrykkes i neuroendokrine tumorer

Also Published As

Publication number Publication date
DE69233724D1 (de) 2008-03-27
DK0576623T3 (da) 2003-02-24
ES2181674T3 (es) 2003-03-01
CA2102208C (fr) 2003-04-29
IL101728A (en) 2007-08-19
JP4430891B2 (ja) 2010-03-10
DK0933082T3 (da) 2010-10-25
DK0930365T3 (da) 2008-06-02
AU675203B2 (en) 1997-01-30
JP2008005843A (ja) 2008-01-17
JP2011135886A (ja) 2011-07-14
JP2004065243A (ja) 2004-03-04
IL101728A0 (en) 1992-12-30
EP0576623A1 (fr) 1994-01-05
IE921367A1 (en) 1992-11-04
EP0930365A2 (fr) 1999-07-21
DE69232832T3 (de) 2008-02-28
AU1919792A (en) 1992-12-21
JP4604227B2 (ja) 2011-01-05
EP0930366A3 (fr) 1999-07-28
EP0576623B2 (fr) 2007-10-03
DK0576623T4 (da) 2008-01-02
EP0930365B1 (fr) 2008-02-13
JPH07503123A (ja) 1995-04-06
ATE397661T1 (de) 2008-06-15
DE69233735D1 (de) 2008-07-17
JP2011155979A (ja) 2011-08-18
EP0930365A3 (fr) 1999-07-28
DE69232832D1 (de) 2002-11-28
WO1992019734A1 (fr) 1992-11-12
DE69233724T2 (de) 2009-04-02
IE20030774A1 (en) 2003-12-10
EP0930366B1 (fr) 2008-06-04
ES2303363T3 (es) 2008-08-01
ES2310933T3 (es) 2009-01-16
JP4604228B2 (ja) 2011-01-05
DE69232832T2 (de) 2003-06-18
EP0930366A2 (fr) 1999-07-21
DE69233791D1 (de) 2010-08-26
JP2007330258A (ja) 2007-12-27
US5849869A (en) 1998-12-15
ES2181674T5 (es) 2008-03-01
EP0933082A1 (fr) 1999-08-04
JP2007330259A (ja) 2007-12-27
EP0576623B1 (fr) 2002-10-23
DK0930366T3 (da) 2008-10-13
EP0576623A4 (fr) 1995-01-18
IE85350B1 (en) 2009-10-14
ATE386116T1 (de) 2008-03-15
ATE473754T1 (de) 2010-07-15
ATE226633T1 (de) 2002-11-15
ES2348919T3 (es) 2010-12-16
EP0933082B1 (fr) 2010-07-14

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Effective date: 20120501