CA2127457A1 - Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone - Google Patents

Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone

Info

Publication number
CA2127457A1
CA2127457A1 CA002127457A CA2127457A CA2127457A1 CA 2127457 A1 CA2127457 A1 CA 2127457A1 CA 002127457 A CA002127457 A CA 002127457A CA 2127457 A CA2127457 A CA 2127457A CA 2127457 A1 CA2127457 A1 CA 2127457A1
Authority
CA
Canada
Prior art keywords
compound
pharmaceutical composition
mammalian subject
formula
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002127457A
Other languages
English (en)
French (fr)
Inventor
Walter P. Cullen
Mark T. Jefferson
Mikel P. Moyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2127457A1 publication Critical patent/CA2127457A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
CA002127457A 1992-01-06 1992-12-03 Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone Abandoned CA2127457A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81723592A 1992-01-06 1992-01-06
US817,235 1992-01-06

Publications (1)

Publication Number Publication Date
CA2127457A1 true CA2127457A1 (en) 1993-07-22

Family

ID=25222638

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002127457A Abandoned CA2127457A1 (en) 1992-01-06 1992-12-03 Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone

Country Status (15)

Country Link
JP (1) JPH06510913A (pt)
KR (1) KR940703923A (pt)
CN (1) CN1074937A (pt)
AU (1) AU3225693A (pt)
BR (1) BR9207024A (pt)
CA (1) CA2127457A1 (pt)
CZ (1) CZ390592A3 (pt)
FI (1) FI943207A0 (pt)
HU (1) HU9401936D0 (pt)
IL (1) IL104289A0 (pt)
MX (1) MX9300011A (pt)
NO (1) NO942532L (pt)
PT (1) PT101169A (pt)
WO (1) WO1993014215A1 (pt)
ZA (1) ZA9333B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2166320A1 (en) * 1993-06-29 1995-01-12 Randall James Gallaschun Ansamycin derivatives as antioncogene and anticancer agents
US5932566A (en) * 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US6852496B1 (en) 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
US6872715B2 (en) * 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
EP1435939B1 (en) 2001-09-24 2008-02-27 Conforma Therapeutic Corporation Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins
EP1923061A1 (en) 2001-09-24 2008-05-21 Conforma Therapeutic Corporation Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins
EP1472230B1 (en) 2002-02-08 2009-06-17 Conforma Therapeutic Corporation Ansamycins having improved pharmacological and biological properties
TW200303363A (en) * 2002-02-25 2003-09-01 Upjohn Co Process to prepare and isolate geldanamycin
WO2005009345A2 (en) 2003-06-13 2005-02-03 Kosan Biosciences, Inc. 2-desmethyl ansamycin compounds
US6875863B1 (en) 2003-11-12 2005-04-05 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
JP4717003B2 (ja) 2003-11-12 2011-07-06 コーサン バイオサイエンシーズ， インコーポレイテッド １１−ｏ−メチルゲルダナマイシン化合物
US6855705B1 (en) 2003-11-12 2005-02-15 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6887993B1 (en) 2003-11-12 2005-05-03 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
CA2546649A1 (en) * 2003-11-26 2005-06-16 Entelos, Inc. Treatment of rheumatoid arthritis with hypoxia-inducible factor 1.alpha. antagonists
US20060019941A1 (en) * 2003-12-23 2006-01-26 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins and methods of use thereof
ZA200604863B (en) * 2003-12-23 2007-12-27 Infinity Pharmaceuticals Inc Analogs of benzoquinone-containing ansamycins for the treatment of cancer
BRPI0418147A (pt) 2003-12-23 2007-04-17 Infinity Pharmaceuticals Inc análogos de ansamicinas contendo benzoquinona e seus métodos de uso
CA2602257A1 (en) 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors
BRPI0718564A2 (pt) * 2006-11-09 2014-03-11 Biotica Tech Ltd Composto, métodos para preparar um composto, para gerar análogos de ansamicina, para tratar uma doença, e para produzir um composto, análogo de ansamicina, composição farmacêutica, uso de um análogo de ansamicina, cepa engenheirada, e, uso de uma cepa engenheirada.
PE20081506A1 (es) 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
CN100500668C (zh) * 2006-12-19 2009-06-17 中国人民解放军军事医学科学院毒物药物研究所 格尔德霉素衍生物及其制备方法和制备药物的用途
CN101688227B (zh) 2007-01-26 2013-07-24 科森生物科学公司 通过工程化生物合成制备的大环内酰胺
EP2297109A4 (en) * 2008-04-21 2011-06-22 Biocon Ltd METHOD FOR ISOLATING AND PURIFYING GELDANAMYCIN
WO2010045442A1 (en) 2008-10-15 2010-04-22 Infinity Discovery, Inc. Ansamycin hydroquinone compositions
CN102030764B (zh) * 2010-11-12 2012-07-04 中国医学科学院医药生物技术研究所 4，5双氢噻嗪酮格尔德霉素及其制备方法
CN103305563B (zh) * 2013-06-14 2014-12-03 湖南农业大学 一种以链霉菌提制阿里沙霉素的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595955A (en) * 1969-03-26 1971-07-27 Upjohn Co Geldanamycin and process for producing same

Also Published As

Publication number Publication date
CN1074937A (zh) 1993-08-04
HU9401936D0 (en) 1994-09-28
FI943207A7 (fi) 1994-07-05
JPH06510913A (ja) 1994-12-08
KR940703923A (ko) 1994-12-12
NO942532D0 (no) 1994-07-05
MX9300011A (es) 1993-12-01
BR9207024A (pt) 1995-12-05
NO942532L (no) 1994-07-05
IL104289A0 (en) 1993-05-13
PT101169A (pt) 1994-03-31
FI943207L (fi) 1994-07-05
CZ390592A3 (en) 1993-08-11
AU3225693A (en) 1993-08-03
WO1993014215A1 (en) 1993-07-22
ZA9333B (en) 1994-07-05
FI943207A0 (fi) 1994-07-05

Similar Documents

Publication Publication Date Title
CA2127457A1 (en) Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone
CA1335083C (en) Fr901228 substance and preparation thereof
EP0132082B1 (en) Antibiotic/antitumor compounds and their production
US5015578A (en) BMY-41950 antitumor antibiotic
JPH08175990A (ja) Ｐｉ３キナーゼ阻害剤とその製造法
EP0185456B1 (en) Cl-1577d and cl-1577e antibiotic/antitumor compounds, their production and use
JP2863637B2 (ja) 新規なアミノオリゴ糖誘導体およびその製造方法
US4578383A (en) CL 1565 antibiotic compounds
EP0087021B1 (en) Cl 1565 antibiotic compounds and their production
US5756536A (en) Microbial transformation of taxol and cephalomannine
JP3715651B2 (ja) 抗腫瘍イソクマリン類
EP0042172B1 (en) Antibiotic compounds, pharmaceutical compositions containing such compounds, process for production thereof
EP0046641B1 (en) Novel antibiotics, the microbiological preparation of antibiotics, and a novel microorganism
US3873529A (en) Novel antibiotic ascofuranone and process for the production thereof
EP0066400A1 (en) Antibiotic roridin L-2 and its production
EP0002589A1 (en) A-40104 antibiotics, their preparation, and formulations containing them
US6090610A (en) Macrolide compound 0406
US5087567A (en) Antitumor antibiotic BMY-42428
CA2017276C (en) Carcinostatic or antitumor antibiotic, conagenin, and production and uses thereof
US4908316A (en) Streptomyces sp. N664-30 which produces an ionophore antibacterial agent
AU616946B2 (en) Antibacterial and antitumor agents ll-e33288epsilon-i and ll-e33288-epsilonbr, with processes and intermediates for producing said agents
US6693085B2 (en) Macrolide compound JK
JPH0639480B2 (ja) 新規マクロライド系抗生物質ｍ１１９
EP0289354A2 (en) Antibiotic TAN-950A, its production and use
EP0452683A2 (en) Streptomyces antitumor compounds and process for preparing the same

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued