CA2148108A1 - Ophthalmic solution and method of use - Google Patents

Ophthalmic solution and method of use

Info

Publication number: CA2148108A1
Authority: CA; Canada
Prior art keywords: solution; dermatan sulfate; eye; sulfate; daltons
Prior art date: 1992-10-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002148108A

Other languages

English (en)

French (fr)

Inventor

Jeffrey S. Kiel

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

CYTRIX Corp

Original Assignee

CYTRIX Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-28

Filing date

1993-10-28

Publication date

1994-05-11

1993-10-28 Application filed by CYTRIX Corp filed Critical CYTRIX Corp

1994-05-11 Publication of CA2148108A1 publication Critical patent/CA2148108A1/en

Status Abandoned legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims description 14
229940054534 ophthalmic solution Drugs 0.000 title 1
239000002997 ophthalmic solution Substances 0.000 title 1
229920000045 Dermatan sulfate Polymers 0.000 claims abstract description 37
AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims abstract description 28
229940051593 dermatan sulfate Drugs 0.000 claims abstract description 28
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 14
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
239000003974 emollient agent Substances 0.000 claims description 12
239000011780 sodium chloride Substances 0.000 claims description 10
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
-1 hydroxypropyl Chemical group 0.000 claims description 7
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
239000000203 mixture Substances 0.000 claims description 6
239000000645 desinfectant Substances 0.000 claims description 5
229920000136 polysorbate Polymers 0.000 claims description 5
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 4
239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
229950008882 polysorbate Drugs 0.000 claims description 4
229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
229940068984 polyvinyl alcohol Drugs 0.000 claims description 4
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 3
229940123208 Biguanide Drugs 0.000 claims description 3
229920002307 Dextran Polymers 0.000 claims description 3
235000011187 glycerol Nutrition 0.000 claims description 3
229920000609 methyl cellulose Polymers 0.000 claims description 3
239000001923 methylcellulose Substances 0.000 claims description 3
229940068886 polyethylene glycol 300 Drugs 0.000 claims description 3
229920005862 polyol Polymers 0.000 claims description 3
150000003077 polyols Chemical class 0.000 claims description 3
229940069328 povidone Drugs 0.000 claims description 3
239000004166 Lanolin Substances 0.000 claims description 2
241001465754 Metazoa Species 0.000 claims description 2
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
229940039717 lanolin Drugs 0.000 claims description 2
235000019388 lanolin Nutrition 0.000 claims description 2
239000000178 monomer Substances 0.000 claims description 2
239000002674 ointment Substances 0.000 claims description 2
239000012188 paraffin wax Substances 0.000 claims description 2
235000010199 sorbic acid Nutrition 0.000 claims description 2
239000004334 sorbic acid Substances 0.000 claims description 2
229940075582 sorbic acid Drugs 0.000 claims description 2
239000001993 wax Substances 0.000 claims description 2
239000003937 drug carrier Substances 0.000 claims 5
108010010803 Gelatin Proteins 0.000 claims 2
239000004354 Hydroxyethyl cellulose Substances 0.000 claims 2
229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
239000001768 carboxy methyl cellulose Substances 0.000 claims 2
229920000159 gelatin Polymers 0.000 claims 2
239000008273 gelatin Substances 0.000 claims 2
235000019322 gelatine Nutrition 0.000 claims 2
235000011852 gelatine desserts Nutrition 0.000 claims 2
229960005150 glycerol Drugs 0.000 claims 2
235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 2
235000010981 methylcellulose Nutrition 0.000 claims 2
235000019271 petrolatum Nutrition 0.000 claims 2
229940068918 polyethylene glycol 400 Drugs 0.000 claims 2
229960004063 propylene glycol Drugs 0.000 claims 2
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 2
229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 2
239000004264 Petrolatum Substances 0.000 claims 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
229940059904 light mineral oil Drugs 0.000 claims 1
229940056211 paraffin Drugs 0.000 claims 1
229940066842 petrolatum Drugs 0.000 claims 1
239000003871 white petrolatum Substances 0.000 claims 1
229940045860 white wax Drugs 0.000 claims 1
238000001356 surgical procedure Methods 0.000 abstract description 7
238000005406 washing Methods 0.000 abstract description 3
239000000243 solution Substances 0.000 description 64
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 34
230000000249 desinfective effect Effects 0.000 description 16
239000003889 eye drop Substances 0.000 description 16
150000002500 ions Chemical class 0.000 description 16
229940012356 eye drops Drugs 0.000 description 14
OEANUJAFZLQYOD-CXAZCLJRSA-N (2r,3s,4r,5r,6r)-6-[(2r,3r,4r,5r,6r)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]oxy-4,5-dihydroxy-3-methoxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](OC)O[C@H](CO)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](OC)[C@H](C(O)=O)O1 OEANUJAFZLQYOD-CXAZCLJRSA-N 0.000 description 8
229940079593 drug Drugs 0.000 description 8
239000003814 drug Substances 0.000 description 8
239000000499 gel Substances 0.000 description 7
230000027455 binding Effects 0.000 description 6
239000003795 chemical substances by application Substances 0.000 description 6
239000006196 drop Substances 0.000 description 6
230000001050 lubricating effect Effects 0.000 description 6
229920002683 Glycosaminoglycan Polymers 0.000 description 5
230000015556 catabolic process Effects 0.000 description 5
238000004140 cleaning Methods 0.000 description 5
108090000790 Enzymes Proteins 0.000 description 4
102000004190 Enzymes Human genes 0.000 description 4
229940088598 enzyme Drugs 0.000 description 4
239000012530 fluid Substances 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 description 4
238000002791 soaking Methods 0.000 description 4
239000000126 substance Substances 0.000 description 4
239000004094 surface-active agent Substances 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 3
208000003464 asthenopia Diseases 0.000 description 3
210000000744 eyelid Anatomy 0.000 description 3
238000001914 filtration Methods 0.000 description 3
230000007794 irritation Effects 0.000 description 3
229920000642 polymer Polymers 0.000 description 3
239000003755 preservative agent Substances 0.000 description 3
239000011734 sodium Substances 0.000 description 3
KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
208000003556 Dry Eye Syndromes Diseases 0.000 description 2
206010013774 Dry eye Diseases 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
206010020751 Hypersensitivity Diseases 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
108091005804 Peptidases Proteins 0.000 description 2
102000035195 Peptidases Human genes 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
230000007815 allergy Effects 0.000 description 2
230000000845 anti-microbial effect Effects 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
229960003260 chlorhexidine Drugs 0.000 description 2
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
239000007789 gas Substances 0.000 description 2
WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 2
238000005461 lubrication Methods 0.000 description 2
210000004072 lung Anatomy 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000008279 sol Substances 0.000 description 2
238000003860 storage Methods 0.000 description 2
231100000331 toxic Toxicity 0.000 description 2
230000002588 toxic effect Effects 0.000 description 2
239000005526 vasoconstrictor agent Substances 0.000 description 2
229920002554 vinyl polymer Polymers 0.000 description 2
238000009736 wetting Methods 0.000 description 2
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 1
239000004155 Chlorine dioxide Substances 0.000 description 1
102100026735 Coagulation factor VIII Human genes 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
241000518994 Conta Species 0.000 description 1
241001232464 Delma Species 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
BALXUFOVQVENIU-GNAZCLTHSA-N Ephedrine hydrochloride Chemical compound Cl.CN[C@@H](C)[C@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-GNAZCLTHSA-N 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
208000020564 Eye injury Diseases 0.000 description 1
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
206010053317 Hydrophobia Diseases 0.000 description 1
HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
102000016943 Muramidase Human genes 0.000 description 1
108010014251 Muramidase Proteins 0.000 description 1
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
241001602876 Nata Species 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000004365 Protease Substances 0.000 description 1
240000001987 Pyrus communis Species 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
239000000443 aerosol Substances 0.000 description 1
239000003732 agents acting on the eye Substances 0.000 description 1
239000013566 allergen Substances 0.000 description 1
230000004075 alteration Effects 0.000 description 1
150000008064 anhydrides Chemical class 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000001384 anti-glaucoma Effects 0.000 description 1
239000003146 anticoagulant agent Substances 0.000 description 1
229940127219 anticoagulant drug Drugs 0.000 description 1
229940125715 antihistaminic agent Drugs 0.000 description 1
239000000739 antihistaminic agent Substances 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
BYFMCKSPFYVMOU-UHFFFAOYSA-N bendazac Chemical compound C12=CC=CC=C2C(OCC(=O)O)=NN1CC1=CC=CC=C1 BYFMCKSPFYVMOU-UHFFFAOYSA-N 0.000 description 1
229960005149 bendazac Drugs 0.000 description 1
230000008901 benefit Effects 0.000 description 1
229960000686 benzalkonium chloride Drugs 0.000 description 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
235000019398 chlorine dioxide Nutrition 0.000 description 1
229960004926 chlorobutanol Drugs 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
239000000850 decongestant Substances 0.000 description 1
229940124581 decongestants Drugs 0.000 description 1
150000002016 disaccharides Chemical group 0.000 description 1
230000000694 effects Effects 0.000 description 1
229960002179 ephedrine Drugs 0.000 description 1
239000003885 eye ointment Substances 0.000 description 1
231100001261 hazardous Toxicity 0.000 description 1
229920002674 hyaluronan Polymers 0.000 description 1
229960003160 hyaluronic acid Drugs 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
239000007788 liquid Substances 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
239000004325 lysozyme Substances 0.000 description 1
229960000274 lysozyme Drugs 0.000 description 1
235000010335 lysozyme Nutrition 0.000 description 1
238000002483 medication Methods 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000003641 microbiacidal effect Effects 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
239000011707 mineral Substances 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
210000003097 mucus Anatomy 0.000 description 1
APVPOHHVBBYQAV-UHFFFAOYSA-N n-(4-aminophenyl)sulfonyloctadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 APVPOHHVBBYQAV-UHFFFAOYSA-N 0.000 description 1
239000012457 nonaqueous media Substances 0.000 description 1
229940023490 ophthalmic product Drugs 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
150000002978 peroxides Chemical class 0.000 description 1
229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000004926 polymethyl methacrylate Substances 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000008569 process Effects 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
230000005855 radiation Effects 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000010703 silicon Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
230000019635 sulfation Effects 0.000 description 1
238000005670 sulfation reaction Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
150000003751 zinc Chemical class 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/141—Biguanides, e.g. chlorhexidine
- A61L12/142—Polymeric biguanides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/12—Non-macromolecular oxygen-containing compounds, e.g. hydrogen peroxide or ozone
- A61L12/124—Hydrogen peroxide; Peroxy compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/143—Quaternary ammonium compounds
- A61L12/145—Polymeric quaternary ammonium compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Ophthalmology & Optometry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002148108A 1992-10-28 1993-10-28 Ophthalmic solution and method of use Abandoned CA2148108A1 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US967,611		1978-12-08
US96761192A	1992-10-28	1992-10-28
US13248493A	1993-10-06	1993-10-06
US132,484		1993-10-06

Publications (1)

Publication Number	Publication Date
CA2148108A1 true CA2148108A1 (en)	1994-05-11

Family

ID=26830403

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002148108A Abandoned CA2148108A1 (en)	1992-10-28	1993-10-28	Ophthalmic solution and method of use

Country Status (5)

Country	Link
EP (1)	EP0667779A1 (de)
JP (1)	JPH08503701A (de)
AU (1)	AU5454594A (de)
CA (1)	CA2148108A1 (de)
WO (1)	WO1994009794A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5518732A (en) *	1995-02-14	1996-05-21	Chiron Vision, Inc.	Bio-erodible ophthalmic shield
JPH09206362A (ja) *	1996-02-05	1997-08-12	Tomey Technol Corp	コンタクトレンズ用消毒洗浄組成物及びそれを用いたコンタクトレンズの消毒洗浄方法
GB2323180A (en) *	1997-01-23	1998-09-16	Waverley Pharma Ltd	Hydrogen peroxide contact lens solution
JP3883739B2 (ja) *	1998-05-22	2007-02-21	株式会社メニコン	コンタクトレンズ用殺菌液
TW586945B (en)	2001-01-12	2004-05-11	Novartis Ag	Lens care product containing dexpanthenol
KR20070114130A (ko)	2005-02-14	2007-11-29	존슨 앤드 존슨 비젼 케어, 인코포레이티드	착용감이 편안한 안용 장치 및 이의 제조방법
TW200722109A (en) *	2005-03-31	2007-06-16	Bausch & Lomb	Polysaccharide and polyol composition for treating dry eye and related methods of manufacture and methods of use
US9052529B2 (en)	2006-02-10	2015-06-09	Johnson & Johnson Vision Care, Inc.	Comfortable ophthalmic device and methods of its production
TWI551305B (zh)	2007-08-31	2016-10-01	諾華公司	相對黏稠封裝溶液之用途
US8689971B2 (en)	2007-08-31	2014-04-08	Novartis Ag	Contact lens packaging solutions
JP6595120B2 (ja)	2015-12-03	2019-10-23	ノバルティスアーゲー	コンタクトレンズパッケージング溶液

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5141928B1 (en) *	1989-12-20	1995-11-14	Brujo Inc	Ophthalmic medication

1993
- 1993-10-28 CA CA002148108A patent/CA2148108A1/en not_active Abandoned
- 1993-10-28 JP JP6511317A patent/JPH08503701A/ja active Pending
- 1993-10-28 EP EP93925100A patent/EP0667779A1/de not_active Withdrawn
- 1993-10-28 WO PCT/US1993/010352 patent/WO1994009794A1/en not_active Ceased
- 1993-10-28 AU AU54545/94A patent/AU5454594A/en not_active Abandoned

Also Published As

Publication number	Publication date
WO1994009794A1 (en)	1994-05-11
EP0667779A1 (de)	1995-08-23
JPH08503701A (ja)	1996-04-23
AU5454594A (en)	1994-05-24

Legal Events

Date	Code	Title	Description
1996-04-28	FZDE	Dead

Publication	Publication Date	Title
EP0929292B1 (de)	2001-05-30	Verfahren und zusammensetzung zur wiederbenetzung von kontaktlinsen und linderung der augentrockenheit
EP0110609B1 (de)	1986-06-18	Sterilisationsverfahren mit Wasserstoffperoxid und Neutralisation von rückständigen Mengen davon
CN101932301B (zh)	2013-03-27	含有两性表面活性剂和透明质酸的眼科组合物
CA2431719C (en)	2008-12-23	Prevention of preservative uptake into biomaterials
EP1581211A1 (de)	2005-10-05	Kontaktlinsen- und augentropfennachfeuchtzusammensetzungenund ihre verwendungen
JPH02184631A (ja)	1990-07-19	眼科用製剤中の安定化された二酸化塩素の用途
KR20100016091A (ko)	2010-02-12	콘택트 렌즈 관리 및 약제학적 조성물의 보존용 인지질 조성물
AU2002233984A1 (en)	2002-08-29	Prevention of preservative uptake into biomaterials
CA2148108A1 (en)	1994-05-11	Ophthalmic solution and method of use
EP0441003A2 (de)	1991-08-14	Ophthalmische Medikamente
NL2002214C2 (en)	2010-05-18	Contact lens care solution.
CA2457116A1 (en)	2003-02-27	Composition and method for inhibiting uptake of biguanide antimicrobials by hydrogels
KR100348237B1 (ko)	2002-11-29	콘택트렌즈의소독·중화·세정용일액형조합제제및소독·중화·세정방법
JP4850513B2 (ja)	2012-01-11	点眼用組成物
JPH07223966A (ja)	1995-08-22	眼科用人工涙液
RU2201213C1 (ru)	2003-03-27	Глазные капли "карнозин"
CN104136005A (zh)	2014-11-05	含有烷氧基化天然蜡的眼科组合物
KR19990074047A (ko)	1999-10-05	콘택트렌즈용 세척, 소독 및 보존제 조성물
US4539330A (en)	1985-09-03	Imidazolidinyl urea and derivatives thereof for use in opthalmic solutions
JPH08182746A (ja)	1996-07-16	コンタクトレンズ用洗浄消毒液およびそれを用いたコンタクトレンズの洗浄消毒方法
Ghormley	1992	Ultracare™—disinfectant/neutralizer
HK1021619B (en)	2002-02-22	Method and composition for rewetting contact lenses and relieving eye dryness
HK1059945B (en)	2006-10-27	Prevention of preservative uptake into ophthalmic lences