CA2155129C - Combinaisons d'inhibiteurs retroviraux - Google Patents
Combinaisons d'inhibiteurs retrovirauxInfo
- Publication number
- CA2155129C CA2155129C CA002155129A CA2155129A CA2155129C CA 2155129 C CA2155129 C CA 2155129C CA 002155129 A CA002155129 A CA 002155129A CA 2155129 A CA2155129 A CA 2155129A CA 2155129 C CA2155129 C CA 2155129C
- Authority
- CA
- Canada
- Prior art keywords
- benzyl
- compound
- formula
- compounds
- benzyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003112 inhibitor Substances 0.000 title description 9
- 230000001177 retroviral effect Effects 0.000 title description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 55
- 238000011282 treatment Methods 0.000 claims abstract description 15
- -1 2-quinolylcarbonyl Chemical group 0.000 claims description 97
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- 150000003839 salts Chemical class 0.000 claims description 18
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- 239000003814 drug Substances 0.000 claims description 13
- 208000031886 HIV Infections Diseases 0.000 claims description 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 6
- 208000037357 HIV infectious disease Diseases 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 5
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 150000004677 hydrates Chemical class 0.000 claims description 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 3
- 125000004346 phenylpentyl group Chemical group C1(=CC=CC=C1)CCCCC* 0.000 claims description 3
- LDECUSDQMXVUMP-UHFFFAOYSA-N benzyl 3-[6-[[2-(butylamino)-1-[3-methoxycarbonyl-4-(2-methoxy-2-oxoethoxy)phenyl]-2-oxoethyl]-hexylamino]-6-oxohexyl]-4-methyl-2-oxo-6-(4-phenylphenyl)-1,6-dihydropyrimidine-5-carboxylate Chemical compound O=C1NC(C=2C=CC(=CC=2)C=2C=CC=CC=2)C(C(=O)OCC=2C=CC=CC=2)=C(C)N1CCCCCC(=O)N(CCCCCC)C(C(=O)NCCCC)C1=CC=C(OCC(=O)OC)C(C(=O)OC)=C1 LDECUSDQMXVUMP-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
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- 208000030507 AIDS Diseases 0.000 abstract description 19
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- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 206010038997 Retroviral infections Diseases 0.000 abstract description 2
- 239000000460 chlorine Substances 0.000 description 21
- 125000000217 alkyl group Chemical group 0.000 description 20
- 229910052736 halogen Chemical group 0.000 description 13
- 150000002367 halogens Chemical group 0.000 description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 13
- 125000003545 alkoxy group Chemical group 0.000 description 12
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 12
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- 238000000034 method Methods 0.000 description 12
- 125000001589 carboacyl group Chemical group 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 10
- HTJGLYIJVSDQAE-VWNXEWBOSA-N [(1s,6s,7s,8r,8ar)-1,7,8-trihydroxy-1,2,3,5,6,7,8,8a-octahydroindolizin-6-yl] butanoate Chemical compound O[C@H]1[C@H](O)[C@@H](OC(=O)CCC)CN2CC[C@H](O)[C@@H]21 HTJGLYIJVSDQAE-VWNXEWBOSA-N 0.000 description 9
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 9
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- 230000003612 virological effect Effects 0.000 description 9
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 description 8
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- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 4
- 231100000673 dose–response relationship Toxicity 0.000 description 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
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- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La combinaison d'esters de castanospermine et d'analogues peptidiques courts peut être utilisée dans le traitement des infections rétrovirales. La combinaison peut être utilisée pour traiter le sida et le para-sida et d'autres maladies provoquées par le rétrovirus VIH ou autres virus connexes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939303518A GB9303518D0 (en) | 1993-02-22 | 1993-02-22 | Combinations of retroviral inhibitors |
| GB9303518.6 | 1993-02-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2155129A1 CA2155129A1 (fr) | 1994-09-01 |
| CA2155129C true CA2155129C (fr) | 1999-04-13 |
Family
ID=10730826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002155129A Expired - Fee Related CA2155129C (fr) | 1993-02-22 | 1994-01-18 | Combinaisons d'inhibiteurs retroviraux |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0684836A1 (fr) |
| JP (1) | JPH08509469A (fr) |
| KR (1) | KR100293299B1 (fr) |
| CN (1) | CN1118142A (fr) |
| AU (1) | AU679497B2 (fr) |
| CA (1) | CA2155129C (fr) |
| GB (1) | GB9303518D0 (fr) |
| HU (1) | HUT72493A (fr) |
| IL (1) | IL108696A (fr) |
| MX (1) | MXPA94001311A (fr) |
| NO (1) | NO307738B1 (fr) |
| NZ (1) | NZ261740A (fr) |
| WO (1) | WO1994019008A1 (fr) |
| ZA (1) | ZA941036B (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2889014A1 (fr) | 2005-07-22 | 2007-01-26 | Nextamp Sa | Procede et dispositif de tatouage d'horodates, procede et dispositif de decodage d'horodates, applications et produits programmes d'ordinateur correspondants |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3526015A1 (de) * | 1985-07-20 | 1987-01-22 | Philips Patentverwaltung | Verfahren zum bestimmen der raeumlichen verteilung der streuquerschnitte fuer elastisch gestreute roentgenstrahlung und anordnung zur durchfuehrung des verfahrens |
| US5004746A (en) * | 1987-09-29 | 1991-04-02 | Merrell Dow Pharmaceuticals Inc. | Anti-retroviral castanospermine esters |
| US4999146A (en) * | 1990-02-12 | 1991-03-12 | Thermax Wire Corp. | Process for manufacture of low density polytetrofluoroethylene insulated cable |
| DK0565631T3 (da) * | 1991-01-02 | 1996-10-07 | Merrell Pharma Inc | Antivirale forbindelser |
-
1993
- 1993-02-22 GB GB939303518A patent/GB9303518D0/en active Pending
-
1994
- 1994-01-18 EP EP94907268A patent/EP0684836A1/fr not_active Withdrawn
- 1994-01-18 NZ NZ261740A patent/NZ261740A/en unknown
- 1994-01-18 CN CN94191250A patent/CN1118142A/zh active Pending
- 1994-01-18 JP JP6518971A patent/JPH08509469A/ja not_active Ceased
- 1994-01-18 AU AU60918/94A patent/AU679497B2/en not_active Ceased
- 1994-01-18 HU HU9502451A patent/HUT72493A/hu unknown
- 1994-01-18 WO PCT/US1994/000710 patent/WO1994019008A1/fr not_active Ceased
- 1994-01-18 CA CA002155129A patent/CA2155129C/fr not_active Expired - Fee Related
- 1994-01-18 KR KR1019950703531A patent/KR100293299B1/ko not_active Expired - Fee Related
- 1994-02-15 ZA ZA941036A patent/ZA941036B/xx unknown
- 1994-02-17 IL IL10869694A patent/IL108696A/en not_active IP Right Cessation
- 1994-02-21 MX MXPA94001311A patent/MXPA94001311A/es unknown
-
1995
- 1995-08-21 NO NO953272A patent/NO307738B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1118142A (zh) | 1996-03-06 |
| JPH08509469A (ja) | 1996-10-08 |
| NO953272L (no) | 1995-08-21 |
| CA2155129A1 (fr) | 1994-09-01 |
| HU9502451D0 (en) | 1995-10-30 |
| KR100293299B1 (ko) | 2001-09-17 |
| AU679497B2 (en) | 1997-07-03 |
| WO1994019008A1 (fr) | 1994-09-01 |
| NO307738B1 (no) | 2000-05-22 |
| ZA941036B (en) | 1994-08-25 |
| KR960700743A (ko) | 1996-02-24 |
| NO953272D0 (no) | 1995-08-21 |
| GB9303518D0 (en) | 1993-04-07 |
| MXPA94001311A (es) | 2003-11-13 |
| IL108696A0 (en) | 1994-05-30 |
| AU6091894A (en) | 1994-09-14 |
| NZ261740A (en) | 1996-10-28 |
| IL108696A (en) | 1999-06-20 |
| EP0684836A1 (fr) | 1995-12-06 |
| HUT72493A (en) | 1996-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed | ||
| MKLA | Lapsed |
Effective date: 20060118 |