CA2181390A1 - Formulations a base de phospholipides - Google Patents

Formulations a base de phospholipides

Info

Publication number: CA2181390A1
Authority: CA; Canada
Prior art keywords: phosphatidylcholine; cellulose; molecular weights; dipalmitoyl; polyoxyethylene
Prior art date: 1995-07-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA002181390A

Other languages

English (en)

Other versions

CA2181390C (fr

Inventor

Pankaj Modi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Generex Pharmaceuticals Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-18

Filing date

1996-07-17

Publication date

1997-01-19

1996-07-17 Application filed by Individual filed Critical Individual

1997-01-19 Publication of CA2181390A1 publication Critical patent/CA2181390A1/fr

2001-04-24 Application granted granted Critical

2001-04-24 Publication of CA2181390C publication Critical patent/CA2181390C/fr

2016-07-17 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

238000009472 formulation Methods 0.000 title abstract 3
239000000203 mixture Substances 0.000 title abstract 3
150000003904 phospholipids Chemical class 0.000 title 1
-1 brain sphingomyelin Chemical compound 0.000 abstract 8
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 4
229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 4
229920002472 Starch Polymers 0.000 abstract 2
210000004556 brain Anatomy 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 2
WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 2
229920001451 polypropylene glycol Polymers 0.000 abstract 2
239000008107 starch Substances 0.000 abstract 2
235000019698 starch Nutrition 0.000 abstract 2
WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 abstract 1
JSPNNZKWADNWHI-PNANGNLXSA-N (2r)-2-hydroxy-n-[(2s,3r,4e,8e)-3-hydroxy-9-methyl-1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadeca-4,8-dien-2-yl]heptadecanamide Chemical compound CCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@H]([C@H](O)\C=C\CC\C=C(/C)CCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JSPNNZKWADNWHI-PNANGNLXSA-N 0.000 abstract 1
CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 abstract 1
KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 abstract 1
SLKDGVPOSSLUAI-PGUFJCEWSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine zwitterion Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCCCC SLKDGVPOSSLUAI-PGUFJCEWSA-N 0.000 abstract 1
PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 abstract 1
SNKAWJBJQDLSFF-NVKMUCNASA-N 1,2-dioleoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC SNKAWJBJQDLSFF-NVKMUCNASA-N 0.000 abstract 1
NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 abstract 1
TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 abstract 1
OZSITQMWYBNPMW-GDLZYMKVSA-N 1,2-ditetradecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCC OZSITQMWYBNPMW-GDLZYMKVSA-N 0.000 abstract 1
BIABMEZBCHDPBV-MPQUPPDSSA-N 1,2-palmitoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-MPQUPPDSSA-N 0.000 abstract 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 abstract 1
IJFVSSZAOYLHEE-UHFFFAOYSA-N 2,3-di(dodecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCC(=O)OCC(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCC IJFVSSZAOYLHEE-UHFFFAOYSA-N 0.000 abstract 1
HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
239000001856 Ethyl cellulose Substances 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 abstract 1
ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 abstract 1
229930186217 Glycolipid Natural products 0.000 abstract 1
229920000663 Hydroxyethyl cellulose Polymers 0.000 abstract 1
239000004354 Hydroxyethyl cellulose Substances 0.000 abstract 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
102000014150 Interferons Human genes 0.000 abstract 1
108010050904 Interferons Proteins 0.000 abstract 1
102000015696 Interleukins Human genes 0.000 abstract 1
108010063738 Interleukins Proteins 0.000 abstract 1
239000004909 Moisturizer Substances 0.000 abstract 1
SGXDXUYKISDCAZ-UHFFFAOYSA-N N,N-diethylglycine Chemical compound CCN(CC)CC(O)=O SGXDXUYKISDCAZ-UHFFFAOYSA-N 0.000 abstract 1
229920002873 Polyethylenimine Polymers 0.000 abstract 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
229930006000 Sucrose Natural products 0.000 abstract 1
BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 abstract 1
PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 abstract 1
ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 abstract 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 abstract 1
229920002988 biodegradable polymer Polymers 0.000 abstract 1
239000004621 biodegradable polymer Substances 0.000 abstract 1
229920001400 block copolymer Polymers 0.000 abstract 1
239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
229920002301 cellulose acetate Polymers 0.000 abstract 1
229930183167 cerebroside Natural products 0.000 abstract 1
RIZIAUKTHDLMQX-UHFFFAOYSA-N cerebroside D Natural products CCCCCCCCCCCCCCCCC(O)C(=O)NC(C(O)C=CCCC=C(C)CCCCCCCCC)COC1OC(CO)C(O)C(O)C1O RIZIAUKTHDLMQX-UHFFFAOYSA-N 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229920001577 copolymer Polymers 0.000 abstract 1
239000002537 cosmetic Substances 0.000 abstract 1
229960003724 dimyristoylphosphatidylcholine Drugs 0.000 abstract 1
229960005160 dimyristoylphosphatidylglycerol Drugs 0.000 abstract 1
ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 abstract 1
BPHQZTVXXXJVHI-AJQTZOPKSA-N ditetradecanoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-AJQTZOPKSA-N 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229920001249 ethyl cellulose Polymers 0.000 abstract 1
239000008103 glucose Substances 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
229940088597 hormone Drugs 0.000 abstract 1
239000005556 hormone Substances 0.000 abstract 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 abstract 1
229920003063 hydroxymethyl cellulose Polymers 0.000 abstract 1
229940031574 hydroxymethyl cellulose Drugs 0.000 abstract 1
239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
229940047124 interferons Drugs 0.000 abstract 1
229940047122 interleukins Drugs 0.000 abstract 1
239000002502 liposome Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000001333 moisturizer Effects 0.000 abstract 1
150000008104 phosphatidylethanolamines Chemical class 0.000 abstract 1
150000003905 phosphatidylinositols Chemical class 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1
229920000136 polysorbate Polymers 0.000 abstract 1
229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
235000019422 polyvinyl alcohol Nutrition 0.000 abstract 1
229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
239000000661 sodium alginate Substances 0.000 abstract 1
235000010413 sodium alginate Nutrition 0.000 abstract 1
229940005550 sodium alginate Drugs 0.000 abstract 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 1
WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1
239000005720 sucrose Substances 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1
VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 abstract 1
PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 abstract 1
229940117972 triolein Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Dispersion Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)

CA002181390A 1995-07-18 1996-07-17 Formulations a base de phospholipides Expired - Fee Related CA2181390C (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US147395P	1995-07-18	1995-07-18
US60/001,473		1995-07-18

Publications (2)

Publication Number	Publication Date
CA2181390A1 true CA2181390A1 (fr)	1997-01-19
CA2181390C CA2181390C (fr)	2001-04-24

Family

ID=21696188

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002181390A Expired - Fee Related CA2181390C (fr)	1995-07-18	1996-07-17	Formulations a base de phospholipides

Country Status (1)

Country	Link
CA (1)	CA2181390C (fr)

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WO1998046287A3 (fr) *	1997-04-15	1999-02-11	Univ Toronto	Administration de medicaments par l'intermediaire d'hydrogels therapeutiques
EP0971699A4 (fr) *	1997-01-31	2006-05-24	Skyepharma Inc	Procede servant a utiliser des lipides neutres afin de modifier la liberation in vivo depuis des liposomes a vesicules multiples
EP1578325A4 (fr) *	2002-12-31	2006-09-13	Perricone Nicholas V Dr	Compositions stables pour une administration de medicament topique
RU2325151C2 (ru) *	2006-06-29	2008-05-27	ООО "Научно-производственный центр "Амфион"	Способ получения системы доставки водонерастворимых и плохорастворимых биологически активных веществ и лекарственная форма на ее основе
US7875288B2 (en)	2006-03-30	2011-01-25	The Research Foundation Of State University Of New York	Method for treating blood coagulation disorders
US7875289B2 (en)	2006-03-30	2011-01-25	The Research Foundation Of State University Of New York	Compositions of less immunogenic and long-circulating protein-lipid complexes
US8668937B2 (en)	2011-03-17	2014-03-11	Transdermal Biotechnology, Inc.	Topical nitric oxide systems and methods of use thereof
US8871255B2 (en)	2012-09-19	2014-10-28	Transdermal Biotechnology, Inc.	Treatment of skin and soft tissue infection with nitric oxide
US8871261B2 (en)	2012-09-19	2014-10-28	Transdermal Biotechnology, Inc.	Cancer treatments and compositions for use thereof
US8871258B2 (en)	2012-09-19	2014-10-28	Transdermal Biotechnology, Inc.	Treatment and prevention of learning and memory disorders
US8871260B2 (en)	2012-09-19	2014-10-28	Transdermal Biotechnology, Inc.	Methods and compositions for muscular and neuromuscular diseases
US8871257B2 (en)	2012-09-19	2014-10-28	Transdermal Biotechnology, Inc.	Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US8871254B2 (en)	2012-09-19	2014-10-28	Transdermal Biotechnology, Inc.	Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US8871262B2 (en)	2012-09-19	2014-10-28	Transdermal Biotechnology, Inc.	Compositions and methods for treatment of osteoporosis and other indications
US8871256B2 (en)	2012-09-19	2014-10-28	Transdermal Biotechnology, Inc.	Methods and systems for treatment of inflammatory diseases with nitric oxide
US8871259B2 (en)	2012-09-19	2014-10-28	Transdermal Biotechnology, Inc.	Techniques and systems for treatment of neuropathic pain and other indications
US9050248B2 (en)	2002-05-31	2015-06-09	Transdermal Biotechnology, Inc.	Methods of delivering stable topical drug compositions
US9241899B2 (en)	2013-03-13	2016-01-26	Transdermal Biotechnology, Inc.	Topical systems and methods for treating sexual dysfunction
US9295637B2 (en)	2013-03-13	2016-03-29	Transdermal Biotechnology, Inc.	Compositions and methods for affecting mood states
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US9339457B2 (en)	2013-03-13	2016-05-17	Transdermal Biotechnology, Inc.	Cardiovascular disease treatment and prevention
US9387159B2 (en)	2013-03-13	2016-07-12	Transdermal Biotechnology, Inc.	Treatment of skin, including aging skin, to improve appearance
US9393264B2 (en)	2013-03-13	2016-07-19	Transdermal Biotechnology, Inc.	Immune modulation using peptides and other compositions
US9393265B2 (en)	2013-03-13	2016-07-19	Transdermal Biotechnology, Inc.	Wound healing using topical systems and methods
US9585931B2 (en)	2013-03-13	2017-03-07	Transdermal Biotechnology, Inc.	Cardiovascular disease treatment and prevention
US9597400B2 (en)	2013-03-13	2017-03-21	Transdermal Biotechnology, Inc.	Peptide systems and methods for metabolic conditions
US9597401B2 (en)	2013-03-13	2017-03-21	Transdermal Biotechnology, Inc.	Systems and methods for delivery of peptides
US9687520B2 (en)	2013-03-13	2017-06-27	Transdermal Biotechnology, Inc.	Memory or learning improvement using peptide and other compositions
US9849160B2 (en)	2013-03-13	2017-12-26	Transdermal Biotechnology, Inc.	Methods and systems for treating or preventing cancer
US10034914B2 (en)	2013-03-13	2018-07-31	Transdermal Biotechnology, Inc.	Brain and neural treatments comprising peptides and other compositions
US10226511B2 (en)	2013-03-13	2019-03-12	Transdermal Biotechnology, Inc.	Memory or learning improvement using peptide and other compositions
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CN119970641A (zh) *	2023-11-10	2025-05-13	中国科学院上海药物研究所	一种具有可控释放行为的非水制剂及其应用

1996
- 1996-07-17 CA CA002181390A patent/CA2181390C/fr not_active Expired - Fee Related

Cited By (105)

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US6475516B2 (en)	1996-04-12	2002-11-05	Dicosmo Frank	Drug delivery via therapeutic hydrogels
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