CA2182986A1 - Utilisation de sensibilisateurs a l'insuline dans le traitement de l'insuffisance renale - Google Patents
Utilisation de sensibilisateurs a l'insuline dans le traitement de l'insuffisance renaleInfo
- Publication number
- CA2182986A1 CA2182986A1 CA002182986A CA2182986A CA2182986A1 CA 2182986 A1 CA2182986 A1 CA 2182986A1 CA 002182986 A CA002182986 A CA 002182986A CA 2182986 A CA2182986 A CA 2182986A CA 2182986 A1 CA2182986 A1 CA 2182986A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- insulin sensitiser
- group
- insulin
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000005720 sucrose Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 210000004926 tubular epithelial cell Anatomy 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
L'invention se rapporte à un procédé de traitement et/ou à la prophylaxie des insuffisances rénales, y compris la néphropathie diabétique, la glomérulonéphrite, la glomérulosclérose, le syndrome néphrotique, la néphrosclérose hypertensive et l'insuffisance rénale au stade ultime ainsi que la microalbuminurie. Ce procédé consiste à administrer une dose efficace, non-toxique, d'un sensibilisateur à l'insuline à un être humain ou à un mammifère nécessitant ce traitement.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9402624A GB9402624D0 (en) | 1994-02-10 | 1994-02-10 | Novel method |
| GB9402624.2 | 1994-02-10 | ||
| GB9410214.2 | 1994-05-21 | ||
| GB9410214A GB9410214D0 (en) | 1994-05-21 | 1994-05-21 | Novel method |
| GBGB9426019.7A GB9426019D0 (en) | 1994-12-22 | 1994-12-22 | Novel method |
| GB9426019.7 | 1994-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2182986A1 true CA2182986A1 (fr) | 1995-08-17 |
Family
ID=27267046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002182986A Abandoned CA2182986A1 (fr) | 1994-02-10 | 1995-02-07 | Utilisation de sensibilisateurs a l'insuline dans le traitement de l'insuffisance renale |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0777469A1 (fr) |
| JP (1) | JPH09512249A (fr) |
| CN (2) | CN1083715C (fr) |
| AP (1) | AP553A (fr) |
| AU (1) | AU700826B2 (fr) |
| CA (1) | CA2182986A1 (fr) |
| IL (1) | IL112590A (fr) |
| MX (1) | MX9603338A (fr) |
| SG (1) | SG47100A1 (fr) |
| TW (1) | TW475896B (fr) |
| WO (1) | WO1995021608A1 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA973848B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
| US5889025A (en) * | 1996-05-06 | 1999-03-30 | Reddy's Research Foundation | Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| US5885997A (en) * | 1996-07-01 | 1999-03-23 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| CA2258949C (fr) | 1996-07-01 | 2008-05-06 | Reddy-Cheminor, Inc. | Nouveaux composes heterocycliques, leur procede de preparation, compositions pharmaceutiques les contenant et utilisation de ces composes dans le traitement du diabete et des maladies associees |
| US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6313113B1 (en) | 1997-04-15 | 2001-11-06 | Reddy-Cheminor, Inc. | Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US6011031A (en) * | 1997-05-30 | 2000-01-04 | Dr. Reddy's Research Foundation | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them |
| GB9711683D0 (en) * | 1997-06-05 | 1997-08-06 | Smithkline Beecham Plc | Composition |
| GB9726566D0 (en) * | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB9726563D0 (en) * | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
| US20020137940A1 (en) | 1997-12-16 | 2002-09-26 | Smithkline Beecham P.L.C. | 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| EP1903043A1 (fr) | 1999-04-23 | 2008-03-26 | SmithKline Beecham P.L.C. | Nouveau composé pharmaceutique |
| WO2001012628A1 (fr) * | 1999-08-17 | 2001-02-22 | Smithkline Beecham P.L.C. | Compositions pharmaceutiques contenant des derives de thiazolidinedione et procede de preparation |
| EP1284291A4 (fr) * | 2000-05-25 | 2005-06-08 | Yamanouchi Pharma Co Ltd | Promoteur de pgc-1 humain |
| GB0019223D0 (en) * | 2000-08-04 | 2000-09-27 | Smithkline Beecham Plc | Novel pharmaceutical |
| US7767682B2 (en) * | 2005-03-03 | 2010-08-03 | Glaxosmithkline Llc | Medicaments |
| WO2008134828A2 (fr) | 2007-05-04 | 2008-11-13 | Katholieke Universiteit Leuven | Protection contre la dégénérescence tissulaire |
| CN117597123A (zh) * | 2021-04-01 | 2024-02-23 | 阿克里普斯二有限公司 | 肾脏疾病的治疗 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0842925A1 (fr) * | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Thiazolidinédiones substituées |
| GB9023584D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JPH05310719A (ja) * | 1992-04-28 | 1993-11-22 | Terumo Corp | チアゾリジン−２，４−ジオン誘導体 |
-
1995
- 1995-02-07 CA CA002182986A patent/CA2182986A1/fr not_active Abandoned
- 1995-02-07 CN CN95192362A patent/CN1083715C/zh not_active Expired - Fee Related
- 1995-02-07 MX MX9603338A patent/MX9603338A/es unknown
- 1995-02-07 JP JP7520956A patent/JPH09512249A/ja not_active Ceased
- 1995-02-07 EP EP95907653A patent/EP0777469A1/fr not_active Withdrawn
- 1995-02-07 WO PCT/EP1995/000441 patent/WO1995021608A1/fr not_active Ceased
- 1995-02-07 AU AU15783/95A patent/AU700826B2/en not_active Ceased
- 1995-02-07 SG SG1996007235A patent/SG47100A1/en unknown
- 1995-02-08 AP APAP/P/1995/000717A patent/AP553A/en active
- 1995-02-09 IL IL11259095A patent/IL112590A/en not_active IP Right Cessation
- 1995-02-10 TW TW084101155A patent/TW475896B/zh not_active IP Right Cessation
-
2001
- 2001-03-30 CN CN01112436A patent/CN1318372A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL112590A0 (en) | 1995-06-29 |
| JPH09512249A (ja) | 1997-12-09 |
| CN1318372A (zh) | 2001-10-24 |
| AP553A (en) | 1996-11-06 |
| EP0777469A1 (fr) | 1997-06-11 |
| WO1995021608A1 (fr) | 1995-08-17 |
| CN1145027A (zh) | 1997-03-12 |
| AP9500717A0 (en) | 1995-04-30 |
| TW475896B (en) | 2002-02-11 |
| AU700826B2 (en) | 1999-01-14 |
| MX9603338A (es) | 1997-03-29 |
| CN1083715C (zh) | 2002-05-01 |
| AU1578395A (en) | 1995-08-29 |
| IL112590A (en) | 2002-08-14 |
| SG47100A1 (en) | 1998-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |