CA2183531A1 - Derives 4-amino de l'acide mycophenolique substitue en 5 - Google Patents

Derives 4-amino de l'acide mycophenolique substitue en 5

Info

Publication number
CA2183531A1
CA2183531A1 CA002183531A CA2183531A CA2183531A1 CA 2183531 A1 CA2183531 A1 CA 2183531A1 CA 002183531 A CA002183531 A CA 002183531A CA 2183531 A CA2183531 A CA 2183531A CA 2183531 A1 CA2183531 A1 CA 2183531A1
Authority
CA
Canada
Prior art keywords
methyl
formula
lower alkyl
compound
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002183531A
Other languages
English (en)
Inventor
Dean Richard Artis
Todd Richard Elworthy
Ronald Charles Hawley
David Garrett Loughhead
David John Morgans, Jr.
Peter Harold Nelson
John William Patterson, Jr.
Eric Brian Sjogren
David Bernard Smith
Ann Marie Waltos
Robert James Weikert
Alicia Cervantes Garcia
Mario Fernandez Zertuche
Fidencio Franco Andrade
Maria Teresa Lara Hernandez
Francisco Xavier Talamas Murra
Teresa Alejandra Trejo Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2183531A1 publication Critical patent/CA2183531A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

L'invention porte sur des dérivés de l'acide mycophénolique de formule (IE) servant d'agents thérapeutiques traitant avantageusement les états morbides relevant de l'acide mycophénolique et/ou du mycophénolate mofétil et d'autres agents immunodépresseurs. Dans cette formule, Z est une chaîne latérale de formule (ZA, ZB, ZC, ZD, ZE, ZF, ZG ou ZH).
CA002183531A 1994-02-18 1995-02-16 Derives 4-amino de l'acide mycophenolique substitue en 5 Abandoned CA2183531A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US198,732 1994-02-18
US08/198,732 US5512568A (en) 1994-02-18 1994-02-18 Method of using 4-amino derivatives of 5-substituted mycophenolic acid

Publications (1)

Publication Number Publication Date
CA2183531A1 true CA2183531A1 (fr) 1995-08-24

Family

ID=22734572

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002183531A Abandoned CA2183531A1 (fr) 1994-02-18 1995-02-16 Derives 4-amino de l'acide mycophenolique substitue en 5

Country Status (21)

Country Link
US (2) US5512568A (fr)
EP (1) EP0745072B1 (fr)
JP (1) JPH09509173A (fr)
CN (1) CN1141039A (fr)
AT (1) ATE165826T1 (fr)
AU (1) AU1875395A (fr)
BR (1) BR9506838A (fr)
CA (1) CA2183531A1 (fr)
CO (1) CO4340732A1 (fr)
DE (1) DE69502380T2 (fr)
DK (1) DK0745072T3 (fr)
ES (1) ES2116078T3 (fr)
FI (1) FI963220A7 (fr)
IL (1) IL112666A (fr)
LV (1) LV12149B (fr)
MX (1) MX9603484A (fr)
PH (1) PH31426A (fr)
SI (1) SI0745072T1 (fr)
TW (1) TW438788B (fr)
WO (1) WO1995022537A2 (fr)
ZA (1) ZA951293B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6811998B2 (en) * 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
WO2006115509A2 (fr) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
CA3026241A1 (fr) 2016-06-02 2017-12-07 Steven Baranowitz Prevention et traitement d'infections virales

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5542995B2 (fr) * 1972-02-24 1980-11-04
US3825571A (en) * 1971-07-31 1974-07-23 Chugai Pharmaceutical Co Ltd Mycophenolic acid derivatives
JPS5529994B2 (fr) * 1972-03-02 1980-08-07
US4686234A (en) * 1985-11-27 1987-08-11 Syntex (U.S.A) Inc. Mycophenolic acid derivatives in the treatment of inflammatory diseases, in particular rheumatoid arthritis
US4725622A (en) * 1986-01-23 1988-02-16 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4959387A (en) * 1986-01-23 1990-09-25 Syntex (U.S.A.) Inc. Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
US4727069A (en) * 1987-01-30 1988-02-23 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions
US4861776A (en) * 1987-01-30 1989-08-29 Syntex (U.S.A) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use
US4748173A (en) * 1987-01-30 1988-05-31 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions
JPH0637486B2 (ja) * 1988-05-18 1994-05-18 三共株式会社 新規抗生物質フタレキシンおよびその製造法
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid

Also Published As

Publication number Publication date
JPH09509173A (ja) 1997-09-16
ES2116078T3 (es) 1998-07-01
WO1995022537A2 (fr) 1995-08-24
EP0745072A1 (fr) 1996-12-04
LV12149A (lv) 1998-10-20
AU1875395A (en) 1995-09-04
DK0745072T3 (da) 1999-01-18
FI963220A0 (fi) 1996-08-16
DE69502380T2 (de) 1998-10-08
CN1141039A (zh) 1997-01-22
FI963220A7 (fi) 1996-10-16
US5538969A (en) 1996-07-23
TW438788B (en) 2001-06-07
ATE165826T1 (de) 1998-05-15
CO4340732A1 (es) 1996-07-30
US5512568A (en) 1996-04-30
IL112666A0 (en) 1995-05-26
PH31426A (en) 1998-10-29
MX9603484A (es) 1998-01-31
DE69502380D1 (de) 1998-06-10
BR9506838A (pt) 1997-09-30
HK1010784A1 (en) 1999-06-25
ZA951293B (en) 1996-08-16
SI0745072T1 (en) 1998-10-31
WO1995022537A3 (fr) 1995-10-26
LV12149B (en) 1998-12-20
IL112666A (en) 2000-01-31
EP0745072B1 (fr) 1998-05-06

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued