CA2193809A1 - Recepteurs modifies lies a des proteines g - Google Patents

Recepteurs modifies lies a des proteines g

Info

Publication number
CA2193809A1
CA2193809A1 CA 2193809 CA2193809A CA2193809A1 CA 2193809 A1 CA2193809 A1 CA 2193809A1 CA 2193809 CA2193809 CA 2193809 CA 2193809 A CA2193809 A CA 2193809A CA 2193809 A1 CA2193809 A1 CA 2193809A1
Authority
CA
Canada
Prior art keywords
receptor
modified
protein coupled
coupled receptor
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2193809
Other languages
English (en)
Inventor
Catherine D. Strader
Maria-Luisa Rios Candelore
Xiaoming Guan
Richard Dixon
George Mcallister
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2193809A1 publication Critical patent/CA2193809A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

On a identifié des récepteurs modifiés couplés à des protéines G présentant des délétions dans le troisième domaine intracellulaire et développé des procédés de production de ces récepteurs modifiés. Cette invention concerne les récepteurs modifiés, des dosages employant les récepteurs modifiés, des cellules exprimant les récepteurs modifiés et des composés identifiés à l'aide desdits récepteurs modifiés, y compris des modulateurs de ces récepteurs.
CA 2193809 1994-06-29 1995-06-02 Recepteurs modifies lies a des proteines g Abandoned CA2193809A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26814794A 1994-06-29 1994-06-29
US26798794A 1994-06-29 1994-06-29
US268,147 1994-06-29
US267,987 1994-06-29

Publications (1)

Publication Number Publication Date
CA2193809A1 true CA2193809A1 (fr) 1996-01-11

Family

ID=26952801

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2193809 Abandoned CA2193809A1 (fr) 1994-06-29 1995-06-02 Recepteurs modifies lies a des proteines g

Country Status (4)

Country Link
EP (1) EP0770094A4 (fr)
JP (1) JPH10502245A (fr)
CA (1) CA2193809A1 (fr)
WO (1) WO1996000739A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606126D0 (en) * 1996-03-22 1996-05-22 British Biotech Pharm Biosensors
CA2344591A1 (fr) * 1998-09-01 2000-03-09 Basf Aktiengesellschaft Methodes permettant d'ameliorer la fonction des recepteurs heterologues couples a la proteine g
US7094593B1 (en) 1998-09-01 2006-08-22 Basf Aktiengesellschaft Method for improving the function of heterologous G protein-coupled receptors
WO2001087976A2 (fr) * 2000-05-12 2001-11-22 3-Dimensional Pharmaceuticals, Inc. Gpcr comprenant des faisceaux à 4 hélices et à 5 hélices
BRPI0410491A8 (pt) * 2003-04-24 2017-10-24 Univ Vanderbilt Composições e métodos para o controle de insetos

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5462856A (en) * 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins

Also Published As

Publication number Publication date
WO1996000739A1 (fr) 1996-01-11
JPH10502245A (ja) 1998-03-03
EP0770094A4 (fr) 1999-05-19
EP0770094A1 (fr) 1997-05-02

Similar Documents

Publication Publication Date Title
EP1584683B1 (fr) Récepteur humaine orphelin RUP3 couplé à une protéine g
US5595880A (en) DNA encoding an α2B adrenergic receptor and uses thereof
JPH10508486A (ja) 修飾神経ペプチドｙレセプター
JPH07503611A (ja) ソマトスタチン受容体
JPH10510709A (ja) 摂食行動を変える方法、該方法に有用な化合物、および視床下部の異型神経ペプチドｙ／ペプチドｙｙ受容体（ｙ５）をコードするｄｎａ
US7108991B2 (en) Human orphan G protein-coupled receptors
CA2231748A1 (fr) Nouveau recepteur couple a la proteine g (hfgan72x)
JPH10327889A (ja) 新規ｇ−タンパク質結合レセプター（ｈｆｇａｎ７２ｙ）
AU718311B2 (en) A C5a-like seven transmembrane receptor
WO1996000739A1 (fr) Recepteurs modifies lies a des proteines g
US8198049B2 (en) Nucleic acids encoding RUP3 and methods of using same
JP4106094B2 (ja) クローン化グルカゴン様ペプチド２受容体
US20020142346A1 (en) Binding compounds and methods for identifying binding compounds
EP0576609A1 (fr) Recepteur pour peptide analogue a la bombesine
WO1998053062A1 (fr) Homologue du recepteur edg-6 humain
US6441133B1 (en) Thyrotropin-releasing hormone receptor 2(TRHR-2)
EP1268521A1 (fr) Composes de liaison avec un recepteur et leurs methodes d'identification
USRE42190E1 (en) Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors
JPH09278798A (ja) 新規ｇ蛋白質共役型レセプター蛋白質、その製造法および用途
US20030139589A1 (en) G protein coupled receptor A4
JPH07304797A (ja) ヒトｔｒｈレセプター蛋白質、その製造法および用途
CA2204491A1 (fr) Recepteurs neuropeptidiques y modifies
HK1077081B (en) Human orphan g protein-coupled receptor rup3
HK1077081A1 (en) Human orphan g protein-coupled receptor rup3

Legal Events

Date Code Title Description
FZDE Dead