CA2201944C - Analogues du facteur de croissance des keratinocytes ayant une stabilite de temperature amelioree - Google Patents
Analogues du facteur de croissance des keratinocytes ayant une stabilite de temperature amelioree Download PDFInfo
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- CA2201944C CA2201944C CA002201944A CA2201944A CA2201944C CA 2201944 C CA2201944 C CA 2201944C CA 002201944 A CA002201944 A CA 002201944A CA 2201944 A CA2201944 A CA 2201944A CA 2201944 C CA2201944 C CA 2201944C
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- Prior art keywords
- analog
- afgf
- amino acid
- naturally occurring
- kgf
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention permet d'obtenir des analogues des protéines de la famille des FGF. Ces analogues sont plus stables que les protéines naturelles correspondantes. Une stabilité accrue peut être obtenue en substituant au moins un acide aminé ayant un potentiel de formation de boucle plus élevée par un résidu d'acide aminé ayant un potentiel de formation de boucle plus faible dans une région identifiée de formation de boucle dans la séquence d'acides aminés de la protéine. Les analogues issus de la présente invention sont particulièrement utiles dans des applications thérapeutiques.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32347394A | 1994-10-13 | 1994-10-13 | |
| US08/323,473 | 1994-10-13 | ||
| PCT/US1995/012907 WO1996022369A1 (fr) | 1994-10-13 | 1995-10-12 | Analogues de facteur de croissance du fibroblaste acide a stabilite et activite biologique renforcees |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2201944A1 CA2201944A1 (fr) | 1996-07-25 |
| CA2201944C true CA2201944C (fr) | 2002-12-31 |
Family
ID=23259345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002201944A Expired - Lifetime CA2201944C (fr) | 1994-10-13 | 1995-10-12 | Analogues du facteur de croissance des keratinocytes ayant une stabilite de temperature amelioree |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0786000A1 (fr) |
| JP (1) | JPH10507929A (fr) |
| CN (1) | CN1169158A (fr) |
| AU (1) | AU3828195A (fr) |
| CA (1) | CA2201944C (fr) |
| CZ (1) | CZ98097A3 (fr) |
| HU (1) | HUT77746A (fr) |
| NO (1) | NO971508L (fr) |
| SK (1) | SK43297A3 (fr) |
| WO (1) | WO1996022369A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2201762C (fr) * | 1994-10-13 | 2001-12-18 | Eric W. Hsu | Procede pour purifier des facteurs de croissance des keratinocytes |
| US6077692A (en) | 1995-02-14 | 2000-06-20 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
| US6693077B1 (en) | 1995-02-14 | 2004-02-17 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
| US7232667B2 (en) | 1995-02-14 | 2007-06-19 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 polynucleotides |
| US6743422B1 (en) | 1996-10-15 | 2004-06-01 | Amgen, Inc. | Keratinocyte growth factor-2 products |
| WO1998039436A2 (fr) * | 1997-03-03 | 1998-09-11 | Eisai Co., Ltd. | Compositions de muteine du facteur de croissance des fibroblastes, et procedes d'utilisation de ces compositions |
| EP1041996A4 (fr) | 1997-12-22 | 2003-05-14 | Human Genome Sciences Inc | Formulations du facteur-2 de croissance des keratinocytes |
| US6869927B1 (en) | 1997-12-22 | 2005-03-22 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 formulations |
| US6274712B1 (en) | 1997-12-23 | 2001-08-14 | 3-Dimensional Pharmaceuticals, Inc. | Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137 |
| IL139380A0 (en) * | 2000-10-31 | 2001-11-25 | Prochon Biotech Ltd | Active variants of fibroblast growth factor |
| TWI634898B (zh) * | 2013-10-07 | 2018-09-11 | 雅祥生技醫藥股份有限公司 | 經修飾之人類酸性纖維母細胞生長因子及其組合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06503962A (ja) * | 1990-12-18 | 1994-05-12 | アムジエン・インコーポレーテツド | 増強された安定性及び生物学的活性を有する酸性線維芽細胞成長因子の類似体 |
-
1995
- 1995-10-12 EP EP95936275A patent/EP0786000A1/fr not_active Withdrawn
- 1995-10-12 SK SK432-97A patent/SK43297A3/sk unknown
- 1995-10-12 CA CA002201944A patent/CA2201944C/fr not_active Expired - Lifetime
- 1995-10-12 AU AU38281/95A patent/AU3828195A/en not_active Abandoned
- 1995-10-12 CZ CZ97980A patent/CZ98097A3/cs unknown
- 1995-10-12 JP JP8517875A patent/JPH10507929A/ja not_active Withdrawn
- 1995-10-12 HU HU9800740A patent/HUT77746A/hu unknown
- 1995-10-12 WO PCT/US1995/012907 patent/WO1996022369A1/fr not_active Ceased
- 1995-10-12 CN CN95196717A patent/CN1169158A/zh active Pending
-
1997
- 1997-04-03 NO NO971508A patent/NO971508L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CZ98097A3 (en) | 1997-12-17 |
| EP0786000A1 (fr) | 1997-07-30 |
| HUT77746A (hu) | 1998-07-28 |
| MX9702475A (es) | 1997-07-31 |
| NO971508L (no) | 1997-06-13 |
| CA2201944A1 (fr) | 1996-07-25 |
| NO971508D0 (no) | 1997-04-03 |
| JPH10507929A (ja) | 1998-08-04 |
| SK43297A3 (en) | 1998-01-14 |
| AU3828195A (en) | 1996-08-07 |
| CN1169158A (zh) | 1997-12-31 |
| WO1996022369A1 (fr) | 1996-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20151013 |