JPH10507929A - 高い安定性と生物活性をもつ酸性繊維芽細胞増殖因子の類似体 - Google Patents

高い安定性と生物活性をもつ酸性繊維芽細胞増殖因子の類似体

Info

Publication number
JPH10507929A
JPH10507929A JP8517875A JP51787596A JPH10507929A JP H10507929 A JPH10507929 A JP H10507929A JP 8517875 A JP8517875 A JP 8517875A JP 51787596 A JP51787596 A JP 51787596A JP H10507929 A JPH10507929 A JP H10507929A
Authority
JP
Japan
Prior art keywords
analog
afgf
amino acid
kgf
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP8517875A
Other languages
English (en)
Japanese (ja)
Inventor
アラカワ，ツトム
フオツクス，ギヤリイ・マイケル
Original Assignee
アムジエン・インコーポレーテツド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アムジエン・インコーポレーテツド filed Critical アムジエン・インコーポレーテツド
Publication of JPH10507929A publication Critical patent/JPH10507929A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP8517875A 1994-10-13 1995-10-12 高い安定性と生物活性をもつ酸性繊維芽細胞増殖因子の類似体 Withdrawn JPH10507929A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32347394A 1994-10-13 1994-10-13
US08/323,473 1994-10-13
PCT/US1995/012907 WO1996022369A1 (fr) 1994-10-13 1995-10-12 Analogues de facteur de croissance du fibroblaste acide a stabilite et activite biologique renforcees

Publications (1)

Publication Number Publication Date
JPH10507929A true JPH10507929A (ja) 1998-08-04

Family

ID=23259345

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8517875A Withdrawn JPH10507929A (ja) 1994-10-13 1995-10-12 高い安定性と生物活性をもつ酸性繊維芽細胞増殖因子の類似体

Country Status (10)

Country Link
EP (1) EP0786000A1 (fr)
JP (1) JPH10507929A (fr)
CN (1) CN1169158A (fr)
AU (1) AU3828195A (fr)
CA (1) CA2201944C (fr)
CZ (1) CZ98097A3 (fr)
HU (1) HUT77746A (fr)
NO (1) NO971508L (fr)
SK (1) SK43297A3 (fr)
WO (1) WO1996022369A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2201762C (fr) * 1994-10-13 2001-12-18 Eric W. Hsu Procede pour purifier des facteurs de croissance des keratinocytes
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
WO1998039436A2 (fr) * 1997-03-03 1998-09-11 Eisai Co., Ltd. Compositions de muteine du facteur de croissance des fibroblastes, et procedes d'utilisation de ces compositions
EP1041996A4 (fr) 1997-12-22 2003-05-14 Human Genome Sciences Inc Formulations du facteur-2 de croissance des keratinocytes
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
IL139380A0 (en) * 2000-10-31 2001-11-25 Prochon Biotech Ltd Active variants of fibroblast growth factor
TWI634898B (zh) * 2013-10-07 2018-09-11 雅祥生技醫藥股份有限公司 經修飾之人類酸性纖維母細胞生長因子及其組合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06503962A (ja) * 1990-12-18 1994-05-12 アムジエン・インコーポレーテツド 増強された安定性及び生物学的活性を有する酸性線維芽細胞成長因子の類似体

Also Published As

Publication number Publication date
CZ98097A3 (en) 1997-12-17
EP0786000A1 (fr) 1997-07-30
HUT77746A (hu) 1998-07-28
MX9702475A (es) 1997-07-31
NO971508L (no) 1997-06-13
CA2201944A1 (fr) 1996-07-25
NO971508D0 (no) 1997-04-03
SK43297A3 (en) 1998-01-14
AU3828195A (en) 1996-08-07
CA2201944C (fr) 2002-12-31
CN1169158A (zh) 1997-12-31
WO1996022369A1 (fr) 1996-07-25

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Legal Events

Date Code Title Description
A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20040630