CA2263764A1 - Procede et nouveaux intermediaires - Google Patents

Procede et nouveaux intermediaires Download PDF

Info

Publication number
CA2263764A1
CA2263764A1 CA002263764A CA2263764A CA2263764A1 CA 2263764 A1 CA2263764 A1 CA 2263764A1 CA 002263764 A CA002263764 A CA 002263764A CA 2263764 A CA2263764 A CA 2263764A CA 2263764 A1 CA2263764 A1 CA 2263764A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
substituted
formula
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002263764A
Other languages
English (en)
Inventor
Michael John Martinelli
Samantha Kristi Janisse
David Warren Hoard
John Eldon Toth
Eric David Moher
Darrell Robert Hutchison
David Lee Varie
Kevin Alan Sullivan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hawaiʻi at Mānoa
Wayne State University
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2263764A1 publication Critical patent/CA2263764A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Intermédiaires et procédés utiles pour la préparation de composés cryptophycine.
CA002263764A 1996-09-06 1997-09-05 Procede et nouveaux intermediaires Abandoned CA2263764A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2552196P 1996-09-06 1996-09-06
US60/025,521 1996-09-06
PCT/US1997/015703 WO1998009955A1 (fr) 1996-09-06 1997-09-05 Procede et nouveaux intermediaires

Publications (1)

Publication Number Publication Date
CA2263764A1 true CA2263764A1 (fr) 1998-03-12

Family

ID=21826566

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002263764A Abandoned CA2263764A1 (fr) 1996-09-06 1997-09-05 Procede et nouveaux intermediaires

Country Status (5)

Country Link
EP (1) EP0929535A4 (fr)
JP (1) JP2001502298A (fr)
AU (1) AU4335297A (fr)
CA (1) CA2263764A1 (fr)
WO (1) WO1998009955A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034252A2 (fr) * 1998-12-07 2000-06-15 Eli Lilly And Company Procede de crotylboration permettant de produire des composes de cryptophycine
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
EP1481268A4 (fr) 2002-02-07 2005-06-29 Covalent Partners Llc Compositions pour nanofilms et membrane
JP2012522746A (ja) * 2009-04-01 2012-09-27 レツク・フアーマシユーテイカルズ・デー・デー 活性メチレン基のジメチル化の方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3567834A (en) * 1969-06-16 1971-03-02 Bristol Myers Co Method of producing sedation
US4739120A (en) * 1986-08-21 1988-04-19 The Dow Chemical Company Process for the hydrogenation of nitriles to primary amines
DE3904119A1 (de) * 1989-02-11 1990-08-16 Hoechst Ag Polymerfixiertes methotrexat, verfahren zur herstellung und verwendung
IT1239029B (it) * 1989-10-12 1993-09-20 Poli Ind Chimica Spa Processo per la preparazione dell'acido 3-(l-piroglutamil)-l- tiazolidin-4-carbossilico e suoi derivati.
EP0518295A3 (en) * 1991-06-14 1993-09-01 Millipore Corporation Allyl side chain protection in peptide synthesis
ATE203016T1 (de) * 1993-12-21 2001-07-15 Univ Hawaii Cryptophycine
CN1085560C (zh) * 1993-12-28 2002-05-29 罗纳布朗克化学公司 用于将腈催化氢化为胺的催化剂及其制备方法与用途
DE69633667T2 (de) * 1995-03-07 2006-03-02 University Of Hawaii, Honolulu Neue synthetische cryptophycine
ATE201018T1 (de) * 1996-02-27 2001-05-15 Lilly Co Eli Cryptophycinderivate und ihre verwendung als antimikrotubuli mittel

Also Published As

Publication number Publication date
EP0929535A1 (fr) 1999-07-21
EP0929535A4 (fr) 2001-05-23
AU4335297A (en) 1998-03-26
WO1998009955A1 (fr) 1998-03-12
JP2001502298A (ja) 2001-02-20

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Legal Events

Date Code Title Description
FZDE Discontinued