CA2284705A1 - Formulations chimiquement et thermiquement stables de norastemizole - Google Patents

Formulations chimiquement et thermiquement stables de norastemizole Download PDF

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Publication number
CA2284705A1
CA2284705A1 CA002284705A CA2284705A CA2284705A1 CA 2284705 A1 CA2284705 A1 CA 2284705A1 CA 002284705 A CA002284705 A CA 002284705A CA 2284705 A CA2284705 A CA 2284705A CA 2284705 A1 CA2284705 A1 CA 2284705A1
Authority
CA
Canada
Prior art keywords
norastemizole
pharmaceutically acceptable
lactose
pharmaceutical composition
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002284705A
Other languages
English (en)
Inventor
Martin P. Redmon
Hal T. Butler
Stephen A. Wald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma America Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2284705A1 publication Critical patent/CA2284705A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des formulations chimiquement et thermiquement stables de norastémizole qui est un antihistaminique puissant. Ces compositions, ou certains de leurs sels pharmaceutiquement admis, sont exemptes de lactose, sont non hygroscopiques, sont anhydres, comprennent des grandes particules de norastémizole ou du norastémizole enrobé de façon inerte. Les composés de l'invention sont stables et faciles à fabriquer.
CA002284705A 1997-03-26 1998-03-25 Formulations chimiquement et thermiquement stables de norastemizole Abandoned CA2284705A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US82447797A 1997-03-26 1997-03-26
US85178697A 1997-05-06 1997-05-06
US08/851,786 1997-05-06
US08/824,477 1997-05-06
PCT/US1998/005701 WO1998042379A2 (fr) 1997-03-26 1998-03-25 Formulations chimiquement et thermiquement stables de norastemizole

Publications (1)

Publication Number Publication Date
CA2284705A1 true CA2284705A1 (fr) 1998-10-01

Family

ID=27124816

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002284705A Abandoned CA2284705A1 (fr) 1997-03-26 1998-03-25 Formulations chimiquement et thermiquement stables de norastemizole

Country Status (13)

Country Link
EP (1) EP1035869A1 (fr)
JP (1) JP2002512614A (fr)
KR (1) KR20010005746A (fr)
CN (1) CN1257431A (fr)
AR (1) AR012187A1 (fr)
BR (1) BR9808428A (fr)
CA (1) CA2284705A1 (fr)
HU (1) HUP0001823A3 (fr)
NO (1) NO994655L (fr)
NZ (3) NZ527200A (fr)
RU (1) RU2214245C2 (fr)
WO (1) WO1998042379A2 (fr)
ZA (1) ZA982562B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ289261B6 (cs) * 2000-07-11 2001-12-12 Léčiva, A.S. Tableta vyrobitelná přímým tabletováním, obsahující aktivní látku kyselinu 4-amino-1-hydroxybutyliden-1,1-bisfosfonovou, a způsob její výroby
EP2201982A1 (fr) * 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonistes du récepteur H4 de l'histamine pour le traitement de troubles vestibulaires
EP2496217B1 (fr) * 2009-08-24 2019-03-27 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi Comprimés d'otilonium obtenus par compression directe

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1327579C (fr) * 1986-02-03 1994-03-08 Frans Eduard Janssens Compositions antihistaminiques renfermant des n-heterocyclylpiperidin-4-amines
DE4037426A1 (de) * 1990-11-24 1992-05-27 Kali Chemie Pharma Gmbh Piperidinoalkylbenzoxazin- und -thiazin-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DK0920865T3 (da) * 1992-09-03 2004-04-19 Sepracor Inc Farmaceutiske sammensætninger indeholdende norastemizol
JPH11513991A (ja) * 1995-11-17 1999-11-30 ヘキスト・マリオン・ルセル・インコーポレイテツド アレルギー性疾患の治療に有用な置換４−（１ｈ−ベンズイミダゾル−２−イル−アミノ）ピペリジン
SK20099A3 (en) * 1996-08-16 2000-08-14 Schering Corp Treatment of upper airway allergic responses with a combination of histamine receptor antagonists

Also Published As

Publication number Publication date
WO1998042379A2 (fr) 1998-10-01
ZA982562B (en) 1998-10-01
AU735257B2 (en) 2001-07-05
NZ527200A (en) 2004-12-24
RU2214245C2 (ru) 2003-10-20
BR9808428A (pt) 2000-05-23
EP1035869A1 (fr) 2000-09-20
HUP0001823A2 (hu) 2001-04-28
NO994655D0 (no) 1999-09-24
AR012187A1 (es) 2000-09-27
KR20010005746A (ko) 2001-01-15
AU6868098A (en) 1998-10-20
HUP0001823A3 (en) 2002-04-29
NZ527201A (en) 2004-12-24
NZ517472A (en) 2003-08-29
WO1998042379A3 (fr) 2001-03-01
CN1257431A (zh) 2000-06-21
NO994655L (no) 1999-11-15
JP2002512614A (ja) 2002-04-23

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20060327