CA2295616C - Utilisation d'inhibiteurs de la phosphodiesterase dans le traitement de maladies de la prostate - Google Patents
Utilisation d'inhibiteurs de la phosphodiesterase dans le traitement de maladies de la prostate Download PDFInfo
- Publication number
- CA2295616C CA2295616C CA002295616A CA2295616A CA2295616C CA 2295616 C CA2295616 C CA 2295616C CA 002295616 A CA002295616 A CA 002295616A CA 2295616 A CA2295616 A CA 2295616A CA 2295616 C CA2295616 C CA 2295616C
- Authority
- CA
- Canada
- Prior art keywords
- hydroxy
- benzyl
- quinazoline
- pyrimidin
- propyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
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- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 125000005498 phthalate group Chemical class 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
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- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- ZPWFUIUNWDIYCJ-UHFFFAOYSA-N propan-2-yl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C ZPWFUIUNWDIYCJ-UHFFFAOYSA-N 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
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- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- RNVYQYLELCKWAN-UHFFFAOYSA-N solketal Chemical compound CC1(C)OCC(CO)O1 RNVYQYLELCKWAN-UHFFFAOYSA-N 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
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- 239000003549 soybean oil Substances 0.000 description 1
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- 241000894007 species Species 0.000 description 1
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- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- 239000008158 vegetable oil Substances 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne l'utilisation d'inhibiteurs de la phosphordiestérase I, IV et V pour la prévention et le traitement de maladies de la prostate, plus particulièrement l'utilisation de a) 2- (2-propoxy-phényl)-8-azapurin-6-one (zaprinast); b) dipyridamole; c) 1-(3-chlorophénylamino)-4-phénylphtalazine (M5445); d) 2-(N-(4-carboxypipéridine-6-chloro-4-(3,4-(méthylène-dioxy)benzyl)amino)qinazoline (E 4021, ER 21355); e) 2,3-dihydro-8- hydroxy-7-nitro-1, 4-benzodioxine-2-méthanol, alpha-nitrate (E 4701); f) 4-((3,4-(méthylènedioxy) benzyl)amino)-6, 7,8-triméthoxy-quinazoline; g) 1-méthyl-3-propyl-6- (5-(N-(4-méthylmorpholino) sulfonyl)-2-éthoxyphényl)pyrazole [4,5]pyrimidine-4(5H)one (sildenafil); i) 1-cyclopentyl-3-méthyl-6- (4-pyridinyl)pyrazolo (3, 4-d)pyrimidine-4(5H)one (WIN 58237); j) 7-(3-(4-acétyl-3- hydroxy-2-propyl-phénoxy) -2-hydroxy-propoxy)-2-carboxy-2, 3-didéhydro-chromane-4-one (FPL-557212); k) quinazolines et leur dérivés triméthoxy; l) pyrazolopyrimidones; ainsi que leurs sels pharmaceutiquement compatibles, des quinazolines et leur dérivés triméthoxy, des pyrazolopyrimidones ou leurs sels compatibles pour une administration locale et par voie générale.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1997/003617 WO1999002161A1 (fr) | 1997-07-09 | 1997-07-09 | Utilisation d'inhibiteurs de la phosphordiesterase dans le traitement de maladies de la prostate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2295616A1 CA2295616A1 (fr) | 1999-01-21 |
| CA2295616C true CA2295616C (fr) | 2009-05-12 |
Family
ID=8166680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002295616A Expired - Lifetime CA2295616C (fr) | 1997-07-09 | 1997-07-09 | Utilisation d'inhibiteurs de la phosphodiesterase dans le traitement de maladies de la prostate |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU3621097A (fr) |
| CA (1) | CA2295616C (fr) |
| WO (1) | WO1999002161A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6200591B1 (en) * | 1998-06-25 | 2001-03-13 | Anwar A. Hussain | Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction |
| DE19834506A1 (de) * | 1998-07-31 | 2000-02-03 | Hexal Ag | Transmucosales therapeutisches System zur Anwendung von Sildenafil |
| IL132406A0 (en) * | 1998-10-21 | 2001-03-19 | Pfizer Prod Inc | Treatment of bph with cgmp elevators |
| IL130968A (en) | 1999-07-15 | 2002-12-01 | Shmuel Simon | Pharmaceutical composition comprising sildenafil or its analogs, useful for the treatment of tinnitus and hearing loss |
| US6828473B2 (en) | 2000-11-01 | 2004-12-07 | Pfizer Inc. | Modulation of PDE11A activity |
| US20050107394A1 (en) * | 2001-12-17 | 2005-05-19 | Ardeschir Ghofrani | Novel use of selective pde5 inhibitors |
| FR2845993B1 (fr) * | 2002-10-16 | 2005-02-11 | Univ Pasteur | Composes pharmaceutiques inhibiteurs specifiques de la pde5 du muscle lisse, compositions pharmaceutiques les contenant et utilisations therapeutiques |
| WO2005077374A1 (fr) * | 2004-02-06 | 2005-08-25 | Becton, Dickinson And Company | Formulations d'inhibiteurs de la phosphodiesterase 5 et procedes d'utilisation |
| WO2007047282A1 (fr) * | 2005-10-12 | 2007-04-26 | Lilly Icos Llc | Traitement d'une hypertrophie benigne de la prostate et de symptomes dans les voies urinaires inferieures |
| EP1965863A2 (fr) * | 2005-12-20 | 2008-09-10 | Pfizer Products Inc. | Combinaison pharmaceutique utilisee pour traiter des troubles urinaires du bas appareil (tuba) |
| AT512084A1 (de) | 2011-10-20 | 2013-05-15 | Univ Wien Tech | Diazabicyclo- und diazaspiro-alkanderivate als phosphodiesterase-5 inhibitoren |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19540642A1 (de) * | 1995-11-01 | 1997-05-07 | Stief Christian Georg Priv Doz | Verwendung von Inhibitoren der Phosphodiesterase bei der Behandlung von Prostataerkrankungen |
-
1997
- 1997-07-09 CA CA002295616A patent/CA2295616C/fr not_active Expired - Lifetime
- 1997-07-09 WO PCT/EP1997/003617 patent/WO1999002161A1/fr not_active Ceased
- 1997-07-09 AU AU36210/97A patent/AU3621097A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2295616A1 (fr) | 1999-01-21 |
| AU3621097A (en) | 1999-02-08 |
| WO1999002161A1 (fr) | 1999-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20170710 |