CA2305394C - Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile - Google Patents

Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile Download PDF

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Publication number
CA2305394C
CA2305394C CA002305394A CA2305394A CA2305394C CA 2305394 C CA2305394 C CA 2305394C CA 002305394 A CA002305394 A CA 002305394A CA 2305394 A CA2305394 A CA 2305394A CA 2305394 C CA2305394 C CA 2305394C
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Prior art keywords
phosphodiesterase inhibitor
phosphodiesterase
type
use according
formulation
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Expired - Lifetime
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CA002305394A
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CA2305394A1 (fr
Inventor
Paul C. Doherty, Jr.
Virgil A. Place
William L. Smith
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Vivus LLC
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Vivus LLC
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Priority claimed from US09/181,070 external-priority patent/US6037346A/en
Application filed by Vivus LLC filed Critical Vivus LLC
Publication of CA2305394A1 publication Critical patent/CA2305394A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

L'invention concerne un procédé de traitement du dysfonctionnement érectile chez un individu mâle mammifère. Ce procédé consiste à apporter localement un inhibiteur des phosphodiestérases, ou un sel, ester, amide ou dérivé de celui-ci, acceptable sur le plan pharmacologique, dans le cadre d'un schéma posologique efficace. Un mode préféré d'administration est un mode transurétral. L'invention concerne également des formulations et des coffrets pharmaceutiques.
CA002305394A 1997-10-28 1998-10-28 Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile Expired - Lifetime CA2305394C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95881697A 1997-10-28 1997-10-28
US08/958,816 1997-10-28
US09/181,070 US6037346A (en) 1997-10-28 1998-10-27 Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US09/181,070 1998-10-27
PCT/US1998/022928 WO1999021558A2 (fr) 1997-10-28 1998-10-28 Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile

Publications (2)

Publication Number Publication Date
CA2305394A1 CA2305394A1 (fr) 1999-05-06
CA2305394C true CA2305394C (fr) 2006-12-12

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Family Applications (1)

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CA002305394A Expired - Lifetime CA2305394C (fr) 1997-10-28 1998-10-28 Apport local d'inhibiteurs de phosphodiesterases, dans le traitement du dysfonctionnement erectile

Country Status (5)

Country Link
EP (1) EP1027054A4 (fr)
JP (1) JP2003525845A (fr)
AU (1) AU734734B2 (fr)
CA (1) CA2305394C (fr)
WO (1) WO1999021558A2 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
EP1005336A4 (fr) 1997-07-09 2001-01-17 Androsolutions Inc Compositions et procedes perfectionnes de traitement des troubles de l'erection chez l'homme
US6103765A (en) 1997-07-09 2000-08-15 Androsolutions, Inc. Methods for treating male erectile dysfunction
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AU734734B2 (en) 2001-06-21
CA2305394A1 (fr) 1999-05-06
EP1027054A4 (fr) 2002-11-04
WO1999021558A3 (fr) 2000-10-26
EP1027054A1 (fr) 2000-08-16
WO1999021558A2 (fr) 1999-05-06
AU1125499A (en) 1999-05-17

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