CA2306632A1 - Composes antibacteriens, compositions et procedes de traitement aux carbapenemes - Google Patents

Composes antibacteriens, compositions et procedes de traitement aux carbapenemes Download PDF

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Publication number
CA2306632A1
CA2306632A1 CA002306632A CA2306632A CA2306632A1 CA 2306632 A1 CA2306632 A1 CA 2306632A1 CA 002306632 A CA002306632 A CA 002306632A CA 2306632 A CA2306632 A CA 2306632A CA 2306632 A1 CA2306632 A1 CA 2306632A1
Authority
CA
Canada
Prior art keywords
groups
substituted
straight
group
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002306632A
Other languages
English (en)
Inventor
Frank P. Dininno
Milton L. Hammond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9807362.0A external-priority patent/GB9807362D0/en
Application filed by Individual filed Critical Individual
Publication of CA2306632A1 publication Critical patent/CA2306632A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne des agents antibactériens au carbapénème tricyclique dans lesquels le noyau de carbapénème est condensé avec un noyau carbocyclique à 6 chaînons. De plus, ce composé est substitué par divers groupes dont au moins un groupe cationique. Les composés sont représentés par la formule (I). L'invention concerne également des compositions pharmaceutiques et des procédés d'utilisation.
CA002306632A 1997-10-23 1998-10-19 Composes antibacteriens, compositions et procedes de traitement aux carbapenemes Abandoned CA2306632A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6324197P 1997-10-23 1997-10-23
US60/063,241 1997-10-23
GBGB9807362.0A GB9807362D0 (en) 1998-04-06 1998-04-06 Carbapenem antibacterial compounds,compositions containing such compounds and mehods of treatment
GB9807362.0 1998-04-06
PCT/US1998/022111 WO1999020270A1 (fr) 1997-10-23 1998-10-19 Composes antibacteriens, compositions et procedes de traitement aux carbapenemes

Publications (1)

Publication Number Publication Date
CA2306632A1 true CA2306632A1 (fr) 1999-04-29

Family

ID=26313439

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002306632A Abandoned CA2306632A1 (fr) 1997-10-23 1998-10-19 Composes antibacteriens, compositions et procedes de traitement aux carbapenemes

Country Status (5)

Country Link
EP (1) EP1032384A4 (fr)
JP (1) JP2001520192A (fr)
AU (1) AU732995B2 (fr)
CA (1) CA2306632A1 (fr)
WO (1) WO1999020270A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5905496B2 (ja) * 2013-03-05 2016-04-20 田岡化学工業株式会社 フルオレノン誘導体の製造方法
CN109942527A (zh) * 2019-04-26 2019-06-28 新乡市润宇新材料科技有限公司 一种3-溴二苯并呋喃的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ435990A3 (cs) * 1989-09-08 1999-11-17 Glaxo S.P.A. Kyselina 10-(1-hydroxyethyl)-11-oxo-1-azatricyklo/7,2,0,03,8/-undec-2en-2-karboxylová a její deriváty, způsob jejich výroby, použití pro výrobu farmaceutických prostředků a farmaceutické prostředky s jejich obsahem
EP0507313A1 (fr) * 1991-04-05 1992-10-07 Takeda Chemical Industries, Ltd. Composés polycycliques de carbapénèmes, leur préparation et leur utilisation
GB9218240D0 (en) * 1992-08-27 1992-10-14 Glaxo Spa Heterocyclic compounds

Also Published As

Publication number Publication date
AU1103199A (en) 1999-05-10
EP1032384A4 (fr) 2001-11-21
AU732995B2 (en) 2001-05-03
JP2001520192A (ja) 2001-10-30
WO1999020270A1 (fr) 1999-04-29
EP1032384A1 (fr) 2000-09-06

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