CA2307850A1 - Use of macrolides for the treatment of cancer and macular degeneration - Google Patents

Use of macrolides for the treatment of cancer and macular degeneration Download PDF

Info

Publication number: CA2307850A1
Authority: CA; Canada
Prior art keywords: substituted; heteroaryl; aryl; previously defined; alkyl
Prior art date: 1997-10-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002307850A

Other languages

English (en)

French (fr)

Inventor

Yat Sun Or

Jacob J. Plattner

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott Laboratories

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-31

Filing date

1998-10-30

Publication date

1999-05-14

1998-10-30 Application filed by Individual filed Critical Individual

1999-05-14 Publication of CA2307850A1 publication Critical patent/CA2307850A1/en

Status Abandoned legal-status Critical Current

Links

206010028980 Neoplasm Diseases 0.000 title claims abstract description 22
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-1 (i) -CN Chemical class 0.000 claims description 37
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239000011630 iodine Substances 0.000 description 1
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SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
238000002955 isolation Methods 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
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125000000842 isoxazolyl group Chemical group 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
229940001447 lactate Drugs 0.000 description 1
229940099584 lactobionate Drugs 0.000 description 1
JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 description 1
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208000020816 lung neoplasm Diseases 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
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VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
239000000347 magnesium hydroxide Substances 0.000 description 1
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125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
KVBGVZZKJNLNJU-UHFFFAOYSA-M naphthalene-2-sulfonate Chemical compound C1=CC=CC2=CC(S(=O)(=O)[O-])=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-M 0.000 description 1
125000001624 naphthyl group Chemical group 0.000 description 1
229940097496 nasal spray Drugs 0.000 description 1
239000007922 nasal spray Substances 0.000 description 1
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235000001968 nicotinic acid Nutrition 0.000 description 1
239000011664 nicotinic acid Substances 0.000 description 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
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208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
229940049964 oleate Drugs 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
229940041678 oral spray Drugs 0.000 description 1
239000000668 oral spray Substances 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
125000001715 oxadiazolyl group Chemical group 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
125000002971 oxazolyl group Chemical group 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
230000009589 pathological growth Effects 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
238000011422 pharmacological therapy Methods 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
229940075930 picrate Drugs 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
125000004193 piperazinyl group Chemical group 0.000 description 1
125000003386 piperidinyl group Chemical group 0.000 description 1
229950010765 pivalate Drugs 0.000 description 1
IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
230000002980 postoperative effect Effects 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
125000006308 propyl amino group Chemical group 0.000 description 1
238000000746 purification Methods 0.000 description 1
125000003373 pyrazinyl group Chemical group 0.000 description 1
125000003072 pyrazolidinyl group Chemical group 0.000 description 1
125000002755 pyrazolinyl group Chemical group 0.000 description 1
125000003226 pyrazolyl group Chemical group 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
125000000714 pyrimidinyl group Chemical group 0.000 description 1
125000000719 pyrrolidinyl group Chemical group 0.000 description 1
125000000168 pyrrolyl group Chemical group 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
125000001453 quaternary ammonium group Chemical group 0.000 description 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
230000005855 radiation Effects 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
210000000664 rectum Anatomy 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
239000003340 retarding agent Substances 0.000 description 1
210000001525 retina Anatomy 0.000 description 1
238000012552 review Methods 0.000 description 1
239000003813 safflower oil Substances 0.000 description 1
235000005713 safflower oil Nutrition 0.000 description 1
229930195734 saturated hydrocarbon Natural products 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
230000037390 scarring Effects 0.000 description 1
230000001953 sensory effect Effects 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
231100000161 signs of toxicity Toxicity 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
239000003206 sterilizing agent Substances 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
239000011593 sulfur Chemical group 0.000 description 1
125000004434 sulfur atom Chemical group 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
230000002123 temporal effect Effects 0.000 description 1
238000012360 testing method Methods 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
125000001113 thiadiazolyl group Chemical group 0.000 description 1
125000001984 thiazolidinyl group Chemical group 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical class CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
230000029663 wound healing Effects 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1
235000014692 zinc oxide Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

CA002307850A 1997-10-31 1998-10-30 Use of macrolides for the treatment of cancer and macular degeneration Abandoned CA2307850A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US96147397A	1997-10-31	1997-10-31
US08/961,473		1997-10-31
PCT/US1998/023043 WO1999022722A2 (en)	1997-10-31	1998-10-30	Use of macrolides for the treatment of cancer and macular degeneration

Publications (1)

Publication Number	Publication Date
CA2307850A1 true CA2307850A1 (en)	1999-05-14

Family

ID=25504514

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002307850A Abandoned CA2307850A1 (en)	1997-10-31	1998-10-30	Use of macrolides for the treatment of cancer and macular degeneration

Country Status (17)

Country	Link
EP (1)	EP1027060A2 (no)
JP (1)	JP2001521891A (no)
KR (1)	KR20010031577A (no)
CN (1)	CN1278178A (no)
AR (1)	AR043071A1 (no)
AU (1)	AU1206799A (no)
BG (1)	BG104436A (no)
BR (1)	BR9813318A (no)
CA (1)	CA2307850A1 (no)
HU (1)	HUP0100012A3 (no)
IL (1)	IL135518A0 (no)
NO (1)	NO20002189L (no)
PL (1)	PL340604A1 (no)
SK (1)	SK6172000A3 (no)
TR (1)	TR200001147T2 (no)
WO (1)	WO1999022722A2 (no)
ZA (1)	ZA989885B (no)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2405958C (en)	2000-04-13	2011-08-09	Biotica Technology Limited	Hybrid glycosylated products and their production and use
ES2428354T3 (es)	2002-09-18	2013-11-07	Trustees Of The University Of Pennsylvania	Rapamicina para usar en la inhibición o prevención de la neovascularización coroidea
AR043050A1 (es)	2002-09-26	2005-07-13	Rib X Pharmaceuticals Inc	Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
US7354574B2 (en)	2002-11-07	2008-04-08	Advanced Ocular Systems Limited	Treatment of ocular disease
EP1608626A1 (en)	2003-03-28	2005-12-28	Cornell Research Foundation, Inc.	Migrastatin analog compositions and uses thereof
US7083802B2 (en)	2003-07-31	2006-08-01	Advanced Ocular Systems Limited	Treatment of ocular disease
JP2007505932A (ja)	2003-09-18	2007-03-15	マクサイト，インコーポレイテッド	経強膜送達
US7083803B2 (en)	2003-09-19	2006-08-01	Advanced Ocular Systems Limited	Ocular solutions
US7087237B2 (en) *	2003-09-19	2006-08-08	Advanced Ocular Systems Limited	Ocular solutions
CN108101948A (zh) *	2004-02-27	2018-06-01	瑞伯-X医药品有限公司	大环化合物以及其制作和使用方法
EP2716647A3 (en) *	2004-02-27	2014-08-20	Rib-X Pharmaceuticals, Inc.	Macrocyclic compounds and methods of making and using the same
JP5149001B2 (ja)	2004-05-25	2013-02-20	スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ	癌の処置におけるマイグラスタチンアナログ
US8188141B2 (en)	2004-09-23	2012-05-29	Sloan-Kettering Institute For Cancer Research	Isomigrastatin analogs in the treatment of cancer
WO2006086750A1 (en)	2005-02-09	2006-08-17	Macusight, Inc.	Liquid formulations for treatment of diseases or conditions
PL1904056T3 (pl)	2005-07-18	2009-09-30	Minu Llc	Zastosowanie makrolidu do przywracania czucia rogówkowego
JP2009506066A (ja)	2005-08-24	2009-02-12	リブ−エックスファーマシューティカルズ，インコーポレイテッド	トリアゾール化合物ならびにこれを作製する方法および使用する方法
US8470985B2 (en)	2005-08-24	2013-06-25	Rib-X Pharmaceuticals, Inc.	Triazole compounds and methods of making and using the same
US8492400B2 (en)	2006-02-09	2013-07-23	Santen Pharmaceutical Co., Ltd.	Stable formulations, and methods of their preparation and use
CN101443004B (zh)	2006-03-23	2013-03-06	参天制药株式会社	用于与血管通透性有关的疾病或病症的制剂
CN106317146B (zh) *	2015-06-18	2019-06-21	沈阳药科大学	双环克拉霉素衍生物及其作为肿瘤细胞增值抑制剂的用途

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6461090A (en) *	1989-10-30	1991-05-02	Abbott Laboratories	Injectable formulation for lipophilic drugs
US5498424A (en) *	1994-11-30	1996-03-12	Klein; Ira	Method of treating obesity

1998
- 1998-10-29 ZA ZA989885A patent/ZA989885B/xx unknown
- 1998-10-29 AR ARP980105434A patent/AR043071A1/es unknown
- 1998-10-30 EP EP98955206A patent/EP1027060A2/en not_active Withdrawn
- 1998-10-30 CA CA002307850A patent/CA2307850A1/en not_active Abandoned
- 1998-10-30 SK SK617-2000A patent/SK6172000A3/sk unknown
- 1998-10-30 JP JP2000518656A patent/JP2001521891A/ja not_active Withdrawn
- 1998-10-30 IL IL13551898A patent/IL135518A0/xx unknown
- 1998-10-30 PL PL98340604A patent/PL340604A1/xx unknown
- 1998-10-30 TR TR2000/01147T patent/TR200001147T2/xx unknown
- 1998-10-30 AU AU12067/99A patent/AU1206799A/en not_active Abandoned
- 1998-10-30 HU HU0100012A patent/HUP0100012A3/hu unknown
- 1998-10-30 KR KR1020007004625A patent/KR20010031577A/ko not_active Ceased
- 1998-10-30 WO PCT/US1998/023043 patent/WO1999022722A2/en not_active Ceased
- 1998-10-30 CN CN98810825A patent/CN1278178A/zh active Pending
- 1998-10-30 BR BR9813318-7A patent/BR9813318A/pt not_active Application Discontinuation
2000
- 2000-04-27 NO NO20002189A patent/NO20002189L/no unknown
- 2000-05-15 BG BG104436A patent/BG104436A/xx unknown

Also Published As

Publication number	Publication date
EP1027060A2 (en)	2000-08-16
ZA989885B (en)	1999-05-05
HUP0100012A3 (en)	2003-07-28
IL135518A0 (en)	2001-05-20
HUP0100012A2 (hu)	2001-05-28
WO1999022722A2 (en)	1999-05-14
NO20002189D0 (no)	2000-04-27
PL340604A1 (en)	2001-02-12
KR20010031577A (ko)	2001-04-16
CN1278178A (zh)	2000-12-27
BR9813318A (pt)	2000-08-22
SK6172000A3 (en)	2001-03-12
WO1999022722A3 (en)	1999-08-05
BG104436A (en)	2000-12-29
AR043071A1 (es)	2005-07-20
NO20002189L (no)	2000-06-28
JP2001521891A (ja)	2001-11-13
TR200001147T2 (tr)	2000-08-21
AU1206799A (en)	1999-05-24

Legal Events

Date	Code	Title	Description
2003-09-24	EEER	Examination request
2007-10-30	FZDE	Discontinued

Publication	Publication Date	Title
AU1206799A (en)	1999-05-24	Use of macrolides for the treatment of cancer and macular degeneration
US5827895A (en)	1998-10-27	Hexahydrolupulones useful as anticancer agents
EP0483077A2 (en)	1992-04-29	A method for carrying out the synthesis of a contraceptive and menstrual cycle controlling drug having oncostatic, antikinetosic, preventive and therapeutic properties for treatment of mammary tumours and melanomas.
EP1025114B1 (en)	2004-02-25	3'-n-modified 6-o-substituted erythromycin ketolide derivatives having antibacterial activity
HU211337A9 (en)	1995-11-28	4"-deoxyerythromycin derivatives
CN1269803A (zh)	2000-10-11	6,9－桥红霉素衍生物
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