CA2309534A1 - Peptides synthetiques contenant une citrulline reconnue par les serums de malades atteints de polyarthrite rhumatoide comme des outils de diagnostic et de traitement - Google Patents
Peptides synthetiques contenant une citrulline reconnue par les serums de malades atteints de polyarthrite rhumatoide comme des outils de diagnostic et de traitement Download PDFInfo
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- CA2309534A1 CA2309534A1 CA002309534A CA2309534A CA2309534A1 CA 2309534 A1 CA2309534 A1 CA 2309534A1 CA 002309534 A CA002309534 A CA 002309534A CA 2309534 A CA2309534 A CA 2309534A CA 2309534 A1 CA2309534 A1 CA 2309534A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Rehabilitation Therapy (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention porte sur un procédé de production de certains peptides contenant des résidus de citrulline qui constituent des déterminants immunogènes d'anticorps présents dans les sérums de patients atteints de polyarthrite rhumatoïde, et dans lesquels la présence d'au moins une citrulline est une condition préalable à la réaction avec lesdit anticorps. L'invention porte également sur un procédé de production desdits anticorps et sur l'utilisation desdits peptides pour le diagnostic et le traitement de la polyarthrite rhumatoïde.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97870195 | 1997-11-28 | ||
| EP97870195.1 | 1997-11-28 | ||
| EP98870078A EP0949270A1 (fr) | 1998-04-09 | 1998-04-09 | Peptides synthétiques contenant de la citrulline et reconnus par les sérums de patients souffrant d'arthrite rhumatoide utilisés comme outils de diagnostic et de traitement |
| EP98870078.7 | 1998-04-09 | ||
| PCT/EP1998/007714 WO1999028344A2 (fr) | 1997-11-28 | 1998-11-30 | Peptides synthetiques contenant une citrulline reconnue par les serums de malades atteints de polyarthrite rhumatoide comme des outils de diagnostic et de traitement |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2309534A1 true CA2309534A1 (fr) | 1999-06-10 |
Family
ID=26148315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002309534A Abandoned CA2309534A1 (fr) | 1997-11-28 | 1998-11-30 | Peptides synthetiques contenant une citrulline reconnue par les serums de malades atteints de polyarthrite rhumatoide comme des outils de diagnostic et de traitement |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1034186A2 (fr) |
| JP (1) | JP2002512939A (fr) |
| AU (1) | AU2155899A (fr) |
| CA (1) | CA2309534A1 (fr) |
| CZ (1) | CZ20001963A3 (fr) |
| HU (1) | HUP0004338A2 (fr) |
| PL (1) | PL344534A1 (fr) |
| WO (1) | WO1999028344A2 (fr) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7184426B2 (en) | 2002-12-12 | 2007-02-27 | Qualcomm, Incorporated | Method and apparatus for burst pilot for a time division multiplex system |
| FR2773078B1 (fr) * | 1997-12-30 | 2000-05-26 | Univ Toulouse | Utilisation de peptides citrullines derives de la filaggrine pour le traitement de la polyarthrite rhumatoide |
| EP1240180A2 (fr) * | 1999-12-21 | 2002-09-18 | Innogenetics N.V. | Peptides permettant de diagnostiquer et de traiter la polyarthrite rhumatoide |
| FR2826124B1 (fr) | 2001-06-13 | 2004-01-02 | Bio Merieux | Procede de detection d'auto-anticorps specifiques de la polyarthrite rhumatoide |
| NL1019540C2 (nl) * | 2001-12-11 | 2003-07-01 | Stichting Tech Wetenschapp | Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit. |
| RU2359270C2 (ru) | 2003-07-29 | 2009-06-20 | Зольвай Фармасьютиклз Гмбх | Способ анализа панкреатита и содержащих его композиций |
| AT413768B (de) * | 2003-07-29 | 2006-05-15 | Herkner Kurt Dipl Ing Dr Techn | Biochemisches diagnostikum zur erkennung rheumatoider arthritis |
| PT1882946E (pt) * | 2003-12-23 | 2010-04-21 | Roche Diagnostics Gmbh | Método para avaliar artrite reumatóide através da medição de anti-ccp e interleucina 6 |
| EP1721162B1 (fr) | 2004-02-27 | 2008-09-24 | Roche Diagnostics GmbH | Methode d'evaluation de la polyarthrite rheumatoide consistant a mesurer la concentration d'anti-ccp et de serum amyloide a |
| RU2413532C2 (ru) | 2005-07-29 | 2011-03-10 | Зольвай Фармасьютиклз Гмбх | Способ получения стерилизованного порошкообразного панкреатина |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| GB0525492D0 (en) * | 2005-12-15 | 2006-01-25 | Univ Dundee | Filaggrin |
| FR2900657B1 (fr) * | 2006-05-03 | 2009-04-17 | Univ Toulouse | Identification de modulateurs de l'activation des macrophages, utilisables pour le traitement de la polyarthrite rhumatoide |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| JP2010506147A (ja) | 2006-09-29 | 2010-02-25 | エフ．ホフマン−ラ ロシュ アーゲー | 関節リウマチを有する患者のための疾患進行のリスク評価 |
| AU2008331381B2 (en) * | 2007-12-03 | 2013-08-22 | Sqi Diagnostics Systems Inc. | Synthetic peptides immuno-reactive with rheumatoid arthritis auto-antibodies |
| DK2294086T3 (en) * | 2008-06-04 | 2018-01-02 | Modiquest B V | ANTI-INFLAMMATORY AGENTS |
| WO2010117694A2 (fr) * | 2009-03-30 | 2010-10-14 | Prometheus Laboratories Inc. | Peptides citrullinés pour diagnostiquer et pronostiquer une polyarthrite rhumatoïde |
| EP2325195A1 (fr) | 2009-11-23 | 2011-05-25 | Toscana Biomarkers S.r.l. | Peptides à citrulline et utilisations associées |
| EP2336769A1 (fr) | 2009-12-18 | 2011-06-22 | F. Hoffmann-La Roche AG | Test pour différencier les troubles rhumatismaux des troubles non rhumatismaux |
| EP2402368A1 (fr) | 2010-07-02 | 2012-01-04 | Toscana Biomarkers S.r.l. | Peptides de citrulline histone et utilisations associées |
| EP2527841A1 (fr) | 2011-05-25 | 2012-11-28 | Toscana Biomarkers S.r.l. | Procédés pour le diagnostic de l'arthrite rhumatoïde |
| JP6040228B2 (ja) * | 2011-05-27 | 2016-12-07 | ノルディック・ビオサイエンス・エー／エスＮｏｒｄｉｃ Ｂｉｏｓｃｉｅｎｃｅ Ａ／Ｓ | 診断用ペプチドの検出 |
| US9322822B2 (en) * | 2011-08-12 | 2016-04-26 | Hiroshima University | Method for detecting asbestos |
| EA201490897A1 (ru) | 2011-12-16 | 2015-03-31 | Олема Фармасьютикалс, Инк. | Новые бензопирановые соединения, композиции и их применение |
| US9975944B2 (en) * | 2013-03-12 | 2018-05-22 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Synthetic peptides for the treatment of autoimmune diseases |
| US20160159922A1 (en) | 2013-07-24 | 2016-06-09 | Vilara Ab | Novel Antibodies for the Diagnosis and Treatment of Rheumatoid Arthritis |
| KR101634958B1 (ko) * | 2014-06-13 | 2016-06-30 | 한국생명공학연구원 | 필라그린 유전자 돌연변이 검출용 프로브, 키트 및 방법 |
| EP3056904A1 (fr) | 2015-02-13 | 2016-08-17 | F. Hoffmann-La Roche AG | Procédé pour l'évaluation de l'arthrite rhumatoïde par la mesure de l'anti-CCP et de l'anti-MCM3 |
| EP3056903A1 (fr) | 2015-02-13 | 2016-08-17 | F. Hoffmann-La Roche AG | Procédé d'évaluation de l'arthrite rhumatoïde par la mesure de l'anti-CCP et de l'anti-Casp8 |
| CN107484423A (zh) | 2015-02-13 | 2017-12-15 | 豪夫迈·罗氏有限公司 | 通过测量抗ccp和抗pik3cd来评估类风湿性关节炎的方法 |
| CN111007262A (zh) * | 2019-12-25 | 2020-04-14 | 漳州卫生职业学院 | 一种用于辅助诊断ra的试剂盒及检测方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5660994A (en) * | 1986-11-10 | 1997-08-26 | Progen Biotechnik Gmbh | Method of detecting tissue-specific, insoluble cytoskeletal proteins |
| WO1992019649A1 (fr) * | 1991-04-26 | 1992-11-12 | Clonatec | Antigenes reconnus par des anticorps de la polyarthrite rhumatoide, leur preparation et leurs applications |
| FR2752842B1 (fr) * | 1996-08-30 | 1998-11-06 | Biomerieux Sa | Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide |
| NL1004539C2 (nl) * | 1996-11-15 | 1998-05-20 | Stichting Tech Wetenschapp | Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen. |
-
1998
- 1998-11-30 CA CA002309534A patent/CA2309534A1/fr not_active Abandoned
- 1998-11-30 AU AU21558/99A patent/AU2155899A/en not_active Withdrawn
- 1998-11-30 PL PL98344534A patent/PL344534A1/xx unknown
- 1998-11-30 CZ CZ20001963A patent/CZ20001963A3/cs unknown
- 1998-11-30 JP JP2000523235A patent/JP2002512939A/ja active Pending
- 1998-11-30 EP EP98965715A patent/EP1034186A2/fr not_active Withdrawn
- 1998-11-30 HU HU0004338A patent/HUP0004338A2/hu unknown
- 1998-11-30 WO PCT/EP1998/007714 patent/WO1999028344A2/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20001963A3 (cs) | 2002-04-17 |
| EP1034186A2 (fr) | 2000-09-13 |
| JP2002512939A (ja) | 2002-05-08 |
| WO1999028344A2 (fr) | 1999-06-10 |
| AU2155899A (en) | 1999-06-16 |
| WO1999028344A3 (fr) | 1999-08-12 |
| HUP0004338A2 (hu) | 2001-02-28 |
| PL344534A1 (en) | 2001-11-05 |
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