CA2322207A1 - Composes d'acide meta-azacyclique amino benzoique et derives antagonistes de l'integrine - Google Patents

Composes d'acide meta-azacyclique amino benzoique et derives antagonistes de l'integrine Download PDF

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Publication number
CA2322207A1
CA2322207A1 CA002322207A CA2322207A CA2322207A1 CA 2322207 A1 CA2322207 A1 CA 2322207A1 CA 002322207 A CA002322207 A CA 002322207A CA 2322207 A CA2322207 A CA 2322207A CA 2322207 A1 CA2322207 A1 CA 2322207A1
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CA
Canada
Prior art keywords
added
condition treated
product
reaction mixture
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002322207A
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English (en)
Inventor
Thomas E. Rogers
Peter G. Ruminski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2322207A1 publication Critical patent/CA2322207A1/fr
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne des composés représentés par la formule (1) ainsi que des sels pharmaceutiquement acceptables et des isomères de ces composés convenant comme antagonistes de la .alpha.¿v?.beta.¿3?.
CA002322207A 1998-03-04 1999-02-22 Composes d'acide meta-azacyclique amino benzoique et derives antagonistes de l'integrine Abandoned CA2322207A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3427098A 1998-03-04 1998-03-04
US09/034,270 1998-03-04
PCT/US1999/003281 WO1999044994A1 (fr) 1998-03-04 1999-02-22 Composes d'acide meta-azacyclique amino benzoique et derives antagonistes de l'integrine

Publications (1)

Publication Number Publication Date
CA2322207A1 true CA2322207A1 (fr) 1999-09-10

Family

ID=21875345

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002322207A Abandoned CA2322207A1 (fr) 1998-03-04 1999-02-22 Composes d'acide meta-azacyclique amino benzoique et derives antagonistes de l'integrine

Country Status (29)

Country Link
EP (1) EP1060164A1 (fr)
JP (1) JP2002505323A (fr)
KR (1) KR20010041584A (fr)
CN (1) CN1214011C (fr)
AP (1) AP1244A (fr)
AR (1) AR018139A1 (fr)
AU (1) AU753230B2 (fr)
BG (1) BG104740A (fr)
BR (1) BR9908470A (fr)
CA (1) CA2322207A1 (fr)
EA (1) EA200000804A1 (fr)
EE (1) EE200000506A (fr)
GE (1) GEP20033118B (fr)
HR (1) HRP20000574A2 (fr)
HU (1) HUP0100865A3 (fr)
ID (1) ID25591A (fr)
IL (1) IL137653A0 (fr)
IS (1) IS5582A (fr)
MY (1) MY123908A (fr)
NO (1) NO315703B1 (fr)
NZ (1) NZ506598A (fr)
OA (1) OA11530A (fr)
PL (1) PL342726A1 (fr)
SK (1) SK13002000A3 (fr)
TR (1) TR200002542T2 (fr)
UA (1) UA71906C2 (fr)
WO (1) WO1999044994A1 (fr)
YU (1) YU52000A (fr)
ZA (1) ZA994406B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9805655D0 (en) 1998-03-16 1998-05-13 Celltech Therapeutics Ltd Chemical compounds
GB9814414D0 (en) 1998-07-03 1998-09-02 Celltech Therapeutics Ltd Chemical compounds
GB9821061D0 (en) 1998-09-28 1998-11-18 Celltech Therapeutics Ltd Chemical compounds
GB9826174D0 (en) 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
US6455539B2 (en) 1999-12-23 2002-09-24 Celltech R&D Limited Squaric acid derivates
AU2001248553A1 (en) 2000-04-17 2001-10-30 Celltech R And D Limited Enamine derivatives as cell adhesion molecules
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
US6403608B1 (en) 2000-05-30 2002-06-11 Celltech R&D, Ltd. 3-Substituted isoquinolin-1-yl derivatives
US6921767B2 (en) * 2000-06-15 2005-07-26 Pharmacia Corporation Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
EP1305291A1 (fr) 2000-08-02 2003-05-02 Celltech R&D Limited Derives d'isoquinoline-1-yl substitues en 3
MXPA05006732A (es) * 2002-12-20 2005-09-08 Pharmacia Corp El isomero r de compuesto de beta-aminoacido como derivados de antagonistas de receptor de la integrina.
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
CA2612979A1 (fr) * 2005-06-10 2006-12-21 Bipar Sciences, Inc. Modulateurs de parp et traitement du cancer
WO2008108944A2 (fr) 2007-03-01 2008-09-12 Mallinckrodt Inc. Petites molécules photoactives intégrées et leurs utilisations
JP4792124B1 (ja) * 2010-11-15 2011-10-12 エフイートレード株式会社 車両用保護フィルムの型取り方法、及び、車両用保護フィルムの製造方法
WO2014015054A1 (fr) 2012-07-18 2014-01-23 Saint Louis University Dérivés d'acides bêta aminés en tant qu'antagonistes d'intégrine
US8716226B2 (en) 2012-07-18 2014-05-06 Saint Louis University 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
SG11201609050UA (en) 2014-05-30 2016-12-29 Pfizer Carbonitrile derivatives as selective androgen receptor modulators
CN106659162B (zh) * 2014-06-04 2020-10-27 孟山都技术公司 3,6-二氯水杨酸化合物以及相关合成方法
BR112018012981A2 (pt) 2015-12-30 2018-12-04 Saint Louis University derivados do ácido meta-azacíclico amino benzoico como antagonistas de pan integrina com melhores propriedades farmacocinéticas
EP4151632A4 (fr) 2020-05-14 2024-04-24 UBE Corporation Dérivé de 1,4,5,6-tétrahydropyrimidine-2-amine
WO2023275715A1 (fr) 2021-06-30 2023-01-05 Pfizer Inc. Métabolites de modulateurs sélectifs du récepteur des androgènes
US20250049806A1 (en) 2021-11-12 2025-02-13 Ube Corporation Pharmaceutical composition for providing treatment for or preventing alport syndrome

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9610422A (pt) * 1995-08-30 1999-07-13 Searle & Co Derivados de meta-guanidina uréia tiouréia ou ácido aminobenzóico azacíclico como antagonistas de integrina

Also Published As

Publication number Publication date
IL137653A0 (en) 2001-10-31
CN1291978A (zh) 2001-04-18
SK13002000A3 (sk) 2001-07-10
UA71906C2 (en) 2005-01-17
JP2002505323A (ja) 2002-02-19
GEP20033118B (en) 2003-11-25
NO20004316D0 (no) 2000-08-30
AP1244A (en) 2004-02-04
NO315703B1 (no) 2003-10-13
IS5582A (is) 2000-08-04
BR9908470A (pt) 2000-12-05
AP2000001893A0 (en) 2000-09-30
HUP0100865A3 (en) 2001-11-28
BG104740A (en) 2001-02-28
WO1999044994A1 (fr) 1999-09-10
MY123908A (en) 2006-06-30
OA11530A (en) 2004-05-17
NZ506598A (en) 2003-07-25
YU52000A (sh) 2003-02-28
EA200000804A1 (ru) 2001-04-23
EE200000506A (et) 2002-04-15
AR018139A1 (es) 2001-10-31
AU3294799A (en) 1999-09-20
HUP0100865A2 (hu) 2001-08-28
AU753230B2 (en) 2002-10-10
EP1060164A1 (fr) 2000-12-20
ZA994406B (en) 2000-02-11
ID25591A (id) 2000-10-19
HRP20000574A2 (en) 2001-08-31
PL342726A1 (en) 2001-07-02
KR20010041584A (ko) 2001-05-25
NO20004316L (no) 2000-11-06
CN1214011C (zh) 2005-08-10
TR200002542T2 (tr) 2001-05-21

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued