SK13002000A3 - Deriváty meta-azacyklickej aminobenzoovej kyseliny a ich deriváty, ktoré sú antagonisty integrínu - Google Patents

Deriváty meta-azacyklickej aminobenzoovej kyseliny a ich deriváty, ktoré sú antagonisty integrínu Download PDF

Info

Publication number: SK13002000A3
Authority: SK; Slovakia
Prior art keywords: added; solution; mol; reaction mixture; product
Prior art date: 1998-03-04

Application number

SK1300-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Thomas E. Rogers

Peter G. Ruminski

Original Assignee

G. D. Searle & Co.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-04

Filing date

1999-02-22

Publication date

2001-07-10

1999-02-22 Application filed by G. D. Searle & Co. filed Critical G. D. Searle & Co.

2001-07-10 Publication of SK13002000A3 publication Critical patent/SK13002000A3/sk

Links

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150000001875 compounds Chemical class 0.000 claims abstract description 89
150000003839 salts Chemical class 0.000 claims abstract description 15
238000000034 method Methods 0.000 claims description 55
238000011282 treatment Methods 0.000 claims description 26
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125000005843 halogen group Chemical group 0.000 claims description 8
239000008194 pharmaceutical composition Substances 0.000 claims description 8
208000001132 Osteoporosis Diseases 0.000 claims description 7
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239000003937 drug carrier Substances 0.000 claims description 7
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208000037147 Hypercalcaemia Diseases 0.000 claims description 3
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125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
230000000148 hypercalcaemia Effects 0.000 claims description 3
230000036210 malignancy Effects 0.000 claims description 3
230000001404 mediated effect Effects 0.000 claims description 3
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208000030915 hypercalcemia disease Diseases 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims 9
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Classifications

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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
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Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
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Oncology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SK1300-2000A 1998-03-04 1999-02-22 Deriváty meta-azacyklickej aminobenzoovej kyseliny a ich deriváty, ktoré sú antagonisty integrínu SK13002000A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3427098A	1998-03-04	1998-03-04
PCT/US1999/003281 WO1999044994A1 (fr)	1998-03-04	1999-02-22	Composes d'acide meta-azacyclique amino benzoique et derives antagonistes de l'integrine

Publications (1)

Publication Number	Publication Date
SK13002000A3 true SK13002000A3 (sk)	2001-07-10

Family

ID=21875345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1300-2000A SK13002000A3 (sk)	1998-03-04	1999-02-22	Deriváty meta-azacyklickej aminobenzoovej kyseliny a ich deriváty, ktoré sú antagonisty integrínu

Country Status (29)

Country	Link
EP (1)	EP1060164A1 (fr)
JP (1)	JP2002505323A (fr)
KR (1)	KR20010041584A (fr)
CN (1)	CN1214011C (fr)
AP (1)	AP1244A (fr)
AR (1)	AR018139A1 (fr)
AU (1)	AU753230B2 (fr)
BG (1)	BG104740A (fr)
BR (1)	BR9908470A (fr)
CA (1)	CA2322207A1 (fr)
EA (1)	EA200000804A1 (fr)
EE (1)	EE200000506A (fr)
GE (1)	GEP20033118B (fr)
HR (1)	HRP20000574A2 (fr)
HU (1)	HUP0100865A3 (fr)
ID (1)	ID25591A (fr)
IL (1)	IL137653A0 (fr)
IS (1)	IS5582A (fr)
MY (1)	MY123908A (fr)
NO (1)	NO315703B1 (fr)
NZ (1)	NZ506598A (fr)
OA (1)	OA11530A (fr)
PL (1)	PL342726A1 (fr)
SK (1)	SK13002000A3 (fr)
TR (1)	TR200002542T2 (fr)
UA (1)	UA71906C2 (fr)
WO (1)	WO1999044994A1 (fr)
YU (1)	YU52000A (fr)
ZA (1)	ZA994406B (fr)

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GB9805655D0 (en)	1998-03-16	1998-05-13	Celltech Therapeutics Ltd	Chemical compounds
GB9814414D0 (en)	1998-07-03	1998-09-02	Celltech Therapeutics Ltd	Chemical compounds
GB9821061D0 (en)	1998-09-28	1998-11-18	Celltech Therapeutics Ltd	Chemical compounds
GB9826174D0 (en)	1998-11-30	1999-01-20	Celltech Therapeutics Ltd	Chemical compounds
US6518283B1 (en)	1999-05-28	2003-02-11	Celltech R&D Limited	Squaric acid derivatives
US6455539B2 (en)	1999-12-23	2002-09-24	Celltech R&D Limited	Squaric acid derivates
DE60130910T2 (de)	2000-04-17	2008-07-10	Ucb Pharma, S.A.	Enamin-derivate als zell-adhäsionsmoleküle
US6403608B1 (en)	2000-05-30	2002-06-11	Celltech R&D, Ltd.	3-Substituted isoquinolin-1-yl derivatives
US6545013B2 (en)	2000-05-30	2003-04-08	Celltech R&D Limited	2,7-naphthyridine derivatives
US6921767B2 (en) *	2000-06-15	2005-07-26	Pharmacia Corporation	Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
CA2417059A1 (fr)	2000-08-02	2002-02-07	Celltech R&D Limited	Derives d'isoquinoline-1-yl substitues en 3
EP1572210A1 (fr) *	2002-12-20	2005-09-14	Pharmacia Corporation	Isomere r de composes d'acides amines beta en tant que derives antagonistes du recepteur des integrines
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
AU2006257815A1 (en) *	2005-06-10	2006-12-21	Bipar Sciences, Inc.	PARP modulators and treatment of cancer
EP2131861A2 (fr)	2007-03-01	2009-12-16	Mallinckrodt Inc.	Petites molécules photoactives intégrées et leurs utilisations
JP4792124B1 (ja) *	2010-11-15	2011-10-12	エフイートレード株式会社	車両用保護フィルムの型取り方法、及び、車両用保護フィルムの製造方法
IN2015DN00099A (fr)	2012-07-18	2015-05-29	Univ Saint Louis
US8716226B2 (en)	2012-07-18	2014-05-06	Saint Louis University	3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
ES2864079T3 (es)	2014-05-30	2021-10-13	Pfizer	Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
WO2015187774A1 (fr) *	2014-06-04	2015-12-10	Monsanto Technology Llc	Composés d'acide 3,6-dichlorosalicylique et procédés de synthèse associés
HK1244806A1 (zh)	2015-12-30	2018-08-17	Saint Louis University	作為過氧乙醯硝酸整聯蛋白拮抗劑的間氮雜環氨基苯甲酸衍生物
JP7661969B2 (ja)	2020-05-14	2025-04-15	Ｕｂｅ株式会社	１，４，５，６－テトラヒドロピリミジン－２－アミン誘導体
WO2023275715A1 (fr)	2021-06-30	2023-01-05	Pfizer Inc.	Métabolites de modulateurs sélectifs du récepteur des androgènes
JPWO2023085396A1 (fr)	2021-11-12	2023-05-19

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MX9801716A (es) *	1995-08-30	1998-05-31	Searle & Co	Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina.

1999
- 1999-02-11 ZA ZA9904406A patent/ZA994406B/xx unknown
- 1999-02-22 SK SK1300-2000A patent/SK13002000A3/sk unknown
- 1999-02-22 PL PL99342726A patent/PL342726A1/xx unknown
- 1999-02-22 JP JP2000534538A patent/JP2002505323A/ja active Pending
- 1999-02-22 BR BR9908470-8A patent/BR9908470A/pt not_active Application Discontinuation
- 1999-02-22 EE EEP200000506A patent/EE200000506A/xx unknown
- 1999-02-22 ID IDW20001695A patent/ID25591A/id unknown
- 1999-02-22 CN CNB998035815A patent/CN1214011C/zh not_active Expired - Fee Related
- 1999-02-22 NZ NZ506598A patent/NZ506598A/en unknown
- 1999-02-22 YU YU52000A patent/YU52000A/sh unknown
- 1999-02-22 HU HU0100865A patent/HUP0100865A3/hu unknown
- 1999-02-22 AU AU32947/99A patent/AU753230B2/en not_active Ceased
- 1999-02-22 WO PCT/US1999/003281 patent/WO1999044994A1/fr not_active Ceased
- 1999-02-22 HR HR20000574A patent/HRP20000574A2/hr not_active Application Discontinuation
- 1999-02-22 UA UA2000095148A patent/UA71906C2/uk unknown
- 1999-02-22 EA EA200000804A patent/EA200000804A1/ru unknown
- 1999-02-22 GE GEAP19995537A patent/GEP20033118B/en unknown
- 1999-02-22 EP EP99937927A patent/EP1060164A1/fr active Pending
- 1999-02-22 CA CA002322207A patent/CA2322207A1/fr not_active Abandoned
- 1999-02-22 TR TR2000/02542T patent/TR200002542T2/xx unknown
- 1999-02-22 IL IL13765399A patent/IL137653A0/xx unknown
- 1999-02-22 OA OA1200000238A patent/OA11530A/en unknown
- 1999-02-22 AP APAP/P/2000/001893A patent/AP1244A/en active
- 1999-02-22 KR KR1020007009774A patent/KR20010041584A/ko not_active Ceased
- 1999-03-02 AR ARP990100880A patent/AR018139A1/es unknown
- 1999-03-03 MY MYPI99000772A patent/MY123908A/en unknown
2000
- 2000-08-04 IS IS5582A patent/IS5582A/is unknown
- 2000-08-30 NO NO20004316A patent/NO315703B1/no not_active IP Right Cessation
- 2000-09-01 BG BG104740A patent/BG104740A/xx unknown

Also Published As

Publication number	Publication date
BR9908470A (pt)	2000-12-05
ID25591A (id)	2000-10-19
TR200002542T2 (tr)	2001-05-21
MY123908A (en)	2006-06-30
PL342726A1 (en)	2001-07-02
NZ506598A (en)	2003-07-25
JP2002505323A (ja)	2002-02-19
NO20004316D0 (no)	2000-08-30
NO315703B1 (no)	2003-10-13
IS5582A (is)	2000-08-04
EE200000506A (et)	2002-04-15
AU3294799A (en)	1999-09-20
EP1060164A1 (fr)	2000-12-20
AP1244A (en)	2004-02-04
EA200000804A1 (ru)	2001-04-23
HUP0100865A3 (en)	2001-11-28
KR20010041584A (ko)	2001-05-25
ZA994406B (en)	2000-02-11
GEP20033118B (en)	2003-11-25
CA2322207A1 (fr)	1999-09-10
AR018139A1 (es)	2001-10-31
WO1999044994A1 (fr)	1999-09-10
YU52000A (sh)	2003-02-28
IL137653A0 (en)	2001-10-31
NO20004316L (no)	2000-11-06
CN1291978A (zh)	2001-04-18
OA11530A (en)	2004-05-17
CN1214011C (zh)	2005-08-10
HUP0100865A2 (hu)	2001-08-28
BG104740A (en)	2001-02-28
AU753230B2 (en)	2002-10-10
HRP20000574A2 (en)	2001-08-31
UA71906C2 (en)	2005-01-17
AP2000001893A0 (en)	2000-09-30

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EP1157985A1 (fr)	2001-11-28	Dérivés de phénylène para-substitués et leur utilisation comme antagonistes d'intégrin