AU753230B2 - Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists - Google Patents

Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists Download PDF

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Publication number: AU753230B2
Authority: AU; Australia
Prior art keywords: added; compound; pct; reaction mixture; product
Prior art date: 1998-03-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU32947/99A

Other languages

English (en)

Other versions

AU3294799A (en

Inventor

Thomas E. Rogers

Peter G. Ruminski

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

GD Searle LLC

Original Assignee

GD Searle LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-04

Filing date

1999-02-22

Publication date

2002-10-10

1999-02-22 Application filed by GD Searle LLC filed Critical GD Searle LLC

1999-09-20 Publication of AU3294799A publication Critical patent/AU3294799A/en

2002-10-10 Application granted granted Critical

2002-10-10 Publication of AU753230B2 publication Critical patent/AU753230B2/en

2019-02-22 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Engineering & Computer Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Obesity (AREA)
Immunology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Oncology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AU32947/99A 1998-03-04 1999-02-22 Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists Ceased AU753230B2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US3427098A	1998-03-04	1998-03-04
US09/034270		1998-03-04
PCT/US1999/003281 WO1999044994A1 (fr)	1998-03-04	1999-02-22	Composes d'acide meta-azacyclique amino benzoique et derives antagonistes de l'integrine

Publications (2)

Publication Number	Publication Date
AU3294799A AU3294799A (en)	1999-09-20
AU753230B2 true AU753230B2 (en)	2002-10-10

Family

ID=21875345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU32947/99A Ceased AU753230B2 (en)	1998-03-04	1999-02-22	Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists

Country Status (29)

Country	Link
EP (1)	EP1060164A1 (fr)
JP (1)	JP2002505323A (fr)
KR (1)	KR20010041584A (fr)
CN (1)	CN1214011C (fr)
AP (1)	AP1244A (fr)
AR (1)	AR018139A1 (fr)
AU (1)	AU753230B2 (fr)
BG (1)	BG104740A (fr)
BR (1)	BR9908470A (fr)
CA (1)	CA2322207A1 (fr)
EA (1)	EA200000804A1 (fr)
EE (1)	EE200000506A (fr)
GE (1)	GEP20033118B (fr)
HR (1)	HRP20000574A2 (fr)
HU (1)	HUP0100865A3 (fr)
ID (1)	ID25591A (fr)
IL (1)	IL137653A0 (fr)
IS (1)	IS5582A (fr)
MY (1)	MY123908A (fr)
NO (1)	NO315703B1 (fr)
NZ (1)	NZ506598A (fr)
OA (1)	OA11530A (fr)
PL (1)	PL342726A1 (fr)
SK (1)	SK13002000A3 (fr)
TR (1)	TR200002542T2 (fr)
UA (1)	UA71906C2 (fr)
WO (1)	WO1999044994A1 (fr)
YU (1)	YU52000A (fr)
ZA (1)	ZA994406B (fr)

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GB9805655D0 (en)	1998-03-16	1998-05-13	Celltech Therapeutics Ltd	Chemical compounds
GB9814414D0 (en)	1998-07-03	1998-09-02	Celltech Therapeutics Ltd	Chemical compounds
GB9821061D0 (en)	1998-09-28	1998-11-18	Celltech Therapeutics Ltd	Chemical compounds
GB9826174D0 (en)	1998-11-30	1999-01-20	Celltech Therapeutics Ltd	Chemical compounds
US6518283B1 (en)	1999-05-28	2003-02-11	Celltech R&D Limited	Squaric acid derivatives
US6455539B2 (en)	1999-12-23	2002-09-24	Celltech R&D Limited	Squaric acid derivates
AU2001248553A1 (en)	2000-04-17	2001-10-30	Celltech R And D Limited	Enamine derivatives as cell adhesion molecules
US6545013B2 (en)	2000-05-30	2003-04-08	Celltech R&D Limited	2,7-naphthyridine derivatives
US6403608B1 (en)	2000-05-30	2002-06-11	Celltech R&D, Ltd.	3-Substituted isoquinolin-1-yl derivatives
US6921767B2 (en) *	2000-06-15	2005-07-26	Pharmacia Corporation	Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
EP1305291A1 (fr)	2000-08-02	2003-05-02	Celltech R&D Limited	Derives d'isoquinoline-1-yl substitues en 3
MXPA05006732A (es) *	2002-12-20	2005-09-08	Pharmacia Corp	El isomero r de compuesto de beta-aminoacido como derivados de antagonistas de receptor de la integrina.
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
CA2612979A1 (fr) *	2005-06-10	2006-12-21	Bipar Sciences, Inc.	Modulateurs de parp et traitement du cancer
WO2008108944A2 (fr)	2007-03-01	2008-09-12	Mallinckrodt Inc.	Petites molécules photoactives intégrées et leurs utilisations
JP4792124B1 (ja) *	2010-11-15	2011-10-12	エフイートレード株式会社	車両用保護フィルムの型取り方法、及び、車両用保護フィルムの製造方法
WO2014015054A1 (fr)	2012-07-18	2014-01-23	Saint Louis University	Dérivés d'acides bêta aminés en tant qu'antagonistes d'intégrine
US8716226B2 (en)	2012-07-18	2014-05-06	Saint Louis University	3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
SG11201609050UA (en)	2014-05-30	2016-12-29	Pfizer	Carbonitrile derivatives as selective androgen receptor modulators
CN106659162B (zh) *	2014-06-04	2020-10-27	孟山都技术公司	3,6-二氯水杨酸化合物以及相关合成方法
BR112018012981A2 (pt)	2015-12-30	2018-12-04	Saint Louis University	derivados do ácido meta-azacíclico amino benzoico como antagonistas de pan integrina com melhores propriedades farmacocinéticas
EP4151632A4 (fr)	2020-05-14	2024-04-24	UBE Corporation	Dérivé de 1,4,5,6-tétrahydropyrimidine-2-amine
WO2023275715A1 (fr)	2021-06-30	2023-01-05	Pfizer Inc.	Métabolites de modulateurs sélectifs du récepteur des androgènes
US20250049806A1 (en)	2021-11-12	2025-02-13	Ube Corporation	Pharmaceutical composition for providing treatment for or preventing alport syndrome

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1999
- 1999-02-11 ZA ZA9904406A patent/ZA994406B/xx unknown
- 1999-02-22 UA UA2000095148A patent/UA71906C2/uk unknown
- 1999-02-22 WO PCT/US1999/003281 patent/WO1999044994A1/fr not_active Ceased
- 1999-02-22 BR BR9908470-8A patent/BR9908470A/pt not_active Application Discontinuation
- 1999-02-22 GE GEAP19995537A patent/GEP20033118B/en unknown
- 1999-02-22 TR TR2000/02542T patent/TR200002542T2/xx unknown
- 1999-02-22 KR KR1020007009774A patent/KR20010041584A/ko not_active Ceased
- 1999-02-22 EP EP99937927A patent/EP1060164A1/fr active Pending
- 1999-02-22 PL PL99342726A patent/PL342726A1/xx unknown
- 1999-02-22 YU YU52000A patent/YU52000A/sh unknown
- 1999-02-22 AP APAP/P/2000/001893A patent/AP1244A/en active
- 1999-02-22 EA EA200000804A patent/EA200000804A1/ru unknown
- 1999-02-22 CN CNB998035815A patent/CN1214011C/zh not_active Expired - Fee Related
- 1999-02-22 OA OA1200000238A patent/OA11530A/en unknown
- 1999-02-22 EE EEP200000506A patent/EE200000506A/xx unknown
- 1999-02-22 SK SK1300-2000A patent/SK13002000A3/sk unknown
- 1999-02-22 NZ NZ506598A patent/NZ506598A/en unknown
- 1999-02-22 HU HU0100865A patent/HUP0100865A3/hu unknown
- 1999-02-22 HR HR20000574A patent/HRP20000574A2/hr not_active Application Discontinuation
- 1999-02-22 AU AU32947/99A patent/AU753230B2/en not_active Ceased
- 1999-02-22 JP JP2000534538A patent/JP2002505323A/ja active Pending
- 1999-02-22 ID IDW20001695A patent/ID25591A/id unknown
- 1999-02-22 CA CA002322207A patent/CA2322207A1/fr not_active Abandoned
- 1999-02-22 IL IL13765399A patent/IL137653A0/xx unknown
- 1999-03-02 AR ARP990100880A patent/AR018139A1/es unknown
- 1999-03-03 MY MYPI99000772A patent/MY123908A/en unknown
2000
- 2000-08-04 IS IS5582A patent/IS5582A/is unknown
- 2000-08-30 NO NO20004316A patent/NO315703B1/no not_active IP Right Cessation
- 2000-09-01 BG BG104740A patent/BG104740A/xx unknown

Patent Citations (1)

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Also Published As

Publication number	Publication date
IL137653A0 (en)	2001-10-31
CN1291978A (zh)	2001-04-18
SK13002000A3 (sk)	2001-07-10
UA71906C2 (en)	2005-01-17
JP2002505323A (ja)	2002-02-19
GEP20033118B (en)	2003-11-25
NO20004316D0 (no)	2000-08-30
AP1244A (en)	2004-02-04
NO315703B1 (no)	2003-10-13
IS5582A (is)	2000-08-04
BR9908470A (pt)	2000-12-05
AP2000001893A0 (en)	2000-09-30
CA2322207A1 (fr)	1999-09-10
HUP0100865A3 (en)	2001-11-28
BG104740A (en)	2001-02-28
WO1999044994A1 (fr)	1999-09-10
MY123908A (en)	2006-06-30
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EA200000804A1 (ru)	2001-04-23
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AR018139A1 (es)	2001-10-31
AU3294799A (en)	1999-09-20
HUP0100865A2 (hu)	2001-08-28
EP1060164A1 (fr)	2000-12-20
ZA994406B (en)	2000-02-11
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KR20010041584A (ko)	2001-05-25
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Publication	Publication Date	Title
AU753230B2 (en)	2002-10-10	Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists
AU765294B2 (en)	2003-09-11	Heterocyclic glycyl beta-alanine derivatives as vitronectin antagonists
CA2250586C (fr)	2007-04-17	Derives meta-substitues du sulphonamide de phenylene
US5773644A (en)	1998-06-30	Cyclopropyl alkanoic acid derivatives
JP2000510098A (ja)	2000-08-08	桂皮酸誘導体
JPH11510814A (ja)	1999-09-21	インテグリンアンタゴニストとしてのメタ−グアニジン、尿素、チオ尿素またはアザ環状アミノ安息香酸誘導体
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MXPA05006732A (es)	2005-09-08	El isomero r de compuesto de beta-aminoacido como derivados de antagonistas de receptor de la integrina.
US6013651A (en)	2000-01-11	Meta-azacyclic amino benzoic acid compounds and derivatives thereof
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US6689754B1 (en)	2004-02-10	Heterocyclic glycyl β-alanine derivatives
US6172256B1 (en)	2001-01-09	Chiral-β-amino acid compounds and derivatives thereof
US6720327B2 (en)	2004-04-13	Lactone integrin antagonists
US20040019206A1 (en)	2004-01-29	Lactone integrin antagonists
CZ20003218A3 (cs)	2001-03-14	Deriváty meta-azacyklické aminobenzoové kyseliny a jejich deriváty, které jsou antagonisty integrinu
MXPA00008427A (en)	2002-07-25	Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists
MXPA00009967A (en)	2001-07-31	Heterocyclic glycyl beta-alanine derivatives as vitronectin antagonists