CA2331299A1 - Guanidines et diaminonitroethenes substituees, preparation et applications - Google Patents

Guanidines et diaminonitroethenes substituees, preparation et applications Download PDF

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Publication number
CA2331299A1
CA2331299A1 CA002331299A CA2331299A CA2331299A1 CA 2331299 A1 CA2331299 A1 CA 2331299A1 CA 002331299 A CA002331299 A CA 002331299A CA 2331299 A CA2331299 A CA 2331299A CA 2331299 A1 CA2331299 A1 CA 2331299A1
Authority
CA
Canada
Prior art keywords
cyano
trifluoromethyl
guanidine
bis
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002331299A
Other languages
English (en)
Inventor
Tina Moller Tagmose
John Patrick Mogensen
John Bondo Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2331299A1 publication Critical patent/CA2331299A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cette invention, qui a trait à des dérivés de guanidine et de diaminonitroéthène correspondant à la formule (I), X, R?1¿, R?2¿, R?3¿ et R?4¿ étant définis dans le descriptif, concerne également des compositions à base de ces substances ainsi que des procédés de préparation des composés décrits. Ces composés s'avèrent des plus utiles en matière de traitement de maladies du système nerveux central, du système cardio-vasculaire, du système pulmonaire, de l'appareil digestif et du système endocrinien.
CA002331299A 1998-05-11 1999-05-06 Guanidines et diaminonitroethenes substituees, preparation et applications Abandoned CA2331299A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK0634/98 1998-05-11
DK63498 1998-05-11
PCT/DK1999/000251 WO1999058497A1 (fr) 1998-05-11 1999-05-06 Guanidines et diaminonitroethenes substituees, preparation et applications

Publications (1)

Publication Number Publication Date
CA2331299A1 true CA2331299A1 (fr) 1999-11-18

Family

ID=8095813

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002331299A Abandoned CA2331299A1 (fr) 1998-05-11 1999-05-06 Guanidines et diaminonitroethenes substituees, preparation et applications

Country Status (5)

Country Link
EP (1) EP1077933A1 (fr)
JP (1) JP2002514621A (fr)
AU (1) AU3595799A (fr)
CA (1) CA2331299A1 (fr)
WO (1) WO1999058497A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268284B1 (en) 1998-10-07 2001-07-31 Tokyo Electron Limited In situ titanium aluminide deposit in high aspect ratio features
NZ523882A (en) * 2000-08-21 2004-11-26 Pacific Corp Novel thiourea derivatives and the pharmaceutical compositions containing the same
WO2006000607A1 (fr) * 2004-06-23 2006-01-05 Neurotec Pharma, S.L. Composes destines au traitement de l'inflammation du systeme nerveux central
HUE062616T2 (hu) 2011-09-08 2023-11-28 Sage Therapeutics Inc Neuroaktív szteroidok, készítmények és alkalmazásaik
FI3932932T3 (fi) 2013-03-13 2025-10-15 Sage Therapeutics Inc Neuroaktiivisia steroideja ja niiden käyttömenetelmiä
JP6628745B2 (ja) 2014-06-18 2020-01-15 セージ セラピューティクス， インコーポレイテッド オキシステロールおよびその使用方法
DK3812392T3 (da) 2015-07-06 2025-07-21 Sage Therapeutics Inc Oxysteroler og fremgangsmåder til anvendelse deraf
PT3319611T (pt) 2015-07-06 2021-04-22 Sage Therapeutics Inc Oxisteróis e métodos de utilização dos mesmos
ES2921010T3 (es) 2016-04-01 2022-08-16 Sage Therapeutics Inc Oxisteroles y procedimientos de uso de los mismos
WO2017193046A1 (fr) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxystérols et méthodes d'utilisation associées
WO2018009867A1 (fr) 2016-07-07 2018-01-11 Sage Therapeutics, Inc. Oxystérols et leurs méthodes d'utilisation
MA46351A (fr) 2016-09-30 2021-06-02 Sage Therapeutics Inc Oxystérols substitués en c7 et procédés en tant que modulateurs nmda
KR102521573B1 (ko) 2016-10-18 2023-04-14 세이지 테라퓨틱스, 인크. 옥시스테롤 및 그의 사용 방법
DK3529257T3 (da) 2016-10-18 2023-08-07 Sage Therapeutics Inc Oxysteroler og fremgangsmåder til anvendelse deraf

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3232462A1 (de) * 1982-09-01 1984-03-01 Bayer Ag, 5090 Leverkusen 2-nitro-1,1-ethendiamine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
EP0254553B1 (fr) * 1986-07-23 1993-01-13 Hitachi Chemical Company, Ltd. Médium d'enregistrement optique
EP0310545A3 (fr) * 1987-09-02 1989-07-26 Ciba-Geigy Ag Cyanoguanidines comme durcisseur de résines epoxydes
JP2749639B2 (ja) * 1989-06-28 1998-05-13 鐘紡株式会社 シアノグアニジン誘導体
JPH0558985A (ja) * 1991-08-29 1993-03-09 Kanebo Ltd シアノグアニジン誘導体の製造法
DK41193D0 (da) * 1993-04-07 1993-04-07 Neurosearch As Ionkanalaabnere
JP3270789B2 (ja) * 1994-01-31 2002-04-02 カネボウ株式会社 養毛剤

Also Published As

Publication number Publication date
JP2002514621A (ja) 2002-05-21
WO1999058497A1 (fr) 1999-11-18
EP1077933A1 (fr) 2001-02-28
AU3595799A (en) 1999-11-29

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