CA2331299A1 - Guanidines et diaminonitroethenes substituees, preparation et applications - Google Patents

Guanidines et diaminonitroethenes substituees, preparation et applications Download PDF

Info

Publication number
CA2331299A1
CA2331299A1 CA002331299A CA2331299A CA2331299A1 CA 2331299 A1 CA2331299 A1 CA 2331299A1 CA 002331299 A CA002331299 A CA 002331299A CA 2331299 A CA2331299 A CA 2331299A CA 2331299 A1 CA2331299 A1 CA 2331299A1
Authority
CA
Canada
Prior art keywords
cyano
trifluoromethyl
guanidine
bis
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002331299A
Other languages
English (en)
Inventor
Tina Moller Tagmose
John Patrick Mogensen
John Bondo Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2331299A1 publication Critical patent/CA2331299A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cette invention, qui a trait à des dérivés de guanidine et de diaminonitroéthène correspondant à la formule (I), X, R?1¿, R?2¿, R?3¿ et R?4¿ étant définis dans le descriptif, concerne également des compositions à base de ces substances ainsi que des procédés de préparation des composés décrits. Ces composés s'avèrent des plus utiles en matière de traitement de maladies du système nerveux central, du système cardio-vasculaire, du système pulmonaire, de l'appareil digestif et du système endocrinien.
CA002331299A 1998-05-11 1999-05-06 Guanidines et diaminonitroethenes substituees, preparation et applications Abandoned CA2331299A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK63498 1998-05-11
DK0634/98 1998-05-11
PCT/DK1999/000251 WO1999058497A1 (fr) 1998-05-11 1999-05-06 Guanidines et diaminonitroethenes substituees, preparation et applications

Publications (1)

Publication Number Publication Date
CA2331299A1 true CA2331299A1 (fr) 1999-11-18

Family

ID=8095813

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002331299A Abandoned CA2331299A1 (fr) 1998-05-11 1999-05-06 Guanidines et diaminonitroethenes substituees, preparation et applications

Country Status (5)

Country Link
EP (1) EP1077933A1 (fr)
JP (1) JP2002514621A (fr)
AU (1) AU3595799A (fr)
CA (1) CA2331299A1 (fr)
WO (1) WO1999058497A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268284B1 (en) 1998-10-07 2001-07-31 Tokyo Electron Limited In situ titanium aluminide deposit in high aspect ratio features
CA2417507A1 (fr) * 2000-08-21 2002-02-28 Pacific Corporation Nouveaux derives de thiourea et compositions pharmaceutiques renfermant ceux-ci
EP1782812A1 (fr) * 2004-06-23 2007-05-09 Neurotec Pharma, S.L. Composes destines au traitement de l'inflammation du systeme nerveux central
CA2848212C (fr) 2011-09-08 2022-03-29 Sage Therapeutics, Inc. Steroides neuroactifs, compositions et leurs utilisations
PT2968369T (pt) 2013-03-13 2018-12-05 Sage Therapeutics Inc Esteroides neuroativos e métodos para o seu uso
US10259840B2 (en) 2014-06-18 2019-04-16 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
EP3828194B1 (fr) 2015-07-06 2025-04-16 Sage Therapeutics, Inc. Oxystérols et leurs procédés d'utilisation
HUE071964T2 (hu) 2015-07-06 2025-10-28 Sage Therapeutics Inc Oxiszterolok és alkalmazási eljárásaik
SMT202200300T1 (it) 2016-04-01 2022-09-14 Sage Therapeutics Inc Ossisteroli e relativi metodi d'uso
WO2017193046A1 (fr) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxystérols et méthodes d'utilisation associées
ES2884071T3 (es) 2016-07-07 2021-12-10 Sage Therapeutics Inc 24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA
ES2935057T3 (es) 2016-09-30 2023-03-01 Sage Therapeutics Inc C7 oxisteroles sustituidos y estos compuestos para su uso como moduladores de la NMDA
KR20230051723A (ko) 2016-10-18 2023-04-18 세이지 테라퓨틱스, 인크. 옥시스테롤 및 그의 사용 방법
RU2019115113A (ru) 2016-10-18 2020-11-24 Сейдж Терапьютикс, Инк. Оксистеролы и способы их применения

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3232462A1 (de) * 1982-09-01 1984-03-01 Bayer Ag, 5090 Leverkusen 2-nitro-1,1-ethendiamine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3783529T2 (de) * 1986-07-23 1993-05-13 Hitachi Chemical Co Ltd Optisches aufzeichnungsmedium.
EP0310545A3 (fr) * 1987-09-02 1989-07-26 Ciba-Geigy Ag Cyanoguanidines comme durcisseur de résines epoxydes
JP2749639B2 (ja) * 1989-06-28 1998-05-13 鐘紡株式会社 シアノグアニジン誘導体
JPH0558985A (ja) * 1991-08-29 1993-03-09 Kanebo Ltd シアノグアニジン誘導体の製造法
DK41193D0 (da) * 1993-04-07 1993-04-07 Neurosearch As Ionkanalaabnere
JP3270789B2 (ja) * 1994-01-31 2002-04-02 カネボウ株式会社 養毛剤

Also Published As

Publication number Publication date
WO1999058497A1 (fr) 1999-11-18
JP2002514621A (ja) 2002-05-21
AU3595799A (en) 1999-11-29
EP1077933A1 (fr) 2001-02-28

Similar Documents

Publication Publication Date Title
AU757693B2 (en) Fused 1,2,4-thiadiazine derivatives, their preparation and use
CN1137125C (zh) 稠合的1,2,4-噻二嗪衍生物、其制备方法和用途
CA2331299A1 (fr) Guanidines et diaminonitroethenes substituees, preparation et applications
US7459585B2 (en) Benzene derivatives and pharmaceutical use thereof
US5441984A (en) Urea, thiourea and guanidine derivatives
JPH09501918A (ja) 酸化窒素合成酵素活性を有するアミジン誘導体
AU2009245837A1 (en) Quinazolinones as potassium channel modulators
JPH09504278A (ja) Ｎｏシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体
US20040054171A1 (en) Polymorphic forms of a 4H-thieno[3,2-E]-1,2,4-thiadiazine 1,1-dioxide derivative
US6147098A (en) Substituted guanidines and diaminonitroethenes, their preparation and use
US4386099A (en) Imidazolylphenyl amidines, pharmaceutical compositions containing same and use thereof
JPH02188568A (ja) 抗アテローム性動脈硬化症性ジアリール化合物
CZ178092A3 (en) Amidine compounds and process for preparing thereof
EP0782567B1 (fr) Derives d'isothiouree en tant qu'inhibiteurs de no synthase
PT1569896E (pt) Derivados de tetra-hidronaftaleno
WO1992000273A1 (fr) Derives orthosubstitues d'amidine de diphenyle et de guanidine de diphenyle, et agents antidiabetiques ou hypoglycemiants les contenant
WO2004089881A1 (fr) Derives sulfonyle d'aminonaphtols
RU2648242C2 (ru) Производное имидазопиридина, используемое для лечения сахарного диабета
CN1134414A (zh) 取代的苯磺酰脲和苯磺酰硫脲、其制备方法、作为药物或诊断药的用途，以及含有它的药品
US6232310B1 (en) Fused 1,4-thiazine-2-carbonitrile derivatives, their preparation and use
US20050075324A1 (en) Melanin concentrating hormone antagonists
US6362205B2 (en) Substituted 3,3-diamino-2-propenenitriles, their preparation and use
CZ20023075A3 (cs) Antagonisté IL-8 receptoru
US6365609B1 (en) Substituted 3,3-diamino-2-propenenitriles, their preparation and use
FR2501206A1 (fr) Alkyl-phenylsulfonylguanidines substituees contenant un heterocycle, leur preparation et leurs utilisations therapeutiques

Legal Events

Date Code Title Description
FZDE Dead