CA2362533A1 - Variations de sequences geniques presentant une utilite pour la selection du traitement d'une maladie - Google Patents

Variations de sequences geniques presentant une utilite pour la selection du traitement d'une maladie Download PDF

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CA2362533A1
CA2362533A1 CA002362533A CA2362533A CA2362533A1 CA 2362533 A1 CA2362533 A1 CA 2362533A1 CA 002362533 A CA002362533 A CA 002362533A CA 2362533 A CA2362533 A CA 2362533A CA 2362533 A1 CA2362533 A1 CA 2362533A1
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disease
gene
variance
treatment
patient
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CA002362533A
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Vincent Stanton Jr.
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Century Technology Inc
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Abstract

La présente invention se rapporte à l'utilisation d'informations de variance génétique relatives à des gènes impliqués dans des mécanismes génétiques, pour la sélection de méthodes efficaces de traitement d'une maladie ou d'un trouble. Ces informations de variance sont représentatives de la réponse attendue chez un patient à une méthode de traitement. L'invention se rapporte également à des méthodes de sélection d'informations de variance pertinentes et à d'autres méthodes d'utilisation de telles informations de variance.
CA002362533A 1999-02-22 2000-01-20 Variations de sequences geniques presentant une utilite pour la selection du traitement d'une maladie Abandoned CA2362533A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US12104799P 1999-02-22 1999-02-22
US60/121,047 1999-02-22
US13944099P 1999-06-15 1999-06-15
US60/139,440 1999-06-15
US35774399A 1999-07-20 1999-07-20
US09/357,743 1999-07-20
PCT/US2000/001392 WO2000050639A2 (fr) 1999-02-22 2000-01-20 Variations de sequences geniques presentant une utilite pour la selection du traitement d'une maladie

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CA2362533A1 true CA2362533A1 (fr) 2000-08-31

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CA002362533A Abandoned CA2362533A1 (fr) 1999-02-22 2000-01-20 Variations de sequences geniques presentant une utilite pour la selection du traitement d'une maladie

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EP (1) EP1224322A2 (fr)
JP (1) JP2003516111A (fr)
AU (1) AU3997300A (fr)
CA (1) CA2362533A1 (fr)
WO (1) WO2000050639A2 (fr)

Families Citing this family (64)

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Publication number Priority date Publication date Assignee Title
US7058517B1 (en) 1999-06-25 2006-06-06 Genaissance Pharmaceuticals, Inc. Methods for obtaining and using haplotype data
US9694121B2 (en) 1999-08-09 2017-07-04 Cardiokinetix, Inc. Systems and methods for improving cardiac function
US8377114B2 (en) 1999-08-09 2013-02-19 Cardiokinetix, Inc. Sealing and filling ventricular partitioning devices to improve cardiac function
US8529430B2 (en) 2002-08-01 2013-09-10 Cardiokinetix, Inc. Therapeutic methods and devices following myocardial infarction
US7674222B2 (en) 1999-08-09 2010-03-09 Cardiokinetix, Inc. Cardiac device and methods of use thereof
US8257428B2 (en) 1999-08-09 2012-09-04 Cardiokinetix, Inc. System for improving cardiac function
US8500795B2 (en) 1999-08-09 2013-08-06 Cardiokinetix, Inc. Retrievable devices for improving cardiac function
US10307147B2 (en) 1999-08-09 2019-06-04 Edwards Lifesciences Corporation System for improving cardiac function by sealing a partitioning membrane within a ventricle
EP1248832A4 (fr) * 2000-01-21 2004-07-07 Variagenics Inc Identification de composantes genetiques dans la reaction au medicament
US6931326B1 (en) 2000-06-26 2005-08-16 Genaissance Pharmaceuticals, Inc. Methods for obtaining and using haplotype data
US9332993B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
US9078660B2 (en) 2000-08-09 2015-07-14 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
US10064696B2 (en) 2000-08-09 2018-09-04 Edwards Lifesciences Corporation Devices and methods for delivering an endocardial device
US9332992B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Method for making a laminar ventricular partitioning device
US20040170993A1 (en) * 2001-02-07 2004-09-02 Fishman Mark C. Methods for diagnosing and treating heart disease
DE10130973A1 (de) * 2001-06-27 2003-01-16 Moises Hans W Verfahren zur Diagnose und Behandlung neuropsychiatrischer Störungen basierend auf der Proteinsynthese-Dynamik als Krankheitspathway
DE60239634D1 (de) * 2001-12-10 2011-05-12 Novartis Ag Verfahren zur behandlung von psychosen und schizophrenie auf der basis eines polymorphismus im cntf gen
US6897025B2 (en) * 2002-01-07 2005-05-24 Perlegen Sciences, Inc. Genetic analysis systems and methods
CN101721362B (zh) 2002-02-14 2018-07-03 中外制药株式会社 包含抗体的溶液制剂
EP3225625A1 (fr) 2002-09-11 2017-10-04 Chugai Seiyaku Kabushiki Kaisha Procédé de purification de protéines
US8688385B2 (en) 2003-02-20 2014-04-01 Mayo Foundation For Medical Education And Research Methods for selecting initial doses of psychotropic medications based on a CYP2D6 genotype
JP5348840B2 (ja) 2003-02-20 2013-11-20 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 薬物を選択する方法
WO2005040427A2 (fr) * 2003-09-19 2005-05-06 Decode Genetics Ehf. Inversion du chromosome 8p23: facteur de risque des troubles de l'anxiete, de la depression et des troubles bipolaires
WO2005044274A1 (fr) * 2003-11-06 2005-05-19 Cyclacel Limited Traitement a la roscovitine du lymphome de cellule du manteau
EP1825002A4 (fr) * 2004-12-09 2008-04-09 Perlegen Sciences Inc Marqueurs du syndrome metabolique, de l'obesite et de la resistance a l'insuline
AU2006213677A1 (en) * 2005-02-09 2006-08-17 Pgxhealth, Llc Genetic markers in the CSF2RB gene associated with an adverse hematological response to drugs
WO2006116873A1 (fr) * 2005-05-05 2006-11-09 Mount Sinai Hospital Diagnostic et traitement de l'endometriose
JP2009517186A (ja) 2005-11-29 2009-04-30 チルドレンズ ホスピタル メディカル センター 薬物選択及び投薬の最適化及び個別化
WO2007130724A2 (fr) 2006-02-06 2007-11-15 Northwind Ventures Systèmes et procédés de réduction de volume
US7811824B2 (en) 2006-03-30 2010-10-12 Randox Laboratories Limited Method and apparatus for monitoring the properties of a biological or chemical sample
DE102007045935B4 (de) * 2007-09-25 2015-02-12 Philipps-Universität Marburg Fertilitätstest
WO2009101619A2 (fr) * 2008-02-11 2009-08-20 Ramot At Tel-Aviv University Ltd. Procédés pour prédire la réponse d'un patient à un traitement au lithium
PL2255184T3 (pl) 2008-02-28 2013-12-31 Univ Virginia Patent Foundation Gen transportera serotoniny i leczenie alkoholizmu
CA2744100C (fr) 2008-10-21 2020-06-30 The General Hospital Corporation Transplantation de cellules
EP2493417B1 (fr) 2009-10-26 2017-06-21 Cardiokinetix, Inc. Réduction du volume ventriculaire
US7985551B2 (en) 2009-11-04 2011-07-26 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US7951542B2 (en) 2009-11-04 2011-05-31 Surgene, LLC Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US7972793B2 (en) 2009-11-04 2011-07-05 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US7951543B2 (en) 2009-11-04 2011-05-31 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US20130203054A1 (en) 2010-05-04 2013-08-08 Universite D'aix-Marseille Antiviral treatment susceptibility gene and uses thereof
PL2801625T3 (pl) 2010-07-02 2018-06-29 University Of Virginia Patent Foundation Molekularne, genetyczne podejście do leczenia i diagnozy uzależnienia od alkoholu i leków
CN108504539B (zh) 2010-08-06 2021-11-02 通用医院公司以麻省总医院名义经营 用于细胞处理相关应用的系统和设备
US7932042B1 (en) 2010-10-13 2011-04-26 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the olanzapine poor response predictor genetic signature
WO2012058598A1 (fr) * 2010-10-29 2012-05-03 The Trustees Of Columbia University In The City Of New York Procédés de prévention et de traitement de l'hyperlipidémie ou de l'athérosclérose
EP3045173A3 (fr) 2011-09-09 2016-09-14 The University of Virginia Patent Foundation Approche génétique moléculaire pour le traitement et le diagnostic de dépendance à l'alcool et aux drogues
US9250172B2 (en) 2012-09-21 2016-02-02 Ethicon Endo-Surgery, Inc. Systems and methods for predicting metabolic and bariatric surgery outcomes
EP2898101A4 (fr) 2012-09-21 2016-08-03 Ethicon Endo Surgery Inc Prédicteurs cliniques de la perte de poids
US10242756B2 (en) 2012-09-21 2019-03-26 Ethicon Endo-Surgery, Inc. Systems and methods for predicting metabolic and bariatric surgery outcomes
EP2952899A1 (fr) * 2014-06-06 2015-12-09 Fundacio Institut mar d'Investigacions Médiques (IMIM) NKG2C en tant que marqueur de pronostic dans la sclérose en plaques
BR112017006248A2 (pt) 2014-09-28 2017-12-12 Cardiokinetix Inc aparelhos para o tratamento de insuficiência cardíaca
WO2016123163A2 (fr) 2015-01-27 2016-08-04 Kardiatonos, Inc. Biomarqueurs de maladies vasculaires
US10300089B2 (en) * 2016-11-08 2019-05-28 University Of Central Florida Research Foundation, Inc. Methods for high scale therapeutic production of memory NK cells
US20200004928A1 (en) * 2018-06-29 2020-01-02 Roche Sequencing Solutions, Inc. Computing device with improved user interface for interpreting and visualizing data
US10468141B1 (en) * 2018-11-28 2019-11-05 Asia Genomics Pte. Ltd. Ancestry-specific genetic risk scores
KR20220062230A (ko) * 2019-05-14 2022-05-16 프로베넌스 바이오 엘엘씨 퍼옥시좀에서 변형 단백질의 발현
KR102089032B1 (ko) * 2019-08-02 2020-05-29 경북대학교 산학협력단 보체 성분 c8 감마를 이용한 알츠하이머병의 진단방법
CN112442527B (zh) * 2019-08-27 2022-11-11 深圳市英马诺生物科技有限公司 孤独症诊断试剂盒、基因芯片、基因靶点筛选方法及应用
WO2022006470A1 (fr) 2020-07-01 2022-01-06 Vanderbilt University Méthodes de traitement d'une maladie rénale
WO2022125871A1 (fr) * 2020-12-11 2022-06-16 Memorial Sloan Kettering Cancer Center Procédés de personnalisation d'un régime analgésique chez les patients atteints de cancer en fonction de la transcriptomique des tumeurs
KR102254631B1 (ko) * 2021-01-15 2021-05-21 씨제이제일제당 주식회사 신규한 펩타이드 메티오닌 설폭사이드 환원효소 변이체 및 이를 이용한 imp 생산 방법
CN113134004A (zh) * 2021-03-29 2021-07-20 中国医学科学院医学生物学研究所 一种3-甲基腺嘌呤在制备预防铜绿假单胞菌诱导的急性肺炎药物中的应用
CN116004854B (zh) * 2023-01-06 2025-08-19 山西农业大学 一种prlr基因的snp突变位点及应用
CN117089609B (zh) * 2023-05-22 2025-01-21 山东大学齐鲁医院 检测样本中apob基因变异或蛋白变异的试剂在制备筛查家族性高胆固醇血症患者的产品的应用
CN119964784B (zh) * 2025-03-12 2026-04-24 重庆医科大学 一种心血管疾病与前庭功能障碍关联的研究方法

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