CA2384525C - Thienylhydrazone possedant des proprietes analogues a celles de la digitale (effets inotropes positifs) - Google Patents
Thienylhydrazone possedant des proprietes analogues a celles de la digitale (effets inotropes positifs) Download PDFInfo
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- CA2384525C CA2384525C CA002384525A CA2384525A CA2384525C CA 2384525 C CA2384525 C CA 2384525C CA 002384525 A CA002384525 A CA 002384525A CA 2384525 A CA2384525 A CA 2384525A CA 2384525 C CA2384525 C CA 2384525C
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- 230000008673 vomiting Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne un composé représenté par la formule (I), dans laquelle R1 est sélectionné dans le groupe constitué par hydrogène, alkyle doté de 1 à 6 atomes de carbone, phényle non substitué et phényle substitué ; R2 est sélectionné dans le groupe constitué par H, alcène, phénol non substitué et phényle substitué ; et des sels pharmaceutiquement acceptables de ce composé qui possèdent des propriétés analogues à celles de la digitale. L'invention concerne en outre un nouveau procédé de synthèse de 3,4-méthylènedioxybenzoyl-2-thiénylhydrazone (LASSBio-294). LASSBio-294 a un effet positif inotrope sur les muscles cardiaque et squelettiques. L'invention est utile dans le traitement d'insuffisance cardiaque congestive et de fatigue musculaire. Elle ne comporte pas les effets toxiques observés chez des glycosides de digitale.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14035299P | 1999-06-21 | 1999-06-21 | |
| US60/140,352 | 1999-06-21 | ||
| PCT/US2000/017024 WO2000078754A1 (fr) | 1999-06-21 | 2000-06-21 | Thienylhydrazone possedant des proprietes analogues a celles de la digitale (effets inotropes positifs) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2384525A1 CA2384525A1 (fr) | 2000-12-28 |
| CA2384525C true CA2384525C (fr) | 2007-03-06 |
Family
ID=22490853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002384525A Expired - Fee Related CA2384525C (fr) | 1999-06-21 | 2000-06-21 | Thienylhydrazone possedant des proprietes analogues a celles de la digitale (effets inotropes positifs) |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1532140A1 (fr) |
| AU (1) | AU5628700A (fr) |
| CA (1) | CA2384525C (fr) |
| WO (1) | WO2000078754A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0403363A (pt) * | 2004-08-20 | 2006-05-02 | Univ Rio De Janeiro | relaxantes musculares seletivos e composições farmacêuticas |
| BRPI0601885A (pt) * | 2006-05-15 | 2008-03-25 | Univ Rio De Janeiro | composição farmacêutica antiinflamatória e analgésica contendo derivados n-acilidrazÈnicos do safrol, uso, e processo para sua preparação |
| US8513301B2 (en) * | 2007-01-31 | 2013-08-20 | Guangzhou Zhongwei Biotechnology Ltd. | Kind of piperphentonamine hydrochloride lyophilized powder for injection and preparation and use thereof |
| CN103304561B (zh) * | 2013-06-21 | 2016-06-01 | 天津药物研究院 | 一类具有抗血栓作用的化合物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4410540A (en) * | 1981-11-04 | 1983-10-18 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 4-aroylimidazolidin-2-ones |
| CA1266268A (fr) * | 1985-10-15 | 1990-02-27 | J. Martin Grisar | Aroylthiazolones cardiotoniques |
-
2000
- 2000-06-21 CA CA002384525A patent/CA2384525C/fr not_active Expired - Fee Related
- 2000-06-21 EP EP00941596A patent/EP1532140A1/fr not_active Withdrawn
- 2000-06-21 WO PCT/US2000/017024 patent/WO2000078754A1/fr not_active Ceased
- 2000-06-21 AU AU56287/00A patent/AU5628700A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000078754A1 (fr) | 2000-12-28 |
| EP1532140A1 (fr) | 2005-05-25 |
| CA2384525A1 (fr) | 2000-12-28 |
| AU5628700A (en) | 2001-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |