CA2408997C - Revetements et pellicules pour instruments medicaux a base de poly(trifluoro-ethoxyphosphazene) - Google Patents

Revetements et pellicules pour instruments medicaux a base de poly(trifluoro-ethoxyphosphazene) Download PDF

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Publication number
CA2408997C
CA2408997C CA 2408997 CA2408997A CA2408997C CA 2408997 C CA2408997 C CA 2408997C CA 2408997 CA2408997 CA 2408997 CA 2408997 A CA2408997 A CA 2408997A CA 2408997 C CA2408997 C CA 2408997C
Authority
CA
Canada
Prior art keywords
film
microstructured
carbon atoms
solvent
sheathing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA 2408997
Other languages
English (en)
Other versions
CA2408997A1 (fr
Inventor
Michael Grunze
Claudia Gries
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celonova Bioscience Inc
Original Assignee
Celonova Biosciences Germany GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10019982A external-priority patent/DE10019982A1/de
Application filed by Celonova Biosciences Germany GmbH filed Critical Celonova Biosciences Germany GmbH
Publication of CA2408997A1 publication Critical patent/CA2408997A1/fr
Application granted granted Critical
Publication of CA2408997C publication Critical patent/CA2408997C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
    • C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
    • C08G79/025—Polyphosphazenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un polymère antithrombogénique et toléré par le corps, et son utilisation pour la production d'enveloppes et de films faisant partie intégrante de dispositifs thérapeutiques utilisés pour empêcher une prolifération cellulaire excessive. L'invention concerne en outre des films produits à partir dudit polymère ainsi que des enveloppes pour dispositifs médicaux, par exemple des stents. L'invention concerne aussi des dispositifs médicaux qui sont recouverts d'un film ou d'une enveloppe selon l'invention.
CA 2408997 2000-04-11 2001-04-10 Revetements et pellicules pour instruments medicaux a base de poly(trifluoro-ethoxyphosphazene) Expired - Lifetime CA2408997C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19608300P 2000-04-11 2000-04-11
US60/196,083 2000-04-11
DE10019982A DE10019982A1 (de) 2000-04-22 2000-04-22 Umhüllungen und Folien aus Poly-Tri-Fluor-Ethoxypolyphosphazen
DE10019982.8 2000-04-22
PCT/DE2001/001398 WO2001080919A2 (fr) 2000-04-11 2001-04-10 Enveloppes et films en poly-tri-fluoro-ethoxypolyphosphazene

Publications (2)

Publication Number Publication Date
CA2408997A1 CA2408997A1 (fr) 2002-11-14
CA2408997C true CA2408997C (fr) 2008-08-05

Family

ID=26005436

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2408997 Expired - Lifetime CA2408997C (fr) 2000-04-11 2001-04-10 Revetements et pellicules pour instruments medicaux a base de poly(trifluoro-ethoxyphosphazene)

Country Status (10)

Country Link
US (1) US7265199B2 (fr)
EP (1) EP1274471B1 (fr)
JP (1) JP2004500918A (fr)
AT (1) ATE350077T1 (fr)
AU (1) AU2001263760A1 (fr)
CA (1) CA2408997C (fr)
DE (2) DE50111797D1 (fr)
DK (1) DK1274471T3 (fr)
ES (1) ES2278747T3 (fr)
WO (1) WO2001080919A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090004240A1 (en) * 2000-08-11 2009-01-01 Celonova Biosciences, Inc. Implants with a phosphazene-containing coating
EP1179353A1 (fr) * 2000-08-11 2002-02-13 B. Braun Melsungen Ag Implants antithrombotiques avec un revêtement de polyphosphazène et d'un agent actif
DE10100961B4 (de) * 2001-01-11 2005-08-04 Polyzenix Gmbh Körperverträglicher Werkstoff und mit diesem Werkstoff beschichtetes Substrat für die Züchtung von Zellen und künstlichen aus Zellen aufgebauten oder gewachsenen organischen Implantaten
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
DK1432380T3 (da) 2001-08-17 2007-01-15 Polyzenix Gmbh Indretning baseret på nitrol med et overtræk af polyphosphazen
US20050136093A1 (en) * 2002-07-05 2005-06-23 Polyzenix Gmbh Implant for transport and release for pharmacologically active agents as well as a process for producing the same
JP2005532101A (ja) * 2002-07-05 2005-10-27 ポリゼニックス ゲーエムベーハー 薬理学的に活性な薬剤の輸送及び放出のためのインプラントならびにその製造方法
CN1492250A (zh) * 2002-08-16 2004-04-28 �ձ����ŵ绰��ʽ���� 偏振波模式色散补偿方法及偏振波模式色散补偿装置
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
ATE503465T1 (de) * 2004-10-25 2011-04-15 Celonova Biosciences Germany Gmbh Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US8741454B2 (en) * 2005-03-29 2014-06-03 Toyota Motor Engineering & Manufacturing North America, Inc. Proton exchange membrane for fuel cell
US7943675B2 (en) * 2005-03-29 2011-05-17 Toyota Motor Engineering & Manufacturing North America, Inc. Electrolytes for fuel cell electrodes
JP2008536978A (ja) * 2005-04-15 2008-09-11 パラレル ソリューションズ，インク． ピロリドン側基を含む生分解性ポリホスファゼン
US20070255284A1 (en) * 2006-04-28 2007-11-01 Sdgi Holdings, Inc. Orthopedic implant apparatus
BRPI0717738A2 (pt) 2006-10-10 2018-09-11 Celonova Biosciences Inc válvula cardíaca bioprotética, método de fabricação da mesma, método de aperfeiçoamento das qualidades anti-trombogênicas de biocompatibilidade ou hemocaptabilidade de uma válvula cardíaca bioprotética
US20080095816A1 (en) * 2006-10-10 2008-04-24 Celonova Biosciences, Inc. Compositions and Devices Comprising Silicone and Specific Polyphosphazenes
CA2687031A1 (fr) * 2007-05-15 2008-11-20 Chameleon Biosurfaces Limited Revetements polymeres sur dispositifs medicaux
CN102176868A (zh) * 2008-02-11 2011-09-07 西洛诺瓦生物科学公司 组织紧固物品和装置以及相关方法
US20100159195A1 (en) * 2008-12-24 2010-06-24 Quincy Iii Roger B High repellency materials via nanotopography and post treatment

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4311736A (en) 1979-03-19 1982-01-19 The Kendall Company Article having organo-phosphonitrile rubber coating bonded to natural or synthetic rubber and method of making
US4341844A (en) 1979-10-25 1982-07-27 The Kendall Company Article having organo-phosphonitrile rubber coating bonded to natural or synthetic rubber and method of making
US4318947A (en) 1979-12-26 1982-03-09 The Kendall Company Polymer coating and curing process for catheters
JPS5879915A (ja) 1981-11-09 1983-05-13 Nippon Soda Co Ltd 棒状薬剤の製造方法
US4424395A (en) 1982-03-11 1984-01-03 The Dow Chemical Company Carbamates of biphenyls
US4451647A (en) 1982-06-21 1984-05-29 Research Corporation Heparinized polyorganophosphazenes
US4480642A (en) 1982-07-26 1984-11-06 Health Products Research, Inc. Dilation device for the cervix
JPS6038307A (ja) 1983-08-11 1985-02-27 Nippon Daigaku 充填用複合材
US4728345A (en) 1983-12-28 1988-03-01 Monsanto Company Multicomponent gas separation membranes having polyphosphazene coatings
US4911691A (en) 1984-09-21 1990-03-27 Menlo Care, Inc. Assembly for adminstering IV solution
US4883699A (en) 1984-09-21 1989-11-28 Menlo Care, Inc. Polymeric article having high tensile energy to break when hydrated
US4592755A (en) 1985-06-11 1986-06-03 Ethyl Corporation Mammary implant
US4798876A (en) 1985-11-12 1989-01-17 Tyndale Plains-Hunter Ltd. Hydrophilic polyurethane composition
JPS6322843A (ja) 1986-02-14 1988-01-30 Teijin Ltd ポリホスフアゼン成形物及びその製造法
US4880622A (en) 1986-05-20 1989-11-14 Research Corporation Technologies, Inc. Water-soluble phosphazene polymers having pharmacological applications
WO1988009664A1 (fr) 1987-06-10 1988-12-15 Massachusetts Institute Of Technology Systemes de liberation par erosion et diffusion utilisant une matrice de polyphosphazene
US5634946A (en) 1988-08-24 1997-06-03 Focal, Inc. Polymeric endoluminal paving process
US4975280A (en) 1989-01-23 1990-12-04 Ethyl Corporation Bioerodable sustained release implants
US5439446A (en) 1994-06-30 1995-08-08 Boston Scientific Corporation Stent and therapeutic delivery system
FR2679466B1 (fr) 1991-07-25 1994-04-15 Ceramique Technique Membrane de filtration et procede de fabrication.
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
DE4138513A1 (de) 1991-11-23 1993-05-27 Basf Ag Feste pharmazeutische retardform
WO1993021858A1 (fr) 1992-04-24 1993-11-11 Osteotech, Inc. Dispositifs servant a empecher l'adherence de tissus
US5562909A (en) 1993-07-12 1996-10-08 Massachusetts Institute Of Technology Phosphazene polyelectrolytes as immunoadjuvants
US5886026A (en) 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
CA2472404A1 (fr) 1993-07-19 1995-02-02 Angiotech Pharmaceuticals, Inc. Combinaison de stent et d'un facteur anti-angiogenique
GB9407812D0 (en) 1994-04-20 1994-06-15 Nycomed Salutar Inc Compounds
WO1996000103A1 (fr) 1994-06-27 1996-01-04 Endomed, Inc. Polytetrafluoroethylene expanse radialement, et extenseurs endovasculaires expansibles formes avec cette matiere
US5788979A (en) 1994-07-22 1998-08-04 Inflow Dynamics Inc. Biodegradable coating with inhibitory properties for application to biocompatible materials
DE4428056A1 (de) 1994-07-29 1996-02-08 Schering Ag Verwendung von Mikropartikelpräparationen zur Eliminierung gelöster, nicht nierengängiger Substanzen aus dem Blut
US5548060A (en) * 1994-08-08 1996-08-20 Penn State Research Foundation, Inc. Sulfonation of polyphosphazenes
AU719980B2 (en) 1995-02-22 2000-05-18 Menlo Care, Inc. Covered expanding mesh stent
US5686113A (en) 1995-03-21 1997-11-11 Temple University Of The Commonwealth System Of Higher Education Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses
DE19613048C2 (de) 1995-03-30 1997-12-18 Michael Prof Dr Grunze Künstliche Implantate mit antithrombogenen Eigenschaften und Verfahren zu deren Herstellung
US5605696A (en) 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US5914388A (en) 1995-04-26 1999-06-22 The Penn State Research Foundation Synthesis polyphosphazenes with controlled molecular weight and polydisperity
US5674592A (en) * 1995-05-04 1997-10-07 Minnesota Mining And Manufacturing Company Functionalized nanostructured films
AU716005B2 (en) 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
US5718159A (en) 1996-04-30 1998-02-17 Schneider (Usa) Inc. Process for manufacturing three-dimensional braided covered stent
US6254628B1 (en) 1996-12-09 2001-07-03 Micro Therapeutics, Inc. Intracranial stent
US6007573A (en) 1996-09-18 1999-12-28 Microtherapeutics, Inc. Intracranial stent and method of use
US5707597A (en) 1996-11-13 1998-01-13 Virus Research Institute, Inc. Polyhalophosphazene solutions stable against gelation
US5980972A (en) 1996-12-20 1999-11-09 Schneider (Usa) Inc Method of applying drug-release coatings
US5814704A (en) 1997-03-04 1998-09-29 Virus Research Institute, Inc. Recovery of polyphosphazene polyacids or acids salts thereof
WO1998043618A2 (fr) 1997-03-31 1998-10-08 Neorx Corporation Inhibiteur therapeutique des cellules des muscles lisses de la paroi vasculaire
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US20030153985A1 (en) 1997-04-26 2003-08-14 Lee Yong Chan Medical implant
TW586934B (en) 1997-05-19 2004-05-11 Sumitomo Pharma Immunopotentiating composition
US6077916A (en) 1997-06-04 2000-06-20 The Penn State Research Foundation Biodegradable mixtures of polyphoshazene and other polymers
WO1998056312A1 (fr) 1997-06-13 1998-12-17 Scimed Life Systems, Inc. Protheses endovasculaires avec plusieurs couches d'une composition polymere biodegradable
DE19735368A1 (de) 1997-08-14 1999-02-18 Univ Karlsruhe Polymere Metallbeschichtung
DE19744135C1 (de) 1997-09-29 1999-03-25 Schering Ag Beschichtete medizinische Implantate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Restenoseprophylaxe
DE19743373A1 (de) * 1997-09-30 1999-04-15 Univ Heidelberg ·3··2·P-Polyphosphazen
US6485514B1 (en) 1997-12-12 2002-11-26 Supergen, Inc. Local delivery of therapeutic agents
BR9907968B1 (pt) 1998-02-23 2009-12-01 composição de polìmeros com memória de formato biodegradáveis e artigos compreendendo a mesma.
WO1999052356A1 (fr) 1998-04-09 1999-10-21 Charlotte-Mecklenberg Hospital Authority Creation de tissus tridimensionnels
US8029561B1 (en) 2000-05-12 2011-10-04 Cordis Corporation Drug combination useful for prevention of restenosis
US20010029351A1 (en) 1998-04-16 2001-10-11 Robert Falotico Drug combinations and delivery devices for the prevention and treatment of vascular disease
DE69935716T2 (de) 1998-05-05 2007-08-16 Boston Scientific Ltd., St. Michael Stent mit glatten enden
US6254634B1 (en) 1998-06-10 2001-07-03 Surmodics, Inc. Coating compositions
US6153252A (en) 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
DE19843254C2 (de) 1998-09-10 2000-07-06 Schering Ag Verwendung von Polymermischungen, die Cyanacrylat oder Methylenmalonester enthalten, zur Beschichtung medizinischer Geräte und Implantate, medizinische Implantate und Verfahren zu ihrer Herstellung
US5997301A (en) 1998-10-20 1999-12-07 Linden; Lars Ake Treatment of tooth surfaces and substances therefor
CA2353606A1 (fr) 1998-12-03 2000-06-08 Boston Scientific Limited Endoprothese comportant en surface un principe actif sous forme de cristaux
US20030007954A1 (en) 1999-04-12 2003-01-09 Gail K. Naughton Methods for using a three-dimensional stromal tissue to promote angiogenesis
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6503556B2 (en) 2000-12-28 2003-01-07 Advanced Cardiovascular Systems, Inc. Methods of forming a coating for a prosthesis
US6713119B2 (en) 1999-09-03 2004-03-30 Advanced Cardiovascular Systems, Inc. Biocompatible coating for a prosthesis and a method of forming the same
US6790228B2 (en) 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US6203551B1 (en) 1999-10-04 2001-03-20 Advanced Cardiovascular Systems, Inc. Chamber for applying therapeutic substances to an implant device
KR100315630B1 (ko) 1999-11-17 2001-12-12 박호군 온도변화에 따라 상전이 거동을 갖는 분해성폴리포스파젠계 고분자 및 그 제조방법
AU1609701A (en) 1999-11-18 2001-05-30 Sts Biopolymers, Inc. Flexible sealed coil-like devices
US6355058B1 (en) 1999-12-30 2002-03-12 Advanced Cardiovascular Systems, Inc. Stent with radiopaque coating consisting of particles in a binder
CA2402949C (fr) 2000-03-18 2009-09-08 Polyzenix Gmbh Derives de la polyphosphazene resistante aux bacteries et son utilisation
DE10019982A1 (de) 2000-04-22 2001-10-25 Univ Heidelberg Umhüllungen und Folien aus Poly-Tri-Fluor-Ethoxypolyphosphazen
US20020005206A1 (en) 2000-05-19 2002-01-17 Robert Falotico Antiproliferative drug and delivery device
US6627246B2 (en) 2000-05-16 2003-09-30 Ortho-Mcneil Pharmaceutical, Inc. Process for coating stents and other medical devices using super-critical carbon dioxide
EP1179353A1 (fr) 2000-08-11 2002-02-13 B. Braun Melsungen Ag Implants antithrombotiques avec un revêtement de polyphosphazène et d'un agent actif
WO2002024247A1 (fr) 2000-09-22 2002-03-28 Kensey Nash Corporation Protheses d'administration de medicaments et procedes d'utilisation
US20020111590A1 (en) 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
CA2424029C (fr) 2000-09-29 2008-01-29 Cordis Corporation Dispositifs medicaux enrobes
US6746773B2 (en) 2000-09-29 2004-06-08 Ethicon, Inc. Coatings for medical devices
US7261735B2 (en) 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
DE10100961B4 (de) 2001-01-11 2005-08-04 Polyzenix Gmbh Körperverträglicher Werkstoff und mit diesem Werkstoff beschichtetes Substrat für die Züchtung von Zellen und künstlichen aus Zellen aufgebauten oder gewachsenen organischen Implantaten
AU2002340749A1 (en) 2001-05-04 2002-11-18 Concentric Medical Coated combination vaso-occlusive device
US7195640B2 (en) 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US20030065345A1 (en) 2001-09-28 2003-04-03 Kevin Weadock Anastomosis devices and methods for treating anastomotic sites
US20030065377A1 (en) 2001-09-28 2003-04-03 Davila Luis A. Coated medical devices
US8133501B2 (en) 2002-02-08 2012-03-13 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled drug delivery
US6887270B2 (en) 2002-02-08 2005-05-03 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation

Also Published As

Publication number Publication date
EP1274471A2 (fr) 2003-01-15
CA2408997A1 (fr) 2002-11-14
WO2001080919A3 (fr) 2002-05-23
DE10191512D2 (de) 2003-03-13
US7265199B2 (en) 2007-09-04
EP1274471B1 (fr) 2007-01-03
WO2001080919A2 (fr) 2001-11-01
US20040014936A1 (en) 2004-01-22
ATE350077T1 (de) 2007-01-15
DK1274471T3 (da) 2007-04-02
ES2278747T3 (es) 2007-08-16
DE50111797D1 (de) 2007-02-15
AU2001263760A1 (en) 2001-11-07
JP2004500918A (ja) 2004-01-15

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Effective date: 20210412