CA2443092A1 - Use of n-phenyl-2-pyrimidineamine derivatives against mast cell-based diseases like allergic disorders - Google Patents
Use of n-phenyl-2-pyrimidineamine derivatives against mast cell-based diseases like allergic disorders Download PDFInfo
- Publication number
- CA2443092A1 CA2443092A1 CA002443092A CA2443092A CA2443092A1 CA 2443092 A1 CA2443092 A1 CA 2443092A1 CA 002443092 A CA002443092 A CA 002443092A CA 2443092 A CA2443092 A CA 2443092A CA 2443092 A1 CA2443092 A1 CA 2443092A1
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- compound
- lower alkyl
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- free
- methyl
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- 230000000291 postprandial effect Effects 0.000 description 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
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- 239000000454 talc Substances 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
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- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
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- ZBNARPCCDMHDDV-HVMBLDELSA-N trypan blue sulfonic acid Chemical compound C1=C(S(O)(=O)=O)C=C2C=C(S(O)(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S(O)(=O)=O)S(O)(=O)=O)C)=C(O)C2=C1N ZBNARPCCDMHDDV-HVMBLDELSA-N 0.000 description 1
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- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0108606.5A GB0108606D0 (en) | 2001-04-05 | 2001-04-05 | Organic compounds |
| GB0108606.5 | 2001-04-05 | ||
| PCT/US2002/010742 WO2002080925A1 (en) | 2001-04-05 | 2002-04-05 | Use of n-phenyl-2-pyrimidineamine derivativea against mast cell-based diseases like allergic disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2443092A1 true CA2443092A1 (en) | 2002-10-17 |
Family
ID=9912339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002443092A Abandoned CA2443092A1 (en) | 2001-04-05 | 2002-04-05 | Use of n-phenyl-2-pyrimidineamine derivatives against mast cell-based diseases like allergic disorders |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1389113A1 (cs) |
| KR (2) | KR20090034998A (cs) |
| CN (1) | CN1529602A (cs) |
| AU (1) | AU2002307140B2 (cs) |
| BR (1) | BR0208663A (cs) |
| CA (1) | CA2443092A1 (cs) |
| CZ (1) | CZ20032705A3 (cs) |
| GB (1) | GB0108606D0 (cs) |
| HU (1) | HUP0303751A3 (cs) |
| IL (1) | IL158061A0 (cs) |
| MX (1) | MXPA03009058A (cs) |
| NO (1) | NO325454B1 (cs) |
| NZ (1) | NZ528934A (cs) |
| PL (1) | PL363080A1 (cs) |
| RU (1) | RU2304436C2 (cs) |
| SK (1) | SK12312003A3 (cs) |
| WO (1) | WO2002080925A1 (cs) |
| ZA (1) | ZA200307563B (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2415849C2 (ru) * | 2003-02-18 | 2011-04-10 | Сипла Лтд. | Способ получения иматиниба в виде свободного основания или в виде кислотно-аддитивной соли |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2266553T3 (es) | 2001-06-29 | 2007-03-01 | Ab Science | Utilizacion de derivados de la n-fenil-2-pirimidina-amina para tratar las enfermedades inflamatorias. |
| WO2003003006A2 (en) | 2001-06-29 | 2003-01-09 | Ab Science | New potent, selective and non toxic c-kit inhibitors |
| JP2004537542A (ja) | 2001-06-29 | 2004-12-16 | アブ サイエンス | 炎症性腸疾患（ｉｂｄ）を治療するための、チロシンキナーゼ阻害剤の使用 |
| ES2274993T3 (es) | 2001-06-29 | 2007-06-01 | Ab Science | Utilizacion de inhibidores de tirosina cinasa para el tratamiento de enfermedades alergicas. |
| GB0201882D0 (en) * | 2002-01-28 | 2002-03-13 | Novartis Ag | Organic compounds |
| CA2479257A1 (en) * | 2002-03-21 | 2003-10-02 | Dana-Farber Cancer Institute, Inc. | Inhibition of cell death responses induced by oxidative stress |
| MXPA05001277A (es) | 2002-08-02 | 2005-10-06 | Ab Science | 2-(3-aminoaril)amino-4-aril-tiazoles y su uso como inhibidores del c-kit. |
| US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| CA2517308A1 (en) * | 2003-02-27 | 2004-09-10 | Ab Science | Tailored treatment suitable for different forms of mastocytosis |
| AU2003232650A1 (en) * | 2003-05-06 | 2004-11-26 | Il Yang Pharm Co., Ltd. | N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof |
| TWI324604B (en) | 2003-06-18 | 2010-05-11 | Novartis Ag | New use of staurosporine derivatives |
| WO2005115385A1 (en) * | 2004-05-24 | 2005-12-08 | Ab Science | Use of c-kit inhibitors for treating acne |
| JP2008510766A (ja) * | 2004-08-27 | 2008-04-10 | ゲーペーツェー ビオテック アーゲー | ピリミジン誘導体 |
| CA2606716C (en) * | 2005-05-02 | 2013-07-23 | Novartis Ag | Use of pyrimidylaminobenzamide derivatives for the treatment of systematic mastocytosis |
| KR100845278B1 (ko) * | 2006-08-04 | 2008-07-09 | 포항공과대학교 산학협력단 | 비만 세포의 활성을 유도하는 펩타이드 및 이를 포함하는면역조절제 |
| AU2010235334A1 (en) * | 2009-04-06 | 2011-11-24 | Neurotech Pharmaceuticals Co., Ltd. | Pharmaceutical composition for treating or preventing burn injuries |
| CN103058935B (zh) * | 2013-01-15 | 2015-05-06 | 四川大学 | 一种嘧啶类化合物及其制备方法和用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
-
2001
- 2001-04-05 GB GBGB0108606.5A patent/GB0108606D0/en not_active Ceased
-
2002
- 2002-04-05 HU HU0303751A patent/HUP0303751A3/hu unknown
- 2002-04-05 SK SK1231-2003A patent/SK12312003A3/sk not_active Application Discontinuation
- 2002-04-05 WO PCT/US2002/010742 patent/WO2002080925A1/en not_active Ceased
- 2002-04-05 PL PL02363080A patent/PL363080A1/xx unknown
- 2002-04-05 AU AU2002307140A patent/AU2002307140B2/en not_active Expired
- 2002-04-05 CZ CZ20032705A patent/CZ20032705A3/cs unknown
- 2002-04-05 CN CNA028089707A patent/CN1529602A/zh active Pending
- 2002-04-05 KR KR1020097003644A patent/KR20090034998A/ko not_active Ceased
- 2002-04-05 KR KR10-2003-7012939A patent/KR20040007485A/ko not_active Withdrawn
- 2002-04-05 BR BR0208663-8A patent/BR0208663A/pt not_active IP Right Cessation
- 2002-04-05 NZ NZ528934A patent/NZ528934A/en not_active IP Right Cessation
- 2002-04-05 EP EP02763956A patent/EP1389113A1/en not_active Ceased
- 2002-04-05 IL IL15806102A patent/IL158061A0/xx unknown
- 2002-04-05 RU RU2003130635/15A patent/RU2304436C2/ru not_active IP Right Cessation
- 2002-04-05 MX MXPA03009058A patent/MXPA03009058A/es not_active Application Discontinuation
- 2002-04-05 CA CA002443092A patent/CA2443092A1/en not_active Abandoned
-
2003
- 2003-09-29 ZA ZA200307563A patent/ZA200307563B/en unknown
- 2003-10-02 NO NO20034414A patent/NO325454B1/no not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2415849C2 (ru) * | 2003-02-18 | 2011-04-10 | Сипла Лтд. | Способ получения иматиниба в виде свободного основания или в виде кислотно-аддитивной соли |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0108606D0 (en) | 2001-05-23 |
| ZA200307563B (en) | 2004-04-21 |
| AU2002307140B2 (en) | 2006-02-16 |
| NO20034414L (no) | 2003-12-04 |
| RU2304436C2 (ru) | 2007-08-20 |
| EP1389113A1 (en) | 2004-02-18 |
| KR20040007485A (ko) | 2004-01-24 |
| WO2002080925A1 (en) | 2002-10-17 |
| KR20090034998A (ko) | 2009-04-08 |
| NZ528934A (en) | 2006-10-27 |
| RU2003130635A (ru) | 2005-02-10 |
| MXPA03009058A (es) | 2004-11-22 |
| PL363080A1 (en) | 2004-11-15 |
| IL158061A0 (en) | 2004-03-28 |
| NO325454B1 (no) | 2008-05-05 |
| HUP0303751A3 (en) | 2005-06-28 |
| BR0208663A (pt) | 2004-03-09 |
| CN1529602A (zh) | 2004-09-15 |
| CZ20032705A3 (en) | 2004-06-16 |
| SK12312003A3 (sk) | 2004-02-03 |
| HUP0303751A2 (hu) | 2005-04-28 |
| NO20034414D0 (no) | 2003-10-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |