RU2304436C2 - Применение производных n-фенил-2-пиримидинамина против основывающихся на мастоцитах заболеваний, подобных аллергическим нарушениям - Google Patents
Применение производных n-фенил-2-пиримидинамина против основывающихся на мастоцитах заболеваний, подобных аллергическим нарушениям Download PDFInfo
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- 238000000926 separation method Methods 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
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- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
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- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
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- 238000011870 unpaired t-test Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0108606.5A GB0108606D0 (en) | 2001-04-05 | 2001-04-05 | Organic compounds |
| GB0108606.5 | 2001-04-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2003130635A RU2003130635A (ru) | 2005-02-10 |
| RU2304436C2 true RU2304436C2 (ru) | 2007-08-20 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003130635/15A RU2304436C2 (ru) | 2001-04-05 | 2002-04-05 | Применение производных n-фенил-2-пиримидинамина против основывающихся на мастоцитах заболеваний, подобных аллергическим нарушениям |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1389113A1 (cs) |
| KR (2) | KR20090034998A (cs) |
| CN (1) | CN1529602A (cs) |
| AU (1) | AU2002307140B2 (cs) |
| BR (1) | BR0208663A (cs) |
| CA (1) | CA2443092A1 (cs) |
| CZ (1) | CZ20032705A3 (cs) |
| GB (1) | GB0108606D0 (cs) |
| HU (1) | HUP0303751A3 (cs) |
| IL (1) | IL158061A0 (cs) |
| MX (1) | MXPA03009058A (cs) |
| NO (1) | NO325454B1 (cs) |
| NZ (1) | NZ528934A (cs) |
| PL (1) | PL363080A1 (cs) |
| RU (1) | RU2304436C2 (cs) |
| SK (1) | SK12312003A3 (cs) |
| WO (1) | WO2002080925A1 (cs) |
| ZA (1) | ZA200307563B (cs) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2266553T3 (es) | 2001-06-29 | 2007-03-01 | Ab Science | Utilizacion de derivados de la n-fenil-2-pirimidina-amina para tratar las enfermedades inflamatorias. |
| WO2003003006A2 (en) | 2001-06-29 | 2003-01-09 | Ab Science | New potent, selective and non toxic c-kit inhibitors |
| JP2004537542A (ja) | 2001-06-29 | 2004-12-16 | アブ サイエンス | 炎症性腸疾患（ｉｂｄ）を治療するための、チロシンキナーゼ阻害剤の使用 |
| ES2274993T3 (es) | 2001-06-29 | 2007-06-01 | Ab Science | Utilizacion de inhibidores de tirosina cinasa para el tratamiento de enfermedades alergicas. |
| GB0201882D0 (en) * | 2002-01-28 | 2002-03-13 | Novartis Ag | Organic compounds |
| CA2479257A1 (en) * | 2002-03-21 | 2003-10-02 | Dana-Farber Cancer Institute, Inc. | Inhibition of cell death responses induced by oxidative stress |
| MXPA05001277A (es) | 2002-08-02 | 2005-10-06 | Ab Science | 2-(3-aminoaril)amino-4-aril-tiazoles y su uso como inhibidores del c-kit. |
| US8450302B2 (en) | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| GB2398565A (en) * | 2003-02-18 | 2004-08-25 | Cipla Ltd | Imatinib preparation and salts |
| CA2517308A1 (en) * | 2003-02-27 | 2004-09-10 | Ab Science | Tailored treatment suitable for different forms of mastocytosis |
| AU2003232650A1 (en) * | 2003-05-06 | 2004-11-26 | Il Yang Pharm Co., Ltd. | N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof |
| TWI324604B (en) | 2003-06-18 | 2010-05-11 | Novartis Ag | New use of staurosporine derivatives |
| WO2005115385A1 (en) * | 2004-05-24 | 2005-12-08 | Ab Science | Use of c-kit inhibitors for treating acne |
| JP2008510766A (ja) * | 2004-08-27 | 2008-04-10 | ゲーペーツェー ビオテック アーゲー | ピリミジン誘導体 |
| CA2606716C (en) * | 2005-05-02 | 2013-07-23 | Novartis Ag | Use of pyrimidylaminobenzamide derivatives for the treatment of systematic mastocytosis |
| KR100845278B1 (ko) * | 2006-08-04 | 2008-07-09 | 포항공과대학교 산학협력단 | 비만 세포의 활성을 유도하는 펩타이드 및 이를 포함하는면역조절제 |
| AU2010235334A1 (en) * | 2009-04-06 | 2011-11-24 | Neurotech Pharmaceuticals Co., Ltd. | Pharmaceutical composition for treating or preventing burn injuries |
| CN103058935B (zh) * | 2013-01-15 | 2015-05-06 | 四川大学 | 一种嘧啶类化合物及其制备方法和用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO4940418A1 (es) * | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
-
2001
- 2001-04-05 GB GBGB0108606.5A patent/GB0108606D0/en not_active Ceased
-
2002
- 2002-04-05 HU HU0303751A patent/HUP0303751A3/hu unknown
- 2002-04-05 SK SK1231-2003A patent/SK12312003A3/sk not_active Application Discontinuation
- 2002-04-05 WO PCT/US2002/010742 patent/WO2002080925A1/en not_active Ceased
- 2002-04-05 PL PL02363080A patent/PL363080A1/xx unknown
- 2002-04-05 AU AU2002307140A patent/AU2002307140B2/en not_active Expired
- 2002-04-05 CZ CZ20032705A patent/CZ20032705A3/cs unknown
- 2002-04-05 CN CNA028089707A patent/CN1529602A/zh active Pending
- 2002-04-05 KR KR1020097003644A patent/KR20090034998A/ko not_active Ceased
- 2002-04-05 KR KR10-2003-7012939A patent/KR20040007485A/ko not_active Withdrawn
- 2002-04-05 BR BR0208663-8A patent/BR0208663A/pt not_active IP Right Cessation
- 2002-04-05 NZ NZ528934A patent/NZ528934A/en not_active IP Right Cessation
- 2002-04-05 EP EP02763956A patent/EP1389113A1/en not_active Ceased
- 2002-04-05 IL IL15806102A patent/IL158061A0/xx unknown
- 2002-04-05 RU RU2003130635/15A patent/RU2304436C2/ru not_active IP Right Cessation
- 2002-04-05 MX MXPA03009058A patent/MXPA03009058A/es not_active Application Discontinuation
- 2002-04-05 CA CA002443092A patent/CA2443092A1/en not_active Abandoned
-
2003
- 2003-09-29 ZA ZA200307563A patent/ZA200307563B/en unknown
- 2003-10-02 NO NO20034414A patent/NO325454B1/no not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| HEINRICH М С et al. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. BLOOD UNITED STATES. 1 Aug. 2000, V.96, N3, pp.925-932. AKIN СЕМ et al. Effects of the tyrosine kinase inhibitor STI 571 on mutated kit and neoplastic mast cells. 16.11.2000, BLOOD. V.96, N11, part 1, р.747а. WEDEMEYER J. et al. Roles of mast cells and basophils in innate and acquired immunity. CURRENT OPINION IN IMMUNOLOGY. CURRENT BIOLOGY LTD. XX, 01.12.2000, v.12, N 6, pp.624-631. * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB0108606D0 (en) | 2001-05-23 |
| ZA200307563B (en) | 2004-04-21 |
| AU2002307140B2 (en) | 2006-02-16 |
| NO20034414L (no) | 2003-12-04 |
| EP1389113A1 (en) | 2004-02-18 |
| KR20040007485A (ko) | 2004-01-24 |
| WO2002080925A1 (en) | 2002-10-17 |
| KR20090034998A (ko) | 2009-04-08 |
| NZ528934A (en) | 2006-10-27 |
| RU2003130635A (ru) | 2005-02-10 |
| MXPA03009058A (es) | 2004-11-22 |
| PL363080A1 (en) | 2004-11-15 |
| IL158061A0 (en) | 2004-03-28 |
| NO325454B1 (no) | 2008-05-05 |
| CA2443092A1 (en) | 2002-10-17 |
| HUP0303751A3 (en) | 2005-06-28 |
| BR0208663A (pt) | 2004-03-09 |
| CN1529602A (zh) | 2004-09-15 |
| CZ20032705A3 (en) | 2004-06-16 |
| SK12312003A3 (sk) | 2004-02-03 |
| HUP0303751A2 (hu) | 2005-04-28 |
| NO20034414D0 (no) | 2003-10-02 |
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