CA2450922C - Piperidines for use as orexin receptor antagonists - Google Patents

Piperidines for use as orexin receptor antagonists Download PDF

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Publication number
CA2450922C
CA2450922C CA2450922A CA2450922A CA2450922C CA 2450922 C CA2450922 C CA 2450922C CA 2450922 A CA2450922 A CA 2450922A CA 2450922 A CA2450922 A CA 2450922A CA 2450922 C CA2450922 C CA 2450922C
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Prior art keywords
phenyl
optionally substituted
methyl
requires
found
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Expired - Fee Related
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CA2450922A
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English (en)
French (fr)
Other versions
CA2450922A1 (en
Inventor
Clive Leslie Branch
Christopher Norbert Johnson
Geoffrey Stemp
Kevin Thewlis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
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SmithKline Beecham Ltd
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Priority claimed from GB0014823A external-priority patent/GB0014823D0/en
Priority claimed from GB0027704A external-priority patent/GB0027704D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of CA2450922A1 publication Critical patent/CA2450922A1/en
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Publication of CA2450922C publication Critical patent/CA2450922C/en
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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CA2450922A 2000-06-16 2001-06-13 Piperidines for use as orexin receptor antagonists Expired - Fee Related CA2450922C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0014823A GB0014823D0 (en) 2000-06-16 2000-06-16 Compounds
GB0014823.9 2000-06-16
GB0027704A GB0027704D0 (en) 2000-11-11 2000-11-11 Compounds
GB0027704.6 2000-11-11
PCT/EP2001/006752 WO2001096302A1 (en) 2000-06-16 2001-06-13 Piperidines for use as orexin receptor antagonists

Publications (2)

Publication Number Publication Date
CA2450922A1 CA2450922A1 (en) 2001-12-20
CA2450922C true CA2450922C (en) 2010-02-16

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CA2450922A Expired - Fee Related CA2450922C (en) 2000-06-16 2001-06-13 Piperidines for use as orexin receptor antagonists

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US (1) US6677354B2 (de)
EP (1) EP1289955B1 (de)
JP (1) JP4611608B2 (de)
AT (1) ATE293101T1 (de)
AU (1) AU2001272476A1 (de)
CA (1) CA2450922C (de)
DE (1) DE60110066T2 (de)
ES (1) ES2238458T3 (de)
PT (1) PT1289955E (de)
WO (1) WO2001096302A1 (de)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1353918B1 (de) * 2000-11-28 2005-01-12 Smithkline Beecham Plc Morpholinderivate als antagonisten an orexinrezeptoren
WO2002089800A2 (en) * 2001-05-05 2002-11-14 Smithkline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
CZ20032990A3 (cs) 2001-05-05 2004-04-14 Smithkline Beecham P. L. C. N-aroylové cyklické aminy
GB0115862D0 (en) * 2001-06-28 2001-08-22 Smithkline Beecham Plc Compounds
WO2003002561A1 (en) * 2001-06-28 2003-01-09 Smithkline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
GB0124463D0 (en) 2001-10-11 2001-12-05 Smithkline Beecham Plc Compounds
GB0126292D0 (en) 2001-11-01 2002-01-02 Smithkline Beecham Plc Compounds
GB0127145D0 (en) * 2001-11-10 2002-01-02 Smithkline Beecham Compounds
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