CA2520124A1 - Utilisation de composes de benzazole pour l' immunostimulation - Google Patents
Utilisation de composes de benzazole pour l' immunostimulation Download PDFInfo
- Publication number
- CA2520124A1 CA2520124A1 CA002520124A CA2520124A CA2520124A1 CA 2520124 A1 CA2520124 A1 CA 2520124A1 CA 002520124 A CA002520124 A CA 002520124A CA 2520124 A CA2520124 A CA 2520124A CA 2520124 A1 CA2520124 A1 CA 2520124A1
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- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
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- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
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- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45888803P | 2003-03-28 | 2003-03-28 | |
| US60/458,888 | 2003-03-28 | ||
| PCT/US2004/010331 WO2004087153A2 (fr) | 2003-03-28 | 2004-03-29 | Utilisation de petites molecules de composes pour une immunopotentialisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2520124A1 true CA2520124A1 (fr) | 2004-10-14 |
Family
ID=33131836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002520124A Abandoned CA2520124A1 (fr) | 2003-03-28 | 2004-03-29 | Utilisation de composes de benzazole pour l' immunostimulation |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7893096B2 (fr) |
| EP (2) | EP2258365B1 (fr) |
| CA (1) | CA2520124A1 (fr) |
| ES (1) | ES2423800T3 (fr) |
| WO (1) | WO2004087153A2 (fr) |
Families Citing this family (208)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4341949B2 (ja) | 2000-09-01 | 2009-10-14 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | アザ複素環式誘導体およびその治療的使用 |
| JP4361727B2 (ja) | 2000-09-11 | 2009-11-11 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | チロシンキナーゼインヒビターとしてのキノリノン誘導体 |
| US20060142202A1 (en) * | 2000-12-08 | 2006-06-29 | 3M Innovative Properties Company | Compositions and methods for targeted delivery of immune response modifiers |
| ATE447404T1 (de) * | 2002-03-29 | 2009-11-15 | Novartis Vaccines & Diagnostic | Substituierte benzazole und ihre verwendung als raf-kinase-hemmer |
| US8299108B2 (en) * | 2002-03-29 | 2012-10-30 | Novartis Ag | Substituted benzazoles and methods of their use as inhibitors of raf kinase |
| CA2496164C (fr) | 2002-08-23 | 2010-11-09 | Chiron Corporation | Quinolinones de benzimidazole et leurs utilisations |
| BRPI0317188A8 (pt) * | 2002-12-17 | 2018-05-08 | Hamari Chemicals Ltd | novo derivado de 2,4-diamino-1,3,5-triazina |
| MXPA06001669A (es) | 2003-08-12 | 2006-04-28 | 3M Innovative Properties Co | Compuestos que contienen imidazo-oxima sustituidos. |
| NZ545412A (en) | 2003-08-27 | 2008-12-24 | Coley Pharm Group Inc | Aryloxy and arylalkyleneoxy substituted imidazoquinolines |
| JP2007504269A (ja) | 2003-09-05 | 2007-03-01 | スリーエム イノベイティブ プロパティズ カンパニー | Cd5+b細胞リンパ腫の治療方法 |
| US7544697B2 (en) | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| EP1673087B1 (fr) | 2003-10-03 | 2015-05-13 | 3M Innovative Properties Company | Imidazoquinolines a substitution alcoxy |
| CN1906192A (zh) | 2003-11-14 | 2007-01-31 | 3M创新有限公司 | 羟胺取代的咪唑环化合物 |
| WO2005048933A2 (fr) | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | Composes d'un anneau d'imidazo substitues par oxime |
| AU2004293078B2 (en) | 2003-11-25 | 2012-01-19 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
| ATE396970T1 (de) * | 2003-12-23 | 2008-06-15 | Lundbeck & Co As H | 2-(1h-indolylsulfanyl)-benzylaminderivate als ssri |
| JP2007517035A (ja) | 2003-12-29 | 2007-06-28 | スリーエム イノベイティブ プロパティズ カンパニー | アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン |
| EP1699788A2 (fr) | 2003-12-30 | 2006-09-13 | 3M Innovative Properties Company | Sulfonamides d'imidazoquinolinyle, d'imidazopyridinyle et d'imidazonaphtyridinyle |
| WO2005082340A2 (fr) * | 2004-02-20 | 2005-09-09 | Chiron Corporation | Modulation de processus inflammatoires et metastatiques |
| US8697873B2 (en) | 2004-03-24 | 2014-04-15 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
| US20050267145A1 (en) * | 2004-05-28 | 2005-12-01 | Merrill Bryon A | Treatment for lung cancer |
| US8017779B2 (en) | 2004-06-15 | 2011-09-13 | 3M Innovative Properties Company | Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
| WO2006038923A2 (fr) | 2004-06-18 | 2006-04-13 | 3M Innovative Properties Company | Imidazonaphthyridines substituees par aryle |
| WO2006009826A1 (fr) | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Thiazoloquinolines et thiazolonaphtyridines substitues par aryloxy et arylalkyleneoxy |
| US7915281B2 (en) | 2004-06-18 | 2011-03-29 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method |
| WO2006115509A2 (fr) * | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Immuno-potentialisateurs a petites molecules et analyses visant a detecter leur presence |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| EP1786450A4 (fr) * | 2004-08-27 | 2009-11-11 | 3M Innovative Properties Co | Compositions immunostimulatrices contre le vih |
| AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
| JP5313502B2 (ja) | 2004-12-30 | 2013-10-09 | スリーエム イノベイティブ プロパティズ カンパニー | 置換キラル縮合[1,2]イミダゾ[4,5−c]環状化合物 |
| AU2005321912B2 (en) * | 2004-12-30 | 2012-04-05 | 3M Innovative Properties Company | Treatment for cutaneous metastases |
| CA2592904C (fr) | 2004-12-30 | 2015-04-07 | 3M Innovative Properties Company | Composes chiraux a cycle [1,2]imidazo[4,5] fusionne |
| JP2008530022A (ja) | 2005-02-04 | 2008-08-07 | コーリー ファーマシューティカル グループ,インコーポレイテッド | 免疫反応調節物質を含む水性ゲル処方物 |
| EP1846405A2 (fr) | 2005-02-11 | 2007-10-24 | 3M Innovative Properties Company | Composes cycliques imidazo 4,5-c substitues par oxime et hydroxylamine et procedes associes |
| SG164378A1 (en) | 2005-02-17 | 2010-09-29 | Synta Pharmaceuticals Corp | Compounds for the treatment of proliferative disorders |
| SI2351772T1 (sl) | 2005-02-18 | 2016-11-30 | Glaxosmithkline Biologicals Sa | Proteini in nukleinske kisline iz Escherichia coli povezane z meningitisom/sepso |
| JP2008530245A (ja) | 2005-02-18 | 2008-08-07 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | 尿路病原性菌株由来の抗原 |
| CA2602683A1 (fr) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridine-1,4-diamines et analogues associes |
| CA2602590A1 (fr) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | Composes cycliques 1-pyrazolo[3,4-c] substitues comme modulateurs de la biosynthese de cytokine destines au traitement d'infections virales et de maladies neoplastiques |
| JP2008539252A (ja) * | 2005-04-25 | 2008-11-13 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫活性化組成物 |
| AU2006247062A1 (en) | 2005-05-17 | 2006-11-23 | Novartis Ag | Methods for synthesizing heterocyclic compounds |
| US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| US20060293345A1 (en) * | 2005-05-20 | 2006-12-28 | Christoph Steeneck | Heterobicyclic metalloprotease inhibitors |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| EP1909564A4 (fr) | 2005-07-18 | 2010-06-30 | Novartis Ag | Modele petit animal pour une replication hcv |
| TW200804345A (en) * | 2005-08-30 | 2008-01-16 | Novartis Ag | Substituted benzimidazoles and methods of preparation |
| EP1938231A1 (fr) * | 2005-09-19 | 2008-07-02 | BG Medicine, Inc. | Analyse de correlation d'echantillons biologiques |
| NZ567979A (en) | 2005-11-04 | 2012-02-24 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents which is an agonist of Toll-Like Receptor 7 |
| WO2007052155A2 (fr) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Vaccins antigrippaux presentant un taux reduit d'adjuvants de type emulsion |
| ES2377884T3 (es) | 2005-11-04 | 2012-04-02 | Novartis Vaccines And Diagnostics S.R.L. | Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores |
| PL2368572T3 (pl) | 2005-11-04 | 2020-11-16 | Seqirus UK Limited | Szczepionki z adjuwantem z niewirionowymi antygenami otrzymane z wirusów grypy hodowanych w hodowli komórkowej |
| TW201018662A (en) | 2005-12-12 | 2010-05-16 | Astrazeneca Ab | Alkylsulphonamide quinolines |
| US7622128B2 (en) * | 2005-12-13 | 2009-11-24 | University Of Washington | Porphyromonas gingivalis 1435/1449 LPS as an immune modulator |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| BR122019013216B8 (pt) | 2006-01-27 | 2021-07-27 | Seqirus Uk Ltd | ensaio imunológico para análise de uma vacina contra influenza |
| AU2007215247B2 (en) * | 2006-02-10 | 2012-12-13 | Transtech Pharma, Llc | Benzazole derivatives, compositions, and methods of use as Aurora kinase inhibitors |
| EP1988896A4 (fr) | 2006-02-22 | 2011-07-27 | 3M Innovative Properties Co | Conjugués du modificateur de réponse immune |
| EP2007765B1 (fr) * | 2006-03-23 | 2012-06-27 | Novartis AG | Composes de potentialisation immunitaire |
| US20100010217A1 (en) * | 2006-03-23 | 2010-01-14 | Valiante Nicholas M | Methods for the preparation of imidazole-containing compounds |
| WO2007109813A1 (fr) | 2006-03-23 | 2007-09-27 | Novartis Ag | Composés d'imidazoquinoxaline utilisés en tant qu'immunomodulateurs |
| JP2009534303A (ja) | 2006-03-24 | 2009-09-24 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 冷蔵しないインフルエンザワクチンの保存 |
| US20100285062A1 (en) | 2006-03-31 | 2010-11-11 | Novartis Ag | Combined mucosal and parenteral immunization against hiv |
| TW200808739A (en) | 2006-04-06 | 2008-02-16 | Novartis Vaccines & Diagnostic | Quinazolines for PDK1 inhibition |
| ATE522541T1 (de) | 2006-06-09 | 2011-09-15 | Novartis Ag | Bakterielle adhäsine konformere |
| WO2008008432A2 (fr) | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Composés à cycle [1,2] imidazo [4,5-c] fusionné chiral substitué et procédés correspondants |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| US7985753B2 (en) | 2006-08-04 | 2011-07-26 | Merz Pharma Gmbh & Co. Kgaa | Substituted pyrazolo[1,5-A]pyrimidines as metabotropic glutamate receptor modulators |
| EP2586790A3 (fr) | 2006-08-16 | 2013-08-14 | Novartis AG | Immunogènes d'Escherischia coli pathogènes des voies urinaires |
| EP3456348B1 (fr) | 2006-09-11 | 2025-03-26 | Seqirus UK Limited | Fabrication de vaccins contre le virus de la grippe sans utiliser d' oeufs |
| CA2663436A1 (fr) * | 2006-10-04 | 2008-04-10 | Pfizer Products Inc. | Derives de pyrido[4,3-d]pyrimidin-4(3h)-one utilises en tant qu'antagonistes du recepteur calcique |
| WO2008045664A2 (fr) * | 2006-10-06 | 2008-04-17 | Kalypsys, Inc. | Inhibiteurs hétérocycliques de pde4 |
| GB0623012D0 (en) * | 2006-11-17 | 2006-12-27 | Nordic Bioscience As | Diphyllin and other lignans as a medicament for V-ATPase mediated disease |
| PL2121011T3 (pl) | 2006-12-06 | 2014-10-31 | Novartis Ag | Szczepionki zawierające antygeny czterech szczepów wirusa grypy |
| JP5442449B2 (ja) | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | 新規化合物 |
| EP2114941B1 (fr) | 2006-12-22 | 2015-03-25 | Astex Therapeutics Limited | Composés hétérocycliques bicycliques servant d'inhibiteurs des fgfr |
| US20080149123A1 (en) | 2006-12-22 | 2008-06-26 | Mckay William D | Particulate material dispensing hairbrush with combination bristles |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| BRPI0806365B8 (pt) * | 2007-02-06 | 2021-05-25 | Lixte Biotechnology Holdings Inc | composto, uso do composto, composição farmacêutica e uso da composição farmacêutica |
| GB0706072D0 (en) | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
| CL2008001626A1 (es) | 2007-06-05 | 2009-06-05 | Takeda Pharmaceuticals Co | Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer. |
| CN101784283A (zh) | 2007-06-27 | 2010-07-21 | 诺华有限公司 | 低添加流感疫苗 |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| JP5270553B2 (ja) | 2007-08-23 | 2013-08-21 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| KR20100093129A (ko) | 2007-12-20 | 2010-08-24 | 노파르티스 아게 | Pi 3 키나제 억제제로서 사용되는 티아졸 유도체 |
| EP2085398A1 (fr) | 2008-02-01 | 2009-08-05 | Merz Pharma GmbH & Co. KGaA | Pyrazolopyrimidines, leur procédé de préparation et leur utilisation en tant que médicament |
| EP2090576A1 (fr) | 2008-02-01 | 2009-08-19 | Merz Pharma GmbH & Co.KGaA | 6-halo-pyrazolo[1,5-a]pyridines, leur procédé de préparation et leur utilisation en tant que modulateurs des récepteurs metabotropiques du glutamate (mGluR) |
| EP2268309B1 (fr) | 2008-03-18 | 2015-01-21 | Novartis AG | Améliorations dans la préparation des antigènes pour le vaccin contre le virus de la grippe |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| US8697874B2 (en) | 2008-12-01 | 2014-04-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| JO3101B1 (ar) | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | مشتقات بنزوثيازول كعوامل مضادة للسرطان |
| WO2010074284A1 (fr) | 2008-12-26 | 2010-07-01 | 味の素株式会社 | Composé de pyrazolopyrimidine |
| CN102438650A (zh) | 2009-03-06 | 2012-05-02 | 诺华有限公司 | 衣原体抗原 |
| NZ612315A (en) | 2009-04-14 | 2014-10-31 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| FR2949344A1 (fr) | 2009-04-27 | 2011-03-04 | Novartis Ag | Vaccins de protection contre la grippe |
| US8293753B2 (en) | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
| ES2662716T3 (es) | 2009-07-07 | 2018-04-09 | Glaxosmithkline Biologicals Sa | Inmunógenos conservados de Escherichia coli |
| TW201116294A (en) | 2009-07-15 | 2011-05-16 | Novartis Ag | RSV F protein compositions and methods for making same |
| SI2464658T1 (sl) | 2009-07-16 | 2015-02-27 | Novartis Ag | Detoksificirani imunogeni escherichie coli |
| FR2948026B1 (fr) * | 2009-07-17 | 2011-12-02 | Merck Sante Sas | Derives amines de dihydro-1,3,5-triazine |
| GB0918392D0 (en) | 2009-10-20 | 2009-12-02 | Novartis Ag | Diagnostic and therapeutic methods |
| GB0919690D0 (en) | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
| US9173954B2 (en) | 2009-12-30 | 2015-11-03 | Glaxosmithkline Biologicals Sa | Polysaccharide immunogens conjugated to E. coli carrier proteins |
| CA2787598A1 (fr) * | 2010-01-24 | 2012-06-21 | Novartis Ag | Microparticules de polymere biodegradable irradiees |
| CN102933267B (zh) | 2010-05-28 | 2015-05-27 | 泰特里斯在线公司 | 交互式混合异步计算机游戏基础结构 |
| GB201009861D0 (en) | 2010-06-11 | 2010-07-21 | Novartis Ag | OMV vaccines |
| AP2013006706A0 (en) | 2010-07-02 | 2013-02-28 | Gilead Sciences Inc | Napht-2-ylacetic acid derivatives to treat AIDS |
| PH12013500015A1 (en) | 2010-07-02 | 2013-02-18 | Gilead Sciences Inc | 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds |
| US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
| AR082418A1 (es) | 2010-08-02 | 2012-12-05 | Novartis Ag | Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico |
| EP4144368B1 (fr) | 2011-01-26 | 2025-02-26 | GlaxoSmithKline Biologicals S.A. | Régime d'immunisation contre le vrs |
| CA2825605C (fr) | 2011-01-31 | 2019-05-07 | Novartis Ag | Derives heterocycliques |
| WO2012139876A1 (fr) | 2011-04-14 | 2012-10-18 | Merz Pharma Gmbh & Co. Kgaa | Formulations entériques de modulateurs de récepteur de glutamate métabotropique |
| UA111841C2 (uk) | 2011-04-21 | 2016-06-24 | Гіліад Сайєнсіз, Інк. | Сполуки бензотіазолу та їх фармацевтичне застосування |
| US10953012B2 (en) | 2011-04-26 | 2021-03-23 | Bioenergenix Llc | Heterocyclic compounds for the inhibition of pask |
| US10849863B2 (en) * | 2011-04-28 | 2020-12-01 | University Of Louisville Research Foundation, Inc. | Compounds for treating cancer, for administering, and for pharmaceutical compositions |
| CN103842374A (zh) | 2011-05-13 | 2014-06-04 | 诺华股份有限公司 | 融合前的rsv f抗原 |
| CA2838023C (fr) | 2011-06-03 | 2019-08-13 | 3M Innovative Properties Company | Hydrazino 1h-imidazoquinoleine-4-amines et conjugues obtenus a partir de celles-ci |
| EP2717919B1 (fr) | 2011-06-03 | 2016-08-03 | 3M Innovative Properties Company | Lieurs hétérobifonctionnels comportant de segments de polyéthylène glycol et conjugués modificateurs de réponse immunitaire obtenus à partir de ceux-ci |
| EP2722042B1 (fr) | 2011-06-16 | 2019-05-29 | Korea Research Institute of Chemical Technology | Dérivés indanone, leurs isomères optiques ou leurs sels pharmaceutiquement acceptables, leur procédé de préparation, et des compositions pharmaceutiques les contenant en tant que principe actif pour prévenir ou traiter des maladies virales |
| KR101391745B1 (ko) | 2011-06-16 | 2014-05-07 | 카톨리에케 유니버시타이트 로이벤 케이.유. 로이벤 알 앤 디 | 1,3-다이옥소인덴 유도체, 이의 약학적으로 허용되는 염 또는 이의 광학 이성질체, 이의 제조방법 및 이를 유효성분으로 함유하는 항바이러스용 약학적 조성물 |
| EP2729178A1 (fr) | 2011-07-08 | 2014-05-14 | Novartis AG | Procédé de ligature de la tyrosine |
| WO2013029006A1 (fr) * | 2011-08-25 | 2013-02-28 | The Trustees Of Princeton University | Thérapies contre le virus de la dengue et le virus de la fièvre jaune |
| AP2014007595A0 (en) * | 2011-09-30 | 2014-04-30 | Kineta Inc | Anti-viral compounds |
| PH12014500912A1 (en) | 2011-10-28 | 2014-06-09 | Novartis Ag | Novel purine derivatives and their use in the treatment of disease |
| WO2013068949A1 (fr) | 2011-11-07 | 2013-05-16 | Novartis Ag | Molécule porteuse comprenant un antigène spr0096 et un antigène spr2021 |
| WO2013087815A1 (fr) | 2011-12-15 | 2013-06-20 | Merz Pharma Gmbh & Co. Kgaa | Composition pharmaceutique liquide contenant un dérivé de pyrazolopyrimidine et utilisations pharmaceutiques de celle-ci |
| WO2013087808A1 (fr) | 2011-12-15 | 2013-06-20 | Merz Pharma Gmbh & Co. Kgaa | Composition pharmaceutique comprenant une pyrazolopyrimidine et une cyclodextrine |
| WO2013103738A1 (fr) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Dérivés d'acide naphtalène acétique contre l'infection par le vih |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| WO2013108272A2 (fr) | 2012-01-20 | 2013-07-25 | International Centre For Genetic Engineering And Biotechnology | Vaccin antipaludique ciblant le stade sanguin |
| US9096586B2 (en) | 2012-04-20 | 2015-08-04 | Gilead Sciences, Inc. | Therapeutic compounds |
| SG11201406550QA (en) | 2012-05-16 | 2014-11-27 | Novartis Ag | Dosage regimen for a pi-3 kinase inhibitor |
| CA2885625A1 (fr) | 2012-10-02 | 2014-04-10 | Glaxosmithkline Biologicals S.A. | Conjugues saccharidiques non lineaires |
| US9278973B2 (en) | 2012-10-25 | 2016-03-08 | Bioenergenix Llc | Heterocyclic compounds for the inhibition of PASK |
| WO2014066795A1 (fr) | 2012-10-25 | 2014-05-01 | Bioenergenix | Composés hétérocycliques pour l'inhibition de pask |
| US9987344B2 (en) | 2012-11-30 | 2018-06-05 | Glaxosmithkline Biologicals Sa | Pseudomonas antigens and antigen combinations |
| PT3882244T (pt) | 2012-12-14 | 2025-04-04 | Univ Leuven Kath | Composto, sal farmaceuticamente aceitável ou isómero ótico do mesmo, método para a sua preparação e composição farmacêutica para prevenção ou tratamento de doenças virais que contenha o mesmo como ingrediente ativo |
| AU2014203896B2 (en) | 2013-01-07 | 2018-05-31 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cutaneous T cell lymphoma |
| CA2909160C (fr) | 2013-04-09 | 2021-05-25 | Lixte Biotechnology, Inc. | Formulations d'oxabicycloheptanes et d'oxabicycloheptenes |
| WO2014170648A1 (fr) | 2013-04-19 | 2014-10-23 | Astrazeneca Ab | Composé antagoniste du récepteur nk3 (nk3ra) utilisé dans une méthode pour traiter le syndrome des ovaires polykystiques (sopk) |
| EP2870974A1 (fr) | 2013-11-08 | 2015-05-13 | Novartis AG | Vaccins conjugués de salmonelle |
| EP3068398A4 (fr) * | 2013-11-15 | 2017-11-15 | Lixte Biotechnology, Inc. | Inhibiteurs de protéines phosphatases qui traversent la barrière hémato-encéphalique |
| KR20160095035A (ko) | 2013-12-06 | 2016-08-10 | 노파르티스 아게 | 알파-이소형 선택성 포스파티딜이노시톨 3-키나제 억제제를 위한 투여 요법 |
| NO2699580T3 (fr) | 2014-01-24 | 2018-02-24 | ||
| WO2015120304A1 (fr) | 2014-02-07 | 2015-08-13 | Boston Biomedical, Inc. | Dérivé de carbonyle -naphto [2,3-b]furane 3-substitué dérivé ou sel pharmaceutiquement acceptable de celui-ci |
| CN103951602B (zh) * | 2014-03-19 | 2016-06-15 | 河南理工大学 | 具有抗肿瘤活性的吡咯缩氨基硫脲铜、镍配合物的合成方法 |
| WO2015167616A1 (fr) * | 2014-05-02 | 2015-11-05 | Nitor Therapeutics | Guanosine comme potentialisatrice du système immunitaire à médiation par les récepteurs toll |
| CN113501826B (zh) | 2015-01-08 | 2025-04-04 | 美国政府健康及人类服务部 | 作为tdp2的抑制剂的呋喃并喹啉二酮 |
| AU2016217874A1 (en) | 2015-02-11 | 2017-08-10 | Basilea Pharmaceutica International AG | Substituted mono- and polyazanaphthalene derivatives and their use |
| JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
| CN107708686B (zh) | 2015-05-15 | 2021-02-19 | 莱克斯特生物技术公司 | 氧杂二环庚烷前药 |
| WO2017059280A1 (fr) | 2015-10-02 | 2017-04-06 | The University Of North Carolina At Chapel Hill | Nouveaux inhibiteurs de pan-tam et doubles inhibiteurs de mer/axl |
| EP3156404A1 (fr) | 2015-10-15 | 2017-04-19 | Inventiva | Nouveaux composés inhibiteurs de l'interaction yap/taz-tead et leur utilisation dans le traitement du mésothéliome malin |
| KR20180073674A (ko) | 2015-11-02 | 2018-07-02 | 노파르티스 아게 | 포스파티딜이노시톨 3-키나제 억제제에 대한 투여 요법 |
| KR102049140B1 (ko) | 2016-05-31 | 2019-11-26 | 전남대학교산학협력단 | 이소퀴놀리논 유도체, 이의 제조방법 및 이를 함유하는 인플루엔자 바이러스 치료용 약학적 조성물 |
| SG11201901747VA (en) | 2016-08-31 | 2019-03-28 | Agios Pharmaceuticals Inc | Inhibitors of cellular metabolic processes |
| WO2018060833A1 (fr) | 2016-09-27 | 2018-04-05 | Novartis Ag | Schéma posologique pour l'alpelisib, un inhibiteur de la phosphatidylinositol 3-kinase spécifique de l'isoforme alpha |
| WO2018107004A1 (fr) | 2016-12-08 | 2018-06-14 | Lixte Biotechnology, Inc. | Oxabicycloheptanes pour la modulation de la réponse immunitaire |
| KR102652866B1 (ko) | 2017-04-06 | 2024-04-02 | 엥방티바 | Yap/taz-tead 상호작용의 억제제인 신규 화합물 및 악성 중피종의 치료에서의 이들의 용도 |
| BR112019027676A2 (pt) | 2017-06-27 | 2020-09-15 | Janssen Pharmaceutica Nv | compostos de quinolinona |
| US10513515B2 (en) | 2017-08-25 | 2019-12-24 | Biotheryx, Inc. | Ether compounds and uses thereof |
| CN109721620B (zh) * | 2017-10-27 | 2022-05-13 | 药捷安康(南京)科技股份有限公司 | Hpk1抑制剂及其用途 |
| TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗rsv活性之吡唑并嘧啶 |
| AU2019216260B2 (en) | 2018-01-31 | 2023-03-02 | Janssen Sciences Ireland Unlimited Company | Cycloalkyl substituted pyrazolopyrimidines having activity against RSV |
| WO2019166946A1 (fr) | 2018-02-28 | 2019-09-06 | Pfizer Inc. | Variants d'il-15 et leurs utilisations |
| FI3758708T3 (fi) | 2018-03-01 | 2025-02-18 | Astrazeneca Ab | (2s)-{(1s)-1-syano-2-[4-(3-metyyli-2-okso-2,3-dihydro-1,3-bentsoksatsol-5-yyli)fenyyli]etyyli}-1,4-oksatsepaani-2-karboksamidia käsittäviä farmaseuttisia koostumuksia |
| CA3095277A1 (fr) | 2018-04-23 | 2019-10-31 | Janssen Sciences Ireland Unlimited Company | Composes heteroaromatiques ayant une activite contre vrs |
| DK3797121T3 (da) | 2018-05-23 | 2024-07-08 | Pfizer | Antistoffer, der er specifikke for CD3, og anvendelser deraf |
| BR112020022595A2 (pt) | 2018-05-23 | 2021-02-09 | Pfizer Inc. | anticorpos específicos para gucy2c e usos dos mesmos |
| KR20210032431A (ko) | 2018-07-17 | 2021-03-24 | 인스메드 인코포레이티드 | 루푸스 신염을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드 |
| CA3106239A1 (fr) | 2018-07-27 | 2020-01-30 | Biotheryx, Inc. | Composes bifonctionnels agissant par agonisme sur des cdk |
| EP3632908A1 (fr) | 2018-10-02 | 2020-04-08 | Inventiva | Inhibiteurs de l'interaction yap / taz-tead et leur utilisation dans le traitement du cancer |
| WO2020097400A1 (fr) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Dérivés d'imidazopyridine et dérivés d'aza-imidazopyridine utilisés comme inhibiteurs de la janus kinase 2 et utilisations associées |
| EP3876939A4 (fr) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Dérivés benzothiazoles et dérivés 7-aza benzothiazoles comme inhibiteurs de la janus kinase 2 et leurs utilisations |
| EP3876930A4 (fr) | 2018-11-07 | 2022-07-20 | Dana-Farber Cancer Institute, Inc. | Dérivés de benzimidazole et dérivés d'aza-benzimidazole en tant qu'inhibiteurs de janus kinase 2 et leurs utilisations |
| CN113423701A (zh) | 2018-11-13 | 2021-09-21 | 拜欧斯瑞克斯公司 | 取代的异吲哚啉酮 |
| WO2020128893A1 (fr) | 2018-12-21 | 2020-06-25 | Pfizer Inc. | Traitements combinés de cancer comprenant un agoniste de tlr |
| US11702474B2 (en) | 2019-12-17 | 2023-07-18 | Pfizer Inc. | Antibodies specific for CD47, PD-L1, and uses thereof |
| TWI874791B (zh) | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| AU2021224588B2 (en) | 2020-02-18 | 2024-07-18 | Gilead Sciences, Inc. | Antiviral compounds |
| CN115916763B (zh) | 2020-04-20 | 2025-06-03 | 诺华股份有限公司 | 抗病毒素1,3-二氧代茚化合物 |
| KR102894005B1 (ko) | 2020-04-20 | 2025-12-03 | 노파르티스 아게 | 항바이러스 1,3-다이-옥소-인덴 화합물 |
| WO2021222150A2 (fr) | 2020-04-28 | 2021-11-04 | Anwita Biosciences, Inc. | Polypeptides d'interleukine-2 et protéines de fusion de ceux-ci, ainsi que leurs compositions pharmaceutiques et leurs applications thérapeutiques |
| BR112022022409A2 (pt) | 2020-05-06 | 2023-02-07 | Ajax Therapeutics Inc | 6-heteroarilóxi benzimidazóis e azabenzimidazóis como inibidores de jak2 |
| CA3189590A1 (fr) | 2020-07-17 | 2022-01-20 | Pfizer Inc. | Anticorps therapeutiques et leurs utilisations |
| PY2193067A (es) | 2020-10-23 | 2022-06-20 | Ildong Pharmaceutical Co Ltd | Compuestos moduladores del cftr, composiciones y usos de estos |
| TW202237615A (zh) | 2020-12-11 | 2022-10-01 | 南韓商日東製藥股份有限公司 | 作為雄激素受體及磷酸二酯酶雙重抑制劑的新穎化合物 |
| WO2022140527A1 (fr) | 2020-12-23 | 2022-06-30 | Ajax Therapeutics, Inc. | 6-hétéroaryloxy benzimidazoles et azabenzimidazoles utilisés en tant qu'inhibiteurs de jak2 |
| JP7688152B2 (ja) | 2021-04-16 | 2025-06-03 | ギリアード サイエンシーズ, インコーポレイテッド | アミドを使用してカルバヌクレオシドを調製する方法 |
| JP7719954B2 (ja) | 2021-08-18 | 2025-08-06 | ギリアード サイエンシーズ, インコーポレイテッド | リン脂質化合物並びにその製造方法及び使用方法 |
| WO2023067388A1 (fr) * | 2021-10-22 | 2023-04-27 | Ildong Pharmaceutical Co., Ltd. | Utilisations de composés modulateurs de cftr et/ou inhibiteurs de pde4 |
| CA3234638A1 (fr) * | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-hetero-aryloxy-benzimidazoles et azabenzimidazoles en tant qu'inhibiteurs de jak2 |
| TW202404603A (zh) * | 2022-04-20 | 2024-02-01 | 南韓商日東製藥股份有限公司 | 包含cftr活化劑的組成物 |
| CN116240560A (zh) * | 2023-01-03 | 2023-06-09 | 南京工业大学 | 一种利用微通道反应器电化学合成呋喃醌的方法 |
| EP4646265A1 (fr) | 2023-01-06 | 2025-11-12 | Insmed Incorporated | Nouveaux inhibiteurs de dpp1 réversibles et leurs utilisations |
| CN117229207B (zh) * | 2023-09-01 | 2024-09-03 | 浙江工业大学 | 一种苯基萘类化合物及其制备与应用 |
| WO2025104289A1 (fr) | 2023-11-17 | 2025-05-22 | Medincell S.A. | Combinaisons antinéoplasiques |
| US12129257B1 (en) | 2023-12-28 | 2024-10-29 | King Faisal University | Imidazo[1,2-a]pyrazine compounds as CK2 inhibitors |
| CN121494783A (zh) * | 2026-01-13 | 2026-02-10 | 安徽农业大学 | 四氢异喹啉酰胺衍生物及其用途 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4171353A (en) * | 1978-05-16 | 1979-10-16 | Ryan Wayne L | Immunization of animals using choline esters as an immunological adjuvant |
| IE52670B1 (en) | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
| IL73534A (en) | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
| US4806352A (en) | 1986-04-15 | 1989-02-21 | Ribi Immunochem Research Inc. | Immunological lipid emulsion adjuvant |
| EP0273512B1 (fr) | 1986-12-19 | 1991-02-27 | Duphar International Research B.V | Suspension adjuvante stabilisée comprenant du bromure de diméthyl dioctadécyl ammonium |
| ZA881694B (en) | 1987-03-17 | 1988-09-06 | Akzo N.V. | Adjuvant mixture |
| DE3841091A1 (de) | 1988-12-07 | 1990-06-13 | Behringwerke Ag | Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung |
| US5238944A (en) | 1988-12-15 | 1993-08-24 | Riker Laboratories, Inc. | Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine |
| DE68907045T2 (de) | 1989-01-17 | 1993-12-02 | Eniricerche Spa | Synthetische Peptide und deren Verwendung als allgemeine Träger für die Herstellung von immunogenischen Konjugaten, die für die Entwicklung von synthetischen Impfstoffen geeignet sind. |
| US4929624A (en) | 1989-03-23 | 1990-05-29 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo(4,5-c)quinolin-4-amines |
| WO1990014837A1 (fr) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Composition d'adjuvant comprenant une emulsion de gouttelettes d'huile d'une taille inferieure au micron |
| IT1237764B (it) | 1989-11-10 | 1993-06-17 | Eniricerche Spa | Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici. |
| DE69113564T2 (de) | 1990-08-13 | 1996-05-30 | American Cyanamid Co | Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff. |
| US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| US5389640A (en) | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| GB9108547D0 (en) * | 1991-04-22 | 1991-06-05 | Fujisawa Pharmaceutical Co | Quinoline derivatives |
| US5268376A (en) | 1991-09-04 | 1993-12-07 | Minnesota Mining And Manufacturing Company | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| US5266575A (en) | 1991-11-06 | 1993-11-30 | Minnesota Mining And Manufacturing Company | 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines |
| EP0967279B1 (fr) | 1992-03-02 | 2008-01-02 | Novartis Vaccines and Diagnostics S.r.l. | Cytotoxine d' Helicobacter pylori utile dans des vaccins et en diagnostique |
| IT1262896B (it) | 1992-03-06 | 1996-07-22 | Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini. | |
| US5395937A (en) | 1993-01-29 | 1995-03-07 | Minnesota Mining And Manufacturing Company | Process for preparing quinoline amines |
| KR100341341B1 (ko) | 1993-07-15 | 2002-11-25 | 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 | 이미다조[4,5-c]피리딘-4-아민 |
| US5352784A (en) | 1993-07-15 | 1994-10-04 | Minnesota Mining And Manufacturing Company | Fused cycloalkylimidazopyridines |
| US5482936A (en) | 1995-01-12 | 1996-01-09 | Minnesota Mining And Manufacturing Company | Imidazo[4,5-C]quinoline amines |
| IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
| DE19630390A1 (de) | 1996-07-26 | 1998-01-29 | Chiron Behring Gmbh & Co | Proteine, insbesondere Membranproteine von Helicobacter pylori, ihre Herstellung und Verwendung |
| JP4111403B2 (ja) | 1996-10-11 | 2008-07-02 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | 免疫刺激ポリヌクレオチド/免疫調節分子複合体 |
| NZ510991A (en) | 1997-03-05 | 2002-11-26 | Sugen Inc | Use of formulations for hydrophobic pharmaceutical agents in treatment or prevention of cell proliferative disorders |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| GB9711650D0 (en) | 1997-06-05 | 1997-07-30 | Pfizer Ltd | Compounds useful in therapy |
| WO1998055495A2 (fr) | 1997-06-06 | 1998-12-10 | Dynavax Technologies Corporation | Oligonucleotides immunostimulateurs, compositions correspondantes et leurs procedes d'utilisation |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| GB9713156D0 (en) | 1997-06-20 | 1997-08-27 | Microbiological Res Authority | Vaccines |
| AU1145699A (en) | 1997-09-05 | 1999-03-22 | Smithkline Beecham Biologicals (Sa) | Oil in water emulsions containing saponins |
| US7012069B2 (en) | 2001-05-03 | 2006-03-14 | Arch Development Corporation | Liver X receptor agonists |
| EP1900818A3 (fr) | 1997-11-06 | 2008-06-11 | Novartis Vaccines and Diagnostics S.r.l. | Antigènes de Neisserial |
| JP2002536958A (ja) | 1997-11-21 | 2002-11-05 | ジェンセット | Chlamydiapneumoniaeゲノム配列およびポリペプチド、それらのフラグメント、ならびに特に感染症の診断、予防および治療のためのそれらの使用 |
| EP2218732A1 (fr) | 1997-11-28 | 2010-08-18 | Merck Serono Biodevelopment | Séquence génomique de Chlamydia pneumoniae, polypeptides, fragments et leurs utilisations, en particulier pour le diagnostic, la prévention et le traitement de l'infection |
| UA67760C2 (uk) | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Імідазонафтиридин та тетрагідроімідазонафтиридин, фармацевтична композиція, спосіб індукування біосинтезу цитокінів та спосіб лікування вірусної інфекції, проміжні сполуки |
| WO1999036544A2 (fr) | 1998-01-14 | 1999-07-22 | Chiron S.P.A. | Antigenes du $i(neisseria meningitidis) |
| US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
| GB9807721D0 (en) | 1998-04-08 | 1998-06-10 | Chiron Spa | Antigen |
| WO1999052549A1 (fr) | 1998-04-09 | 1999-10-21 | Smithkline Beecham Biologicals S.A. | Compositions adjuvantes |
| EP2261347A3 (fr) | 1998-05-01 | 2012-01-11 | Novartis Vaccines and Diagnostics, Inc. | Antigènes de Neisseria meningitidis et compositions |
| US6589954B1 (en) | 1998-05-22 | 2003-07-08 | Scios, Inc. | Compounds and methods to treat cardiac failure and other disorders |
| AU772477B2 (en) * | 1998-08-28 | 2004-04-29 | Scios Inc. | Inhibitors of p38-alpha kinase |
| AU765401B2 (en) | 1998-09-30 | 2003-09-18 | Wrair Walter Reed Army Institute Of Research | Indolo(2,1-b)quinazole-6,12-dione antimalarial compounds and methods of treating malaria therewith |
| MXPA01003557A (es) | 1998-10-09 | 2004-04-05 | Chiron Corp | Secuencias genomicas de neisseria y metodos para su uso. |
| AU750587B2 (en) | 1998-10-16 | 2002-07-25 | Smithkline Beecham Biologicals (Sa) | Adjuvant systems and vaccines |
| AU1722300A (en) | 1998-11-12 | 2000-05-29 | Regents Of The University Of California, The | Chlamydia pneumoniae genome sequence |
| US6211177B1 (en) | 1998-11-24 | 2001-04-03 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives |
| GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
| JP2002539273A (ja) | 1999-03-19 | 2002-11-19 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | ワクチン |
| NZ513639A (en) | 1999-04-15 | 2004-02-27 | Bristol Myers Squibb Co | Cyclic protein tyrosine kinase inhibitors |
| CN1227030C (zh) | 1999-04-19 | 2005-11-16 | 史密丝克莱恩比彻姆生物有限公司 | 包含皂甙和免疫刺激寡核苷酸的佐剂组合物 |
| AU4989100A (en) | 1999-05-04 | 2000-11-17 | Susan A. Capizzi | Method and apparatus for categorizing and retrieving network pages and sites |
| US6451810B1 (en) * | 1999-06-10 | 2002-09-17 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
| EP1218358B1 (fr) | 1999-09-23 | 2006-09-13 | AstraZeneca AB | Composes therapeutiques de quinazoline |
| CO5200838A1 (es) | 1999-09-24 | 2002-09-27 | Smithkline Beecham Corp | Vacunas |
| CA2871789C (fr) | 2000-01-17 | 2017-04-04 | Novartis Vaccines And Diagnostics S.R.L. | Vaccin a base de vesicule de membrane externe (omv) comprenant des proteines de membrane externe du serogroupe b de n. meningitis |
| AT409085B (de) | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
| FR2805536B1 (fr) | 2000-02-25 | 2002-08-23 | Sanofi Synthelabo | Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant |
| DE60103136T2 (de) | 2000-03-06 | 2004-10-28 | Smithkline Beecham Plc, Brentford | Imidazolderivate als Raf-Kinase Inhibitoren |
| CA2414884A1 (fr) | 2000-07-03 | 2002-01-10 | Chiron S.P.A. | Immunisation contre une infection par chlamydia pneumoniae |
| GB0017256D0 (en) | 2000-07-13 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| DZ3415A1 (fr) | 2000-08-31 | 2002-03-07 | Chiron Corp | Guanidinobenzamides comme mc4-r agonistes. |
| JP4341949B2 (ja) | 2000-09-01 | 2009-10-14 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | アザ複素環式誘導体およびその治療的使用 |
| JP4361727B2 (ja) | 2000-09-11 | 2009-11-11 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | チロシンキナーゼインヒビターとしてのキノリノン誘導体 |
| CA2428191A1 (fr) | 2000-11-07 | 2002-05-30 | Bristol-Myers Squibb Company | Derives d'acide utiles comme inhibiteurs de serines proteases |
| AU2002232439A1 (en) | 2000-11-29 | 2002-06-11 | Glaxo Group Limited | Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors |
| US20030009034A1 (en) | 2001-03-22 | 2003-01-09 | Neil Wishart | Transition metal mediated process |
| EP1767525A1 (fr) | 2001-04-09 | 2007-03-28 | Novartis Vaccines and Diagnostics, Inc. | Composés guanidino comme agonistes du récepteur 4 de la mélanocortine (MC4-R) |
| RU2344123C9 (ru) * | 2001-04-16 | 2009-05-20 | Шеринг Корпорейшн | 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс-хемокинового рецептора |
| GB0112348D0 (en) | 2001-05-19 | 2001-07-11 | Smithkline Beecham Plc | Compounds |
| ITMI20011237A1 (it) * | 2001-06-12 | 2002-12-12 | Enzo Leone | Uso della yohimbina per la preparazione di farmaci ad attivita' immunobiologica |
| ES2193839B1 (es) * | 2001-06-22 | 2005-02-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de 6-fenildihidropirrolpirimidindiona. |
| GB0130789D0 (en) * | 2001-12-21 | 2002-02-06 | King S College London | Application of spores |
| US7338959B2 (en) * | 2002-03-01 | 2008-03-04 | Smithkline Beecham Corporation | Diamino-pyrimidines and their use as angiogenesis inhibitors |
| ATE447404T1 (de) * | 2002-03-29 | 2009-11-15 | Novartis Vaccines & Diagnostic | Substituierte benzazole und ihre verwendung als raf-kinase-hemmer |
| CA2496164C (fr) | 2002-08-23 | 2010-11-09 | Chiron Corporation | Quinolinones de benzimidazole et leurs utilisations |
| US7531553B2 (en) * | 2003-03-21 | 2009-05-12 | Amgen Inc. | Heterocyclic compounds and methods of use |
-
2004
- 2004-03-29 EP EP10180709.7A patent/EP2258365B1/fr not_active Expired - Lifetime
- 2004-03-29 EP EP04758593.0A patent/EP1608369B1/fr not_active Expired - Lifetime
- 2004-03-29 CA CA002520124A patent/CA2520124A1/fr not_active Abandoned
- 2004-03-29 WO PCT/US2004/010331 patent/WO2004087153A2/fr not_active Ceased
- 2004-03-29 US US10/814,480 patent/US7893096B2/en not_active Expired - Fee Related
- 2004-03-29 ES ES10180709T patent/ES2423800T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1608369B1 (fr) | 2013-06-26 |
| WO2004087153A2 (fr) | 2004-10-14 |
| WO2004087153A3 (fr) | 2005-03-17 |
| US7893096B2 (en) | 2011-02-22 |
| US20050136065A1 (en) | 2005-06-23 |
| EP1608369A2 (fr) | 2005-12-28 |
| EP2258365A1 (fr) | 2010-12-08 |
| EP2258365B1 (fr) | 2013-05-29 |
| ES2423800T3 (es) | 2013-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130904 |