CA2615903C - Quinoline derivatives as antibacterial agents - Google Patents

Quinoline derivatives as antibacterial agents Download PDF

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Publication number
CA2615903C
CA2615903C CA2615903A CA2615903A CA2615903C CA 2615903 C CA2615903 C CA 2615903C CA 2615903 A CA2615903 A CA 2615903A CA 2615903 A CA2615903 A CA 2615903A CA 2615903 C CA2615903 C CA 2615903C
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CA
Canada
Prior art keywords
alkyl
formula
compound
het
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2615903A
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English (en)
French (fr)
Other versions
CA2615903A1 (en
Inventor
Jerome Emile Georges Guillemont
Elisabeth Therese Jeanne Pasquier
David Francis Alain Lancois
Koenraad Jozef Lodewijk Marcel Andries
Anil Koul
Leo Jacobus Jozef Backx
Lieven Meerpoel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35744723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2615903(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CA2615903A1 publication Critical patent/CA2615903A1/en
Application granted granted Critical
Publication of CA2615903C publication Critical patent/CA2615903C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2615903A 2005-08-03 2006-07-31 Quinoline derivatives as antibacterial agents Active CA2615903C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05107164 2005-08-03
EP05107164.5 2005-08-03
PCT/EP2006/064858 WO2007014941A2 (en) 2005-08-03 2006-07-31 Quinoline derivatives as antibacterial agents

Publications (2)

Publication Number Publication Date
CA2615903A1 CA2615903A1 (en) 2007-02-08
CA2615903C true CA2615903C (en) 2016-08-30

Family

ID=35744723

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2615903A Active CA2615903C (en) 2005-08-03 2006-07-31 Quinoline derivatives as antibacterial agents

Country Status (30)

Country Link
US (1) US8802671B2 (2)
EP (1) EP1912648B1 (2)
JP (1) JP5302680B2 (2)
KR (1) KR101413997B1 (2)
CN (2) CN101277696B8 (2)
AP (1) AP2654A (2)
AR (1) AR054890A1 (2)
AU (1) AU2006274880B2 (2)
BR (1) BRPI0614493B8 (2)
CA (1) CA2615903C (2)
CY (1) CY1114318T1 (2)
DK (1) DK1912648T3 (2)
EA (1) EA014833B1 (2)
ES (1) ES2414956T3 (2)
HR (1) HRP20130540T1 (2)
IL (1) IL189142A0 (2)
JO (1) JO2855B1 (2)
ME (1) ME01616B (2)
MX (1) MX2008001603A (2)
MY (1) MY159560A (2)
NO (1) NO341242B1 (2)
NZ (1) NZ565947A (2)
PL (1) PL1912648T3 (2)
PT (1) PT1912648E (2)
RS (1) RS52808B (2)
SI (1) SI1912648T1 (2)
TW (1) TWI422374B (2)
UA (1) UA95915C2 (2)
WO (1) WO2007014941A2 (2)
ZA (1) ZA200801110B (2)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004186452A (ja) 2002-12-04 2004-07-02 Renesas Technology Corp 不揮発性半導体記憶装置およびその製造方法
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO3271B1 (ar) * 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
CA2869453C (en) 2012-04-27 2021-03-02 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
KR102110355B1 (ko) 2012-04-27 2020-05-14 얀센 파마슈티카 엔.브이. 항균성 퀴놀린 유도체
US9290476B2 (en) 2012-10-16 2016-03-22 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
CN104884448A (zh) 2012-10-16 2015-09-02 詹森药业有限公司 Rorγt的杂芳基连接的喹啉基调节剂
CN105073729A (zh) 2012-10-16 2015-11-18 詹森药业有限公司 RORγt的苯基连接的喹啉基调节剂
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
BR112016008258A2 (pt) 2013-10-15 2017-10-10 Janssen Pharmaceutica Nv moduladores de ror?t de quinolinila
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
BR112016008215A2 (pt) 2013-10-15 2017-09-26 Janssen Pharmaceutica Nv moduladores de quinolinila ligados por alquila de roryt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
CN109111397B (zh) * 2018-08-28 2021-12-10 广东工业大学 一种喹啉芳香乙烯类衍生物及其制备方法和应用
CN109111396B (zh) * 2018-08-28 2021-09-03 广东工业大学 一种喹啉芳香乙烯衍生物及其制备方法和应用
CN112110907B (zh) * 2020-10-09 2021-12-21 中央民族大学 一种含1，4-二氧六环二聚双噻吩结构的化合物及其制备方法和应用
CN112079825B (zh) * 2020-10-09 2021-12-21 中央民族大学 含1，3-二氧戊环二聚双噻吩结构的化合物及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB807750A (en) 1956-06-15 1959-01-21 Rhone Poulenc Sa Improvements in or relating to piperazine derivatives
GB9317491D0 (en) * 1993-08-23 1993-10-06 Fujisawa Pharmaceutical Co New compound and a process for preparation thereof
US5965572A (en) * 1996-10-28 1999-10-12 The United States Of America As Respresented By The Secretary Of The Army Methods for treating antibiotic-resistant infections
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
DK1527050T3 (da) * 2002-07-25 2010-07-19 Janssen Pharmaceutica Nv Quinolin-derivater og deres anvendelse som mycobakterielle inhibitorer
PL360102A3 (en) 2003-05-13 2004-11-15 "ENERGOMAR-NORD" Sp.z o.o. Method for manufacturing highly reactive calcium sorbing agents and facility designed for manufacturing highly reactive calcium sorbing agents
EA011277B1 (ru) 2004-01-23 2009-02-27 Янссен Фармацевтика Н.В. Производные хинолина и их применение в качестве ингибиторов микобактерий
AP2188A (en) 2004-01-23 2010-12-14 Janssen Pharmaceutica Nv Substituted quinolines and their use as mycobacterial inhibitors.
EA011572B9 (ru) * 2004-01-29 2018-01-31 Янссен Фармацевтика Н.В. Производные хинолина для применения в качестве микобактериальных ингибиторов
CA2528849C (en) * 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
US20070018948A1 (en) 2005-07-22 2007-01-25 Elaine Chen Apparatus for stabilizing an electronic device during data input and device control

Also Published As

Publication number Publication date
CY1114318T1 (el) 2016-08-31
EA014833B1 (ru) 2011-02-28
US20080207687A1 (en) 2008-08-28
ES2414956T3 (es) 2013-07-23
MY159560A (en) 2017-01-13
MX2008001603A (es) 2008-02-19
CN101277696B8 (zh) 2016-07-06
PT1912648E (pt) 2013-06-27
ZA200801110B (en) 2011-10-26
JO2855B1 (en) 2015-03-15
AU2006274880B2 (en) 2012-12-13
BRPI0614493B1 (pt) 2019-11-12
EP1912648A2 (en) 2008-04-23
JP2009503025A (ja) 2009-01-29
RS52808B (sr) 2013-10-31
UA95915C2 (ru) 2011-09-26
CN101277696B (zh) 2015-09-02
HK1124234A1 (zh) 2009-07-10
SI1912648T1 (sl) 2013-07-31
BRPI0614493A2 (pt) 2011-03-29
BRPI0614493B8 (pt) 2021-05-25
EP1912648B1 (en) 2013-04-10
HRP20130540T1 (en) 2013-07-31
AP2654A (en) 2013-04-25
EA200800508A1 (ru) 2008-06-30
WO2007014941A8 (en) 2007-05-31
PL1912648T3 (pl) 2013-08-30
DK1912648T3 (da) 2013-06-24
IL189142A0 (en) 2008-08-07
NZ565947A (en) 2011-05-27
KR101413997B1 (ko) 2014-07-01
NO341242B1 (no) 2017-09-25
US8802671B2 (en) 2014-08-12
KR20080035666A (ko) 2008-04-23
AU2006274880A1 (en) 2007-02-08
ME01616B (me) 2014-09-20
TW200744595A (en) 2007-12-16
JP5302680B2 (ja) 2013-10-02
WO2007014941A2 (en) 2007-02-08
TWI422374B (zh) 2014-01-11
NO20081026L (no) 2008-02-27
CA2615903A1 (en) 2007-02-08
WO2007014941A3 (en) 2007-03-29
AR054890A1 (es) 2007-07-25
CN101277696A (zh) 2008-10-01

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Legal Events

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H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20250131