CA2795158C - Formulations transdermiques empechant les abus constituees d'agonistes et d'agonistes/antagonistes d'opiaces - Google Patents

Formulations transdermiques empechant les abus constituees d'agonistes et d'agonistes/antagonistes d'opiaces Download PDF

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Publication number
CA2795158C
CA2795158C CA2795158A CA2795158A CA2795158C CA 2795158 C CA2795158 C CA 2795158C CA 2795158 A CA2795158 A CA 2795158A CA 2795158 A CA2795158 A CA 2795158A CA 2795158 C CA2795158 C CA 2795158C
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Canada
Prior art keywords
opioid
antagonist
prodrug
mil
layer
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Active
Application number
CA2795158A
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English (en)
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CA2795158A1 (fr
Inventor
Audra Lynn Stinchcomb
Guohua Li
Stan Lee Banks
Jeffery Lynn Howard
Miroslaw Jerzy Golinski
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Buzzz Pharmaceuticals Ltd
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Buzzz Pharmaceuticals Ltd
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Publication of CA2795158A1 publication Critical patent/CA2795158A1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des timbres transdermiques multi-couches empêchant les abus. Lesdits timbres comprennent des opioïdes et des promédicaments opioïdes qui possèdent une couche barrière située entre la couche contenant l'opioïde ou le promédicament opioïde et une couche contenant un antagoniste d'opioïde ou un promédicament d'antagoniste d'opioïde.
CA2795158A 2010-04-02 2011-04-04 Formulations transdermiques empechant les abus constituees d'agonistes et d'agonistes/antagonistes d'opiaces Active CA2795158C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32052610P 2010-04-02 2010-04-02
US61/320,526 2010-04-02
PCT/US2011/031135 WO2011123866A1 (fr) 2010-04-02 2011-04-04 Formulations transdermiques empêchant les abus constituées d'agonistes et d'agonistes/antagonistes d'opiacés

Publications (2)

Publication Number Publication Date
CA2795158A1 CA2795158A1 (fr) 2011-10-06
CA2795158C true CA2795158C (fr) 2019-10-22

Family

ID=44121770

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2795158A Active CA2795158C (fr) 2010-04-02 2011-04-04 Formulations transdermiques empechant les abus constituees d'agonistes et d'agonistes/antagonistes d'opiaces

Country Status (6)

Country Link
US (1) US8481560B2 (fr)
EP (2) EP3064199B1 (fr)
JP (2) JP2013523780A (fr)
CA (1) CA2795158C (fr)
ES (1) ES2592277T3 (fr)
WO (1) WO2011123866A1 (fr)

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Also Published As

Publication number Publication date
JP2016053085A (ja) 2016-04-14
US20110245783A1 (en) 2011-10-06
EP2552425A1 (fr) 2013-02-06
US8481560B2 (en) 2013-07-09
WO2011123866A1 (fr) 2011-10-06
EP3064199A1 (fr) 2016-09-07
EP2552425B1 (fr) 2016-07-27
JP2013523780A (ja) 2013-06-17
ES2592277T3 (es) 2016-11-29
CA2795158A1 (fr) 2011-10-06
JP6212104B2 (ja) 2017-10-11
EP3064199B1 (fr) 2023-12-20

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