CA2804337A1 - Compositions seches et dispositifs les contenant destines a etre utilises dans la therapie photodynamique ou le diagnostic photodynamique - Google Patents

Compositions seches et dispositifs les contenant destines a etre utilises dans la therapie photodynamique ou le diagnostic photodynamique Download PDF

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Publication number
CA2804337A1
CA2804337A1 CA2804337A CA2804337A CA2804337A1 CA 2804337 A1 CA2804337 A1 CA 2804337A1 CA 2804337 A CA2804337 A CA 2804337A CA 2804337 A CA2804337 A CA 2804337A CA 2804337 A1 CA2804337 A1 CA 2804337A1
Authority
CA
Canada
Prior art keywords
pharmaceutical composition
ala
dry pharmaceutical
polymers
irradiation device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2804337A
Other languages
English (en)
Inventor
Bjorn Klem
Norbert Lange
Morten Groseth
Original Assignee
Photocure ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure ASA filed Critical Photocure ASA
Publication of CA2804337A1 publication Critical patent/CA2804337A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des compositions pharmaceutiques sèches contenant un principe actif qui est de l'acide 5-aminolévulinique (5-ALA) ou un précurseur ou un dérivé de 5-ALA, ou un sel pharmaceutiquement acceptable de celui-ci. Ces compositions peuvent être utilisées dans la thérapie photodynamique (TPD) ou le diagnostic photodynamique (DPD) du cancer, des états précancéreux et des états non cancéreux. L'invention concerne également des dispositifs d'irradiation contenant ces compositions sèches, ainsi que l'utilisation de ces dispositifs dans la thérapie ou le diagnostic photodynamique du cancer, des états précancéreux et des états non cancéreux.
CA2804337A 2010-07-09 2011-07-08 Compositions seches et dispositifs les contenant destines a etre utilises dans la therapie photodynamique ou le diagnostic photodynamique Abandoned CA2804337A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10251232.4 2010-07-09
EP10251232 2010-07-09
PCT/EP2011/061688 WO2012004399A1 (fr) 2010-07-09 2011-07-08 Compositions sèches et dispositifs les contenant destinés à être utilisés dans la thérapie photodynamique ou le diagnostic photodynamique

Publications (1)

Publication Number Publication Date
CA2804337A1 true CA2804337A1 (fr) 2012-01-12

Family

ID=44628087

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2804337A Abandoned CA2804337A1 (fr) 2010-07-09 2011-07-08 Compositions seches et dispositifs les contenant destines a etre utilises dans la therapie photodynamique ou le diagnostic photodynamique

Country Status (9)

Country Link
US (1) US20130178787A1 (fr)
EP (1) EP2590714B1 (fr)
JP (1) JP5991970B2 (fr)
KR (1) KR101842732B1 (fr)
AU (1) AU2011275695B2 (fr)
BR (1) BR112013000613A2 (fr)
CA (1) CA2804337A1 (fr)
ES (1) ES2620780T3 (fr)
WO (1) WO2012004399A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2766049A1 (fr) 2011-10-14 2014-08-20 Photocure ASA Diagnostic photodynamique d'anomalies du tissu épithélial sous-jacent de l' sophage au moyen d'un ester de 5-ala
CN102670577B (zh) * 2012-05-18 2018-04-13 上海复旦张江生物医药股份有限公司 一种光敏剂组合物、其使用方法及用途
US20140067024A1 (en) 2012-08-30 2014-03-06 Photocure Asa Dual panel photodynamic therapy lamp
GB201221123D0 (en) 2012-11-23 2013-01-09 Photocure As Device for photodynamic treatment
GB201306369D0 (en) 2013-04-09 2013-05-22 Photocure As Irradiation device
WO2014204001A1 (fr) * 2013-06-21 2014-12-24 国立大学法人 岡山大学 Procédé utilisant la détection de cellules activées anormalement pour tester des tumeurs malignes et appareil thérapeutique d'aphérèse de cellules activées anormalement
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
DK3641882T3 (da) * 2017-06-21 2023-12-18 Photocure Asa Fremgangsmåde til fremstilling af en flydende farmaceutisk sammensætning og indretning til anvendelse i en sådan fremgangsmåde
US20250188521A1 (en) * 2022-03-10 2025-06-12 Singular Genomics Systems, Inc. Nucleic acid delivery scaffolds

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4659096A (en) * 1995-01-30 1996-08-21 Angiomedics Ii Incorporated Photolytic drug delivery systems
HU225148B1 (en) 1995-03-10 2006-07-28 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy or diagnosis, products and kits comprising thereof and method of in vitro diagnosis by their using
GB2360459B (en) * 2000-03-23 2002-08-07 Photo Therapeutics Ltd Therapeutic light source and method
US6551346B2 (en) * 2000-05-17 2003-04-22 Kent Crossley Method and apparatus to prevent infections
GB0018527D0 (en) 2000-07-27 2000-09-13 Photocure Asa Composition
GB0018528D0 (en) 2000-07-27 2000-09-13 Photocure Asa Compounds
GB0118251D0 (en) 2001-07-26 2001-09-19 Photocure Asa Method
EP1423116A1 (fr) * 2001-08-14 2004-06-02 Biotie Therapies Corp. Traitement de l'alcoolisme ou de l'abus d'alcool
EP1312353A1 (fr) 2001-11-16 2003-05-21 Ecole Polytechnique Federale De Lausanne (Epfl) Méthode d'épilation
DE10202487A1 (de) * 2002-01-23 2003-07-31 Photonamic Gmbh & Co Kg Dermales Applikationssystem für Aminolävulinsäure-Derivate
US20050085455A1 (en) * 2003-10-16 2005-04-21 Light Sciences Corporation Photodynamic therapy for local adipocyte reduction
CA2457214A1 (fr) * 2004-02-06 2005-08-06 Qlt Inc. Therapie photodynamique pour le traitement de l'acne
GB0406917D0 (en) 2004-03-26 2004-04-28 Photocure Asa Compounds
GB0424833D0 (en) 2004-11-10 2004-12-15 Photocure Asa Method
JP2008526418A (ja) 2005-01-18 2008-07-24 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 放射線を放出するための電子制御されるカプセル
US20090319008A1 (en) * 2005-03-31 2009-12-24 Esther Mayer Probe device, system and method for photobiomodulation of tissue lining a body cavity
US20070260231A1 (en) * 2005-04-21 2007-11-08 Ondine International, Ltd. Optical probe for delivery of light
DE102006001736A1 (de) * 2006-01-13 2007-07-26 Margull, Matthias, Dipl.-Ing. Vorrichtung zur Applikation von monochromatischem Licht in Körperöffnungen
GB0608315D0 (en) * 2006-04-27 2006-06-07 Univ St Andrews Light emitting device for use in therapeutic and/or cosmetic treatment
US8292935B2 (en) * 2006-09-12 2012-10-23 Bistitec Pharma Marketing Ltd Photonic device and method for treating cervical dysplasia
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use
GB0816027D0 (en) * 2008-09-03 2008-10-08 Lumicure Ltd Controlled light emitting apparatus
GB0823472D0 (en) 2008-12-23 2009-01-28 Photocure Asa Product
GB0900461D0 (en) 2009-01-12 2009-02-11 Photocure Asa Photodynamic therapy device
SI2440199T1 (sl) 2009-06-11 2016-05-31 Photocure Asa Poltrdni sestavki in farmacevtski proizvodi

Also Published As

Publication number Publication date
CN103118742A (zh) 2013-05-22
BR112013000613A2 (pt) 2016-06-28
EP2590714B1 (fr) 2017-03-08
KR101842732B1 (ko) 2018-05-14
WO2012004399A1 (fr) 2012-01-12
AU2011275695A1 (en) 2013-02-14
US20130178787A1 (en) 2013-07-11
JP2013532035A (ja) 2013-08-15
JP5991970B2 (ja) 2016-09-14
AU2011275695B2 (en) 2014-07-31
KR20130083436A (ko) 2013-07-22
EP2590714A1 (fr) 2013-05-15
ES2620780T3 (es) 2017-06-29

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160620

FZDE Discontinued

Effective date: 20190709