CA2824432C - Aerosol pirfenidone and pyridone analog compounds and uses thereof - Google Patents

Aerosol pirfenidone and pyridone analog compounds and uses thereof Download PDF

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Publication number
CA2824432C
CA2824432C CA2824432A CA2824432A CA2824432C CA 2824432 C CA2824432 C CA 2824432C CA 2824432 A CA2824432 A CA 2824432A CA 2824432 A CA2824432 A CA 2824432A CA 2824432 C CA2824432 C CA 2824432C
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CA
Canada
Prior art keywords
pyridone analog
pirfenidone
formulations
analog compounds
aerosol pirfenidone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
CA2824432A
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English (en)
French (fr)
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CA2824432A1 (en
Inventor
Mark William Surber
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Avalyn Pharma Inc
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Avalyn Pharma Inc
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Publication date
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Publication of CA2824432A1 publication Critical patent/CA2824432A1/en
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Publication of CA2824432C publication Critical patent/CA2824432C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2824432A 2011-01-31 2012-01-31 Aerosol pirfenidone and pyridone analog compounds and uses thereof Active CA2824432C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161438203P 2011-01-31 2011-01-31
US61/438,203 2011-01-31
US201161508542P 2011-07-15 2011-07-15
US61/508,542 2011-07-15
US201161559670P 2011-11-14 2011-11-14
US61/559,670 2011-11-14
US201261584119P 2012-01-06 2012-01-06
US61/584,119 2012-01-06
PCT/US2012/023406 WO2012106382A1 (en) 2011-01-31 2012-01-31 Aerosol pirfenidone and pyridone analog compounds and uses thereof

Publications (2)

Publication Number Publication Date
CA2824432A1 CA2824432A1 (en) 2012-08-09
CA2824432C true CA2824432C (en) 2021-10-19

Family

ID=46576305

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2824432A Active CA2824432C (en) 2011-01-31 2012-01-31 Aerosol pirfenidone and pyridone analog compounds and uses thereof

Country Status (10)

Country Link
US (3) US10092552B2 (2)
EP (2) EP4059499A1 (2)
JP (7) JP6021117B2 (2)
AU (2) AU2012212269B2 (2)
CA (1) CA2824432C (2)
DK (1) DK2670242T3 (2)
ES (1) ES2913095T3 (2)
HU (1) HUE058753T2 (2)
LT (1) LT2670242T (2)
WO (1) WO2012106382A1 (2)

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