CA2863339A1 - Formes et sel d'une dihydropyrrolo[1,2-c]imidazolyl aldosterone synthaseou d'un inhibiteur d'aromatase - Google Patents
Formes et sel d'une dihydropyrrolo[1,2-c]imidazolyl aldosterone synthaseou d'un inhibiteur d'aromatase Download PDFInfo
- Publication number
- CA2863339A1 CA2863339A1 CA2863339A CA2863339A CA2863339A1 CA 2863339 A1 CA2863339 A1 CA 2863339A1 CA 2863339 A CA2863339 A CA 2863339A CA 2863339 A CA2863339 A CA 2863339A CA 2863339 A1 CA2863339 A1 CA 2863339A1
- Authority
- CA
- Canada
- Prior art keywords
- salt
- phosphate salt
- dihydro
- fluoro
- benzonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention concerne un sel de phosphate ou un sel de nitrate de 4- (R) -6,7-dihydro -5 H-pyrrolo [l, 2-c] imidazole -5-yl -3-fluoro-benzonitrile ayant la formule suivante: notamment sous forme cristalline, et les formes spécifiques de ces sels ainsi que des modes de réalisation de l'invention. Les sels et les formes de sels permettent le traitement prophylactique et/ou thérapeutique de l'aldostérone synthase et/ou des maladies ou troubles médiées de l'aromatase telle que la maladie de Cushing.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261587280P | 2012-01-17 | 2012-01-17 | |
| US61/587,280 | 2012-01-17 | ||
| PCT/US2013/021521 WO2013109514A1 (fr) | 2012-01-17 | 2013-01-15 | Nouvelles formes et sels d'un inhibiteur de l'aldostérone synthase imidazole dihydropyrrolo [1,2-c] ou ou de l'inhibiteur de l'aromatase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2863339A1 true CA2863339A1 (fr) | 2013-07-25 |
| CA2863339C CA2863339C (fr) | 2021-03-23 |
Family
ID=47604250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2863339A Active CA2863339C (fr) | 2012-01-17 | 2013-01-15 | Formes et sel d'une dihydropyrrolo[1,2-c]imidazolyl aldosterone synthaseou d'un inhibiteur d'aromatase |
Country Status (40)
| Country | Link |
|---|---|
| US (2) | US9334276B2 (fr) |
| EP (1) | EP2804863B1 (fr) |
| JP (1) | JP5749410B2 (fr) |
| KR (2) | KR20140093726A (fr) |
| CN (1) | CN104039793B (fr) |
| AP (1) | AP2014007762A0 (fr) |
| AR (1) | AR089728A1 (fr) |
| AU (1) | AU2013209952B2 (fr) |
| BR (1) | BR112014017260A8 (fr) |
| CA (1) | CA2863339C (fr) |
| CL (1) | CL2014001863A1 (fr) |
| CO (1) | CO7000775A2 (fr) |
| CR (1) | CR20140345A (fr) |
| CU (1) | CU20140086A7 (fr) |
| CY (1) | CY1117914T1 (fr) |
| DK (1) | DK2804863T3 (fr) |
| EA (1) | EA026232B1 (fr) |
| ES (1) | ES2564143T3 (fr) |
| GT (1) | GT201400155A (fr) |
| HR (1) | HRP20160178T1 (fr) |
| HU (1) | HUE026984T2 (fr) |
| IL (1) | IL233541B (fr) |
| IN (1) | IN2014DN06781A (fr) |
| JO (1) | JO3137B1 (fr) |
| MA (1) | MA35858B1 (fr) |
| MX (1) | MX2014008686A (fr) |
| NZ (1) | NZ626277A (fr) |
| PE (1) | PE20142358A1 (fr) |
| PH (1) | PH12014501638A1 (fr) |
| PL (1) | PL2804863T3 (fr) |
| RS (1) | RS54589B1 (fr) |
| SG (1) | SG11201404061YA (fr) |
| SI (1) | SI2804863T1 (fr) |
| SM (1) | SMT201600083B (fr) |
| TN (1) | TN2014000256A1 (fr) |
| TW (1) | TWI609869B (fr) |
| UA (1) | UA114803C2 (fr) |
| UY (1) | UY34576A (fr) |
| WO (1) | WO2013109514A1 (fr) |
| ZA (1) | ZA201404314B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011205290C1 (en) * | 2010-01-14 | 2014-11-06 | Recordati Ag | Use of an adrenal hormone-modifying agent |
| EP2815749A1 (fr) | 2013-06-20 | 2014-12-24 | IP Gesellschaft für Management mbH | Forme solide de 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione ayant un réseau de diffraction de rayons X spécifique |
| SI3166596T1 (sl) * | 2014-07-07 | 2018-10-30 | Novartis Ag | Farmacevtske odmerne oblike |
| HUE054248T2 (hu) | 2015-01-29 | 2021-08-30 | Recordati Ag | Eljárás kondenzált imidazo-származékok elõállítására |
| US20160287565A1 (en) * | 2015-04-06 | 2016-10-06 | Millendo Therapeutics, Inc. | Combination therapy for treating disorders associated with excess cortisol production |
| EP3532056A1 (fr) * | 2016-10-27 | 2019-09-04 | Damian Pharma AG | Inhibiteur de l'aldostérone synthase |
| WO2018078049A1 (fr) * | 2016-10-27 | 2018-05-03 | Damian Pharma Ag | Inhibiteur de l'aldostérone synthase |
| WO2019211394A1 (fr) | 2018-05-03 | 2019-11-07 | Damian Pharma Ag | R-fadrozole destiné à être utilisé dans le traitement de l'aldostéronisme |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1315449A (en) * | 1918-11-15 | 1919-09-09 | Frank B Yingling | Shaper-feed. |
| US4617307A (en) | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
| US5066656A (en) | 1989-11-01 | 1991-11-19 | Janssen Pharmaceutica N.V. | Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives |
| MTP1076B (en) | 1990-01-12 | 1991-09-30 | Ciba Geigy Ag | Hemihydrate |
| CA2127689A1 (fr) | 1992-01-27 | 1993-08-05 | Marcel A. C. Janssen | Derives 1h-benzimidazole a substituants pyrroloimidazolyl et imidazopyridinyl utilises comme inhibiteurs de l'aromatase |
| CA2505752A1 (fr) | 2002-11-18 | 2004-06-03 | Novartis Ag | Derives d'imidazo[1,5a]pyridine et methodes de traitement des maladies mediees par l'aldosterone |
| GT200600381A (es) * | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| CN101578272A (zh) | 2006-12-18 | 2009-11-11 | 诺瓦提斯公司 | 1-取代的咪唑衍生物和它们作为醛固酮合酶抑制剂的用途 |
| US8575160B2 (en) | 2009-11-30 | 2013-11-05 | Novartis Ag | Imidazole derivatives as aldosterone synthase inhibitors |
| AU2011205290C1 (en) * | 2010-01-14 | 2014-11-06 | Recordati Ag | Use of an adrenal hormone-modifying agent |
-
2013
- 2013-01-15 IN IN6781DEN2014 patent/IN2014DN06781A/en unknown
- 2013-01-15 JP JP2014552375A patent/JP5749410B2/ja active Active
- 2013-01-15 UA UAA201406492A patent/UA114803C2/uk unknown
- 2013-01-15 HR HRP20160178T patent/HRP20160178T1/hr unknown
- 2013-01-15 SI SI201330142A patent/SI2804863T1/sl unknown
- 2013-01-15 ES ES13701194.6T patent/ES2564143T3/es active Active
- 2013-01-15 DK DK13701194.6T patent/DK2804863T3/en active
- 2013-01-15 PE PE2014001112A patent/PE20142358A1/es not_active Application Discontinuation
- 2013-01-15 JO JOP/2013/0014A patent/JO3137B1/ar active
- 2013-01-15 AU AU2013209952A patent/AU2013209952B2/en active Active
- 2013-01-15 TW TW102101537A patent/TWI609869B/zh not_active IP Right Cessation
- 2013-01-15 BR BR112014017260A patent/BR112014017260A8/pt not_active Application Discontinuation
- 2013-01-15 AR ARP130100119A patent/AR089728A1/es unknown
- 2013-01-15 NZ NZ626277A patent/NZ626277A/en not_active IP Right Cessation
- 2013-01-15 UY UY0001034576A patent/UY34576A/es not_active Application Discontinuation
- 2013-01-15 RS RS20160109A patent/RS54589B1/sr unknown
- 2013-01-15 EA EA201491374A patent/EA026232B1/ru not_active IP Right Cessation
- 2013-01-15 KR KR1020147016954A patent/KR20140093726A/ko not_active Ceased
- 2013-01-15 WO PCT/US2013/021521 patent/WO2013109514A1/fr not_active Ceased
- 2013-01-15 MX MX2014008686A patent/MX2014008686A/es unknown
- 2013-01-15 CA CA2863339A patent/CA2863339C/fr active Active
- 2013-01-15 HU HUE13701194A patent/HUE026984T2/en unknown
- 2013-01-15 AP AP2014007762A patent/AP2014007762A0/xx unknown
- 2013-01-15 PL PL13701194T patent/PL2804863T3/pl unknown
- 2013-01-15 US US14/370,124 patent/US9334276B2/en active Active
- 2013-01-15 EP EP13701194.6A patent/EP2804863B1/fr active Active
- 2013-01-15 CN CN201380005054.0A patent/CN104039793B/zh active Active
- 2013-01-15 SG SG11201404061YA patent/SG11201404061YA/en unknown
- 2013-01-15 KR KR20147030158A patent/KR20140141687A/ko not_active Ceased
-
2014
- 2014-06-11 ZA ZA2014/04314A patent/ZA201404314B/en unknown
- 2014-06-12 TN TNP2014000256A patent/TN2014000256A1/en unknown
- 2014-07-07 IL IL233541A patent/IL233541B/en active IP Right Grant
- 2014-07-08 CO CO14146898A patent/CO7000775A2/es unknown
- 2014-07-11 MA MA37199A patent/MA35858B1/fr unknown
- 2014-07-15 CU CU2014000086A patent/CU20140086A7/es unknown
- 2014-07-15 CL CL2014001863A patent/CL2014001863A1/es unknown
- 2014-07-17 PH PH12014501638A patent/PH12014501638A1/en unknown
- 2014-07-17 CR CR20140345A patent/CR20140345A/es unknown
- 2014-07-17 GT GT201400155A patent/GT201400155A/es unknown
-
2016
- 2016-02-09 US US15/018,953 patent/US20160176883A1/en not_active Abandoned
- 2016-02-26 CY CY20161100163T patent/CY1117914T1/el unknown
- 2016-03-23 SM SM201600083T patent/SMT201600083B/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20171122 |
|
| H11 | Ip right ceased following rejected request for revival |
Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED Effective date: 20250715 |
|
| H13 | Ip right lapsed |
Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-H100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE AND LATE FEE NOT PAID BY DEADLINE OF NOTICE Effective date: 20251106 |